Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 290
- +49 vs. Q4 2025
- Shares held
- 100.2M
- +16.7M (+20.0%) vs. Q4 2025
- Total value
- $5.80B
- +$2.06B (+55.0%) vs. Q4 2025
- New holders
- 82
- 123 more added
- Sold out
- 33
- 60 more reduced
4 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 10,818,491 | $629.1M | 0.03% | +1,898,241+21.3% | Added |
| Avoro Capital Advisors LLC | 5,777,777 | $336.0M | 3.31% | +353,333+6.5% | Added |
| BlackRock, Inc. | 5,640,118 | $328.0M | 0.01% | +539,834+10.6% | Added |
| Wellington Management Group LLP | 4,829,641 | $280.8M | 0.05% | +64,862+1.4% | Added |
| Driehaus Capital Management LLC | 4,491,653 | $261.2M | 1.92% | −47,038−1.0% | Reduced |
| Polar Capital Holdings Plc | 4,405,312 | $256.2M | 1.12% | +1,939,618+78.7% | Added |
| Janus Henderson Group PLC | 4,175,982 | $242.9M | 0.12% | +91,948+2.3% | Added |
| Capital International Investors | 2,674,727 | $155.5M | 0.04% | −740,232−21.7% | Reduced |
| Citadel Advisors LLC | 2,652,990 | $154.3M | 0.11% | +1,331,777+100.8% | Added |
| JPMorgan Chase & Co | 1,923,610 | $106.9M | 0.01% | +429,578+28.8% | Added |
| State Street Corp | 1,720,533 | $100.0M | 0.00% | +227,983+15.3% | Added |
| Affinity Asset Advisors, LLC | 1,675,000 | $97.4M | 5.71% | +425,000+34.0% | Added |
| Deerfield Management Company, L.P. (Series C) | 1,615,696 | $94.0M | 1.11% | +1,073,676+198.1% | Added |
| Holocene Advisors, LP | 1,518,686 | $88.3M | 0.21% | +236,605+18.5% | Added |
| Westfield Capital Management Co LP | 1,401,483 | $81.5M | 0.34% | +174,712+14.2% | Added |
| Caligan Partners LP | 1,393,027 | $81.0M | 5.73% | +843,362+153.4% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,342,028 | $78.0M | 0.09% | +281,807+26.6% | Added |
| Braidwell LP | 1,338,452 | $77.8M | 2.60% | −486,624−26.7% | Reduced |
| Price T Rowe Associates Inc | 1,329,591 | $77.3M | 0.01% | +467,291+54.2% | Added |
| Jennison Associates LLC | 1,318,814 | $76.7M | 0.05% | +26,759+2.1% | Added |
| Siren, L.L.C. | 1,318,564 | $76.7M | 2.13% | +505,803+62.2% | Added |
| Alyeska Investment Group, L.P. | 1,299,469 | $75.6M | 0.21% | +1,299,469 | New |
| Franklin Resources Inc | 1,280,577 | $74.5M | 0.02% | +522,518+68.9% | Added |
| Geode Capital Management, LLC | 1,092,932 | $63.5M | 0.00% | +140,253+14.7% | Added |
| Alliancebernstein L.P. | 1,403,297 | $62.9M | 0.02% | −190,517−12.0% | Reduced |
| OrbiMed Advisors LLC | 1,059,971 | $61.6M | 1.40% | +612,771+137.0% | Added |
| Federated Hermes, Inc. | 972,237 | $56.5M | 0.09% | +300,000+44.6% | Added |
| T. Rowe Price Investment Management, Inc. | 951,955 | $55.4M | 0.04% | +404,342+73.8% | Added |
| Capital World Investors | 840,072 | $48.9M | 0.01% | +184,335+28.1% | Added |
| Commodore Capital LP | 825,000 | $48.0M | 2.78% | −975,000−54.2% | Reduced |
| First Turn Management, LLC | 786,844 | $45.8M | 5.11% | −12,899−1.6% | Reduced |
| Goldman Sachs Group Inc | 769,875 | $44.8M | 0.01% | +73,828+10.6% | Added |
| Rock Springs Capital Management LP | 763,020 | $44.4M | 2.62% | −24,768−3.1% | Reduced |
| Fiera Capital Corp | 709,529 | $41.3M | 0.14% | +23,473+3.4% | Added |
| American Century Companies Inc | 679,314 | $39.5M | 0.02% | −1,159−0.2% | Reduced |
| Pictet Asset Management Holding SA | 679,709 | $39.2M | 0.04% | +53,724+8.6% | Added |
