Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 356
- +9 vs. Q3 2024
- Shares held
- 160.5M
- +3.10M (+2.0%) vs. Q3 2024
- Total value
- $5.61B
- −$692.3M (−11.0%) vs. Q3 2024
- New holders
- 58
- 119 more added
- Sold out
- 49
- 121 more reduced
7 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Raymond James Financial Inc | 105,619 | $3.69M | 0.00% | +105,619 | New |
| State of Wisconsin Investment Board | 101,231 | $3.54M | 0.01% | +15,065+17.5% | Added |
| Schroder Investment Management Group | 100,659 | $3.52M | 0.00% | +44,437+79.0% | Added |
| Ghisallo Capital Management LLC | 100,000 | $3.50M | 0.20% | −300,000−75.0% | Reduced |
| Neuberger Berman Group LLC | 96,631 | $3.38M | 0.00% | +31,757+49.0% | Added |
| DekaBank Deutsche Girozentrale | 93,807 | $3.32M | 0.01% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 94,157 | $3.29M | 0.00% | −175−0.2% | Reduced |
| Voya Investment Management LLC | 92,531 | $3.23M | 0.00% | −3,290−3.4% | Reduced |
| Deutsche Bank AG | 91,901 | $3.21M | 0.00% | +17,027+22.7% | Added |
| Twin Tree Management, LP | 88,900 | $3.11M | 0.08% | +76,472+615.3% | Added |
| Trexquant Investment LP | 84,913 | $2.97M | 0.03% | −45,945−35.1% | Reduced |
| New York State Common Retirement Fund | 84,261 | $2.95M | 0.00% | −114,498−57.6% | Reduced |
| HSBC Holdings PLC | 83,055 | $2.93M | 0.00% | +83,055 | New |
| DCF Advisers, LLC | 82,882 | $2.90M | 1.46% | +43,382+109.8% | Added |
| Granite Investment Partners, LLC | 73,866 | $2.58M | 0.11% | −11,927−13.9% | Reduced |
| SEI Investments Co | 70,091 | $2.45M | 0.00% | −119,746−63.1% | Reduced |
| Treasurer of the State of North Carolina | 68,803 | $2.40M | 0.01% | +440+0.6% | Added |
| Teacher Retirement System of Texas | 65,792 | $2.30M | 0.01% | +9,093+16.0% | Added |
| Allostery Investments LP | 65,000 | $2.27M | 4.46% | +65,000 | New |
| Janus Henderson Group PLC | 63,877 | $2.23M | 0.00% | +4,900+8.3% | Added |
| Sphera Funds Management Ltd. | 63,821 | $2.23M | 0.41% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 63,206 | $2.21M | 0.01% | +11,431+22.1% | Added |
| Davenport & Co LLC | 62,740 | $2.19M | 0.01% | −12,858−17.0% | Reduced |
| Russell Investments Group, Ltd. | 62,200 | $2.17M | 0.00% | −66,269−51.6% | Reduced |
| Van Eck Associates Corp | 61,619 | $2.15M | 0.00% | +2,613+4.4% | Added |
| Exome Asset Management LLC | 61,367 | $2.15M | 1.61% | +61,367 | New |
| UBS Oconnor LLC | 60,580 | $2.12M | 0.05% | +23,623+63.9% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | $2.08M | 0.01% | 00.0% | Unchanged |
| NEOS Investment Management LLC | 56,844 | $1.99M | 0.05% | −2,400−4.1% | Reduced |
| Tema ETFs LLC | 56,844 | $1.99M | 0.83% | +56,844 | New |
| Police & Firemen's Retirement System of New Jersey | 56,695 | $1.98M | 0.02% | +56,695 | New |
| Public Employees Retirement System of Ohio | 53,748 | $1.88M | 0.01% | −3,077−5.4% | Reduced |
| Ensign Peak Advisors, Inc | 53,320 | $1.86M | 0.00% | −16,560−23.7% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.84M | 0.02% | 00.0% | Unchanged |
| Envestnet Asset Management Inc | 52,688 | $1.84M | 0.00% | −6,126−10.4% | Reduced |
| Alliancebernstein L.P. | 52,136 | $1.82M | 0.00% | −260.0% | Reduced |
| Fieldview Capital Management, LLC | 51,282 | $1.79M | 0.28% | +51,282 | New |
| Creative Planning | 46,803 | $1.64M | 0.00% | +18,421+64.9% | Added |
| Qsemble Capital Management, LP | 46,573 | $1.63M | 0.22% | +46,573 | New |
| Handelsbanken Fonder AB | 43,811 | $1.53M | 0.01% | +800+1.9% | Added |
| Profund Advisors LLC | 43,559 | $1.52M | 0.06% | +5,963+15.9% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.47M | 0.18% | 00.0% | Unchanged |
| Liontrust Investment Partners LLP | 41,621 | $1.46M | 0.02% | −18,023−30.2% | Reduced |
| Arizona State Retirement System | 41,147 | $1.44M | 0.01% | +3,320+8.8% | Added |
| Private Advisor Group, LLC | 40,673 | $1.42M | 0.01% | −3,114−7.1% | Reduced |
| LPL Financial LLC | 40,376 | $1.41M | 0.00% | −2,244−5.3% | Reduced |
| Blair William & Co | 39,882 | $1.39M | 0.00% | −6,769−14.5% | Reduced |
| Jump Financial, LLC | 39,737 | $1.39M | 0.03% | +39,737 | New |
