Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| AQR Capital Management LLC | 28,783 | $2.16M | 0.00% | +10,021+53.4% | Added |
| STRS Ohio | 28,782 | $2.16M | 0.01% | +24,994+659.8% | Added |
| Fred Alger Management, LLC | 28,452 | $2.14M | 0.01% | −9,971−26.0% | Reduced |
| Mutual of America Capital Management LLC | 28,126 | $2.11M | 0.02% | −3,333−10.6% | Reduced |
| Worldquant Millennium Advisors LLC | 27,924 | $2.10M | 0.01% | +10,514+60.4% | Added |
| DeepCurrents Investment Group LLC | 27,422 | $2.06M | 0.08% | +27,422 | New |
| Entropy Technologies, LP | 27,207 | $2.04M | 0.09% | +27,207 | New |
| Bank of Montreal | 26,585 | $2.00M | 0.00% | −9,777−26.9% | Reduced |
| StemPoint Capital LP | 26,385 | $1.98M | 0.38% | +26,385 | New |
| Xponance, Inc. | 26,384 | $1.98M | 0.01% | +3,443+15.0% | Added |
| Profund Advisors LLC | 26,287 | $1.97M | 0.07% | −386−1.4% | Reduced |
| Jain Global LLC | 26,285 | $1.97M | 0.03% | −329,974−92.6% | Reduced |
| Florida Financial Advisors, LLC | 25,886 | $1.94M | 0.47% | +25,886 | New |
| Qsemble Capital Management, LP | 25,758 | $1.93M | 0.15% | −1,821−6.6% | Reduced |
| Jones Financial Companies LLLP | 26,723 | $1.93M | 0.00% | +20,240+312.2% | Added |
| Lazard Asset Management LLC | 25,410 | $1.91M | 0.00% | −20,992−45.2% | Reduced |
| Teachers Retirement System of the State of Kentucky | 24,083 | $1.81M | 0.01% | 00.0% | Unchanged |
| Man Group plc | 24,013 | $1.80M | 0.00% | −142,029−85.5% | Reduced |
| Amundi | 23,958 | $1.80M | 0.00% | −436,989−94.8% | Reduced |
| Natixis Advisors, L.P. | 23,721 | $1.78M | 0.00% | +1,830+8.4% | Added |
| Voleon Capital Management LP | 23,047 | $1.73M | 0.04% | +18,759+437.5% | Added |
| Wolverine Asset Management LLC | 22,815 | $1.71M | 0.03% | −7,700−25.2% | Reduced |
| Great West Life Assurance Co | 22,135 | $1.67M | 0.00% | +1,241+5.9% | Added |
| EAM Investors, LLC | 20,608 | $1.55M | 0.18% | −33,306−61.8% | Reduced |
| Allstate Corp | 20,565 | $1.54M | 0.02% | +20,565 | New |
| Readystate Asset Management LP | 20,436 | $1.53M | 0.09% | +20,436 | New |
| Landscape Capital Management, L.L.C. | 20,146 | $1.51M | 0.10% | −4,009−16.6% | Reduced |
| Legato Capital Management LLC | 19,840 | $1.49M | 0.14% | +13,685+222.3% | Added |
| Calamos Advisors LLC | 19,781 | $1.49M | 0.01% | −13,408−40.4% | Reduced |
| FORA Capital, LLC | 19,693 | $1.48M | 0.11% | +19,693 | New |
| Nicollet Investment Management, Inc. | 19,646 | $1.48M | 0.51% | −877−4.3% | Reduced |
| AlphaCentric Advisors LLC | 19,587 | $1.47M | 1.47% | +1,064+5.7% | Added |
| DnB Asset Management AS | 19,060 | $1.43M | 0.01% | +4,222+28.5% | Added |
| Dana Investment Advisors, Inc. | 18,487 | $1.39M | 0.04% | +461+2.6% | Added |
| Inceptionr LLC | 16,821 | $1.26M | 0.30% | −1,029−5.8% | Reduced |
| North Star Asset Management Inc | 16,610 | $1.25M | 0.05% | 00.0% | Unchanged |
| Public Employees Retirement Association of Colorado | 15,589 | $1.17M | 0.00% | 00.0% | Unchanged |
| Caption Management, LLC | 15,591 | $1.17M | 0.06% | +15,591 | New |
| Brown Advisory Inc | 15,105 | $1.13M | 0.00% | +140+0.9% | Added |
| LMR Partners LLP | 15,000 | $1.13M | 0.01% | 00.0% | Unchanged |
| M&G Plc | 14,423 | $1.08M | 0.01% | 00.0% | Unchanged |
| Davy Global Fund Management Ltd | 14,389 | $1.08M | 0.08% | −779−5.1% | Reduced |
| Bleakley Financial Group, LLC | 14,316 | $1.07M | 0.02% | +441+3.2% | Added |
| Canada Pension Plan Investment Board | 14,100 | $1.06M | 0.00% | +14,100 | New |
| Dynasty Wealth Management, LLC | 14,080 | $1.06M | 0.01% | +90+0.6% | Added |
| The PNC Financial Services Group, Inc. | 13,545 | $1.02M | 0.00% | −271−2.0% | Reduced |
| Westmount Partners, LLC | 12,961 | $973.2K | 0.24% | 00.0% | Unchanged |
| Truist Financial Corp | 12,846 | $964.6K | 0.00% | +187+1.5% | Added |
| Highland Capital Management, LLC | 12,819 | $962.6K | 0.05% | +12,819 | New |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $961.2K | 0.15% | 00.0% | Unchanged |
