Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 363
- +21 vs. Q1 2025
- Shares held
- 168.9M
- +2.14M (+1.3%) vs. Q1 2025
- Total value
- $6.67B
- +$1.64B (+32.6%) vs. Q1 2025
- New holders
- 80
- 121 more added
- Sold out
- 59
- 109 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Amalgamated Bank | 11,526 | $455.0K | 0.00% | +953+9.0% | Added |
| The PNC Financial Services Group, Inc. | 11,411 | $450.8K | 0.00% | +424+3.9% | Added |
| Plancorp, LLC | 11,208 | $442.8K | 0.02% | +80+0.7% | Added |
| Fox Run Management, L.L.C. | 10,988 | $434.1K | 0.07% | +10,988 | New |
| Suvretta Capital Management, LLC | 10,800 | $426.7K | 0.02% | 00.0% | Unchanged |
| Harbor Advisors LLC | 10,500 | $414.9K | 0.07% | 00.0% | Unchanged |
| Colony Group, LLC | 10,056 | $397.3K | 0.00% | +224+2.3% | Added |
| Cypress Capital, LLC | 10,000 | $395.1K | 0.11% | 00.0% | Unchanged |
| Westfield Capital Management Co LP | 9,561 | $377.8K | 0.00% | +9,561 | New |
| Perbak Capital Partners LLP | 9,538 | $376.8K | 0.09% | +9,538 | New |
| Semanteon Capital Management, LP | 9,536 | $376.8K | 0.57% | +1,993+26.4% | Added |
| Fred Alger Management, LLC | 9,464 | $373.9K | 0.00% | +9,464 | New |
| Russell Investments Group, Ltd. | 9,265 | $366.1K | 0.00% | +3,512+61.0% | Added |
| Sectoral Asset Management Inc | 9,205 | $363.7K | 0.24% | −235−2.5% | Reduced |
| MetLife Investment Management | 9,161 | $362.0K | 0.00% | +17+0.2% | Added |
| Jump Financial, LLC | 9,018 | $356.3K | 0.00% | −72,303−88.9% | Reduced |
| Man Group plc | 8,969 | $354.4K | 0.00% | −1,064−10.6% | Reduced |
| Exchange Traded Concepts, LLC | 8,802 | $347.8K | 0.00% | +5,558+171.3% | Added |
| Prudential Financial Inc | 9,254 | $340.9K | 0.00% | +2,991+47.8% | Added |
| Wealth Enhancement Advisory Services, LLC | 7,915 | $340.3K | 0.00% | +7,915 | New |
| Fiduciary Trust Co | 8,551 | $337.9K | 0.00% | +813+10.5% | Added |
| Utah Retirement Systems | 8,400 | $331.9K | 0.00% | 00.0% | Unchanged |
| Aigen Investment Management, LP | 8,298 | $327.9K | 0.04% | +8,298 | New |
| Maryland State Retirement & Pension System | 8,284 | $327.3K | 0.01% | 00.0% | Unchanged |
| International Assets Investment Management, LLC | 8,207 | $324.3K | 0.03% | 00.0% | Unchanged |
| Atria Investments LLC | 8,186 | $323.4K | 0.00% | +8,186 | New |
| Point72 (DIFC) Ltd | 8,087 | $319.5K | 0.03% | −33,260−80.4% | Reduced |
| Principal Financial Group Inc | 7,951 | $314.1K | 0.00% | −2,496−23.9% | Reduced |
| M&T Bank Corp | 7,651 | $303.0K | 0.00% | +7,651 | New |
| Commerce Bank | 7,607 | $300.6K | 0.00% | +332+4.6% | Added |
| Fifth Third Bancorp | 7,598 | $300.2K | 0.00% | −2,391−23.9% | Reduced |
| Jones Financial Companies LLLP | 7,196 | $286.4K | 0.00% | −6,539−47.6% | Reduced |
| Jain Global LLC | 7,195 | $284.3K | 0.00% | −1,400−16.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 7,071 | $281.4K | 0.00% | −1,135−13.8% | Reduced |
| Silvercrest Asset Management Group LLC | 7,068 | $279.3K | 0.00% | +166+2.4% | Added |
| Clearstead Advisors, LLC | 7,000 | $276.6K | 0.00% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 6,813 | $269.2K | 0.00% | +6,813 | New |
| Everence Capital Management Inc | 6,770 | $267.0K | 0.02% | 00.0% | Unchanged |
| Meeder Advisory Services, Inc. | 6,644 | $262.5K | 0.01% | +6,644 | New |
| Teza Capital Management LLC | 6,604 | $260.9K | 0.19% | −3,640−35.5% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 6,148 | $242.9K | 0.00% | +829+15.6% | Added |
| Advisors Asset Management, Inc. | 5,999 | $237.0K | 0.00% | −49−0.8% | Reduced |
| ProShare Advisors LLC | 5,943 | $234.8K | 0.00% | −1,228−17.1% | Reduced |
| Frank, Rimerman Advisors LLC | 5,763 | $227.7K | 0.02% | +5,763 | New |
| Wedmont Private Capital | 5,282 | $226.2K | 0.01% | +5,282 | New |
| Cambridge Investment Research Advisors, Inc. | 5,682 | $224.0K | 0.00% | −1,122−16.5% | Reduced |
