Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 344
- −6 vs. Q4 2024
- Shares held
- 166.7M
- +6.69M (+4.2%) vs. Q4 2024
- Total value
- $5.03B
- −$564.9M (−10.1%) vs. Q4 2024
- New holders
- 54
- 102 more added
- Sold out
- 60
- 123 more reduced
6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| UBS Oconnor LLC | 90,779 | $2.74M | 0.07% | +30,199+49.8% | Added |
| Nicola Wealth Management Ltd. | 87,000 | $2.62M | 0.26% | 00.0% | Unchanged |
| Deutsche Bank AG | 84,810 | $2.56M | 0.00% | −7,091−7.7% | Reduced |
| Manufacturers Life Insurance Company, The | 83,440 | $2.52M | 0.00% | −202,839−70.9% | Reduced |
| Jump Financial, LLC | 81,321 | $2.45M | 0.04% | +41,584+104.6% | Added |
| Rhenman & Partners Asset Management AB | 81,000 | $2.44M | 0.28% | −131,500−61.9% | Reduced |
| New York State Common Retirement Fund | 78,261 | $2.36M | 0.00% | −6,000−7.1% | Reduced |
| HSBC Holdings PLC | 74,833 | $2.22M | 0.00% | −8,222−9.9% | Reduced |
| Susquehanna International Group, LLP | 71,811 | $2.17M | 0.00% | +45,747+175.5% | Added |
| Treasurer of the State of North Carolina | 71,593 | $2.16M | 0.01% | +2,790+4.1% | Added |
| SEI Investments Co | 71,558 | $2.16M | 0.00% | +1,467+2.1% | Added |
| Granite Investment Partners, LLC | 68,434 | $2.06M | 0.10% | −5,432−7.4% | Reduced |
| Janus Henderson Group PLC | 63,877 | $1.99M | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 64,581 | $1.95M | 0.07% | +64,581 | New |
| Sphera Funds Management Ltd. | 63,821 | $1.93M | 0.47% | 00.0% | Unchanged |
| Voya Investment Management LLC | 63,767 | $1.92M | 0.00% | −28,764−31.1% | Reduced |
| Lazard Asset Management LLC | 60,758 | $1.83M | 0.00% | +54,201+826.6% | Added |
| State of New Jersey Common Pension Fund D | 60,662 | $1.83M | 0.01% | −2,544−4.0% | Reduced |
| Avidity Partners Management LP | 60,000 | $1.81M | 0.37% | +60,000 | New |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | $1.80M | 0.01% | 00.0% | Unchanged |
| Capital Fund Management S.A. | 58,014 | $1.75M | 0.02% | +58,014 | New |
| Police & Firemen's Retirement System of New Jersey | 57,549 | $1.74M | 0.02% | +854+1.5% | Added |
| Davenport & Co LLC | 56,393 | $1.70M | 0.01% | −6,347−10.1% | Reduced |
| Ensign Peak Advisors, Inc | 55,100 | $1.66M | 0.00% | +1,780+3.3% | Added |
| Jane Street Group, LLC | 54,117 | $1.63M | 0.00% | −110,517−67.1% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.60M | 0.02% | 00.0% | Unchanged |
| Verition Fund Management LLC | 52,287 | $1.58M | 0.01% | −147,897−73.9% | Reduced |
| Public Employees Retirement System of Ohio | 48,177 | $1.45M | 0.01% | −5,571−10.4% | Reduced |
| Schroder Investment Management Group | 45,950 | $1.43M | 0.00% | −54,709−54.4% | Reduced |
| Readystate Asset Management LP | 46,394 | $1.40M | 0.07% | +46,394 | New |
| Great West Life Assurance Co | 43,853 | $1.33M | 0.00% | +4,639+11.8% | Added |
| Handelsbanken Fonder AB | 43,211 | $1.30M | 0.01% | −600−1.4% | Reduced |
| Raiffeisen Bank International AG | 41,754 | $1.30M | 0.02% | +40,000+2,280.5% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.27M | 0.16% | 00.0% | Unchanged |
| Guggenheim Capital LLC | 41,414 | $1.25M | 0.01% | +6,041+17.1% | Added |
| Point72 (DIFC) Ltd | 41,347 | $1.25M | 0.12% | +41,347 | New |
| Arizona State Retirement System | 40,687 | $1.23M | 0.01% | −460−1.1% | Reduced |
| Blair William & Co | 38,381 | $1.16M | 0.00% | −1,501−3.8% | Reduced |
| Prelude Capital Management, LLC | 37,772 | $1.14M | 0.11% | +22,177+142.2% | Added |
| Grandfield & Dodd, LLC | 37,761 | $1.14M | 0.07% | +1,874+5.2% | Added |
| Capital Counsel LLC | 37,080 | $1.12M | 0.05% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36,509 | $1.10M | 0.00% | +187+0.5% | Added |
| Creative Planning | 36,122 | $1.09M | 0.00% | −10,681−22.8% | Reduced |
| SummitTX Capital, L.P. | 35,103 | $1.06M | 0.05% | +35,103 | New |
| Allostery Investments LP | 35,000 | $1.06M | 1.52% | −30,000−46.2% | Reduced |
| Profund Advisors LLC | 34,887 | $1.05M | 0.05% | −8,672−19.9% | Reduced |
| Private Advisor Group, LLC | 34,531 | $1.04M | 0.01% | −6,142−15.1% | Reduced |
| Pathstone Holdings, LLC | 34,372 | $1.03M | 0.00% | +8,314+31.9% | Added |
