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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 3 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

Q1 2026 vs. Q4 2025

How the institutions holding Ionis Pharmaceuticals Inc changed between Q4 2025 and Q1 2026.

All holders in Q1 2026All holders in Q4 2025

13F holders of IONS: Q4 2025 compared with Q1 2026
MeasureQ4 2025Of which not filed for Q1 2026Q1 2026Change
Holders4945497+8
Shares170.2M16.8M172.6M+19.1M (+12.5%)
Value$13.5B$1.33B$13.0B+$828.1M (+6.8%)

5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (73)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q1 2026 but not at the end of Q4 2025.

Institutions new to IONS in Q1 2026
InstitutionSharesValue% of portfolio
Vanguard Portfolio Management LLC7,808,902$586.4M0.03%
Vanguard Capital Management LLC7,118,330$534.5M0.01%
Vanguard Fiduciary Trust Co1,024,377$76.9M0.02%
Perceptive Advisors LLC504,000$37.8M0.75%
Capital Research Global Investors323,015$24.3M0.00%
TimesSquare Capital Management, LLC275,674$20.7M0.35%
Jump Financial, LLC206,675$15.5M0.23%
Capital Fund Management S.A.142,201$10.7M0.10%
Vanguard Asset Management, Ltd137,507$10.3M0.01%
Braidwell LP130,862$9.83M0.33%
Integral Health Asset Management, LLC125,000$9.39M0.50%
SEB Asset Management AB114,334$8.59M0.04%
Winton Group Ltd106,532$8.00M0.28%
Empowered Funds, LLC103,141$7.74M0.05%
CSS LLC79,093$5.94M0.33%
Vanguard Global Advisers, LLC71,911$5.40M0.00%
Edgestream Partners, L.P.68,369$5.13M0.17%
Polymer Capital Management (HK) LTD61,200$4.60M0.64%
Panagora Asset Management Inc57,446$4.31M0.02%
Carmignac Gestion53,000$3.98M0.06%
E Fund Management Co., Ltd.46,688$3.51M0.10%
Qube Research & Technologies Ltd42,856$3.22M0.00%
Polygon Management Ltd.41,764$3.14M0.62%
Vanguard Investments Australia, Ltd.38,557$2.90M0.01%
DeepCurrents Investment Group LLC27,422$2.06M0.08%
Entropy Technologies, LP27,207$2.04M0.09%
StemPoint Capital LP26,385$1.98M0.38%
Florida Financial Advisors, LLC25,886$1.94M0.47%
Allstate Corp20,565$1.54M0.02%
Readystate Asset Management LP20,436$1.53M0.09%
FORA Capital, LLC19,693$1.48M0.11%
Caption Management, LLC15,591$1.17M0.06%
Canada Pension Plan Investment Board14,100$1.06M0.00%
Highland Capital Management, LLC12,819$962.6K0.05%
Capstone Capital Management Ltd21,447$832.4K0.84%
Ground Swell Capital, LLC7,285$547.0K1.08%
Robeco Institutional Asset Management B.V.5,660$425.0K0.00%
Cynosure Management, LLC5,614$421.6K0.05%
Mesirow Financial Investment Management, Inc.5,460$410.0K0.01%
Virtu Financial LLC5,342$401.0K0.02%
R Squared Ltd4,359$327.3K0.18%
Intrust Bank NA4,056$304.6K0.02%
Optas, LLC4,034$302.9K0.05%
Congress Asset Management Co3,946$296.3K0.00%
Axq Capital, LP3,846$288.8K0.04%
Perigon Wealth Management, LLC3,430$257.6K0.00%
Gsa Capital Partners LLP3,172$238.0K0.01%
QRG Capital Management, Inc.3,094$232.3K0.00%
EntryPoint Capital, LLC2,963$222.5K0.07%
AlphaCore Capital LLC2,762$207.4K0.00%
Integrated Wealth Concepts LLC2,724$204.5K0.00%
New York Life Investment Management LLC2,688$201.8K0.00%
Fideuram Asset Management (Ireland) dac2,213$181.6K0.02%
Stephens Inc26,761$91.4K0.00%
Advisory Services Network, LLC604$45.4K0.00%
Mather Group, LLC.410$30.8K0.00%
Cassaday & Co Wealth Management LLC400$30.0K0.00%
RWM Asset Management, LLC375$28.2K0.00%
Cedar Mountain Advisors, LLC223$16.7K0.00%
Twin Peaks Wealth Advisors, LLC215$16.1K0.00%
CX Institutional202$15.0K0.00%
E Fund Management (Hong Kong) Co., Ltd.195$14.6K0.01%
Owl Creek Wealth Partners LLC170$12.8K0.00%
Main Street Group, LTD100$7.51K0.00%
Clear Investment Research, LLC71$5.33K0.01%
MCF Advisors LLC50$3.75K0.00%
TD Waterhouse Canada Inc.48$3.60K0.00%
Transamerica Financial Advisors, Inc.33$2.48K0.00%
NBT Bank N A20$1.50K0.00%
Whipplewood Advisors, LLC15$1.13K0.00%
Caitong International Asset Management Co., Ltd7$5260.00%
Hughes Financial Services, LLC6$4510.00%
3 Factor Indexing, LLC2$1510.00%

