Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 363
- +21 vs. Q1 2025
- Shares held
- 168.9M
- +2.14M (+1.3%) vs. Q1 2025
- Total value
- $6.67B
- +$1.64B (+32.6%) vs. Q1 2025
- New holders
- 80
- 121 more added
- Sold out
- 59
- 109 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SBI Securities Co., Ltd. | 257 | $10.2K | 0.00% | −3−1.2% | Reduced |
| Westside Investment Management, Inc. | 231 | $9.23K | 0.00% | +231 | New |
| Twin Peaks Wealth Advisors, LLC | 215 | $8.90K | 0.00% | +215 | New |
| Global Trust Asset Management, LLC | 218 | $8.61K | 0.00% | −181−45.4% | Reduced |
| Harbour Investments, Inc. | 200 | $7.90K | 0.00% | −700−77.8% | Reduced |
| Atlantic Union Bankshares Corp | 200 | $7.90K | 0.00% | +200 | New |
| AllSquare Wealth Management LLC | 198 | $7.82K | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 196 | $7.74K | 0.00% | −1,425−87.9% | Reduced |
| Riggs Asset Managment Co. Inc. | 187 | $7.39K | 0.00% | −63−25.2% | Reduced |
| SRS Capital Advisors, Inc. | 156 | $6.17K | 0.00% | +52+50.0% | Added |
| Pacifica Partners Inc. | 150 | $5.97K | 0.00% | 00.0% | Unchanged |
| Wealth Preservation Advisors, LLC | 150 | $5.93K | 0.00% | 00.0% | Unchanged |
| Ameritas Advisory Services, LLC | 146 | $5.77K | 0.00% | +146 | New |
| Geneos Wealth Management Inc. | 139 | $5.49K | 0.00% | +139 | New |
| Golden State Wealth Management, LLC | 126 | $4.98K | 0.00% | 00.0% | Unchanged |
| Spire Wealth Management | 125 | $4.94K | 0.00% | 00.0% | Unchanged |
| GPS Wealth Strategies Group, LLC | 119 | $4.70K | 0.00% | 00.0% | Unchanged |
| Bogart Wealth, LLC | 118 | $4.66K | 0.00% | +16+15.7% | Added |
| MPWM Advisory Solutions, LLC | 110 | $4.35K | 0.00% | 00.0% | Unchanged |
| Kestra Investment Management, LLC | 137 | $4.13K | 0.00% | 00.0% | Unchanged |
| Massmutual Trust Co FSB | 103 | $4.07K | 0.00% | −159−60.7% | Reduced |
| Creekmur Asset Management LLC | 100 | $3.95K | 0.00% | 00.0% | Unchanged |
| Meeder Asset Management Inc | 99 | $3.91K | 0.00% | +4+4.2% | Added |
| Semmax Financial Advisors Inc. | 79 | $3.29K | 0.00% | 00.0% | Unchanged |
| Orion Capital Management LLC | 80 | $3.16K | 0.00% | 00.0% | Unchanged |
| Assetmark, Inc | 75 | $2.96K | 0.00% | +60+400.0% | Added |
| Clear Investment Research, LLC | 71 | $2.81K | 0.00% | +20+39.2% | Added |
| WPG Advisers, LLC | 70 | $2.77K | 0.00% | +70 | New |
| Private Wealth Management Group, LLC | 65 | $2.57K | 0.00% | +49+306.3% | Added |
| Principal Securities, Inc. | 63 | $2.49K | 0.00% | −4−6.0% | Reduced |
| Leonteq Securities AG | 63 | $2.49K | 0.00% | 00.0% | Unchanged |
| Bell Investment Advisors, Inc | 61 | $2.41K | 0.00% | −10−14.1% | Reduced |
| Asset Dedication, LLC | 59 | $2.33K | 0.00% | +59 | New |
| South State Corp. | 51 | $2.02K | 0.00% | −68−57.1% | Reduced |
| Bessemer Group Inc | 39 | $2.00K | 0.00% | −34−46.6% | Reduced |
| CoreCap Advisors, LLC | 45 | $1.78K | 0.00% | −7−13.5% | Reduced |
| Sachetta, LLC | 45 | $1.78K | 0.00% | +29+181.3% | Added |
| TD Private Client Wealth LLC | 44 | $1.74K | 0.00% | +44 | New |
| Highline Wealth Partners LLC | 38 | $1.50K | 0.00% | 00.0% | Unchanged |
| Rossby Financial, LCC | 34 | $1.34K | 0.00% | +34 | New |
| Cheviot Value Management, LLC | 28 | $1.17K | 0.00% | 00.0% | Unchanged |
| Raffa Wealth Management, LLC | 28 | $1.11K | 0.00% | 00.0% | Unchanged |
| Hemington Wealth Management | 44 | $1.00K | 0.00% | −14−24.1% | Reduced |
| Hantz Financial Services, Inc. | 36 | $1.00K | 0.00% | +36 | New |
| Principia Wealth Advisory, LLC | 25 | $988 | 0.00% | +25 | New |
| Bruce G. Allen Investments, LLC | 23 | $909 | 0.00% | +10+76.9% | Added |
