Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 363
- +21 vs. Q1 2025
- Shares held
- 168.9M
- +2.14M (+1.3%) vs. Q1 2025
- Total value
- $6.67B
- +$1.64B (+32.6%) vs. Q1 2025
- New holders
- 80
- 121 more added
- Sold out
- 59
- 109 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Neuberger Berman Group LLC | 114,623 | $4.53M | 0.00% | +12,150+11.9% | Added |
| HSBC Holdings PLC | 108,294 | $4.29M | 0.00% | +33,461+44.7% | Added |
| SEI Investments Co | 98,348 | $3.89M | 0.00% | +26,790+37.4% | Added |
| Superstring Capital Management LP | 98,267 | $3.88M | 4.84% | +98,267 | New |
| State of Wisconsin Investment Board | 96,694 | $3.82M | 0.01% | −11,622−10.7% | Reduced |
| DekaBank Deutsche Girozentrale | 93,807 | $3.72M | 0.01% | 00.0% | Unchanged |
| Susquehanna Portfolio Strategies, LLC | 92,900 | $3.67M | 0.08% | +92,900 | New |
| DCF Advisers, LLC | 91,750 | $3.63M | 1.74% | −3,250−3.4% | Reduced |
| Nicola Wealth Management Ltd. | 87,000 | $3.44M | 0.32% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 86,972 | $3.44M | 0.00% | +8,711+11.1% | Added |
| Deutsche Bank AG | 85,278 | $3.37M | 0.00% | +468+0.6% | Added |
| Manufacturers Life Insurance Company, The | 83,386 | $3.29M | 0.00% | −54−0.1% | Reduced |
| Marex Group plc | 83,361 | $3.29M | 0.06% | +83,361 | New |
| UBS Oconnor LLC | 81,251 | $3.21M | 0.09% | −9,528−10.5% | Reduced |
| Worldquant Millennium Advisors LLC | 74,438 | $2.94M | 0.01% | +74,438 | New |
| Van Eck Associates Corp | 73,617 | $2.91M | 0.00% | +71,460+3,312.9% | Added |
| Treasurer of the State of North Carolina | 72,587 | $2.87M | 0.01% | +994+1.4% | Added |
| Walleye Capital LLC | 66,482 | $2.63M | 0.02% | −28,508−30.0% | Reduced |
| Davenport & Co LLC | 64,843 | $2.56M | 0.01% | +8,450+15.0% | Added |
| Voya Investment Management LLC | 64,517 | $2.55M | 0.00% | +750+1.2% | Added |
| Janus Henderson Group PLC | 63,877 | $2.52M | 0.00% | 00.0% | Unchanged |
| Lazard Asset Management LLC | 60,749 | $2.40M | 0.00% | −90.0% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 59,723 | $2.36M | 0.02% | +2,174+3.8% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | $2.36M | 0.01% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 58,918 | $2.33M | 0.01% | −1,744−2.9% | Reduced |
| Raiffeisen Bank International AG | 56,754 | $2.27M | 0.03% | +15,000+35.9% | Added |
| First Trust Advisors LP | 56,519 | $2.23M | 0.00% | +56,519 | New |
| PDT Partners, LLC | 54,365 | $2.15M | 0.12% | −41,691−43.4% | Reduced |
| Ensign Peak Advisors, Inc | 53,320 | $2.11M | 0.00% | −1,780−3.2% | Reduced |
| Creative Planning | 53,289 | $2.11M | 0.00% | +17,167+47.5% | Added |
| Alliancebernstein L.P. | 52,057 | $2.06M | 0.00% | −48,692−48.3% | Reduced |
| Erste Asset Management GmbH | 51,300 | $2.04M | 0.02% | 00.0% | Unchanged |
| Capital Counsel LLC | 50,205 | $1.98M | 0.08% | +13,125+35.4% | Added |
| Public Employees Retirement System of Ohio | 48,244 | $1.91M | 0.01% | +67+0.1% | Added |
| Great West Life Assurance Co | 46,501 | $1.84M | 0.00% | +2,648+6.0% | Added |
| Schroder Investment Management Group | 45,950 | $1.82M | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 44,040 | $1.74M | 0.01% | +3,353+8.2% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,615 | $1.72M | 0.00% | +7,106+19.5% | Added |
| Handelsbanken Fonder AB | 43,211 | $1.71M | 0.01% | 00.0% | Unchanged |
| Granite Investment Partners, LLC | 43,181 | $1.71M | 0.08% | −25,253−36.9% | Reduced |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.66M | 0.20% | 00.0% | Unchanged |
| Guggenheim Capital LLC | 40,857 | $1.61M | 0.01% | −557−1.3% | Reduced |
| Simplex Trading, LLC | 39,638 | $1.57M | 0.04% | −24,943−38.6% | Reduced |
| Prelude Capital Management, LLC | 39,423 | $1.56M | 0.15% | +1,651+4.4% | Added |
| Algert Global LLC | 38,090 | $1.50M | 0.03% | +38,090 | New |
| Blair William & Co | 37,891 | $1.50M | 0.00% | −490−1.3% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 37,649 | $1.49M | 0.04% | +37,649 | New |
| Grandfield & Dodd, LLC | 37,230 | $1.47M | 0.09% | −531−1.4% | Reduced |
| Mariner, LLC | 36,914 | $1.46M | 0.00% | +3,431+10.2% | Added |
