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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 3 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

Q1 2025 vs. Q4 2024

How the institutions holding Ionis Pharmaceuticals Inc changed between Q4 2024 and Q1 2025.

All holders in Q1 2025All holders in Q4 2024

13F holders of IONS: Q4 2024 compared with Q1 2025
MeasureQ4 2024Of which not filed for Q1 2025Q1 2025Change
Holders3566344−6
Shares160.5M423.2K166.7M+6.69M (+4.2%)
Value$5.61B$14.8M$5.03B−$564.9M (−10.1%)

6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (54)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q1 2025 but not at the end of Q4 2024.

Institutions new to IONS in Q1 2025
InstitutionSharesValue% of portfolio
BVF Inc1,913,385$57.7M2.35%
Nuveen, LLC308,777$9.32M0.00%
Point72 Asset Management, L.P.287,204$8.66M0.02%
Universal- Beteiligungs- und Servicegesellschaft mbH143,870$4.34M0.01%
Edmond de Rothschild Holding S.A.124,200$3.75M0.07%
American Century Companies Inc116,768$3.52M0.00%
Simplex Trading, LLC64,581$1.95M0.07%
Avidity Partners Management LP60,000$1.81M0.37%
Capital Fund Management S.A.58,014$1.75M0.02%
Readystate Asset Management LP46,394$1.40M0.07%
Point72 (DIFC) Ltd41,347$1.25M0.12%
SummitTX Capital, L.P.35,103$1.06M0.05%
Axq Capital, LP30,104$908.2K0.36%
Alpine Global Management, LLC28,097$847.7K0.22%
ExodusPoint Capital Management, LP26,261$792.0K0.01%
HRT Financial LP25,824$779.0K0.00%
Virginia Retirement Systems Et Al16,522$498.5K0.00%
Twinbeech Capital LP15,938$480.8K0.01%
Point72 Hong Kong Ltd12,862$388.0K0.03%
Intech Investment Management LLC12,207$368.3K0.00%
SIH Partners, LLLP11,999$362.0K0.03%
FORA Capital, LLC11,570$349.1K0.04%
Capula Management Ltd10,382$313.2K0.00%
Virtus Investment Advisers, Inc.9,701$292.7K0.08%
Jain Global LLC8,595$259.3K0.01%
Quantinno Capital Management LP8,515$256.9K0.00%
Bayesian Capital Management, LP8,500$256.4K0.04%
Davy Global Fund Management Ltd8,059$243.1K0.03%
Fiduciary Trust Co7,738$233.5K0.00%
Semanteon Capital Management, LP7,543$227.6K0.12%
Prudential Financial Inc6,263$209.5K0.00%
Moisand Fitzgerald Tamayo, LLC5,000$150.8K0.02%
Coldstream Capital Management Inc2,345$70.8K0.00%
Point72 Asia (Singapore) Pte. Ltd.2,082$62.8K0.02%
Ancora Advisors, LLC2,000$60.3K0.00%
Quest Partners LLC635$19.2K0.00%
Eastern Bank300$9.05K0.00%
Oakworth Capital, Inc.300$9.05K0.00%
Wealth Preservation Advisors, LLC150$4.53K0.00%
Kestra Investment Management, LLC137$4.13K0.00%
Anderson Financial Strategies, LLC121$3.65K0.00%
South State Corp.119$3.59K0.00%
MPWM Advisory Solutions, LLC110$3.32K0.00%
Picton Mahoney Asset Management89$3.00K0.00%
Meeder Asset Management Inc95$2.87K0.00%
Dynamic Wealth Strategies, LLC80$2.41K0.00%
Bessemer Group Inc73$2.00K0.00%
Truvestments Capital LLC40$1.21K0.00%
Highline Wealth Partners LLC38$1.15K0.00%
Cheviot Value Management, LLC28$9420.00%
True Wealth Design, LLC13$3930.00%
Bruce G. Allen Investments, LLC13$3920.00%
Hexagon Capital Partners LLC9$2720.00%
Umb Bank N A6$1810.00%

Sold out (60)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q4 2024 and filed for Q1 2025 without it.