| Allianz Asset Management GmbH | 12,601 | $946.2K | 0.00% | −4,115−24.6% | Reduced |
| Susquehanna International Group, LLP | 12,359 | $928.0K | 0.00% | −20,145−62.0% | Reduced |
| SBI Okasan Asset Management Co.Ltd. | 12,600 | $913.8K | 0.04% | 00.0% | Unchanged |
| Amalgamated Bank | 12,054 | $905.0K | 0.01% | −401−3.2% | Reduced |
| Oppenheimer Asset Management Inc. | 11,853 | $890.0K | 0.01% | +589+5.2% | Added |
| Summit Trail Advisors, LLC | 11,549 | $867.2K | 0.01% | +1,606+16.2% | Added |
| Horizon Kinetics Asset Management LLC | 11,428 | $858.1K | 0.01% | −524−4.4% | Reduced |
| JustInvest LLC | 11,414 | $857.1K | 0.01% | −1,047−8.4% | Reduced |
| Cetera Investment Advisers | 11,280 | $847.0K | 0.00% | +424+3.9% | Added |
| Plancorp, LLC | 11,208 | $842.5K | 0.02% | 00.0% | Unchanged |
| Northwestern Mutual Wealth Management Co | 11,123 | $835.2K | 0.00% | −875−7.3% | Reduced |
| Capstone Capital Management Ltd | 21,447 | $832.4K | 0.84% | +21,447 | New |
| Fifth Third Bancorp | 11,011 | $826.8K | 0.00% | +3,123+39.6% | Added |
| Wiley Bros.-Aintree Capital, LLC | 10,909 | $819.2K | 0.00% | +1,186+12.2% | Added |
| Suvretta Capital Management, LLC | 10,800 | $811.0K | 0.02% | 00.0% | Unchanged |
| Virtus Investment Advisers, Inc. | 10,445 | $784.3K | 0.22% | +1,991+23.6% | Added |
| Virginia Retirement Systems Et Al | 10,300 | $773.4K | 0.01% | −300−2.8% | Reduced |
| Federation des caisses Desjardins du Quebec | 10,005 | $751.3K | 0.00% | −2,548−20.3% | Reduced |
| Thrivent Financial for Lutherans | 9,962 | $748.0K | 0.00% | 00.0% | Unchanged |
| Assetmark, Inc | 9,574 | $718.9K | 0.00% | +924+10.7% | Added |
| Vident Advisory, LLC | 9,489 | $712.5K | 0.01% | −746−7.3% | Reduced |
| MetLife Investment Management | 9,224 | $692.6K | 0.00% | −450−4.7% | Reduced |
| Swiss Life Asset Management Ltd | 9,175 | $689.0K | 0.00% | +2,272+32.9% | Added |
| Mirae Asset Global Investments Co., Ltd. | 9,029 | $678.0K | 0.00% | +763+9.2% | Added |
| Aigen Investment Management, LP | 8,790 | $660.0K | 0.17% | −71−0.8% | Reduced |
| Advisor Group Holdings, Inc. | 8,710 | $654.0K | 0.00% | −2,936−25.2% | Reduced |
| Savant Capital, LLC | 8,461 | $635.3K | 0.00% | +1,272+17.7% | Added |
| denkapparat Operations GmbH | 8,364 | $628.1K | 0.26% | 00.0% | Unchanged |
| Utah Retirement Systems | 8,300 | $623.2K | 0.01% | 00.0% | Unchanged |
| Sectoral Asset Management Inc | 7,200 | $617.2K | 0.51% | −1,165−13.9% | Reduced |
| Commerce Bank | 8,165 | $613.1K | 0.00% | +54+0.7% | Added |
| Commonwealth Equity Services, LLC | 7,829 | $587.9K | 0.00% | −3,977−33.7% | Reduced |
| Stratos Wealth Partners, LTD. | 7,715 | $579.3K | 0.01% | −25−0.3% | Reduced |
| O'Shaughnessy Asset Management, LLC | 7,687 | $577.2K | 0.00% | +655+9.3% | Added |
| M&T Bank Corp | 7,671 | $575.5K | 0.00% | −479−5.9% | Reduced |
| Cerity Partners LLC | 7,596 | $570.4K | 0.00% | −16,331−68.3% | Reduced |
| Fiduciary Trust Co | 7,399 | $555.6K | 0.01% | 00.0% | Unchanged |
| ProShare Advisors LLC | 7,390 | $554.9K | 0.00% | +236+3.3% | Added |
| Maryland State Retirement & Pension System | 7,380 | $554.2K | 0.01% | −904−10.9% | Reduced |
| Ground Swell Capital, LLC | 7,285 | $547.0K | 1.08% | +7,285 | New |
| Meeder Advisory Services, Inc. | 7,239 | $543.6K | 0.02% | +83+1.2% | Added |
| Callan Family Office, LLC | 7,082 | $531.8K | 0.01% | −22−0.3% | Reduced |
| Silvercrest Asset Management Group LLC | 7,053 | $529.6K | 0.00% | −189−2.6% | Reduced |
| Principal Financial Group Inc | 7,019 | $527.1K | 0.00% | +3,680+110.2% | Added |
| PSP Research LLC | 6,800 | $510.6K | 0.36% | 00.0% | Unchanged |
| Significant Wealth Partners LLC | 6,664 | $500.4K | 0.62% | −100−1.5% | Reduced |
| Wedmont Private Capital | 6,564 | $492.2K | 0.02% | +1,028+18.6% | Added |
| J. Safra Sarasin Holding AG | 6,431 | $482.9K | 0.01% | −10,973−63.0% | Reduced |
| Mercer Global Advisors Inc | 6,296 | $472.8K | 0.00% | +742+13.4% | Added |
| Everence Capital Management Inc | 6,232 | $468.0K | 0.03% | −538−7.9% | Reduced |