Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 344
- −6 vs. Q4 2024
- Shares held
- 166.7M
- +6.69M (+4.2%) vs. Q4 2024
- Total value
- $5.03B
- −$564.9M (−10.1%) vs. Q4 2024
- New holders
- 54
- 102 more added
- Sold out
- 60
- 123 more reduced
6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Capula Management Ltd | 10,382 | $313.2K | 0.00% | +10,382 | New |
| JustInvest LLC | 10,313 | $311.1K | 0.00% | −1,958−16.0% | Reduced |
| Teza Capital Management LLC | 10,244 | $309.1K | 0.14% | +1,719+20.2% | Added |
| Man Group plc | 10,033 | $302.7K | 0.00% | +1,718+20.7% | Added |
| Cypress Capital, LLC | 10,000 | $301.7K | 0.09% | 00.0% | Unchanged |
| Fifth Third Bancorp | 9,989 | $301.4K | 0.00% | +458+4.8% | Added |
| Tower Research Capital LLC (TRC) | 9,873 | $298.5K | 0.01% | −4,284−30.3% | Reduced |
| Colony Group, LLC | 9,832 | $296.6K | 0.00% | +1,777+22.1% | Added |
| Virtus Investment Advisers, Inc. | 9,701 | $292.7K | 0.08% | +9,701 | New |
| Sectoral Asset Management Inc | 9,440 | $284.8K | 0.22% | +2,240+31.1% | Added |
| Walleye Trading LLC | 9,361 | $282.4K | 0.01% | −559−5.6% | Reduced |
| MetLife Investment Management | 9,144 | $275.9K | 0.00% | −16−0.2% | Reduced |
| Marshall Wace, LLP | 9,102 | $274.6K | 0.00% | −803,204−98.9% | Reduced |
| Jain Global LLC | 8,595 | $259.3K | 0.01% | +8,595 | New |
| Quantinno Capital Management LP | 8,515 | $256.9K | 0.00% | +8,515 | New |
| Bayesian Capital Management, LP | 8,500 | $256.4K | 0.04% | +8,500 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 8,206 | $255.6K | 0.00% | −1,244−13.2% | Reduced |
| Utah Retirement Systems | 8,400 | $253.4K | 0.00% | 00.0% | Unchanged |
| Maryland State Retirement & Pension System | 8,284 | $249.9K | 0.01% | 00.0% | Unchanged |
| International Assets Investment Management, LLC | 8,207 | $247.6K | 0.02% | 00.0% | Unchanged |
| Davy Global Fund Management Ltd | 8,059 | $243.1K | 0.03% | +8,059 | New |
| Fiduciary Trust Co | 7,738 | $233.5K | 0.00% | +7,738 | New |
| Semanteon Capital Management, LP | 7,543 | $227.6K | 0.12% | +7,543 | New |
| Commerce Bank | 7,275 | $219.5K | 0.00% | −6,309−46.4% | Reduced |
| ProShare Advisors LLC | 7,171 | $216.3K | 0.00% | −309−4.1% | Reduced |
| Clearstead Advisors, LLC | 7,000 | $211.2K | 0.00% | −185−2.6% | Reduced |
| Prudential Financial Inc | 6,263 | $209.5K | 0.00% | +6,263 | New |
| Silvercrest Asset Management Group LLC | 6,902 | $208.2K | 0.00% | +285+4.3% | Added |
| Cambridge Investment Research Advisors, Inc. | 6,804 | $205.0K | 0.00% | −961−12.4% | Reduced |
| Everence Capital Management Inc | 6,770 | $204.0K | 0.01% | 00.0% | Unchanged |
| Tanaka Capital Management Inc | 6,714 | $203.0K | 0.48% | −178−2.6% | Reduced |
| KBC Group NV | 6,515 | $197.0K | 0.00% | +31+0.5% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 6,135 | $185.1K | 0.00% | +481+8.5% | Added |
| Advisors Asset Management, Inc. | 6,048 | $182.5K | 0.00% | −22−0.4% | Reduced |
| Russell Investments Group, Ltd. | 5,753 | $173.6K | 0.00% | −56,447−90.8% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 5,319 | $165.7K | 0.00% | +57+1.1% | Added |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $150.8K | 0.02% | +5,000 | New |
| GF Fund Management Co. Ltd. | 4,042 | $121.9K | 0.00% | +727+21.9% | Added |
| Amundi | 3,873 | $110.5K | 0.00% | −7,501−65.9% | Reduced |
| Exchange Traded Concepts, LLC | 3,244 | $97.9K | 0.00% | +3,066+1,722.5% | Added |
| US Bancorp | 3,157 | $95.2K | 0.00% | −1,063−25.2% | Reduced |
| Quarry LP | 3,000 | $90.5K | 0.02% | −3,000−50.0% | Reduced |
| Corebridge Financial, Inc. | 2,657 | $80.2K | 0.00% | −102−3.7% | Reduced |
| Ci Investments Inc. | 2,542 | $77.0K | 0.00% | −1,548−37.8% | Reduced |
| Sandia Investment Management LP | 2,500 | $75.4K | 0.22% | −2,500−50.0% | Reduced |
| CWM, LLC | 2,435 | $73.0K | 0.00% | +384+18.7% | Added |
| Advisor Group Holdings, Inc. | 2,373 | $71.6K | 0.00% | −1,613−40.5% | Reduced |
