Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SEI Investments Co | 157,222 | $11.8M | 0.01% | +41,305+35.6% | Added |
| CenterBook Partners LP | 150,912 | $11.3M | 0.61% | −3,037−2.0% | Reduced |
| Manufacturers Life Insurance Company, The | 149,538 | $11.2M | 0.01% | −3,703−2.4% | Reduced |
| Aquatic Capital Management LLC | 147,379 | $11.1M | 0.32% | +14,553+11.0% | Added |
| Citigroup Inc | 146,541 | $11.0M | 0.01% | +57,201+64.0% | Added |
| Artia Global Partners LP | 144,376 | $10.8M | 2.44% | 00.0% | Unchanged |
| Capital Fund Management S.A. | 142,201 | $10.7M | 0.10% | +142,201 | New |
| Fisher Asset Management, LLC | 141,544 | $10.6M | 0.00% | −71−0.1% | Reduced |
| Vanguard Asset Management, Ltd | 137,507 | $10.3M | 0.01% | +137,507 | New |
| Edmond de Rothschild Holding S.A. | 137,190 | $10.3M | 0.15% | +15,000+12.3% | Added |
| State Board of Administration of Florida Retirement System | 135,878 | $10.2M | 0.02% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 133,827 | $10.0M | 0.13% | +111,636+503.1% | Added |
| Braidwell LP | 130,862 | $9.83M | 0.33% | +130,862 | New |
| Ikarian Capital, LLC | 127,038 | $9.54M | 1.36% | −75,000−37.1% | Reduced |
| HealthInvest Partners AB | 27,873 | $9.40M | 3.03% | −64,504−69.8% | Reduced |
| Integral Health Asset Management, LLC | 125,000 | $9.39M | 0.50% | +125,000 | New |
| Great Lakes Advisors, LLC | 118,926 | $8.93M | 0.07% | −30,254−20.3% | Reduced |
| Algert Global LLC | 116,563 | $8.75M | 0.13% | −10,642−8.4% | Reduced |
| SEB Asset Management AB | 114,334 | $8.59M | 0.04% | +114,334 | New |
| Nomura Holdings Inc | 114,080 | $8.57M | 0.07% | −734,735−86.6% | Reduced |
| Standard Life Aberdeen plc | 113,843 | $8.55M | 0.01% | +84,917+293.6% | Added |
| Kennedy Capital Management, Inc. | 111,830 | $8.40M | 0.18% | +2,539+2.3% | Added |
| Exome Asset Management LLC | 110,064 | $8.26M | 4.86% | −6,451−5.5% | Reduced |
| Victory Capital Management Inc | 108,744 | $8.17M | 0.01% | +28,015+34.7% | Added |
| Winton Group Ltd | 106,532 | $8.00M | 0.28% | +106,532 | New |
| Empowered Funds, LLC | 103,141 | $7.74M | 0.05% | +103,141 | New |
| Gotham Asset Management, LLC | 98,968 | $7.43M | 0.02% | +55,756+129.0% | Added |
| State of Wisconsin Investment Board | 96,491 | $7.25M | 0.02% | +1,730+1.8% | Added |
| Susquehanna Portfolio Strategies, LLC | 95,960 | $7.21M | 0.11% | 00.0% | Unchanged |
| Marshall Wace, LLP | 95,954 | $7.21M | 0.01% | −160,979−62.7% | Reduced |
| EFG International AG | 93,980 | $7.06M | 0.15% | +18,704+24.8% | Added |
| Envestnet Asset Management Inc | 93,382 | $7.01M | 0.00% | +3,463+3.9% | Added |
| Rhenman & Partners Asset Management AB | 92,900 | $6.98M | 0.86% | −65,600−41.4% | Reduced |
| DekaBank Deutsche Girozentrale | 93,807 | $6.92M | 0.01% | 00.0% | Unchanged |
| Sumitomo Mitsui Trust Holdings, Inc. | 81,876 | $6.15M | 0.00% | −11,875−12.7% | Reduced |
| Nikko Asset Management Americas, Inc. | 81,696 | $6.13M | 0.09% | −11,875−12.7% | Reduced |
| XTX Topco Ltd | 80,519 | $6.05M | 0.11% | +63,602+376.0% | Added |
| CSS LLC | 79,093 | $5.94M | 0.33% | +79,093 | New |
| China Universal Asset Management Co., Ltd. | 77,315 | $5.81M | 0.44% | +34,921+82.4% | Added |
| Boothbay Fund Management, LLC | 76,571 | $5.75M | 0.14% | +1,009+1.3% | Added |
| Lisanti Capital Growth, LLC | 75,699 | $5.68M | 1.43% | +42,910+130.9% | Added |
| Vanguard Global Advisers, LLC | 71,911 | $5.40M | 0.00% | +71,911 | New |
| Hillsdale Investment Management Inc. | 70,900 | $5.32M | 0.14% | 00.0% | Unchanged |
| Erste Asset Management GmbH | 71,800 | $5.21M | 0.05% | 00.0% | Unchanged |
| Voya Investment Management LLC | 69,136 | $5.19M | 0.01% | −4,624−6.3% | Reduced |
| Edgestream Partners, L.P. | 68,369 | $5.13M | 0.17% | +68,369 | New |
| Janus Henderson Group PLC | 68,191 | $5.12M | 0.00% | 00.0% | Unchanged |
| Treasurer of the State of North Carolina | 67,701 | $5.08M | 0.02% | +1,439+2.2% | Added |
| Police & Firemen's Retirement System of New Jersey | 67,323 | $5.06M | 0.04% | +474+0.7% | Added |