| Engineers Gate Manager LP | 33,118 | $1.31M | 0.02% | +33,118 | New |
| Brevan Howard Capital Management LP | 32,732 | $1.29M | 0.01% | +9,759+42.5% | Added |
| Nomura Holdings Inc | 32,161 | $1.27M | 0.01% | −204,265−86.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 31,966 | $1.26M | 0.12% | +80+0.3% | Added |
| KLP Kapitalforvaltning AS | 31,500 | $1.24M | 0.01% | +4,100+15.0% | Added |
| Capital Fund Management S.A. | 31,219 | $1.23M | 0.01% | −26,795−46.2% | Reduced |
| Pathstone Holdings, LLC | 30,759 | $1.22M | 0.00% | −3,613−10.5% | Reduced |
| One Capital Management, LLC | 29,865 | $1.18M | 0.04% | +29,865 | New |
| Future Fund LLC | 29,595 | $1.17M | 0.52% | +29,595 | New |
| Entropy Technologies, LP | 29,452 | $1.16M | 0.09% | +29,452 | New |
| Profund Advisors LLC | 28,859 | $1.14M | 0.04% | −6,028−17.3% | Reduced |
| NEOS Investment Management LLC | 28,161 | $1.11M | 0.01% | +3,020+12.0% | Added |
| Tema ETFs LLC | 28,161 | $1.11M | 0.30% | +3,020+12.0% | Added |
| Daiwa Securities Group Inc. | 26,141 | $1.03M | 0.00% | +4,000+18.1% | Added |
| Alpine Global Management, LLC | 25,437 | $1.01M | 0.23% | −2,660−9.5% | Reduced |
| LPL Financial LLC | 24,872 | $982.7K | 0.00% | +906+3.8% | Added |
| Teachers Retirement System of the State of Kentucky | 24,083 | $952.0K | 0.01% | 00.0% | Unchanged |
| Xponance, Inc. | 22,754 | $899.0K | 0.01% | +2,435+12.0% | Added |
| Oxford Asset Management LLP | 22,405 | $885.2K | 0.29% | +22,405 | New |
| Jefferies Financial Group Inc. | 22,381 | $884.3K | 0.01% | −460−2.0% | Reduced |
| Graham Capital Management, L.P. | 20,935 | $827.1K | 0.03% | +20,935 | New |
| Nicollet Investment Management, Inc. | 20,747 | $820.0K | 0.27% | −704−3.3% | Reduced |
| Victory Capital Management Inc | 18,516 | $731.6K | 0.00% | −125−0.7% | Reduced |
| Bleakley Financial Group, LLC | 18,129 | $716.3K | 0.02% | −4,155−18.6% | Reduced |
| Assenagon Asset Management S.A. | 17,654 | $697.5K | 0.00% | +17,654 | New |
| Quantinno Capital Management LP | 17,542 | $693.1K | 0.00% | +9,027+106.0% | Added |
| Fieldview Capital Management, LLC | 17,306 | $683.8K | 0.10% | +17,306 | New |
| SummitTX Capital, L.P. | 17,149 | $677.6K | 0.03% | −17,954−51.1% | Reduced |
| North Star Asset Management Inc | 16,610 | $656.3K | 0.03% | +3,000+22.0% | Added |
| Bayesian Capital Management, LP | 16,600 | $655.9K | 0.10% | +8,100+95.3% | Added |
| E Fund Management Co., Ltd. | 16,160 | $638.5K | 0.03% | −311−1.9% | Reduced |
| Public Employees Retirement Association of Colorado | 15,589 | $616.0K | 0.00% | 00.0% | Unchanged |
| Significant Wealth Partners LLC | 15,504 | $612.6K | 0.30% | +1,899+14.0% | Added |
| Corton Capital Inc. | 14,424 | $569.9K | 0.66% | +14,424 | New |
| Vestmark Advisory Solutions, Inc. | 14,341 | $566.6K | 0.01% | +14,341 | New |
| Gotham Asset Management, LLC | 14,279 | $564.2K | 0.00% | +14,279 | New |
| Commonwealth Equity Services, LLC | 13,942 | $551.0K | 0.00% | −2,456−15.0% | Reduced |
| Envestnet Asset Management Inc | 13,544 | $535.1K | 0.00% | −1,495−9.9% | Reduced |
| Davy Global Fund Management Ltd | 13,263 | $524.0K | 0.05% | +5,204+64.6% | Added |
| Marshall Wace, LLP | 13,100 | $517.6K | 0.00% | +3,998+43.9% | Added |
| Westmount Partners, LLC | 12,961 | $512.1K | 0.14% | 00.0% | Unchanged |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $505.8K | 0.18% | +2,065+19.2% | Added |
| Paloma Partners Management Co | 12,557 | $496.1K | 0.11% | +12,557 | New |
| Virtus Investment Advisers, Inc. | 12,476 | $492.9K | 0.17% | +2,775+28.6% | Added |
| DnB Asset Management AS | 12,271 | $484.8K | 0.00% | +12,271 | New |
| Northwestern Mutual Wealth Management Co | 12,244 | $483.8K | 0.00% | −114−0.9% | Reduced |
| Brown Advisory Inc | 12,191 | $481.7K | 0.00% | +165+1.4% | Added |
| JustInvest LLC | 12,072 | $477.0K | 0.01% | +1,759+17.1% | Added |
| Vident Advisory, LLC | 12,000 | $474.1K | 0.01% | +12,000 | New |
| Horizon Kinetics Asset Management LLC | 11,952 | $472.2K | 0.01% | −524−4.2% | Reduced |
| Wiley Bros.-Aintree Capital, LLC | 11,758 | $464.6K | 0.00% | +754+6.9% | Added |