Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 344
- −6 vs. Q4 2024
- Shares held
- 166.7M
- +6.69M (+4.2%) vs. Q4 2024
- Total value
- $5.03B
- −$564.9M (−10.1%) vs. Q4 2024
- New holders
- 54
- 102 more added
- Sold out
- 60
- 123 more reduced
6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| GPS Wealth Strategies Group, LLC | 119 | $3.59K | 0.00% | 00.0% | Unchanged |
| South State Corp. | 119 | $3.59K | 0.00% | +119 | New |
| Skopos Labs, Inc. | 114 | $3.44K | 0.00% | +34+42.5% | Added |
| First Horizon Advisors, Inc. | 112 | $3.38K | 0.00% | 00.0% | Unchanged |
| MPWM Advisory Solutions, LLC | 110 | $3.32K | 0.00% | +110 | New |
| SRS Capital Advisors, Inc. | 104 | $3.14K | 0.00% | 00.0% | Unchanged |
| Bogart Wealth, LLC | 102 | $3.08K | 0.00% | +31+43.7% | Added |
| Versant Capital Management, Inc | 101 | $3.05K | 0.00% | +46+83.6% | Added |
| Creekmur Asset Management LLC | 100 | $3.02K | 0.00% | 00.0% | Unchanged |
| Picton Mahoney Asset Management | 89 | $3.00K | 0.00% | +89 | New |
| Meeder Asset Management Inc | 95 | $2.87K | 0.00% | +95 | New |
| Semmax Financial Advisors Inc. | 79 | $2.55K | 0.00% | 00.0% | Unchanged |
| Orion Capital Management LLC | 80 | $2.41K | 0.00% | 00.0% | Unchanged |
| Dynamic Wealth Strategies, LLC | 80 | $2.41K | 0.00% | +80 | New |
| Principal Securities, Inc. | 67 | $2.34K | 0.00% | 00.0% | Unchanged |
| Bell Investment Advisors, Inc | 71 | $2.14K | 0.00% | 00.0% | Unchanged |
| Bessemer Group Inc | 73 | $2.00K | 0.00% | +73 | New |
| Leonteq Securities AG | 63 | $1.90K | 0.00% | 00.0% | Unchanged |
| Clear Investment Research, LLC | 51 | $1.78K | 0.00% | 00.0% | Unchanged |
| Blume Capital Management, Inc. | 55 | $1.66K | 0.00% | 00.0% | Unchanged |
| Quent Capital, LLC | 53 | $1.60K | 0.00% | −21−28.4% | Reduced |
| CoreCap Advisors, LLC | 52 | $1.57K | 0.00% | +7+15.6% | Added |
| Wolff Wiese Magana LLC | 41 | $1.24K | 0.00% | 00.0% | Unchanged |
| Truvestments Capital LLC | 40 | $1.21K | 0.00% | +40 | New |
| Highline Wealth Partners LLC | 38 | $1.15K | 0.00% | +38 | New |
| Hemington Wealth Management | 58 | $1.00K | 0.00% | −25−30.1% | Reduced |
| Avion Wealth | 54 | $1.00K | 0.00% | 00.0% | Unchanged |
| Cheviot Value Management, LLC | 28 | $942 | 0.00% | +28 | New |
| Raffa Wealth Management, LLC | 28 | $845 | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 28 | $845 | 0.00% | +25+833.3% | Added |
| CIBC Private Wealth Group, LLC | 30 | $765 | 0.00% | −1,095−97.3% | Reduced |
| TFC Financial Management | 21 | $634 | 0.00% | 00.0% | Unchanged |
| Key Financial Inc | 19 | $573 | 0.00% | 00.0% | Unchanged |
| Bokf, NA | 18 | $543 | 0.00% | 00.0% | Unchanged |
| Sachetta, LLC | 16 | $483 | 0.00% | −11−40.7% | Reduced |
| Private Wealth Management Group, LLC | 16 | $483 | 0.00% | +6+60.0% | Added |
| Assetmark, Inc | 15 | $453 | 0.00% | −17−53.1% | Reduced |
| Mascoma Wealth Management LLC | 14 | $422 | 0.00% | 00.0% | Unchanged |
| True Wealth Design, LLC | 13 | $393 | 0.00% | +13 | New |
| Bruce G. Allen Investments, LLC | 13 | $392 | 0.00% | +13 | New |
| Hexagon Capital Partners LLC | 9 | $272 | 0.00% | +9 | New |
| Umb Bank N A | 6 | $181 | 0.00% | +6 | New |
| MV Capital Management, Inc. | 3 | $91 | 0.00% | −40−93.0% | Reduced |
| AdvisorNet Financial, Inc | 3 | $91 | 0.00% | +2+200.0% | Added |
| Activest Wealth Management | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Clearbridge Investments, LLC | 0 | $0 | 0.00% | −1,618,220−100.0% | Sold out |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −595,000−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −281,813−100.0% | Sold out |
