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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q1 2026

Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
497
+8 vs. Q4 2025
Shares held
172.6M
+19.1M (+12.5%) vs. Q4 2025
Total value
$13.0B
+$828.1M (+6.8%) vs. Q4 2025
New holders
73
179 more added
Sold out
65
158 more reduced

5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 497 institutions
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value heldQ1 2026: $13.0B
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.

Institutions holding IONS in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Truvestments Capital LLC1$560.00%00.0%Unchanged
Nisa Investment Advisors, LLC1$750.00%00.0%Unchanged
3 Factor Indexing, LLC2$1510.00%+2New
Dunhill Financial, LLC2$2010.00%−1−33.3%Reduced
Manchester Capital Management LLC5$3760.00%00.0%Unchanged
Hughes Financial Services, LLC6$4510.00%+6New
Kayne Anderson Rudnick Investment Management LLC7$5260.00%00.0%Unchanged
True Wealth Design, LLC7$5260.00%00.0%Unchanged
Essential Partners LLC7$5260.00%00.0%Unchanged
American Capital Advisory, LLC7$5260.00%+5+250.0%Added
Caitong International Asset Management Co., Ltd7$5260.00%+7New
Cornerstone Planning Group LLC10$7530.00%+5+100.0%Added
Clearstead Advisors, LLC12$9020.00%−3−20.0%Reduced
Rothschild Investment LLC13$9760.00%−6−31.6%Reduced
Mascoma Wealth Management LLC14$1.05K0.00%00.0%Unchanged
South State Corp.14$1.05K0.00%00.0%Unchanged
Cornerstone Financial Management LLC15$1.13K0.00%00.0%Unchanged
Whipplewood Advisors, LLC15$1.13K0.00%+15New
Quaker Wealth Management, LLC15$1.13K0.00%+1+7.1%Added
Fortitude Family Office, LLC17$1.28K0.00%00.0%Unchanged
Cromwell Holdings LLC18$1.35K0.00%00.0%Unchanged
Aspect Partners, LLC20$1.50K0.00%00.0%Unchanged
NBT Bank N A20$1.50K0.00%+20New
TFC Financial Management21$1.58K0.00%00.0%Unchanged
Bruce G. Allen Investments, LLC23$1.73K0.00%00.0%Unchanged
IMA Wealth, Inc.28$2.10K0.00%+23+460.0%Added
Cheviot Value Management, LLC28$2.10K0.00%00.0%Unchanged
Raffa Wealth Management, LLC28$2.10K0.00%00.0%Unchanged
Principia Wealth Advisory, LLC32$2.40K0.00%+6+23.1%Added
Transamerica Financial Advisors, Inc.33$2.48K0.00%+33New
Highline Wealth Partners LLC38$2.85K0.00%00.0%Unchanged
Hantz Financial Services, Inc.36$3.00K0.00%00.0%Unchanged
Sachetta, LLC45$3.38K0.00%00.0%Unchanged
Horizon Investments, LLC48$3.60K0.00%+26+118.2%Added
Crewe Advisors LLC48$3.60K0.00%00.0%Unchanged
TD Waterhouse Canada Inc.48$3.60K0.00%+48New
Triumph Capital Management50$3.75K0.00%00.0%Unchanged
MCF Advisors LLC50$3.75K0.00%+50New
First Horizon Corp56$4.21K0.00%+31+124.0%Added
Bell Investment Advisors, Inc61$4.58K0.00%00.0%Unchanged
Private Wealth Management Group, LLC65$4.88K0.00%00.0%Unchanged
WPG Advisers, LLC70$5.26K0.00%00.0%Unchanged
Clear Investment Research, LLC71$5.33K0.01%+71New
Leonteq Securities AG73$5.48K0.00%+10+15.9%Added
Rossby Financial, LCC74$5.56K0.00%+25+51.0%Added
TD Private Client Wealth LLC80$6.01K0.00%−2−2.4%Reduced