| TFC Financial Management | 21 | $830 | 0.00% | 00.0% | Unchanged |
| Key Financial Inc | 19 | $751 | 0.00% | 00.0% | Unchanged |
| Cromwell Holdings LLC | 18 | $711 | 0.00% | +18 | New |
| Fortitude Family Office, LLC | 17 | $672 | 0.00% | +17 | New |
| Global Retirement Partners, LLC | 16 | $632 | 0.00% | +16 | New |
| Horizon Investments, LLC | 15 | $593 | 0.00% | +15 | New |
| Quaker Wealth Management, LLC | 14 | $554 | 0.00% | +14 | New |
| Mascoma Wealth Management LLC | 14 | $553 | 0.00% | 00.0% | Unchanged |
| Cornerstone Planning Group LLC | 12 | $517 | 0.00% | +12 | New |
| Rothschild Investment LLC | 10 | $395 | 0.00% | +10 | New |
| Parkworth Wealth Management, Inc. | 8 | $316 | 0.00% | +8 | New |
| True Wealth Design, LLC | 7 | $277 | 0.00% | −6−46.2% | Reduced |
| Kayne Anderson Rudnick Investment Management LLC | 7 | $277 | 0.00% | +7 | New |
| IMA Wealth, Inc. | 5 | $198 | 0.00% | +5 | New |
| WealthTrak Capital Management LLC | 5 | $198 | 0.00% | +5 | New |
| CIBC Private Wealth Group, LLC | 2 | $79 | 0.00% | −28−93.3% | Reduced |
| Truvestments Capital LLC | 1 | $30 | 0.00% | −39−97.5% | Reduced |
| OrbiMed Advisors LLC | 0 | $0 | 0.00% | −2,540,136−100.0% | Sold out |
| Camber Capital Management LP | 0 | $0 | 0.00% | −725,000−100.0% | Sold out |
| Baker Bros. Advisors LP | 0 | $0 | 0.00% | −357,915−100.0% | Sold out |
| Susquehanna Fundamental Investments, LLC | 0 | $0 | 0.00% | −158,609−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −71,811−100.0% | Sold out |
| Sphera Funds Management Ltd. | 0 | $0 | 0.00% | −63,821−100.0% | Sold out |
| Avidity Partners Management LP | 0 | $0 | 0.00% | −60,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −54,117−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −46,394−100.0% | Sold out |
| Allostery Investments LP | 0 | $0 | 0.00% | −35,000−100.0% | Sold out |
| Private Advisor Group, LLC | 0 | $0 | 0.00% | −34,531−100.0% | Sold out |
| Liontrust Investment Partners LLP | 0 | $0 | 0.00% | −30,390−100.0% | Sold out |
| Axq Capital, LP | 0 | $0 | 0.00% | −30,104−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −26,261−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −25,824−100.0% | Sold out |
| BlueCrest Capital Management Ltd | 0 | $0 | 0.00% | −24,800−100.0% | Sold out |
| Castle Hook Partners LP | 0 | $0 | 0.00% | −23,940−100.0% | Sold out |
| Toroso Investments, LLC | 0 | $0 | 0.00% | −21,833−100.0% | Sold out |
| Bridgefront Capital, LLC | 0 | $0 | 0.00% | −20,528−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −20,050−100.0% | Sold out |
| NBT Bank N A | 0 | $0 | 0.00% | −17,050−100.0% | Sold out |
| Virginia Retirement Systems Et Al | 0 | $0 | 0.00% | −16,522−100.0% | Sold out |
| Twinbeech Capital LP | 0 | $0 | 0.00% | −15,938−100.0% | Sold out |
| Point72 Hong Kong Ltd | 0 | $0 | 0.00% | −12,862−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −12,404−100.0% | Sold out |
| Intech Investment Management LLC | 0 | $0 | 0.00% | −12,207−100.0% | Sold out |
| SIH Partners, LLLP | 0 | $0 | 0.00% | −11,999−100.0% | Sold out |
| FORA Capital, LLC | 0 | $0 | 0.00% | −11,570−100.0% | Sold out |
| Twin Tree Management, LP | 0 | $0 | 0.00% | −11,385−100.0% | Sold out |
| Capula Management Ltd | 0 | $0 | 0.00% | −10,382−100.0% | Sold out |
| Walleye Trading LLC | 0 | $0 | 0.00% | −9,361−100.0% | Sold out |
| Amundi | 0 | $0 | 0.00% | −3,873−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −2,657−100.0% | Sold out |
| Sandia Investment Management LP | 0 | $0 | 0.00% | −2,500−100.0% | Sold out |
| Coldstream Capital Management Inc | 0 | $0 | 0.00% | −2,345−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −2,082−100.0% | Sold out |