Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2023
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 315
- −18 vs. Q4 2022
- Shares held
- 131.1M
- +517.1K (+0.4%) vs. Q4 2022
- Total value
- $4.69B
- −$238.7M (−4.8%) vs. Q4 2022
- New holders
- 34
- 87 more added
- Sold out
- 52
- 128 more reduced
6 institutions that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Canada Pension Plan Investment Board | 78,619 | $2.81M | 0.00% | +5,719+7.8% | Added |
| PFS Investments Inc. | 72,776 | $2.71M | 0.05% | +651+0.9% | Added |
| Manufacturers Life Insurance Company, The | 72,612 | $2.60M | 0.00% | −9,911−12.0% | Reduced |
| Tudor Investment Corp Et Al | 72,577 | $2.59M | 0.05% | +36,212+99.6% | Added |
| Public Employees Retirement System of Ohio | 70,219 | $2.51M | 0.01% | −6,126−8.0% | Reduced |
| LPL Financial LLC | 68,994 | $2.47M | 0.00% | −5,105−6.9% | Reduced |
| Susquehanna Fundamental Investments, LLC | 67,918 | $2.43M | 0.06% | −25,517−27.3% | Reduced |
| Guggenheim Capital LLC | 63,563 | $2.27M | 0.02% | +1,404+2.3% | Added |
| Treasurer of the State of North Carolina | 61,742 | $2.21M | 0.01% | +440+0.7% | Added |
| Bokf, NA | 60,261 | $2.15M | 0.05% | +60,261 | New |
| Janus Henderson Group PLC | 59,859 | $2.14M | 0.00% | +6,137+11.4% | Added |
| Algert Global LLC | 58,652 | $2.10M | 0.10% | −14,895−20.3% | Reduced |
| Susquehanna International Group, LLP | 55,920 | $2.00M | 0.00% | −1,952−3.4% | Reduced |
| Voya Investment Management LLC | 53,732 | $1.92M | 0.00% | −16,545−23.5% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.79M | 0.03% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 48,600 | $1.74M | 0.00% | −9,904−16.9% | Reduced |
| Private Advisor Group, LLC | 48,467 | $1.73M | 0.02% | −2,541−5.0% | Reduced |
| Ensign Peak Advisors, Inc | 46,310 | $1.66M | 0.00% | −8,581−15.6% | Reduced |
| SEI Investments Co | 45,924 | $1.64M | 0.00% | −170.0% | Reduced |
| Deutsche Bank AG | 45,726 | $1.63M | 0.00% | −20,899−31.4% | Reduced |
| Millennium Management LLC | 45,363 | $1.62M | 0.00% | −70,143−60.7% | Reduced |
| International Biotechnology Trust PLC | 43,000 | $1.54M | 0.43% | +43,000 | New |
| Schonfeld Strategic Advisors LLC | 42,209 | $1.51M | 0.01% | −223,589−84.1% | Reduced |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.50M | 0.23% | 00.0% | Unchanged |
| Bank of Nova Scotia | 41,406 | $1.48M | 0.00% | +10,406+33.6% | Added |
| Capital Counsel LLC | 40,230 | $1.44M | 0.08% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 39,383 | $1.41M | 0.01% | +1,005+2.6% | Added |
| Highland Capital Management, LLC | 37,598 | $1.34M | 0.10% | −2,712−6.7% | Reduced |
| Arizona State Retirement System | 37,043 | $1.32M | 0.01% | +996+2.8% | Added |
| Profund Advisors LLC | 36,409 | $1.30M | 0.08% | +20,564+129.8% | Added |
| Envestnet Asset Management Inc | 35,489 | $1.27M | 0.00% | +60+0.2% | Added |
| Principal Financial Group Inc | 34,666 | $1.24M | 0.00% | −3,656−9.5% | Reduced |
| Engineers Gate Manager LP | 34,340 | $1.23M | 0.05% | +14,363+71.9% | Added |
| Estate Counselors, LLC | 33,110 | $1.18M | 0.16% | +33,110 | New |
| Trexquant Investment LP | 32,612 | $1.17M | 0.03% | −14,333−30.5% | Reduced |
| Janney Montgomery Scott LLC | 32,608 | $1.17M | 0.00% | −450−1.4% | Reduced |
| Grandfield & Dodd, LLC | 32,284 | $1.15M | 0.08% | +810+2.6% | Added |
| Bard Financial Services, Inc. | 31,825 | $1.14M | 0.09% | −22,100−41.0% | Reduced |
| Amalgamated Bank | 29,108 | $1.04M | 0.01% | −2,987−9.3% | Reduced |
| Great West Life Assurance Co | 27,422 | $983.0K | 0.00% | +1,282+4.9% | Added |
| Caption Management, LLC | 27,200 | $972.1K | 0.21% | +14,200+109.2% | Added |
| Assenagon Asset Management S.A. | 27,185 | $971.6K | 0.00% | −414,617−93.8% | Reduced |
| Massachusetts Financial Services Co | 27,153 | $970.4K | 0.00% | +27,153 | New |
| Raymond James Financial Services Advisors, Inc. | 25,652 | $916.8K | 0.00% | −1,073−4.0% | Reduced |
| Magnetar Financial LLC | 23,652 | $845.3K | 0.02% | −10,945−31.6% | Reduced |
| Two Sigma Investments, LP | 23,080 | $824.9K | 0.00% | −178,187−88.5% | Reduced |
| Virginia Retirement Systems Et Al | 22,900 | $818.4K | 0.01% | −7,900−25.6% | Reduced |