Orion Capital Management LLC80$6.01K0.00%00.0%Unchanged
Keating Financial Advisory Services, Inc.90$6.76K0.00%+74+462.5%Added
Bessemer Group Inc94$7.00K0.00%−39−29.3%Reduced
Quent Capital, LLC99$7.43K0.00%00.0%Unchanged
Danske Bank A/S100$7.51K0.00%−1,300−92.9%Reduced
Main Street Group, LTD100$7.51K0.00%+100New
LRI Investments, LLC110$8.26K0.00%00.0%Unchanged
Bogart Wealth, LLC123$9.24K0.00%−5−3.9%Reduced
Spire Wealth Management125$9.39K0.00%00.0%Unchanged
Global X Japan Co., Ltd.128$9.61K0.00%−43−25.1%Reduced
Massmutual Trust Co FSB143$10.7K0.00%+52+57.1%Added
Strategic Wealth Partners, Ltd.150$11.3K0.00%00.0%Unchanged
Wealth Preservation Advisors, LLC150$11.3K0.01%00.0%Unchanged
Meeder Asset Management Inc152$11.4K0.00%−564−78.8%Reduced
United Financial Planning Group LLC158$11.9K0.01%+150+1,875.0%Added
SBI Securities Co., Ltd.161$12.1K0.00%−125−43.7%Reduced
FIL Ltd165$12.4K0.00%+118+251.1%Added
Owl Creek Wealth Partners LLC170$12.8K0.00%+170New
Zions Bancorporation, National Association177$13.3K0.00%−11−5.9%Reduced
Basecamp Wealth Advisors LLC185$13.9K0.00%00.0%Unchanged
Covestor Ltd182$14.0K0.01%−91−33.3%Reduced
E Fund Management (Hong Kong) Co., Ltd.195$14.6K0.01%+195New
CX Institutional202$15.0K0.00%+202New
MH & Associates Securities Management Corp200$15.0K0.01%00.0%Unchanged
Atlantic Union Bankshares Corp200$15.0K0.00%00.0%Unchanged
Elequin Capital LP208$15.6K0.00%−503−70.7%Reduced
Umb Bank N A215$16.1K0.00%+1+0.5%Added
Twin Peaks Wealth Advisors, LLC215$16.1K0.00%+215New
Global Trust Asset Management, LLC218$16.4K0.01%00.0%Unchanged
Aster Capital Management (DIFC) Ltd550$16.6K0.01%+535+3,566.7%Added
Cedar Mountain Advisors, LLC223$16.7K0.00%+223New
Westside Investment Management, Inc.231$17.3K0.00%00.0%Unchanged
Harvest Fund Management Co., Ltd234$18.0K0.00%−4,582−95.1%Reduced
MTM Investment Management, LLC258$19.4K0.01%00.0%Unchanged
Parkside Financial Bank & Trust258$19.4K0.00%+8+3.2%Added
NBC Securities, Inc.273$20.5K0.00%00.0%Unchanged
Capital Advisors, Ltd. LLC295$22.0K0.00%00.0%Unchanged
Steigerwald, Gordon & Koch Inc.295$22.2K0.00%−85−22.4%Reduced
Eastern Bank300$22.5K0.00%00.0%Unchanged
Sound Income Strategies, LLC300$22.5K0.00%+14+4.9%Added
Salomon & Ludwin, LLC332$24.8K0.00%00.0%Unchanged
Wellington-Altus USA Inc.317$25.1K0.01%−34−9.7%Reduced
Brown Brothers Harriman & Co341$25.6K0.00%00.0%Unchanged
Hilton Head Capital Partners, LLC353$26.5K0.01%−246−41.1%Reduced
CoreCap Advisors, LLC370$27.8K0.00%00.0%Unchanged
Employees Retirement System of Texas378$28.0K0.00%−976−72.1%Reduced
RWM Asset Management, LLC375$28.2K0.00%+375New
Golden State Wealth Management, LLC376$28.2K0.00%00.0%Unchanged
ORG Wealth Partners, LLC400$30.0K0.01%00.0%Unchanged
Cassaday & Co Wealth Management LLC400$30.0K0.00%+400New
Mather Group, LLC.410$30.8K0.00%+410New
Bayforest Capital Ltd413$31.0K0.03%−678−62.1%Reduced
Allworth Financial LP522$39.2K0.00%−398−43.3%Reduced
Harbour Investments, Inc.546$41.0K0.00%+318+139.5%Added