Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Exchange Traded Concepts, LLC | 18,070 | $1.18M | 0.01% | +9,268+105.3% | Added |
| Legato Capital Management LLC | 17,300 | $1.13M | 0.12% | +17,300 | New |
| Graham Capital Management, L.P. | 17,163 | $1.12M | 0.04% | −3,772−18.0% | Reduced |
| North Star Asset Management Inc | 16,610 | $1.09M | 0.04% | 00.0% | Unchanged |
| Point72 (DIFC) Ltd | 15,698 | $1.03M | 0.07% | +7,611+94.1% | Added |
| Diversified Trust Co | 15,633 | $1.02M | 0.02% | +15,633 | New |
| Public Employees Retirement Association of Colorado | 15,589 | $1.02M | 0.00% | 00.0% | Unchanged |
| Davy Global Fund Management Ltd | 15,284 | $999.9K | 0.07% | +2,021+15.2% | Added |
| Significant Wealth Partners LLC | 14,967 | $979.1K | 0.48% | −537−3.5% | Reduced |
| Dynasty Wealth Management, LLC | 14,341 | $938.2K | 0.01% | +14,341 | New |
| Brown Advisory Inc | 14,026 | $917.6K | 0.00% | +1,835+15.1% | Added |
| Bleakley Financial Group, LLC | 13,878 | $907.9K | 0.02% | −4,251−23.4% | Reduced |
| Aigen Investment Management, LP | 13,578 | $888.3K | 0.14% | +5,280+63.6% | Added |
| Fieldview Capital Management, LLC | 13,523 | $884.7K | 0.14% | −3,783−21.9% | Reduced |
| Commonwealth Equity Services, LLC | 13,349 | $873.0K | 0.00% | −593−4.3% | Reduced |
| Westmount Partners, LLC | 12,961 | $852.8K | 0.22% | 00.0% | Unchanged |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $837.4K | 0.17% | 00.0% | Unchanged |
| Northwestern Mutual Wealth Management Co | 12,782 | $836.2K | 0.00% | +538+4.4% | Added |
| Wiley Bros.-Aintree Capital, LLC | 12,663 | $828.4K | 0.01% | +905+7.7% | Added |
| Virtus Investment Advisers, Inc. | 12,476 | $816.2K | 0.23% | 00.0% | Unchanged |
| Horizon Kinetics Asset Management LLC | 12,476 | $816.2K | 0.01% | +524+4.4% | Added |
| NEOS Investment Management LLC | 12,306 | $805.1K | 0.01% | −15,855−56.3% | Reduced |
| Tema ETFs LLC | 12,306 | $805.1K | 0.07% | −15,855−56.3% | Reduced |
| Amalgamated Bank | 12,195 | $798.0K | 0.01% | +669+5.8% | Added |
| The PNC Financial Services Group, Inc. | 12,113 | $792.4K | 0.00% | +702+6.2% | Added |
| JustInvest LLC | 12,090 | $790.9K | 0.01% | +18+0.1% | Added |
| Vident Advisory, LLC | 11,551 | $755.7K | 0.01% | −449−3.7% | Reduced |
| Allianz Asset Management GmbH | 11,500 | $752.3K | 0.00% | +11,500 | New |
| Blueshift Asset Management, LLC | 11,460 | $749.7K | 0.23% | +11,460 | New |
| Plancorp, LLC | 11,208 | $733.2K | 0.02% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 10,800 | $706.5K | 0.02% | 00.0% | Unchanged |
| Capstone Investment Advisors, LLC | 10,402 | $680.5K | 0.01% | +10,402 | New |
| Baader Bank INC | 10,228 | $668.4K | 0.06% | +10,228 | New |
| Jefferies Financial Group Inc. | 10,169 | $665.3K | 0.01% | −12,212−54.6% | Reduced |
| Gsa Capital Partners LLP | 10,172 | $665.0K | 0.06% | +10,172 | New |
| Cypress Capital, LLC | 10,000 | $654.2K | 0.19% | 00.0% | Unchanged |
| denkapparat Operations GmbH | 9,968 | $652.1K | 0.42% | +9,968 | New |
| Thrivent Financial for Lutherans | 9,962 | $652.0K | 0.00% | +9,962 | New |
| Brinker Capital Investments, LLC | 9,962 | $651.7K | 0.01% | +4,362+77.9% | Added |
| Advisor Group Holdings, Inc. | 10,167 | $618.0K | 0.00% | +4,871+92.0% | Added |
| MetLife Investment Management | 9,428 | $616.8K | 0.00% | +267+2.9% | Added |
| Prudential Financial Inc | 9,344 | $611.3K | 0.00% | +90+1.0% | Added |
| DnB Asset Management AS | 9,308 | $608.9K | 0.00% | −2,963−24.1% | Reduced |
| Sectoral Asset Management Inc | 9,205 | $602.2K | 0.37% | 00.0% | Unchanged |
| Utah Retirement Systems | 8,300 | $543.0K | 0.01% | −100−1.2% | Reduced |
| Maryland State Retirement & Pension System | 8,284 | $541.9K | 0.01% | 00.0% | Unchanged |
| Empire Financial Management Company, LLC | 8,000 | $523.4K | 0.12% | +8,000 | New |
| Fifth Third Bancorp | 7,944 | $519.7K | 0.00% | +346+4.6% | Added |
| Wealth Enhancement Advisory Services, LLC | 7,439 | $512.8K | 0.00% | −476−6.0% | Reduced |