| Bayesian Capital Management, LP | 21,227 | $758.7K | 0.09% | +21,227 | New |
| Commonwealth Equity Services, LLC | 20,638 | $737.0K | 0.00% | −66−0.3% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,012 | $715.2K | 0.00% | +1,315+7.0% | Added |
| Public Employees Retirement Association of Colorado | 19,604 | $701.0K | 0.00% | 00.0% | Unchanged |
| Castle Rock Wealth Management, LLC | 19,385 | $692.0K | 0.25% | 00.0% | Unchanged |
| Van Eck Associates Corp | 19,175 | $685.0K | 0.00% | +7,133+59.2% | Added |
| Vestmark Advisory Solutions, Inc. | 19,067 | $681.5K | 0.03% | +465+2.5% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 18,856 | $674.0K | 0.00% | −880−4.5% | Reduced |
| Handelsbanken Fonder AB | 18,511 | $662.0K | 0.00% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 18,473 | $660.2K | 0.00% | −8,106−30.5% | Reduced |
| Koss-Olinger Consulting, LLC | 18,268 | $653.0K | 0.08% | −295−1.6% | Reduced |
| Xponance, Inc. | 17,927 | $640.7K | 0.01% | +217+1.2% | Added |
| US Bancorp | 16,122 | $576.2K | 0.00% | +1,302+8.8% | Added |
| Natixis Advisors, L.P. | 16,076 | $575.0K | 0.00% | −127−0.8% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 15,571 | $556.5K | 0.00% | +15,571 | New |
| Victory Capital Management Inc | 15,439 | $551.8K | 0.00% | −348−2.2% | Reduced |
| Neuberger Berman Group LLC | 15,132 | $540.8K | 0.00% | +4,147+37.8% | Added |
| Tower Research Capital LLC (TRC) | 15,119 | $540.0K | 0.02% | +7,847+107.9% | Added |
| Blair William & Co | 14,644 | $523.4K | 0.00% | 00.0% | Unchanged |
| Martingale Asset Management L P | 13,943 | $498.3K | 0.01% | +3,582+34.6% | Added |
| North Star Asset Management Inc | 13,680 | $488.9K | 0.03% | 00.0% | Unchanged |
| Creative Planning | 13,632 | $487.2K | 0.00% | +204+1.5% | Added |
| Westmount Partners, LLC | 13,462 | $481.1K | 0.22% | 00.0% | Unchanged |
| Gotham Asset Management, LLC | 13,233 | $472.9K | 0.01% | −56,663−81.1% | Reduced |
| American Century Companies Inc | 13,163 | $470.4K | 0.00% | −17,709−57.4% | Reduced |
| Lincoln National Corp | 13,034 | $465.8K | 0.01% | −65−0.5% | Reduced |
| Horizon Kinetics Asset Management LLC | 13,000 | $464.6K | 0.01% | +5,000+62.5% | Added |
| Inceptionr LLC | 12,790 | $457.1K | 0.15% | +12,790 | New |
| AtonRa Partners | 12,344 | $441.2K | 0.64% | −1,531−11.0% | Reduced |
| Bleakley Financial Group, LLC | 12,247 | $437.7K | 0.01% | −937−7.1% | Reduced |
| Sawtooth Solutions, LLC | 12,247 | $437.7K | 0.01% | +12,247 | New |
| Illinois Municipal Retirement Fund | 11,866 | $424.0K | 0.01% | 00.0% | Unchanged |
| Storebrand Asset Management AS | 11,641 | $416.0K | 0.00% | −1,421−10.9% | Reduced |
| Brown Advisory Inc | 11,461 | $409.6K | 0.00% | −70−0.6% | Reduced |
| HighTower Advisors, LLC | 11,469 | $409.0K | 0.00% | +303+2.7% | Added |
| E Fund Management Co., Ltd. | 11,372 | $406.0K | 0.03% | +100+0.9% | Added |
| Capital Fund Management S.A. | 11,314 | $404.4K | 0.01% | +11,314 | New |
| Plancorp, LLC | 11,157 | $398.8K | 0.02% | −55−0.5% | Reduced |
| Oppenheimer Asset Management Inc. | 11,055 | $395.1K | 0.01% | +686+6.6% | Added |
| Maryland State Retirement & Pension System | 10,950 | $391.4K | 0.01% | 00.0% | Unchanged |
| Franklin Resources Inc | 10,400 | $371.7K | 0.00% | −3,319−24.2% | Reduced |
| Arden Trust Co | 10,161 | $363.0K | 0.07% | −1,549−13.2% | Reduced |
| Waddell & Associates, LLC | 10,042 | $358.9K | 0.06% | 00.0% | Unchanged |
| ProShare Advisors LLC | 9,911 | $354.2K | 0.00% | −3,992−28.7% | Reduced |
| Vontobel Holding Ltd. | 9,816 | $350.8K | 0.00% | −1,113−10.2% | Reduced |
| Advisor Group Holdings, Inc. | 9,535 | $341.0K | 0.00% | −1,294−11.9% | Reduced |
| Captrust Financial Advisors | 9,458 | $338.0K | 0.00% | −70−0.7% | Reduced |
| Gsa Capital Partners LLP | 9,422 | $337.0K | 0.03% | +9,422 | New |
| Corton Capital Inc. | 9,040 | $323.1K | 0.22% | −3,598−28.5% | Reduced |
| Ameriprise Financial Inc | 8,917 | $318.7K | 0.00% | −4,414−33.1% | Reduced |
| Wrapmanager Inc | 8,673 | $310.0K | 0.10% | +174+2.0% | Added |
| Cambridge Investment Research Advisors, Inc. | 8,474 | $303.0K | 0.00% | −1,081−11.3% | Reduced |
| Nicollet Investment Management, Inc. | 8,465 | $303.0K | 0.16% | +527+6.6% | Added |