Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 341
- +20 vs. Q3 2021
- Shares held
- 123.2M
- +1.71M (+1.4%) vs. Q3 2021
- Total value
- $3.75B
- −$326.3M (−8.0%) vs. Q3 2021
- New holders
- 59
- 106 more added
- Sold out
- 39
- 119 more reduced
5 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Allianz Asset Management GmbH | 81,830 | $2.49M | 0.00% | +62,120+315.2% | Added |
| Parkman Healthcare Partners LLC | 80,238 | $2.44M | 0.55% | −56,142−41.2% | Reduced |
| PFS Investments Inc. | 76,179 | $2.32M | 0.04% | −663−0.9% | Reduced |
| Rhenman & Partners Asset Management AB | 75,000 | $2.29M | 0.15% | 00.0% | Unchanged |
| Guggenheim Capital LLC | 72,978 | $2.22M | 0.01% | +10,341+16.5% | Added |
| National Bank of Canada | 70,000 | $2.13M | 0.01% | +70,000 | New |
| PDT Partners, LLC | 67,697 | $2.06M | 0.16% | +67,697 | New |
| Voya Investment Management LLC | 65,508 | $1.99M | 0.00% | +22,808+53.4% | Added |
| Squarepoint Ops LLC | 61,340 | $1.87M | 0.01% | −108,525−63.9% | Reduced |
| Canada Pension Plan Investment Board | 57,924 | $1.76M | 0.00% | +57,924 | New |
| Point72 Asset Management, L.P. | 53,981 | $1.64M | 0.01% | −165,319−75.4% | Reduced |
| AlphaCrest Capital Management LLC | 52,907 | $1.61M | 0.06% | +823+1.6% | Added |
| Jane Street Group, LLC | 52,550 | $1.60M | 0.00% | −11,926−18.5% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.57M | 0.03% | 00.0% | Unchanged |
| Treasurer of the State of North Carolina | 50,846 | $1.55M | 0.01% | +330+0.7% | Added |
| Alpha DNA Investment Management LLC | 50,614 | $1.54M | 0.98% | +50,614 | New |
| Raymond James Financial Services Advisors, Inc. | 48,981 | $1.49M | 0.00% | +2,825+6.1% | Added |
| Pura Vida Investments, LLC | 48,544 | $1.48M | 0.15% | +48,544 | New |
| Assenagon Asset Management S.A. | 48,401 | $1.47M | 0.01% | +42,379+703.7% | Added |
| Jefferies Group LLC | 44,000 | $1.34M | 0.02% | −137−0.3% | Reduced |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.28M | 0.16% | 00.0% | Unchanged |
| Bard Financial Services, Inc. | 41,520 | $1.26M | 0.10% | +31,795+326.9% | Added |
| Capital Counsel LLC | 40,580 | $1.24M | 0.05% | 00.0% | Unchanged |
| Algert Global LLC | 38,430 | $1.17M | 0.15% | +14,956+63.7% | Added |
| Janney Montgomery Scott LLC | 36,424 | $1.11M | 0.00% | +2,271+6.6% | Added |
| Group One Trading, L.P. | 36,268 | $1.10M | 0.02% | +4,735+15.0% | Added |
| Engineers Gate Manager LP | 34,380 | $1.05M | 0.05% | +17,708+106.2% | Added |
| Arizona State Retirement System | 34,190 | $1.04M | 0.01% | −367−1.1% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 34,069 | $1.04M | 0.00% | +34,069 | New |
| Trexquant Investment LP | 33,903 | $1.03M | 0.06% | +20,606+155.0% | Added |
| Macquarie Group Ltd | 32,549 | $991.0K | 0.00% | +121+0.4% | Added |
| Employees Retirement System of Texas | 32,409 | $986.0K | 0.01% | 00.0% | Unchanged |
| Principal Financial Group Inc | 31,755 | $966.0K | 0.00% | −10,930−25.6% | Reduced |
| Truist Financial Corp | 30,937 | $941.0K | 0.00% | −40−0.1% | Reduced |
| Amalgamated Bank | 29,324 | $892.0K | 0.01% | +3,923+15.4% | Added |
| Koss-Olinger Consulting, LLC | 29,161 | $887.0K | 0.14% | +17,729+155.1% | Added |
| Commonwealth Equity Services, LLC | 28,766 | $875.0K | 0.00% | −9,352−24.5% | Reduced |
| Ensign Peak Advisors, Inc | 28,330 | $862.0K | 0.00% | +28,330 | New |
| Capital Fund Management S.A. | 28,108 | $855.3K | 0.02% | +28,108 | New |
| First Foundation Advisors | 27,972 | $851.0K | 0.03% | −7,774−21.7% | Reduced |
| Eaton Vance Management | 27,692 | $843.0K | 0.00% | +818+3.0% | Added |
| HighTower Advisors, LLC | 27,138 | $826.0K | 0.00% | +17,281+175.3% | Added |
| Occudo Quantitative Strategies LP | 26,650 | $811.0K | 0.07% | +26,650 | New |
| Grandfield & Dodd, LLC | 26,771 | $810.0K | 0.05% | +5,080+23.4% | Added |
| AE Wealth Management LLC | 26,085 | $794.0K | 0.01% | +26,085 | New |
| Janus Henderson Group PLC | 25,716 | $783.0K | 0.00% | +11,968+87.1% | Added |
| Utah Retirement Systems | 25,409 | $773.0K | 0.01% | +100+0.4% | Added |
| MML Investors Services, LLC | 25,217 | $767.0K | 0.01% | +603+2.4% | Added |