| Coldstream Capital Management Inc | 2,345 | $70.8K | 0.00% | +2,345 | New |
| Van Eck Associates Corp | 2,157 | $65.0K | 0.00% | −59,462−96.5% | Reduced |
| Point72 Asia (Singapore) Pte. Ltd. | 2,082 | $62.8K | 0.02% | +2,082 | New |
| Ancora Advisors, LLC | 2,000 | $60.3K | 0.00% | +2,000 | New |
| GWM Advisors LLC | 1,621 | $48.9K | 0.00% | −199−10.9% | Reduced |
| Twin Lakes Capital Management, LLC | 1,500 | $45.3K | 0.03% | 00.0% | Unchanged |
| IFP Advisors, Inc | 1,150 | $42.4K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 1,382 | $41.7K | 0.00% | +433+45.6% | Added |
| Comerica Bank | 1,320 | $39.8K | 0.00% | −6,073−82.1% | Reduced |
| Manchester Capital Management LLC | 1,248 | $37.7K | 0.00% | +243+24.2% | Added |
| EverSource Wealth Advisors, LLC | 1,157 | $34.9K | 0.00% | +689+147.2% | Added |
| Itau Unibanco Holding S.A. | 1,143 | $34.0K | 0.00% | −8−0.7% | Reduced |
| Sterling Capital Management LLC | 1,101 | $33.2K | 0.00% | −1,909−63.4% | Reduced |
| Huntington National Bank | 1,093 | $33.0K | 0.00% | +142+14.9% | Added |
| Steward Partners Investment Advisory, LLC | 1,090 | $32.9K | 0.00% | −1,984−64.5% | Reduced |
| Sunbelt Securities, Inc. | 1,014 | $30.6K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 961 | $29.0K | 0.00% | +215+28.8% | Added |
| Harbour Investments, Inc. | 900 | $27.2K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 745 | $22.5K | 0.00% | −214−22.3% | Reduced |
| Quest Partners LLC | 635 | $19.2K | 0.00% | +635 | New |
| Laurel Wealth Advisors LLC | 600 | $18.1K | 0.00% | 00.0% | Unchanged |
| Archer Investment Corp | 600 | $18.1K | 0.00% | 00.0% | Unchanged |
| Danske Bank A/S | 500 | $15.1K | 0.00% | 00.0% | Unchanged |
| Riverview Trust Co | 476 | $14.4K | 0.01% | 00.0% | Unchanged |
| Lindbrook Capital, LLC | 440 | $13.3K | 0.00% | −596−57.5% | Reduced |
| Farther Finance Advisors, LLC | 472 | $12.9K | 0.00% | −179−27.5% | Reduced |
| Mather Group, LLC. | 410 | $12.4K | 0.00% | −241−37.0% | Reduced |
| Global Trust Asset Management, LLC | 399 | $12.0K | 0.01% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 381 | $11.5K | 0.00% | −705−64.9% | Reduced |
| Parkside Financial Bank & Trust | 377 | $11.4K | 0.00% | −41−9.8% | Reduced |
| ORG Wealth Partners, LLC | 400 | $10.9K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 343 | $10.3K | 0.00% | +325+1,805.6% | Added |
| Eastern Bank | 300 | $9.05K | 0.00% | +300 | New |
| Oakworth Capital, Inc. | 300 | $9.05K | 0.00% | +300 | New |
| Covestor Ltd | 298 | $9.00K | 0.01% | +52+21.1% | Added |
| Union Bancaire Privee, UBP SA | 265 | $8.26K | 0.00% | 00.0% | Unchanged |
| Storebrand Asset Management AS | 271 | $8.18K | 0.00% | 00.0% | Unchanged |
| Massmutual Trust Co FSB | 262 | $7.91K | 0.00% | +29+12.4% | Added |
| MAI Capital Management | 260 | $7.84K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 260 | $7.84K | 0.00% | +4+1.6% | Added |
| Ronald Blue Trust, Inc. | 259 | $7.81K | 0.00% | 00.0% | Unchanged |
| Riggs Asset Managment Co. Inc. | 250 | $7.54K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 223 | $6.59K | 0.00% | −632−73.9% | Reduced |
| Newbridge Financial Services Group, Inc. | 200 | $6.03K | 0.00% | 00.0% | Unchanged |
| AllSquare Wealth Management LLC | 198 | $5.97K | 0.00% | 00.0% | Unchanged |
| Whittier Trust Co | 192 | $5.79K | 0.00% | 00.0% | Unchanged |
| Wealth Preservation Advisors, LLC | 150 | $4.53K | 0.00% | +150 | New |
| Pacifica Partners Inc. | 150 | $4.28K | 0.00% | 00.0% | Unchanged |
| Kestra Investment Management, LLC | 137 | $4.13K | 0.00% | +137 | New |
| Smartleaf Asset Management LLC | 131 | $4.08K | 0.00% | −197−60.1% | Reduced |
| Golden State Wealth Management, LLC | 126 | $3.80K | 0.00% | 00.0% | Unchanged |
| Spire Wealth Management | 125 | $3.77K | 0.00% | 00.0% | Unchanged |
| Anderson Financial Strategies, LLC | 121 | $3.65K | 0.00% | +121 | New |