Institutions that sold out of IONS in Q1 2025
InstitutionShares, Q4 2024Value, Q4 2024
Clearbridge Investments, LLC1,618,220$56.6M
Vestal Point Capital, LP595,000$20.8M
Jacobs Levy Equity Management, Inc281,813$9.85M
Siren, L.L.C.250,000$8.74M
Driehaus Capital Management LLC180,002$6.29M
Alyeska Investment Group, L.P.150,000$5.24M
Assenagon Asset Management S.A.141,917$4.96M
Woodline Partners LP107,610$3.76M
Ghisallo Capital Management LLC100,000$3.50M
Dimensional Fund Advisors LP94,157$3.29M
Trexquant Investment LP84,913$2.97M
Fieldview Capital Management, LLC51,282$1.79M
Qsemble Capital Management, LP46,573$1.63M
D. E. Shaw & Co., Inc.23,123$808.4K
Canada Pension Plan Investment Board19,900$695.7K
Aigen Investment Management, LP17,723$619.6K
Natixis16,626$581.2K
Campbell & CO Investment Adviser LLC15,681$548.2K
Inceptionr LLC14,390$503.1K
Natixis Advisors, L.P.14,313$500.0K
Franklin Resources Inc13,301$465.0K
Stratos Wealth Partners, LTD.12,813$447.9K
Essential Planning, LLC.11,440$428.1K
Landscape Capital Management, L.L.C.10,270$359.0K
Syon Capital LLC10,119$353.8K
Janney Montgomery Scott LLC9,840$344.0K
Torno Capital, LLC9,500$332.1K
Virtus ETF Advisers LLC9,448$330.3K
Y-Intercept (Hong Kong) Ltd9,407$328.9K
Wolverine Trading, LLC8,847$308.9K
Truist Financial Corp6,847$239.4K
EntryPoint Capital, LLC6,382$223.1K
Gotham Asset Management, LLC6,260$218.8K
Castle Rock Wealth Management, LLC6,972$216.4K
M&T Bank Corp6,096$213.6K
Vontobel Holding Ltd.5,865$205.0K
Stevens Capital Management LP5,860$205.0K
Caption Management, LLC5,417$189.4K
Venturi Wealth Management, LLC3,061$107.0K
Horizon Investments, LLC1,174$41.0K
Elequin Capital LP325$11.4K
Global X Japan Co., Ltd.297$10.4K
Tidemark, LLC200$6.99K
Capital Advisors, Ltd. LLC179$6.00K
Whittier Trust Co of Nevada Inc157$5.48K
LRI Investments, LLC136$4.75K
Transce3nd, LLC100$3.50K
Bryn Mawr Trust Co92$3.22K
Raleigh Capital Management Inc.72$2.52K
Coppell Advisory Solutions LLC51$1.78K
Private Trust Co NA48$1.68K
Cornerstone Planning Group LLC25$851
Lee Danner & Bass Inc22$769
Front Row Advisors LLC20$699
Central Trust Co15$525
WealthTrak Capital Management LLC10$350
Principia Wealth Advisory, LLC9$315
Rothschild Investment LLC5$175
Activest Wealth Management1$35
Sandy Spring Bank0$9

Not filed for Q1 2025 yet (6)

Institutions that held Ionis Pharmaceuticals Inc at the end of Q4 2024 and haven't filed a 13F for Q1 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding IONS in Q4 2024 that haven't filed for Q1 2025
InstitutionShares, Q4 2024Value, Q4 2024
Nuveen Asset Management, LLC290,954$10.2M
Swedbank AB124,237$4.34M
AlphaCentric Advisors LLC7,614$266.2K
AlphaMark Advisors, LLC369$13.0K
Global Retirement Partners, LLC72$2.52K
Cassady Schiller Wealth Management, LLC2$70