| Walleye Capital LLC | 65,949 | $4.95M | 0.03% | +65,624+20,192.0% | Added |
| SG Americas Securities, LLC | 63,295 | $4.75M | 0.01% | +29,886+89.5% | Added |
| Russell Investments Group, Ltd. | 62,919 | $4.72M | 0.01% | +19,007+43.3% | Added |
| Brinker Capital Investments, LLC | 61,344 | $4.61M | 0.04% | +37,770+160.2% | Added |
| Polymer Capital Management (HK) LTD | 61,200 | $4.60M | 0.64% | +61,200 | New |
| Rafferty Asset Management, LLC | 60,308 | $4.53M | 0.02% | −13,675−18.5% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 60,239 | $4.52M | 0.01% | +11,318+23.1% | Added |
| Jefferies Financial Group Inc. | 59,065 | $4.44M | 0.05% | +8,670+17.2% | Added |
| One Capital Management, LLC | 58,939 | $4.43M | 0.12% | +12,818+27.8% | Added |
| Future Fund LLC | 58,732 | $4.41M | 1.55% | +12,881+28.1% | Added |
| Panagora Asset Management Inc | 57,446 | $4.31M | 0.02% | +57,446 | New |
| DCF Advisers, LLC | 56,000 | $4.21M | 1.59% | −47,000−45.6% | Reduced |
| Quantinno Capital Management LP | 55,502 | $4.17M | 0.01% | +8,124+17.1% | Added |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 54,269 | $4.08M | 0.14% | −67,359−55.4% | Reduced |
| Carmignac Gestion | 53,000 | $3.98M | 0.06% | +53,000 | New |
| State of New Jersey Common Pension Fund D | 52,588 | $3.95M | 0.02% | −2,195−4.0% | Reduced |
| Creative Planning | 52,228 | $3.92M | 0.00% | −2,546−4.6% | Reduced |
| Nicola Wealth Management Ltd. | 52,000 | $3.90M | 0.47% | −35,000−40.2% | Reduced |
| Adage Capital Partners GP, L.L.C. | 50,000 | $3.75M | 0.01% | −90,000−64.3% | Reduced |
| Capital Counsel LLC | 49,580 | $3.72M | 0.16% | −25−0.1% | Reduced |
| Tudor Investment Corp Et Al | 48,244 | $3.62M | 0.02% | +44,583+1,217.8% | Added |
| E Fund Management Co., Ltd. | 46,688 | $3.51M | 0.10% | +46,688 | New |
| Public Employees Retirement System of Ohio | 46,030 | $3.46M | 0.01% | −1,568−3.3% | Reduced |
| Ensign Peak Advisors, Inc | 46,004 | $3.45M | 0.01% | −7,660−14.3% | Reduced |
| Bamco Inc | 45,000 | $3.38M | 0.01% | +9,000+25.0% | Added |
| West Michigan Advisors, LLC | 44,614 | $3.35M | 0.74% | +6,201+16.1% | Added |
| Guggenheim Capital LLC | 44,050 | $3.31M | 0.03% | +6,341+16.8% | Added |
| Qube Research & Technologies Ltd | 42,856 | $3.22M | 0.00% | +42,856 | New |
| Arizona State Retirement System | 42,266 | $3.17M | 0.02% | −155−0.4% | Reduced |
| Polygon Management Ltd. | 41,764 | $3.14M | 0.62% | +41,764 | New |
| Stanley-Laman Group, Ltd. | 39,306 | $2.95M | 0.36% | +2,794+7.7% | Added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 38,988 | $2.93M | 4.26% | +13,971+55.8% | Added |
| Vanguard Investments Australia, Ltd. | 38,557 | $2.90M | 0.01% | +38,557 | New |
| Intech Investment Management LLC | 38,515 | $2.89M | 0.03% | +28,913+301.1% | Added |
| Grandfield & Dodd, LLC | 37,326 | $2.80M | 0.16% | −495−1.3% | Reduced |
| Prudential Financial Inc | 35,268 | $2.65M | 0.00% | +11,260+46.9% | Added |
| BLB&B Advisors, LLC | 35,170 | $2.64M | 0.11% | −26,350−42.8% | Reduced |
| Raiffeisen Bank International AG | 36,000 | $2.61M | 0.04% | +1,000+2.9% | Added |
| Van Eck Associates Corp | 34,505 | $2.59M | 0.00% | −12,597−26.7% | Reduced |
| PEAK6 LLC | 34,419 | $2.58M | 0.07% | +3,777+12.3% | Added |
| Exchange Traded Concepts, LLC | 33,941 | $2.55M | 0.02% | +12,847+60.9% | Added |
| KLP Kapitalforvaltning AS | 33,900 | $2.55M | 0.01% | +400+1.2% | Added |
| Blair William & Co | 33,857 | $2.54M | 0.01% | +69+0.2% | Added |
| Assenagon Asset Management S.A. | 33,673 | $2.53M | 0.00% | +4,357+14.9% | Added |
| Toroso Investments, LLC | 34,432 | $2.51M | 0.01% | +16,524+92.3% | Added |
| Pathstone Holdings, LLC | 32,835 | $2.47M | 0.01% | −1,469−4.3% | Reduced |
| Swedbank AB | 32,253 | $2.42M | 0.00% | +5,000+18.3% | Added |
| LPL Financial LLC | 31,932 | $2.40M | 0.00% | +863+2.8% | Added |
| KBC Group NV | 30,213 | $2.27M | 0.01% | +21,161+233.8% | Added |
| Prelude Capital Management, LLC | 29,658 | $2.23M | 0.17% | −2,823−8.7% | Reduced |
| Kornitzer Capital Management Inc | 29,105 | $2.19M | 0.05% | 00.0% | Unchanged |