Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| HRT Financial LP | 22,928 | $1.81M | 0.01% | +22,928 | New |
| Verition Fund Management LLC | 22,685 | $1.79M | 0.01% | −14,511−39.0% | Reduced |
| Engineers Gate Manager LP | 22,191 | $1.76M | 0.02% | −3,588−13.9% | Reduced |
| Natixis Advisors, L.P. | 21,891 | $1.73M | 0.00% | +21,891 | New |
| Exchange Traded Concepts, LLC | 21,094 | $1.67M | 0.01% | +3,024+16.7% | Added |
| Great West Life Assurance Co | 20,894 | $1.65M | 0.00% | −25,234−54.7% | Reduced |
| Nicollet Investment Management, Inc. | 20,523 | $1.62M | 0.51% | +115+0.6% | Added |
| Gilder Gagnon Howe & Co LLC | 19,275 | $1.52M | 0.02% | +19,275 | New |
| AQR Capital Management LLC | 18,762 | $1.48M | 0.00% | +11,947+175.3% | Added |
| AlphaCentric Advisors LLC | 18,523 | $1.47M | 1.46% | +18,523 | New |
| Quantedge Capital Pte Ltd | 18,500 | $1.46M | 0.70% | +18,500 | New |
| Elo Mutual Pension Insurance Co | 18,417 | $1.46M | 0.02% | +18,417 | New |
| Dana Investment Advisors, Inc. | 18,026 | $1.43M | 0.04% | −792−4.2% | Reduced |
| Toroso Investments, LLC | 17,908 | $1.42M | 0.01% | +17,908 | New |
| Inceptionr LLC | 17,850 | $1.41M | 0.39% | +10,229+134.2% | Added |
| Worldquant Millennium Advisors LLC | 17,410 | $1.38M | 0.01% | +17,410 | New |
| J. Safra Sarasin Holding AG | 17,404 | $1.38M | 0.02% | +17,404 | New |
| XTX Topco Ltd | 16,917 | $1.34M | 0.04% | +16,917 | New |
| Allianz Asset Management GmbH | 16,716 | $1.32M | 0.00% | +5,216+45.4% | Added |
| North Star Asset Management Inc | 16,610 | $1.31M | 0.05% | 00.0% | Unchanged |
| Public Employees Retirement Association of Colorado | 15,589 | $1.23M | 0.00% | 00.0% | Unchanged |
| Davy Global Fund Management Ltd | 15,168 | $1.20M | 0.08% | −116−0.8% | Reduced |
| LMR Partners LLP | 15,000 | $1.19M | 0.01% | −22,600−60.1% | Reduced |
| Brown Advisory Inc | 14,965 | $1.18M | 0.00% | +939+6.7% | Added |
| DnB Asset Management AS | 14,838 | $1.17M | 0.00% | +5,530+59.4% | Added |
| M&G Plc | 14,423 | $1.14M | 0.01% | +14,423 | New |
| Dynasty Wealth Management, LLC | 13,990 | $1.11M | 0.01% | −351−2.4% | Reduced |
| Bleakley Financial Group, LLC | 13,875 | $1.10M | 0.02% | −30.0% | Reduced |
| The PNC Financial Services Group, Inc. | 13,816 | $1.09M | 0.00% | +1,703+14.1% | Added |
| Cinctive Capital Management LP | 13,726 | $1.09M | 0.06% | −160,093−92.1% | Reduced |
| Friedenthal Financial | 13,115 | $1.04M | 0.53% | +13,115 | New |
| Lighthouse Investment Partners, LLC | 13,082 | $1.03M | 0.03% | +13,082 | New |
| Westmount Partners, LLC | 12,961 | $1.03M | 0.26% | 00.0% | Unchanged |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $1.01M | 0.19% | 00.0% | Unchanged |
| SBI Okasan Asset Management Co.Ltd. | 12,600 | $1.01M | 0.06% | +12,600 | New |
| Dark Forest Capital Management LP | 12,691 | $1.00M | 0.05% | −33,401−72.5% | Reduced |
| Truist Financial Corp | 12,659 | $1.00M | 0.00% | +7,847+163.1% | Added |
| Federation des caisses Desjardins du Quebec | 12,553 | $993.1K | 0.00% | +12,553 | New |
| JustInvest LLC | 12,461 | $985.8K | 0.01% | +371+3.1% | Added |
| Amalgamated Bank | 12,455 | $985.0K | 0.01% | +260+2.1% | Added |
| Northwestern Mutual Wealth Management Co | 11,998 | $949.2K | 0.00% | −784−6.1% | Reduced |
| Horizon Kinetics Asset Management LLC | 11,952 | $945.5K | 0.01% | −524−4.2% | Reduced |
| Commonwealth Equity Services, LLC | 11,806 | $934.0K | 0.00% | −1,543−11.6% | Reduced |
| Advisor Group Holdings, Inc. | 11,646 | $921.3K | 0.00% | +1,479+14.5% | Added |
| Oppenheimer Asset Management Inc. | 11,264 | $891.1K | 0.01% | +11,264 | New |
| Plancorp, LLC | 11,208 | $886.7K | 0.03% | 00.0% | Unchanged |
| Baader Bank INC | 11,097 | $865.8K | 0.07% | +869+8.5% | Added |
| Cetera Investment Advisers | 10,856 | $858.8K | 0.00% | +3,983+58.0% | Added |
| Suvretta Capital Management, LLC | 10,800 | $854.4K | 0.02% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 10,600 | $838.6K | 0.00% | +10,600 | New |
