Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Pitcairn Co | 4,075 | $266.6K | 0.02% | +4,075 | New |
| Prime Capital Investment Advisors, LLC | 3,934 | $257.4K | 0.00% | +3,934 | New |
| Regions Financial Corp | 3,800 | $248.6K | 0.00% | +3,800 | New |
| Mercer Global Advisors Inc | 3,747 | $245.1K | 0.00% | +3,747 | New |
| STRS Ohio | 3,716 | $243.1K | 0.00% | +2+0.1% | Added |
| Nwam LLC | 3,238 | $238.2K | 0.01% | +3,238 | New |
| Sanctuary Advisors, LLC | 3,637 | $237.9K | 0.00% | +3,637 | New |
| Berkshire Asset Management LLC | 3,614 | $236.4K | 0.01% | +3,614 | New |
| Mackenzie Financial Corp | 3,588 | $234.7K | 0.00% | +3,588 | New |
| Resources Investment Advisors, LLC. | 3,588 | $234.7K | 0.00% | +3,588 | New |
| PharVision Advisers, LLC | 3,587 | $234.7K | 0.13% | +3,587 | New |
| Mitchell & Pahl Private Wealth, LLC | 3,572 | $233.7K | 0.10% | +3,572 | New |
| Bank of Nova Scotia | 3,509 | $229.6K | 0.00% | +3,509 | New |
| Massar Capital Management, LP | 3,462 | $226.5K | 0.08% | +3,462 | New |
| EntryPoint Capital, LLC | 3,458 | $226.2K | 0.09% | +3,458 | New |
| GF Fund Management Co. Ltd. | 3,429 | $224.3K | 0.00% | −613−15.2% | Reduced |
| Victrix Investment Advisors | 3,400 | $222.4K | 0.12% | +3,400 | New |
| Anb Bank | 3,231 | $211.4K | 0.09% | +3,231 | New |
| Raab & Moskowitz Asset Management LLC | 3,115 | $203.8K | 0.05% | +3,115 | New |
| Westfield Capital Management Co LP | 3,093 | $202.3K | 0.00% | −6,468−67.6% | Reduced |
| Voleon Capital Management LP | 3,060 | $200.2K | 0.00% | +3,060 | New |
| Point72 Europe (London) LLP | 3,051 | $199.6K | 0.01% | +3,051 | New |
| Tower Research Capital LLC (TRC) | 3,045 | $199.2K | 0.01% | +1,464+92.6% | Added |
| CWM, LLC | 2,488 | $163.0K | 0.00% | +170+7.3% | Added |
| Rockefeller Capital Management L.P. | 2,203 | $144.1K | 0.00% | +2,203 | New |
| Comerica Bank | 2,187 | $143.1K | 0.00% | +570+35.3% | Added |
| Ancora Advisors, LLC | 2,137 | $139.8K | 0.00% | +137+6.9% | Added |
| Signaturefd, LLC | 2,003 | $131.0K | 0.00% | −27−1.3% | Reduced |
| Parallel Advisors, LLC | 1,877 | $122.8K | 0.00% | +5+0.3% | Added |
| Harvest Fund Management Co., Ltd | 1,746 | $114.0K | 0.00% | −83−4.5% | Reduced |
| Abich Financial Wealth Management LLC | 1,708 | $111.7K | 0.04% | +1,708 | New |
| Twin Lakes Capital Management, LLC | 1,500 | $98.1K | 0.05% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 1,465 | $95.8K | 0.01% | 00.0% | Unchanged |
| Ci Investments Inc. | 1,453 | $95.0K | 0.00% | −963−39.9% | Reduced |
| Danske Bank A/S | 1,400 | $91.6K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 1,341 | $87.7K | 0.00% | +411+44.2% | Added |
| Root Financial Partners, LLC | 1,340 | $87.7K | 0.01% | +1,340 | New |
| Manchester Capital Management LLC | 1,248 | $81.6K | 0.01% | 00.0% | Unchanged |
| Wexford Capital LP | 1,192 | $78.0K | 0.02% | −3,557−74.9% | Reduced |
| Itau Unibanco Holding S.A. | 1,121 | $73.3K | 0.00% | −3−0.3% | Reduced |
| Larson Financial Group LLC | 1,110 | $72.6K | 0.00% | +83+8.1% | Added |
| IFP Advisors, Inc | 1,070 | $70.0K | 0.00% | +166+18.4% | Added |
| Steward Partners Investment Advisory, LLC | 1,069 | $69.9K | 0.00% | −152−12.4% | Reduced |
| Sunbelt Securities, Inc. | 1,014 | $66.3K | 0.00% | 00.0% | Unchanged |
| Toronto Dominion Bank | 951 | $62.2K | 0.00% | +951 | New |
| Sterling Capital Management LLC | 898 | $58.7K | 0.00% | −64−6.7% | Reduced |
| Allworth Financial LP | 840 | $55.0K | 0.00% | +100+13.5% | Added |
| EverSource Wealth Advisors, LLC | 827 | $54.1K | 0.00% | −274−24.9% | Reduced |
| Meeder Asset Management Inc | 713 | $46.6K | 0.00% | +614+620.2% | Added |