| Teacher Retirement System of Texas | 24,454 | $744.0K | 0.00% | +4,694+23.8% | Added |
| Handelsbanken Fonder AB | 24,411 | $743.0K | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 23,432 | $713.0K | 0.00% | −10,067−30.1% | Reduced |
| Storebrand Asset Management AS | 22,462 | $683.5K | 0.00% | −12,204−35.2% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 22,121 | $673.0K | 0.00% | +9,304+72.6% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 20,878 | $638.0K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 19,788 | $602.0K | 0.01% | +11,615+142.1% | Added |
| Kestra Advisory Services, LLC | 19,681 | $599.0K | 0.01% | −8,243−29.5% | Reduced |
| Public Employees Retirement Association of Colorado | 19,604 | $597.0K | 0.00% | 00.0% | Unchanged |
| Profund Advisors LLC | 19,417 | $591.0K | 0.02% | −3,474−15.2% | Reduced |
| Advisor Group Holdings, Inc. | 19,147 | $583.0K | 0.00% | +706+3.8% | Added |
| US Bancorp | 19,115 | $582.0K | 0.00% | +2,732+16.7% | Added |
| Vestmark Advisory Solutions, Inc. | 18,578 | $565.0K | 0.03% | −1,455−7.3% | Reduced |
| Oppenheimer & Co Inc | 18,358 | $559.0K | 0.01% | −2,769−13.1% | Reduced |
| Stephens Inc | 17,701 | $539.0K | 0.01% | −3,440−16.3% | Reduced |
| Quantamental Technologies LLC | 17,671 | $538.0K | 0.27% | +17,671 | New |
| Campbell & CO Investment Adviser LLC | 17,346 | $528.0K | 0.18% | −2,550−12.8% | Reduced |
| State of Wisconsin Investment Board | 17,054 | $519.0K | 0.00% | −525−3.0% | Reduced |
| Natixis Advisors, L.P. | 15,895 | $484.0K | 0.00% | −1,833−10.3% | Reduced |
| Arden Trust Co | 15,554 | $474.0K | 0.08% | −543−3.4% | Reduced |
| Castle Rock Wealth Management, LLC | 15,593 | $466.0K | 0.19% | 00.0% | Unchanged |
| Creative Planning | 15,116 | $460.0K | 0.00% | +201+1.3% | Added |
| Xponance, Inc. | 14,890 | $453.0K | 0.01% | +318+2.2% | Added |
| Blair William & Co | 14,464 | $440.0K | 0.00% | −50−0.3% | Reduced |
| Deutsche Bank AG | 14,087 | $428.0K | 0.00% | −36,859−72.3% | Reduced |
| Lincoln National Corp | 14,070 | $428.0K | 0.01% | −200−1.4% | Reduced |
| Brookstone Capital Management | 13,947 | $424.0K | 0.01% | +2,550+22.4% | Added |
| Verition Fund Management LLC | 13,740 | $418.0K | 0.01% | +13,740 | New |
| North Star Asset Management Inc | 13,680 | $416.0K | 0.02% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 13,368 | $407.0K | 0.05% | +13,368 | New |
| Victory Capital Management Inc | 13,147 | $400.0K | 0.00% | −192−1.4% | Reduced |
| Wellington Management Group LLP | 13,134 | $399.0K | 0.00% | +13,134 | New |
| SG Americas Securities, LLC | 12,932 | $394.0K | 0.00% | −6,789−34.4% | Reduced |
| Brown Advisory Securities, LLC | 13,000 | $394.0K | 0.17% | −2,500−16.1% | Reduced |
| Cetera Advisor Networks LLC | 12,825 | $390.0K | 0.00% | +273+2.2% | Added |
| Shell Asset Management Co | 12,651 | $385.0K | 0.01% | +48+0.4% | Added |
| Virtus ETF Advisers LLC | 12,296 | $374.0K | 0.14% | +194+1.6% | Added |
| Comerica Bank | 11,755 | $370.0K | 0.00% | −75−0.6% | Reduced |
| Rockefeller Capital Management L.P. | 12,092 | $366.0K | 0.00% | −1,320,688−99.1% | Reduced |
| Caption Management, LLC | 12,000 | $366.0K | 0.02% | −108,993−90.1% | Reduced |
| Teza Capital Management LLC | 11,845 | $360.0K | 0.10% | +11,845 | New |
| Baird Financial Group, Inc. | 11,356 | $346.0K | 0.00% | +2,407+26.9% | Added |
| Vontobel Holding Ltd. | 11,310 | $344.0K | 0.00% | +11,310 | New |
| Plancorp, LLC | 11,274 | $343.0K | 0.02% | +140+1.3% | Added |
| SEI Investments Co | 11,194 | $339.0K | 0.00% | −2,763−19.8% | Reduced |
| Dynamic Technology Lab Private Ltd | 11,134 | $339.0K | 0.04% | −366−3.2% | Reduced |
| Greenup Street Wealth Management LLC | 11,145 | $339.0K | 0.20% | +11,145 | New |
| Walleye Trading LLC | 10,695 | $325.0K | 0.01% | +1,076+11.2% | Added |
| Cambridge Investment Research Advisors, Inc. | 10,447 | $318.0K | 0.00% | −6,420−38.1% | Reduced |
| Maryland State Retirement & Pension System | 9,956 | $303.0K | 0.01% | 00.0% | Unchanged |
| Oppenheimer Asset Management Inc. | 9,782 | $297.0K | 0.00% | −1,100−10.1% | Reduced |
| Ameriprise Financial Inc | 9,627 | $293.0K | 0.00% | −1,272−11.7% | Reduced |