Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Skandinaviska Enskilda Banken AB (publ) | 0 | $0 | 0.00% | −115,293−100.0% | Sold out |
| Healthcare of Ontario Pension Plan Trust Fund | 0 | $0 | 0.00% | −110,000−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −96,647−100.0% | Sold out |
| Bridgewater Associates, LP | 0 | $0 | 0.00% | −67,706−100.0% | Sold out |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | $0 | 0.00% | −62,073−100.0% | Sold out |
| PDT Partners, LLC | 0 | $0 | 0.00% | −54,365−100.0% | Sold out |
| Alpine Global Management, LLC | 0 | $0 | 0.00% | −53,600−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −47,740−100.0% | Sold out |
| Atika Capital Management LLC | 0 | $0 | 0.00% | −47,488−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −34,691−100.0% | Sold out |
| Twin Tree Management, LP | 0 | $0 | 0.00% | −32,476−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −22,685−100.0% | Sold out |
| Gilder Gagnon Howe & Co LLC | 0 | $0 | 0.00% | −19,275−100.0% | Sold out |
| Quantedge Capital Pte Ltd | 0 | $0 | 0.00% | −18,500−100.0% | Sold out |
| Elo Mutual Pension Insurance Co | 0 | $0 | 0.00% | −18,417−100.0% | Sold out |
| Cinctive Capital Management LP | 0 | $0 | 0.00% | −13,726−100.0% | Sold out |
| Friedenthal Financial | 0 | $0 | 0.00% | −13,115−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −12,691−100.0% | Sold out |
| Baader Bank INC | 0 | $0 | 0.00% | −11,097−100.0% | Sold out |
| Ares Systematic Credit Ltd | 0 | $0 | 0.00% | −9,916−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −9,649−100.0% | Sold out |
| NEOS Investment Management LLC | 0 | $0 | 0.00% | −8,557−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −7,807−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −7,596−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −6,087−100.0% | Sold out |
| Dymon Asia Capital (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −5,350−100.0% | Sold out |
| Skopos Labs, Inc. | 0 | $0 | 0.00% | −4,669−100.0% | Sold out |
| AE Wealth Management LLC | 0 | $0 | 0.00% | −4,403−100.0% | Sold out |
| Bank of Nova Scotia | 0 | $0 | 0.00% | −4,189−100.0% | Sold out |
| Janney Montgomery Scott LLC | 0 | $0 | 0.00% | −4,177−100.0% | Sold out |
| Avanza Fonder AB | 0 | $0 | 0.00% | −3,596−100.0% | Sold out |
| Park Avenue Securities LLC | 0 | $0 | 0.00% | −3,571−100.0% | Sold out |
| Cambridge Investment Research Advisors, Inc. | 0 | $0 | 0.00% | −2,957−100.0% | Sold out |
| Impact Partnership Wealth, LLC | 0 | $0 | 0.00% | −2,905−100.0% | Sold out |
| Axxcess Wealth Management, LLC | 0 | $0 | 0.00% | −2,877−100.0% | Sold out |
| Clearbridge Investments, LLC | 0 | $0 | 0.00% | −2,715−100.0% | Sold out |
| Kerntke Otto McGlone Wealth Management Group | 0 | $0 | 0.00% | −2,695−100.0% | Sold out |
| IFG Advisory, LLC | 0 | $0 | 0.00% | −2,678−100.0% | Sold out |
| PharVision Advisers, LLC | 0 | $0 | 0.00% | −2,661−100.0% | Sold out |
| Motley Fool Asset Management LLC | 0 | $0 | 0.00% | −2,630−100.0% | Sold out |
| Twin Lakes Capital Management, LLC | 0 | $0 | 0.00% | −1,500−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −774−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −748−100.0% | Sold out |
| Quest Partners LLC | 0 | $0 | 0.00% | −670−100.0% | Sold out |
| Laurel Wealth Advisors LLC | 0 | $0 | 0.00% | −600−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −481−100.0% | Sold out |
| Strategic Advocates LLC | 0 | $0 | 0.00% | −287−100.0% | Sold out |
| SageView Advisory Group, LLC | 0 | $0 | 0.00% | −215−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −180−100.0% | Sold out |
| Torren Management, LLC | 0 | $0 | 0.00% | −137−100.0% | Sold out |
| Garner Asset Management Corp | 0 | $0 | 0.00% | −115−100.0% | Sold out |
| Rakuten Securities, Inc. | 0 | $0 | 0.00% | −90−100.0% | Sold out |
| Kemnay Advisory Services Inc. | 0 | $0 | 0.00% | −71−100.0% | Sold out |
| Activest Wealth Management | 0 | $0 | 0.00% | −32−100.0% | Sold out |
| Optima Capital LLC | 0 | $0 | 0.00% | −12−100.0% | Sold out |
| Private Trust Co NA | 0 | $0 | 0.00% | −11−100.0% | Sold out |
| Marquette Asset Management, LLC | 0 | $0 | 0.00% | −7−100.0% | Sold out |
| Cape Investment Advisory, Inc. | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Bare Financial Services, Inc | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Rachor Investment Advisory Services, LLC | 0 | $0 | 0.00% | −4−100.0% | Sold out |
| Stone House Investment Management, LLC | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| Avion Wealth | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| Norges Bank | – | – | – | – | Not filed |
| Comerica Bank | – | – | – | – | Not filed |
| Global Retirement Partners, LLC | – | – | – | – | Not filed |
| CIBC Private Wealth Group, LLC | – | – | – | – | Not filed |