| Blueshift Asset Management, LLC | 10,443 | $826.1K | 0.24% | −1,017−8.9% | Reduced |
| Vident Advisory, LLC | 10,235 | $809.7K | 0.01% | −1,316−11.4% | Reduced |
| Cypress Capital, LLC | 10,000 | $791.1K | 0.22% | 00.0% | Unchanged |
| Thrivent Financial for Lutherans | 9,962 | $788.0K | 0.00% | 00.0% | Unchanged |
| Summit Trail Advisors, LLC | 9,943 | $786.6K | 0.01% | +3,738+60.2% | Added |
| Ares Systematic Credit Ltd | 9,916 | $784.5K | 0.64% | +9,916 | New |
| Wiley Bros.-Aintree Capital, LLC | 9,723 | $769.2K | 0.00% | −2,940−23.2% | Reduced |
| MetLife Investment Management | 9,674 | $765.3K | 0.00% | +246+2.6% | Added |
| Two Sigma Securities, LLC | 9,649 | $763.3K | 0.10% | +9,649 | New |
| Intech Investment Management LLC | 9,602 | $759.6K | 0.01% | +9,602 | New |
| KBC Group NV | 9,052 | $716.0K | 0.00% | +4,353+92.6% | Added |
| Aigen Investment Management, LP | 8,861 | $701.0K | 0.16% | −4,717−34.7% | Reduced |
| Assetmark, Inc | 8,650 | $684.3K | 0.00% | +8,575+11,433.3% | Added |
| NEOS Investment Management LLC | 8,557 | $676.9K | 0.00% | −3,749−30.5% | Reduced |
| Tema ETFs LLC | 8,557 | $676.9K | 0.05% | −3,749−30.5% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 8,256 | $672.8K | 0.00% | +817+11.0% | Added |
| Virtus Investment Advisers, Inc. | 8,454 | $668.8K | 0.18% | −4,022−32.2% | Reduced |
| Sectoral Asset Management Inc | 8,365 | $661.8K | 0.53% | −840−9.1% | Reduced |
| denkapparat Operations GmbH | 8,364 | $661.7K | 0.36% | −1,604−16.1% | Reduced |
| Utah Retirement Systems | 8,300 | $656.6K | 0.01% | 00.0% | Unchanged |
| Maryland State Retirement & Pension System | 8,284 | $655.3K | 0.01% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 8,266 | $653.9K | 0.00% | +2,104+34.1% | Added |
| M&T Bank Corp | 8,150 | $644.1K | 0.00% | +2,140+35.6% | Added |
| Commerce Bank | 8,111 | $641.7K | 0.00% | +504+6.6% | Added |
| Fifth Third Bancorp | 7,888 | $624.0K | 0.00% | −56−0.7% | Reduced |
| Persistent Asset Partners Ltd | 7,807 | $617.6K | 0.30% | +7,807 | New |
| Stratos Wealth Partners, LTD. | 7,740 | $612.3K | 0.01% | −24−0.3% | Reduced |
| Graham Capital Management, L.P. | 7,596 | $600.9K | 0.02% | −9,567−55.7% | Reduced |
| Fiduciary Trust Co | 7,399 | $585.3K | 0.01% | +1,022+16.0% | Added |
| Silvercrest Asset Management Group LLC | 7,242 | $572.9K | 0.00% | +124+1.7% | Added |
| Savant Capital, LLC | 7,189 | $568.7K | 0.00% | −48−0.7% | Reduced |
| Meeder Advisory Services, Inc. | 7,156 | $566.1K | 0.02% | +386+5.7% | Added |
| ProShare Advisors LLC | 7,154 | $566.0K | 0.00% | +1,476+26.0% | Added |
| Callan Family Office, LLC | 7,104 | $562.0K | 0.01% | +7,104 | New |
| O'Shaughnessy Asset Management, LLC | 7,032 | $556.3K | 0.00% | +1,735+32.8% | Added |
| Swiss Life Asset Management Ltd | 6,903 | $546.1K | 0.00% | +76+1.1% | Added |
| PSP Research LLC | 6,800 | $537.9K | 0.47% | +6,800 | New |
| Everence Capital Management Inc | 6,770 | $536.0K | 0.03% | 00.0% | Unchanged |
| Significant Wealth Partners LLC | 6,764 | $535.1K | 0.60% | −8,203−54.8% | Reduced |
| Coldstream Capital Management Inc | 6,619 | $523.6K | 0.01% | +2,140+47.8% | Added |
| Jones Financial Companies LLLP | 6,483 | $512.9K | 0.00% | −351−5.1% | Reduced |
| Legato Capital Management LLC | 6,155 | $486.9K | 0.04% | −11,145−64.4% | Reduced |
| Regions Financial Corp | 6,089 | $481.7K | 0.00% | +2,289+60.2% | Added |
| Natixis | 6,087 | $481.5K | 0.00% | −139,199−95.8% | Reduced |
| Wedmont Private Capital | 5,536 | $460.4K | 0.02% | +173+3.2% | Added |
| Frank, Rimerman Advisors LLC | 5,781 | $457.3K | 0.03% | +16+0.3% | Added |
| Atria Investments LLC | 5,655 | $447.4K | 0.01% | −1,375−19.6% | Reduced |
| Mercer Global Advisors Inc | 5,554 | $439.4K | 0.00% | +1,807+48.2% | Added |
| North Dakota State Investment Board | 5,480 | $433.5K | 0.02% | +5,480 | New |
| Dymon Asia Capital (Singapore) Pte. Ltd. | 5,350 | $423.2K | 0.09% | +5,350 | New |