| Siren, L.L.C. | 0 | $0 | 0.00% | −250,000−100.0% | Sold out |
| Driehaus Capital Management LLC | 0 | $0 | 0.00% | −180,002−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −141,917−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −107,610−100.0% | Sold out |
| Ghisallo Capital Management LLC | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −94,157−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −84,913−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −51,282−100.0% | Sold out |
| Qsemble Capital Management, LP | 0 | $0 | 0.00% | −46,573−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −23,123−100.0% | Sold out |
| Canada Pension Plan Investment Board | 0 | $0 | 0.00% | −19,900−100.0% | Sold out |
| Aigen Investment Management, LP | 0 | $0 | 0.00% | −17,723−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −16,626−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −15,681−100.0% | Sold out |
| Inceptionr LLC | 0 | $0 | 0.00% | −14,390−100.0% | Sold out |
| Natixis Advisors, L.P. | 0 | $0 | 0.00% | −14,313−100.0% | Sold out |
| Franklin Resources Inc | 0 | $0 | 0.00% | −13,301−100.0% | Sold out |
| Stratos Wealth Partners, LTD. | 0 | $0 | 0.00% | −12,813−100.0% | Sold out |
| Essential Planning, LLC. | 0 | $0 | 0.00% | −11,440−100.0% | Sold out |
| Landscape Capital Management, L.L.C. | 0 | $0 | 0.00% | −10,270−100.0% | Sold out |
| Syon Capital LLC | 0 | $0 | 0.00% | −10,119−100.0% | Sold out |
| Janney Montgomery Scott LLC | 0 | $0 | 0.00% | −9,840−100.0% | Sold out |
| Torno Capital, LLC | 0 | $0 | 0.00% | −9,500−100.0% | Sold out |
| Virtus ETF Advisers LLC | 0 | $0 | 0.00% | −9,448−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −9,407−100.0% | Sold out |
| Wolverine Trading, LLC | 0 | $0 | 0.00% | −8,847−100.0% | Sold out |
| Truist Financial Corp | 0 | $0 | 0.00% | −6,847−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −6,382−100.0% | Sold out |
| Gotham Asset Management, LLC | 0 | $0 | 0.00% | −6,260−100.0% | Sold out |
| Castle Rock Wealth Management, LLC | 0 | $0 | 0.00% | −6,972−100.0% | Sold out |
| M&T Bank Corp | 0 | $0 | 0.00% | −6,096−100.0% | Sold out |
| Vontobel Holding Ltd. | 0 | $0 | 0.00% | −5,865−100.0% | Sold out |
| Stevens Capital Management LP | 0 | $0 | 0.00% | −5,860−100.0% | Sold out |
| Caption Management, LLC | 0 | $0 | 0.00% | −5,417−100.0% | Sold out |
| Venturi Wealth Management, LLC | 0 | $0 | 0.00% | −3,061−100.0% | Sold out |
| Horizon Investments, LLC | 0 | $0 | 0.00% | −1,174−100.0% | Sold out |
| Elequin Capital LP | 0 | $0 | 0.00% | −325−100.0% | Sold out |
| Global X Japan Co., Ltd. | 0 | $0 | 0.00% | −297−100.0% | Sold out |
| Tidemark, LLC | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Capital Advisors, Ltd. LLC | 0 | $0 | 0.00% | −179−100.0% | Sold out |
| Whittier Trust Co of Nevada Inc | 0 | $0 | 0.00% | −157−100.0% | Sold out |
| LRI Investments, LLC | 0 | $0 | 0.00% | −136−100.0% | Sold out |
| Transce3nd, LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Bryn Mawr Trust Co | 0 | $0 | 0.00% | −92−100.0% | Sold out |
| Raleigh Capital Management Inc. | 0 | $0 | 0.00% | −72−100.0% | Sold out |
| Coppell Advisory Solutions LLC | 0 | $0 | 0.00% | −51−100.0% | Sold out |
| Private Trust Co NA | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Cornerstone Planning Group LLC | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Lee Danner & Bass Inc | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| Front Row Advisors LLC | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Central Trust Co | 0 | $0 | 0.00% | −15−100.0% | Sold out |