| Brinker Capital Investments, LLC | 5,600 | $221.3K | 0.00% | +5,600 | New |
| Savant Capital, LLC | 5,570 | $220.1K | 0.00% | +5,570 | New |
| Franklin Resources Inc | 5,556 | $219.5K | 0.00% | +5,556 | New |
| Castle Rock Wealth Management, LLC | 5,122 | $215.2K | 0.05% | +5,122 | New |
| Callan Family Office, LLC | 5,400 | $213.4K | 0.01% | +5,400 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 5,398 | $213.3K | 0.00% | −737−12.0% | Reduced |
| HighTower Advisors, LLC | 5,357 | $211.7K | 0.00% | +5,357 | New |
| Advisor Group Holdings, Inc. | 5,296 | $208.8K | 0.00% | +2,923+123.2% | Added |
| Pinnacle Wealth Planning Services, Inc. | 5,284 | $208.8K | 0.03% | +5,284 | New |
| Empowered Funds, LLC | 5,067 | $200.2K | 0.00% | +5,067 | New |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $197.6K | 0.02% | 00.0% | Unchanged |
| Wexford Capital LP | 4,749 | $187.6K | 0.05% | +4,749 | New |
| KBC Group NV | 4,699 | $186.0K | 0.00% | −1,816−27.9% | Reduced |
| US Bancorp | 4,285 | $169.3K | 0.00% | +1,128+35.7% | Added |
| GF Fund Management Co. Ltd. | 4,042 | $159.7K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 3,714 | $146.7K | 0.00% | +3,714 | New |
| Ci Investments Inc. | 2,416 | $95.0K | 0.00% | −126−5.0% | Reduced |
| CWM, LLC | 2,318 | $92.0K | 0.00% | −117−4.8% | Reduced |
| Allianz SE | 2,100 | $83.0K | 0.00% | +2,100 | New |
| Signaturefd, LLC | 2,030 | $80.2K | 0.00% | +648+46.9% | Added |
| Ancora Advisors, LLC | 2,000 | $79.0K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 1,872 | $74.0K | 0.00% | +1,127+151.3% | Added |
| Harvest Fund Management Co., Ltd | 1,829 | $72.0K | 0.00% | +1,829 | New |
| Comerica Bank | 1,617 | $63.9K | 0.00% | +297+22.5% | Added |
| Tower Research Capital LLC (TRC) | 1,581 | $62.5K | 0.00% | −8,292−84.0% | Reduced |
| Twin Lakes Capital Management, LLC | 1,500 | $59.3K | 0.04% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 1,465 | $57.9K | 0.01% | +1,364+1,350.5% | Added |
| Danske Bank A/S | 1,400 | $55.3K | 0.00% | +900+180.0% | Added |
| Manchester Capital Management LLC | 1,248 | $49.3K | 0.01% | 00.0% | Unchanged |
| IFP Advisors, Inc | 904 | $48.8K | 0.00% | −246−21.4% | Reduced |
| Steward Partners Investment Advisory, LLC | 1,221 | $48.2K | 0.00% | +131+12.0% | Added |
| Itau Unibanco Holding S.A. | 1,124 | $44.4K | 0.00% | −19−1.7% | Reduced |
| EverSource Wealth Advisors, LLC | 1,101 | $43.5K | 0.00% | −56−4.8% | Reduced |
| Larson Financial Group LLC | 1,027 | $40.6K | 0.00% | +684+199.4% | Added |
| Sterling Capital Management LLC | 962 | $38.0K | 0.00% | −139−12.6% | Reduced |
| GAMMA Investing LLC | 930 | $36.7K | 0.00% | −31−3.2% | Reduced |
| Sunbelt Securities, Inc. | 1,014 | $35.4K | 0.00% | 00.0% | Unchanged |
| Quest Partners LLC | 835 | $33.0K | 0.00% | +200+31.5% | Added |
| Huntington National Bank | 795 | $31.4K | 0.00% | −298−27.3% | Reduced |
| Allworth Financial LP | 740 | $29.2K | 0.00% | +517+231.8% | Added |
| Archer Investment Corp | 600 | $23.7K | 0.01% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 438 | $17.3K | 0.00% | +61+16.2% | Added |
| Farther Finance Advisors, LLC | 433 | $17.1K | 0.00% | −39−8.3% | Reduced |
| AdvisorNet Financial, Inc | 428 | $16.9K | 0.00% | +425+14,166.7% | Added |
| MAI Capital Management | 426 | $16.8K | 0.00% | +166+63.8% | Added |
| ORG Wealth Partners, LLC | 400 | $16.0K | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 305 | $12.0K | 0.01% | +7+2.3% | Added |
| Capital Advisors, Ltd. LLC | 295 | $12.0K | 0.00% | +295 | New |
| Eastern Bank | 300 | $11.9K | 0.00% | 00.0% | Unchanged |
| Storebrand Asset Management AS | 271 | $10.7K | 0.00% | 00.0% | Unchanged |
| Skopos Labs, Inc. | 268 | $10.6K | 0.00% | +154+135.1% | Added |
| Union Bancaire Privee, UBP SA | 265 | $10.5K | 0.00% | 00.0% | Unchanged |
| Global X Japan Co., Ltd. | 259 | $10.2K | 0.00% | +259 | New |
| MTM Investment Management, LLC | 258 | $10.2K | 0.00% | +258 | New |