| Mariner, LLC | 33,483 | $1.01M | 0.00% | +5,822+21.0% | Added |
| China Universal Asset Management Co., Ltd. | 31,886 | $962.0K | 0.09% | −1,594−4.8% | Reduced |
| Liontrust Investment Partners LLP | 30,390 | $916.9K | 0.01% | −11,231−27.0% | Reduced |
| Axq Capital, LP | 30,104 | $908.2K | 0.36% | +30,104 | New |
| Alpine Global Management, LLC | 28,097 | $847.7K | 0.22% | +28,097 | New |
| KLP Kapitalforvaltning AS | 27,400 | $826.7K | 0.00% | −1,800−6.2% | Reduced |
| ExodusPoint Capital Management, LP | 26,261 | $792.0K | 0.01% | +26,261 | New |
| HRT Financial LP | 25,824 | $779.0K | 0.00% | +25,824 | New |
| NEOS Investment Management LLC | 25,141 | $758.5K | 0.01% | −31,703−55.8% | Reduced |
| Tema ETFs LLC | 25,141 | $758.5K | 0.23% | −31,703−55.8% | Reduced |
| BlueCrest Capital Management Ltd | 24,800 | $748.2K | 0.12% | −1,400−5.3% | Reduced |
| Teachers Retirement System of the State of Kentucky | 24,083 | $727.0K | 0.01% | 00.0% | Unchanged |
| LPL Financial LLC | 23,966 | $723.1K | 0.00% | −16,410−40.6% | Reduced |
| Castle Hook Partners LP | 23,940 | $722.3K | 0.02% | 00.0% | Unchanged |
| Brevan Howard Capital Management LP | 22,973 | $693.1K | 0.02% | +1,607+7.5% | Added |
| Jefferies Financial Group Inc. | 22,841 | $689.1K | 0.01% | +460+2.1% | Added |
| Bleakley Financial Group, LLC | 22,284 | $672.3K | 0.02% | +5,342+31.5% | Added |
| Daiwa Securities Group Inc. | 22,141 | $667.0K | 0.00% | +21,600+3,992.6% | Added |
| Toroso Investments, LLC | 21,833 | $658.7K | 0.01% | +4,426+25.4% | Added |
| Nicollet Investment Management, Inc. | 21,451 | $647.0K | 0.23% | +1,665+8.4% | Added |
| Bridgefront Capital, LLC | 20,528 | $619.3K | 0.18% | −1,274−5.8% | Reduced |
| Xponance, Inc. | 20,319 | $613.0K | 0.01% | +980+5.1% | Added |
| SG Americas Securities, LLC | 20,050 | $605.0K | 0.00% | −3,877−16.2% | Reduced |
| Victory Capital Management Inc | 18,641 | $562.4K | 0.00% | +637+3.5% | Added |
| NBT Bank N A | 17,050 | $514.4K | 0.04% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 16,522 | $498.5K | 0.00% | +16,522 | New |
| E Fund Management Co., Ltd. | 16,471 | $496.9K | 0.02% | −397−2.4% | Reduced |
| Commonwealth Equity Services, LLC | 16,398 | $495.0K | 0.00% | −5,428−24.9% | Reduced |
| Twinbeech Capital LP | 15,938 | $480.8K | 0.01% | +15,938 | New |
| Public Employees Retirement Association of Colorado | 15,589 | $470.0K | 0.00% | 00.0% | Unchanged |
| Envestnet Asset Management Inc | 15,039 | $453.7K | 0.00% | −37,649−71.5% | Reduced |
| Jones Financial Companies LLLP | 13,735 | $427.8K | 0.00% | +4,397+47.1% | Added |
| North Star Asset Management Inc | 13,610 | $410.6K | 0.02% | −30−0.2% | Reduced |
| Significant Wealth Partners LLC | 13,605 | $410.5K | 0.21% | +2,700+24.8% | Added |
| Westmount Partners, LLC | 12,961 | $391.0K | 0.12% | −501−3.7% | Reduced |
| Point72 Hong Kong Ltd | 12,862 | $388.0K | 0.03% | +12,862 | New |
| Horizon Kinetics Asset Management LLC | 12,476 | $376.4K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 12,404 | $374.2K | 0.02% | −12,958−51.1% | Reduced |
| Northwestern Mutual Wealth Management Co | 12,358 | $372.8K | 0.00% | +1,031+9.1% | Added |
| Intech Investment Management LLC | 12,207 | $368.3K | 0.00% | +12,207 | New |
| Brown Advisory Inc | 12,026 | $362.8K | 0.00% | −704−5.5% | Reduced |
| SIH Partners, LLLP | 11,999 | $362.0K | 0.03% | +11,999 | New |
| FORA Capital, LLC | 11,570 | $349.1K | 0.04% | +11,570 | New |
| Twin Tree Management, LP | 11,385 | $343.5K | 0.01% | −77,515−87.2% | Reduced |
| Wiley Bros.-Aintree Capital, LLC | 11,004 | $342.8K | 0.00% | +687+6.7% | Added |
| Plancorp, LLC | 11,128 | $335.7K | 0.01% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 10,987 | $331.5K | 0.00% | −7−0.1% | Reduced |
| Suvretta Capital Management, LLC | 10,800 | $325.8K | 0.01% | 00.0% | Unchanged |
| Annis Gardner Whiting Capital Advisors, LLC | 10,736 | $323.9K | 0.14% | 00.0% | Unchanged |
| Amalgamated Bank | 10,573 | $319.0K | 0.00% | +281+2.7% | Added |
| Harbor Advisors LLC | 10,500 | $316.8K | 0.06% | 00.0% | Unchanged |
| Principal Financial Group Inc | 10,447 | $315.2K | 0.00% | −3,169−23.3% | Reduced |