| Johnson Financial Group, Inc. | 670 | $43.8K | 0.00% | +670 | New |
| Huntington National Bank | 654 | $42.8K | 0.00% | −141−17.7% | Reduced |
| Quadrant Capital Group LLC | 616 | $40.3K | 0.00% | +616 | New |
| Archer Investment Corp | 600 | $39.3K | 0.01% | 00.0% | Unchanged |
| Quarry LP | 588 | $38.5K | 0.01% | +588 | New |
| Farther Finance Advisors, LLC | 566 | $37.0K | 0.00% | +133+30.7% | Added |
| AdvisorNet Financial, Inc | 469 | $30.7K | 0.00% | +41+9.6% | Added |
| Quest Partners LLC | 453 | $29.6K | 0.00% | −382−45.7% | Reduced |
| Mather Group, LLC. | 410 | $26.8K | 0.00% | +410 | New |
| ORG Wealth Partners, LLC | 400 | $26.2K | 0.01% | 00.0% | Unchanged |
| Steigerwald, Gordon & Koch Inc. | 380 | $24.9K | 0.00% | +380 | New |
| Golden State Wealth Management, LLC | 376 | $24.6K | 0.00% | +250+198.4% | Added |
| Salomon & Ludwin, LLC | 332 | $23.0K | 0.00% | +332 | New |
| Global X Japan Co., Ltd. | 321 | $21.0K | 0.00% | +62+23.9% | Added |
| Eastern Bank | 300 | $19.6K | 0.00% | 00.0% | Unchanged |
| Capital Advisors, Ltd. LLC | 295 | $19.0K | 0.00% | 00.0% | Unchanged |
| Strategic Advocates LLC | 287 | $18.8K | 0.00% | +287 | New |
| NBC Securities, Inc. | 273 | $17.9K | 0.00% | +273 | New |
| Storebrand Asset Management AS | 271 | $17.7K | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 267 | $17.5K | 0.00% | −159−37.3% | Reduced |
| SBI Securities Co., Ltd. | 267 | $17.5K | 0.00% | +10+3.9% | Added |
| Union Bancaire Privee, UBP SA | 265 | $17.0K | 0.00% | 00.0% | Unchanged |
| MTM Investment Management, LLC | 258 | $16.9K | 0.01% | 00.0% | Unchanged |
| Wealthspire Advisors, LLC | 245 | $16.0K | 0.00% | +245 | New |
| Covestor Ltd | 246 | $16.0K | 0.01% | −59−19.3% | Reduced |
| Parkside Financial Bank & Trust | 240 | $15.7K | 0.00% | −198−45.2% | Reduced |
| Advisory Services Network, LLC | 238 | $15.5K | 0.00% | +238 | New |
| Westside Investment Management, Inc. | 231 | $15.2K | 0.00% | 00.0% | Unchanged |
| Global Trust Asset Management, LLC | 218 | $14.3K | 0.01% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 210 | $13.7K | 0.00% | +10+5.0% | Added |
| Atlantic Union Bankshares Corp | 200 | $13.1K | 0.00% | 00.0% | Unchanged |
| Umb Bank N A | 200 | $13.1K | 0.00% | +200 | New |
| AllSquare Wealth Management LLC | 198 | $13.0K | 0.01% | 00.0% | Unchanged |
| Bayforest Capital Ltd | 154 | $10.1K | 0.00% | +154 | New |
| Pacifica Partners Inc. | 150 | $9.87K | 0.00% | 00.0% | Unchanged |
| Wealth Preservation Advisors, LLC | 150 | $9.81K | 0.01% | 00.0% | Unchanged |
| Bessemer Group Inc | 133 | $9.00K | 0.00% | +94+241.0% | Added |
| Spire Wealth Management | 125 | $8.18K | 0.00% | 00.0% | Unchanged |
| GPS Wealth Strategies Group, LLC | 119 | $7.79K | 0.00% | 00.0% | Unchanged |
| Bogart Wealth, LLC | 118 | $7.72K | 0.00% | 00.0% | Unchanged |
| Principal Securities, Inc. | 111 | $7.26K | 0.00% | +48+76.2% | Added |
| Smartleaf Asset Management LLC | 104 | $6.67K | 0.00% | +104 | New |
| Creekmur Asset Management LLC | 100 | $6.54K | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 98 | $6.41K | 0.00% | +98 | New |
| Massmutual Trust Co FSB | 89 | $5.82K | 0.00% | −14−13.6% | Reduced |
| Ameritas Advisory Services, LLC | 87 | $5.69K | 0.00% | −59−40.4% | Reduced |
| Orion Capital Management LLC | 80 | $5.23K | 0.00% | 00.0% | Unchanged |
| TD Private Client Wealth LLC | 80 | $5.23K | 0.00% | +36+81.8% | Added |
| Assetmark, Inc | 75 | $4.91K | 0.00% | 00.0% | Unchanged |
| Clear Investment Research, LLC | 71 | $4.64K | 0.01% | 00.0% | Unchanged |
| WPG Advisers, LLC | 70 | $4.58K | 0.00% | 00.0% | Unchanged |