Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Captrust Financial Advisors | 5,293 | $418.7K | 0.00% | +5,293 | New |
| Vontobel Holding Ltd. | 5,240 | $414.5K | 0.00% | +5,240 | New |
| US Bancorp | 5,141 | $406.7K | 0.00% | +437+9.3% | Added |
| HighTower Advisors, LLC | 5,122 | $405.2K | 0.00% | −336−6.2% | Reduced |
| CWM, LLC | 5,049 | $399.0K | 0.00% | +2,561+102.9% | Added |
| CIBC Asset Management Inc | 5,017 | $396.9K | 0.00% | +409+8.9% | Added |
| Resources Investment Advisors, LLC. | 5,006 | $396.0K | 0.00% | +1,418+39.5% | Added |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $395.6K | 0.04% | 00.0% | Unchanged |
| GWM Advisors LLC | 4,938 | $390.6K | 0.00% | +116+2.4% | Added |
| Inspire Advisors, LLC | 4,851 | $383.8K | 0.04% | +4,851 | New |
| Harvest Fund Management Co., Ltd | 4,816 | $381.0K | 0.01% | +3,070+175.8% | Added |
| Granite Investment Partners, LLC | 4,806 | $380.2K | 0.02% | −23,227−82.9% | Reduced |
| Farallon Capital Management, L.L.C. | 4,800 | $379.7K | 0.00% | 00.0% | Unchanged |
| Prospera Financial Services Inc | 4,759 | $376.5K | 0.01% | +178+3.9% | Added |
| Skopos Labs, Inc. | 4,669 | $373.4K | 0.02% | +4,669 | New |
| Sanctuary Advisors, LLC | 4,502 | $356.2K | 0.00% | +865+23.8% | Added |
| Kestra Advisory Services, LLC | 4,451 | $352.1K | 0.00% | −521−10.5% | Reduced |
| Credit Agricole S A | 4,410 | $348.9K | 0.00% | −300−6.4% | Reduced |
| AE Wealth Management LLC | 4,403 | $348.3K | 0.00% | +4,403 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 4,334 | $342.3K | 0.00% | −2,097−32.6% | Reduced |
| Vise Technologies, Inc. | 4,305 | $340.6K | 0.01% | +4,305 | New |
| Voleon Capital Management LP | 4,288 | $339.2K | 0.01% | +1,228+40.1% | Added |
| Checchi Capital Advisers, LLC | 4,272 | $338.0K | 0.02% | +39+0.9% | Added |
| Bank of Nova Scotia | 4,189 | $331.4K | 0.00% | +680+19.4% | Added |
| Janney Montgomery Scott LLC | 4,177 | $330.0K | 0.00% | +4,177 | New |
| Comerica Bank | 3,997 | $316.2K | 0.00% | +1,810+82.8% | Added |
| Prime Capital Investment Advisors, LLC | 3,981 | $314.9K | 0.00% | +47+1.2% | Added |
| Mackenzie Financial Corp | 3,891 | $306.7K | 0.00% | +303+8.4% | Added |
| Pinnacle Wealth Planning Services, Inc. | 3,864 | $305.7K | 0.03% | −1,249−24.4% | Reduced |
| STRS Ohio | 3,788 | $299.7K | 0.00% | +72+1.9% | Added |
| Group One Trading, L.P. | 3,778 | $298.9K | 0.01% | −1,018−21.2% | Reduced |
| Cambria Investment Management, L.P. | 3,684 | $291.4K | 0.02% | +3,684 | New |
| Tudor Investment Corp Et Al | 3,661 | $289.6K | 0.00% | +3,661 | New |
| Berkshire Asset Management LLC | 3,630 | $287.2K | 0.01% | +16+0.4% | Added |
| Avanza Fonder AB | 3,596 | $284.5K | 0.01% | +3,596 | New |
| Park Avenue Securities LLC | 3,571 | $283.0K | 0.00% | +3,571 | New |
| Marex Group plc | 3,524 | $278.8K | 0.00% | −3,198−47.6% | Reduced |
| Everhart Financial Group, Inc. | 3,465 | $274.1K | 0.03% | +3,465 | New |
| Mitchell & Pahl Private Wealth, LLC | 3,379 | $267.3K | 0.11% | −193−5.4% | Reduced |
| Principal Financial Group Inc | 3,339 | $264.1K | 0.00% | −1,446−30.2% | Reduced |
| Nwam LLC | 3,238 | $262.3K | 0.01% | 00.0% | Unchanged |
| Eurizon Capital SGR S.p.A. | 3,314 | $261.4K | 0.00% | +3,314 | New |
| MML Investors Services, LLC | 3,264 | $258.2K | 0.00% | +3,264 | New |
| Tower Research Capital LLC (TRC) | 3,263 | $258.1K | 0.01% | +218+7.2% | Added |
| Anb Bank | 3,193 | $252.6K | 0.10% | −38−1.2% | Reduced |
| GF Fund Management Co. Ltd. | 3,183 | $251.8K | 0.00% | −246−7.2% | Reduced |
| Westfield Capital Management Co LP | 3,157 | $249.8K | 0.00% | +64+2.1% | Added |
| Raab & Moskowitz Asset Management LLC | 3,115 | $246.4K | 0.05% | 00.0% | Unchanged |
| Crossmark Global Holdings, Inc. | 3,102 | $245.4K | 0.00% | +3,102 | New |