| Great West Life Assurance Co | 39,214 | $1.37M | 0.00% | −621−1.6% | Reduced |
| Capital Counsel LLC | 37,080 | $1.30M | 0.06% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36,322 | $1.27M | 0.00% | +5,400+17.5% | Added |
| Grandfield & Dodd, LLC | 35,887 | $1.25M | 0.08% | +1,074+3.1% | Added |
| Guggenheim Capital LLC | 35,373 | $1.24M | 0.01% | −1,786−4.8% | Reduced |
| China Universal Asset Management Co., Ltd. | 33,480 | $1.17M | 0.11% | +5,359+19.1% | Added |
| KLP Kapitalforvaltning AS | 29,200 | $1.02M | 0.00% | +29,200 | New |
| PDT Partners, LLC | 28,994 | $1.01M | 0.09% | +15,594+116.4% | Added |
| Mariner, LLC | 27,661 | $967.0K | 0.00% | +4,534+19.6% | Added |
| BlueCrest Capital Management Ltd | 26,200 | $916.0K | 0.05% | +26,200 | New |
| Susquehanna International Group, LLP | 26,064 | $911.2K | 0.00% | −31,175−54.5% | Reduced |
| Pathstone Holdings, LLC | 26,058 | $911.0K | 0.00% | −1,749−6.3% | Reduced |
| XTX Topco Ltd | 25,362 | $886.7K | 0.07% | +8,557+50.9% | Added |
| Teachers Retirement System of the State of Kentucky | 24,083 | $842.0K | 0.01% | 00.0% | Unchanged |
| Castle Hook Partners LP | 23,940 | $836.9K | 0.02% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 23,927 | $836.0K | 0.00% | +16,508+222.5% | Added |
| D. E. Shaw & Co., Inc. | 23,123 | $808.4K | 0.00% | −121,968−84.1% | Reduced |
| Jefferies Financial Group Inc. | 22,381 | $782.4K | 0.01% | −30,400−57.6% | Reduced |
| Commonwealth Equity Services, LLC | 21,826 | $763.0K | 0.00% | +373+1.7% | Added |
| Bridgefront Capital, LLC | 21,802 | $762.2K | 0.26% | +10,606+94.7% | Added |
| Brevan Howard Capital Management LP | 21,366 | $747.0K | 0.02% | −7,113−25.0% | Reduced |
| Canada Pension Plan Investment Board | 19,900 | $695.7K | 0.00% | +8,700+77.7% | Added |
| Nicollet Investment Management, Inc. | 19,786 | $692.0K | 0.24% | −616−3.0% | Reduced |
| Xponance, Inc. | 19,339 | $676.1K | 0.01% | +318+1.7% | Added |
| Victory Capital Management Inc | 18,004 | $629.4K | 0.00% | −346−1.9% | Reduced |
| Aigen Investment Management, LP | 17,723 | $619.6K | 0.11% | +6,111+52.6% | Added |
| Toroso Investments, LLC | 17,407 | $608.5K | 0.00% | −1,501−7.9% | Reduced |
| NBT Bank N A | 17,050 | $596.1K | 0.04% | 00.0% | Unchanged |
| Bleakley Financial Group, LLC | 16,942 | $592.3K | 0.02% | +264+1.6% | Added |
| E Fund Management Co., Ltd. | 16,868 | $589.7K | 0.03% | +4,116+32.3% | Added |
| Natixis | 16,626 | $581.2K | 0.00% | +16,626 | New |
| Walleye Capital LLC | 16,255 | $568.3K | 0.01% | −107,861−86.9% | Reduced |
| Campbell & CO Investment Adviser LLC | 15,681 | $548.2K | 0.04% | +15,681 | New |
| Prelude Capital Management, LLC | 15,595 | $545.2K | 0.05% | +15,595 | New |
| Public Employees Retirement Association of Colorado | 15,589 | $545.0K | 0.00% | 00.0% | Unchanged |
| Inceptionr LLC | 14,390 | $503.1K | 0.11% | +14,390 | New |
| Natixis Advisors, L.P. | 14,313 | $500.0K | 0.00% | −6,767−32.1% | Reduced |
| Tower Research Capital LLC (TRC) | 14,157 | $494.9K | 0.01% | +9,856+229.2% | Added |
| North Star Asset Management Inc | 13,640 | $476.9K | 0.02% | 00.0% | Unchanged |
| Principal Financial Group Inc | 13,616 | $476.0K | 0.00% | +504+3.8% | Added |
| Commerce Bank | 13,584 | $474.9K | 0.00% | −63,969−82.5% | Reduced |
| Westmount Partners, LLC | 13,462 | $470.6K | 0.14% | 00.0% | Unchanged |
| Franklin Resources Inc | 13,301 | $465.0K | 0.00% | +3,146+31.0% | Added |
| Stratos Wealth Partners, LTD. | 12,813 | $447.9K | 0.01% | +25+0.2% | Added |
| Brown Advisory Inc | 12,730 | $445.0K | 0.00% | −16−0.1% | Reduced |
| Horizon Kinetics Asset Management LLC | 12,476 | $436.2K | 0.01% | +524+4.4% | Added |
| JustInvest LLC | 12,271 | $429.0K | 0.01% | +3,867+46.0% | Added |
| Essential Planning, LLC. | 11,440 | $428.1K | 0.00% | +11,440 | New |
| Northwestern Mutual Wealth Management Co | 11,327 | $396.0K | 0.00% | +64+0.6% | Added |
| Plancorp, LLC | 11,128 | $389.0K | 0.02% | −158−1.4% | Reduced |
| Amundi | 11,374 | $387.9K | 0.00% | −116,925−91.1% | Reduced |
| The PNC Financial Services Group, Inc. | 10,994 | $384.4K | 0.00% | +1,101+11.1% | Added |