| Stratos Wealth Partners, LTD. | 7,764 | $507.9K | 0.01% | +7,764 | New |
| Inceptionr LLC | 7,621 | $498.6K | 0.12% | +7,621 | New |
| Commerce Bank | 7,607 | $497.6K | 0.00% | 00.0% | Unchanged |
| Savant Capital, LLC | 7,237 | $473.4K | 0.00% | +1,667+29.9% | Added |
| Silvercrest Asset Management Group LLC | 7,118 | $465.7K | 0.00% | +50+0.7% | Added |
| Atria Investments LLC | 7,030 | $459.9K | 0.01% | −1,156−14.1% | Reduced |
| Cetera Investment Advisers | 6,873 | $449.7K | 0.00% | +6,873 | New |
| Swiss Life Asset Management Ltd | 6,827 | $446.6K | 0.00% | +6,827 | New |
| Everence Capital Management Inc | 6,770 | $443.0K | 0.03% | 00.0% | Unchanged |
| Meeder Advisory Services, Inc. | 6,770 | $442.9K | 0.02% | +126+1.9% | Added |
| Marex Group plc | 6,722 | $439.8K | 0.01% | −76,639−91.9% | Reduced |
| AQR Capital Management LLC | 6,815 | $438.7K | 0.00% | +6,815 | New |
| Jones Financial Companies LLLP | 6,834 | $438.0K | 0.00% | −362−5.0% | Reduced |
| Franklin Resources Inc | 6,593 | $431.3K | 0.00% | +1,037+18.7% | Added |
| CI Private Wealth, LLC | 6,590 | $431.1K | 0.00% | −231,250−97.2% | Reduced |
| Fiduciary Trust Co | 6,377 | $417.2K | 0.00% | −2,174−25.4% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 6,431 | $412.5K | 0.00% | −640−9.1% | Reduced |
| Fisher Asset Management, LLC | 6,210 | $406.3K | 0.00% | +6,210 | New |
| Summit Trail Advisors, LLC | 6,205 | $405.9K | 0.01% | +6,205 | New |
| Mirae Asset Global Investments Co., Ltd. | 6,162 | $403.1K | 0.00% | +14+0.2% | Added |
| PEAK6 LLC | 6,112 | $399.8K | 0.01% | +6,112 | New |
| M&T Bank Corp | 6,010 | $392.7K | 0.00% | −1,641−21.4% | Reduced |
| Frank, Rimerman Advisors LLC | 5,765 | $377.1K | 0.02% | +20.0% | Added |
| ProShare Advisors LLC | 5,678 | $371.5K | 0.00% | −265−4.5% | Reduced |
| Wedmont Private Capital | 5,363 | $369.7K | 0.01% | +81+1.5% | Added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 5,463 | $357.4K | 0.52% | +5,463 | New |
| HighTower Advisors, LLC | 5,458 | $357.1K | 0.00% | +101+1.9% | Added |
| Advisors Asset Management, Inc. | 5,454 | $356.8K | 0.01% | −545−9.1% | Reduced |
| Edgestream Partners, L.P. | 5,450 | $356.5K | 0.01% | +5,450 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 5,407 | $353.7K | 0.00% | +9+0.2% | Added |
| O'Shaughnessy Asset Management, LLC | 5,297 | $346.5K | 0.00% | +5,297 | New |
| SG Americas Securities, LLC | 5,150 | $337.0K | 0.00% | +5,150 | New |
| Pinnacle Wealth Planning Services, Inc. | 5,113 | $334.5K | 0.04% | −171−3.2% | Reduced |
| International Assets Investment Management, LLC | 8,207 | $327.8K | 0.03% | 00.0% | Unchanged |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $327.1K | 0.04% | 00.0% | Unchanged |
| Kestra Advisory Services, LLC | 4,972 | $325.3K | 0.00% | +4,972 | New |
| GWM Advisors LLC | 4,822 | $315.5K | 0.00% | +4,626+2,360.2% | Added |
| Truist Financial Corp | 4,812 | $314.8K | 0.00% | +4,812 | New |
| Farallon Capital Management, L.L.C. | 4,800 | $314.0K | 0.00% | +4,800 | New |
| Group One Trading, L.P. | 4,796 | $313.8K | 0.01% | +4,796 | New |
| Principal Financial Group Inc | 4,785 | $313.0K | 0.00% | −3,166−39.8% | Reduced |
| Requisite Capital Management, LLC | 4,734 | $309.7K | 0.05% | +4,734 | New |
| Credit Agricole S A | 4,710 | $308.1K | 0.00% | +4,710 | New |
| US Bancorp | 4,704 | $307.7K | 0.00% | +419+9.8% | Added |
| KBC Group NV | 4,699 | $307.0K | 0.00% | 00.0% | Unchanged |
| CIBC Asset Management Inc | 4,608 | $301.5K | 0.00% | +4,608 | New |
| Prospera Financial Services Inc | 4,581 | $299.7K | 0.01% | +4,581 | New |
| Brevan Howard Capital Management LP | 4,516 | $295.4K | 0.00% | −28,216−86.2% | Reduced |
| Coldstream Capital Management Inc | 4,479 | $293.0K | 0.00% | +4,479 | New |
| Perbak Capital Partners LLP | 4,426 | $289.5K | 0.05% | −5,112−53.6% | Reduced |
| Checchi Capital Advisers, LLC | 4,233 | $276.9K | 0.02% | +4,233 | New |