| Venturi Wealth Management, LLC | 3,061 | $242.2K | 0.01% | +3,061 | New |
| Argent Trust Co | 3,018 | $238.8K | 0.01% | +3,018 | New |
| National Asset Management, Inc. | 2,975 | $235.3K | 0.01% | +2,975 | New |
| Cambridge Investment Research Advisors, Inc. | 2,957 | $234.0K | 0.00% | +2,957 | New |
| Norden Group LLC | 2,935 | $232.2K | 0.02% | +2,935 | New |
| HB Wealth Management, LLC | 2,922 | $231.2K | 0.00% | +2,922 | New |
| Impact Partnership Wealth, LLC | 2,905 | $229.8K | 0.03% | +2,905 | New |
| Axxcess Wealth Management, LLC | 2,877 | $227.6K | 0.00% | +2,877 | New |
| Advisors Asset Management, Inc. | 2,835 | $224.3K | 0.00% | −2,619−48.0% | Reduced |
| Campbell & CO Investment Adviser LLC | 2,784 | $220.2K | 0.01% | +2,784 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 2,750 | $219.1K | 0.00% | −2,657−49.1% | Reduced |
| Rockefeller Capital Management L.P. | 2,726 | $215.7K | 0.00% | +523+23.7% | Added |
| Clearbridge Investments, LLC | 2,715 | $214.8K | 0.00% | +2,715 | New |
| Montis Financial, LLC | 2,700 | $213.6K | 0.04% | +2,700 | New |
| Kerntke Otto McGlone Wealth Management Group | 2,695 | $213.2K | 0.15% | +2,695 | New |
| IFG Advisory, LLC | 2,678 | $211.9K | 0.01% | +2,678 | New |
| PharVision Advisers, LLC | 2,661 | $210.5K | 0.11% | −926−25.8% | Reduced |
| Motley Fool Asset Management LLC | 2,630 | $208.1K | 0.01% | +2,630 | New |
| Ancora Advisors, LLC | 2,342 | $185.3K | 0.00% | +205+9.6% | Added |
| Larson Financial Group LLC | 2,340 | $185.1K | 0.01% | +1,230+110.8% | Added |
| Signaturefd, LLC | 2,041 | $161.5K | 0.00% | +38+1.9% | Added |
| Parallel Advisors, LLC | 1,882 | $148.9K | 0.00% | +5+0.3% | Added |
| Global Retirement Partners, LLC | 1,876 | $148.4K | 0.00% | +1,853+8,056.5% | Added |
| GAMMA Investing LLC | 1,733 | $137.1K | 0.01% | +392+29.2% | Added |
| Sterling Capital Management LLC | 1,713 | $135.5K | 0.00% | +815+90.8% | Added |
| Twin Lakes Capital Management, LLC | 1,500 | $118.7K | 0.05% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 1,496 | $118.3K | 0.01% | +31+2.1% | Added |
| Danske Bank A/S | 1,400 | $110.8K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 1,388 | $109.6K | 0.00% | +1,284+1,234.6% | Added |
| Employees Retirement System of Texas | 1,354 | $107.0K | 0.00% | +1,354 | New |
| Root Financial Partners, LLC | 1,339 | $105.9K | 0.01% | −1−0.1% | Reduced |
| International Assets Investment Management, LLC | 1,217 | $96.3K | 0.01% | −6,990−85.2% | Reduced |
| Farther Finance Advisors, LLC | 1,199 | $94.9K | 0.00% | +633+111.8% | Added |
| EverSource Wealth Advisors, LLC | 1,137 | $89.9K | 0.00% | +310+37.5% | Added |
| Bayforest Capital Ltd | 1,091 | $86.3K | 0.06% | +937+608.4% | Added |
| Steward Partners Investment Advisory, LLC | 1,069 | $84.6K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 1,014 | $80.2K | 0.00% | −56−5.2% | Reduced |
| Sunbelt Securities, Inc. | 1,014 | $80.2K | 0.01% | 00.0% | Unchanged |
| Allworth Financial LP | 920 | $72.8K | 0.00% | +80+9.5% | Added |
| MAI Capital Management | 900 | $71.2K | 0.00% | +633+237.1% | Added |
| SRS Capital Advisors, Inc. | 774 | $61.2K | 0.00% | +774 | New |
| Clear Street Markets LLC | 748 | $59.2K | 0.01% | +748 | New |
| Meeder Asset Management Inc | 716 | $56.6K | 0.00% | +3+0.4% | Added |
| Elequin Capital LP | 711 | $56.2K | 0.01% | +711 | New |
| Huntington National Bank | 695 | $55.0K | 0.00% | +41+6.3% | Added |
| Quest Partners LLC | 670 | $53.0K | 0.00% | +217+47.9% | Added |
| Los Angeles Capital Management LLC | 700 | $51.9K | 0.00% | +700 | New |
| Quadrant Capital Group LLC | 616 | $48.7K | 0.00% | 00.0% | Unchanged |
| AdvisorNet Financial, Inc | 613 | $48.5K | 0.00% | +144+30.7% | Added |
| Archer Investment Corp | 600 | $47.5K | 0.01% | 00.0% | Unchanged |
| Laurel Wealth Advisors LLC | 600 | $47.5K | 0.01% | +600 | New |