Sold out (65)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q4 2025 and filed for Q1 2026 without it.

Institutions that sold out of IONS in Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
Two Sigma Advisers, LP3,052,111$241.5M
Tri Locum Partners LP557,174$44.1M
Balyasny Asset Management LLC120,577$9.54M
Skandinaviska Enskilda Banken AB (publ)115,293$9.12M
Healthcare of Ontario Pension Plan Trust Fund110,000$8.70M
Simplex Trading, LLC96,647$7.65M
Bridgewater Associates, LP67,706$5.36M
BI Asset Management Fondsmaeglerselskab A/S62,073$4.91M
PDT Partners, LLC54,365$4.30M
Alpine Global Management, LLC53,600$4.24M
Mariner, LLC47,740$3.78M
Atika Capital Management LLC47,488$3.76M
Acadian Asset Management LLC34,691$2.74M
Twin Tree Management, LP32,476$2.57M
Verition Fund Management LLC22,685$1.79M
Gilder Gagnon Howe & Co LLC19,275$1.52M
Quantedge Capital Pte Ltd18,500$1.46M
Elo Mutual Pension Insurance Co18,417$1.46M
Cinctive Capital Management LP13,726$1.09M
Friedenthal Financial13,115$1.04M
Dark Forest Capital Management LP12,691$1.00M
Baader Bank INC11,097$865.8K
Ares Systematic Credit Ltd9,916$784.5K
Two Sigma Securities, LLC9,649$763.3K
NEOS Investment Management LLC8,557$676.9K
Persistent Asset Partners Ltd7,807$617.6K
Graham Capital Management, L.P.7,596$600.9K
Natixis6,087$481.5K
Dymon Asia Capital (Singapore) Pte. Ltd.5,350$423.2K
Skopos Labs, Inc.4,669$373.4K
AE Wealth Management LLC4,403$348.3K
Bank of Nova Scotia4,189$331.4K
Janney Montgomery Scott LLC4,177$330.0K
Avanza Fonder AB3,596$284.5K
Park Avenue Securities LLC3,571$283.0K
Cambridge Investment Research Advisors, Inc.2,957$234.0K
Impact Partnership Wealth, LLC2,905$229.8K
Axxcess Wealth Management, LLC2,877$227.6K
Clearbridge Investments, LLC2,715$214.8K
Kerntke Otto McGlone Wealth Management Group2,695$213.2K
IFG Advisory, LLC2,678$211.9K
PharVision Advisers, LLC2,661$210.5K
Motley Fool Asset Management LLC2,630$208.1K
Twin Lakes Capital Management, LLC1,500$118.7K
SRS Capital Advisors, Inc.774$61.2K
Clear Street Markets LLC748$59.2K
Quest Partners LLC670$53.0K
Laurel Wealth Advisors LLC600$47.5K
Daiwa Securities Group Inc.481$38.0K
Strategic Advocates LLC287$22.7K
SageView Advisory Group, LLC215$17.0K
Quarry LP180$14.2K
Torren Management, LLC137$10.8K
Garner Asset Management Corp115$9.10K
Rakuten Securities, Inc.90$7.12K
Kemnay Advisory Services Inc.71$5.62K
Activest Wealth Management32$2.53K
Optima Capital LLC12$949
Private Trust Co NA11$870
Marquette Asset Management, LLC7$554
Cape Investment Advisory, Inc.6$475
Bare Financial Services, Inc6$475
Rachor Investment Advisory Services, LLC4$317
Stone House Investment Management, LLC3$237
Avion Wealth6$0

Not filed for Q1 2026 yet (5)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q4 2025 and haven't filed a 13F for Q1 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding IONS in Q4 2025 that haven't filed for Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
Vanguard Group Inc16,440,459$1.30B
Norges Bank320,160$25.3M
Comerica Bank3,997$316.2K
Global Retirement Partners, LLC1,876$148.4K
CIBC Private Wealth Group, LLC99$7.83K