| Vestal Point Capital, LP | 639,900 | $37.2M | 1.04% | +39,900+6.7% | Added |
| Standard Life Aberdeen plc | 609,929 | $35.5M | 0.06% | −140,362−18.7% | Reduced |
| Two Sigma Investments, LP | 606,085 | $35.2M | 0.03% | +169,342+38.8% | Added |
| MPM Oncology Impact Management LP | 588,706 | $34.2M | 2.64% | +103,086+21.2% | Added |
| Loomis Sayles & Co L P | 564,897 | $32.8M | 0.04% | −47,135−7.7% | Reduced |
| Vanguard Portfolio Management LLC | 543,062 | $31.6M | 0.00% | +543,062 | New |
| Northern Trust Corp | 527,783 | $30.7M | 0.00% | +89,069+20.3% | Added |
| Parkman Healthcare Partners LLC | 497,035 | $28.9M | 3.00% | +342,851+222.4% | Added |
| Tudor Investment Corp Et Al | 495,591 | $28.8M | 0.16% | +241,589+95.1% | Added |
| Octagon Capital Advisors LP | 490,000 | $28.5M | 3.15% | +490,000 | New |
| Novo Holdings A/S | 485,438 | $28.2M | 2.29% | +485,438 | New |
| Candriam Luxembourg S.C.A. | 476,494 | $27.7M | 0.14% | +59,092+14.2% | Added |
| Morgan Stanley | 473,759 | $27.5M | 0.00% | +179,427+61.0% | Added |
| Adage Capital Partners GP, L.L.C. | 470,000 | $27.3M | 0.04% | −215,100−31.4% | Reduced |
| Logos Global Management LP | 450,000 | $26.2M | 1.35% | +450,000 | New |
| Trails Edge Capital Partners, LP | 440,000 | $25.6M | 6.02% | −157,092−26.3% | Reduced |
| Bank of New York Mellon Corp | 396,138 | $23.0M | 0.00% | +8,980+2.3% | Added |
| UBS Asset Management Americas Inc | 375,166 | $21.8M | 0.00% | +374,930+158,868.6% | Added |
| Baker Bros. Advisors LP | 370,208 | $21.5M | 0.12% | 00.0% | Unchanged |
| TimesSquare Capital Management, LLC | 359,293 | $20.9M | 0.35% | −173,447−32.6% | Reduced |
| Schonfeld Strategic Advisors LLC | 324,722 | $18.9M | 0.15% | +324,722 | New |
| Sofinnova Investments, Inc. | 305,216 | $17.7M | 0.89% | +245,316+409.5% | Added |
| Renaissance Technologies LLC | 300,500 | $17.5M | 0.03% | +300,500 | New |
| Soleus Capital Management, L.P. | 292,000 | $17.0M | 0.69% | +292,000 | New |
| Boothbay Fund Management, LLC | 270,412 | $15.7M | 0.37% | +234,731+657.9% | Added |
| Bank of America Corp | 265,267 | $15.4M | 0.00% | +43,899+19.8% | Added |
| Algert Global LLC | 264,200 | $15.4M | 0.23% | +141,011+114.5% | Added |
| Redmile Group, LLC | 262,674 | $15.3M | 1.01% | +128,792+96.2% | Added |
| State of Wisconsin Investment Board | 254,483 | $14.8M | 0.03% | +48,914+23.8% | Added |
| DAFNA Capital Management LLC | 250,772 | $14.6M | 3.32% | −37,167−12.9% | Reduced |
| Nuveen, LLC | 250,036 | $14.5M | 0.00% | +33,798+15.6% | Added |
| Nan Fung Trinity (HK) Ltd | 247,765 | $14.4M | 1.58% | +20,800+9.2% | Added |
| Nicholas Investment Partners, LP | 247,101 | $14.4M | 1.04% | +4,112+1.7% | Added |
| Allspring Global Investments Holdings, LLC | 246,306 | $14.0M | 0.02% | +246,306 | New |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 238,600 | $13.9M | 0.47% | +238,600 | New |
| Barclays PLC | 238,209 | $13.9M | 0.00% | −362,755−60.4% | Reduced |
| Balyasny Asset Management LLC | 233,905 | $13.6M | 0.03% | +149,545+177.3% | Added |
| ADAR1 Capital Management, LLC | 228,899 | $13.3M | 0.80% | +24,930+12.2% | Added |
| Patient Square Capital LP | 227,000 | $13.2M | 2.34% | +90,500+66.3% | Added |
| Millennium Management LLC | 201,785 | $11.7M | 0.01% | −433,271−68.2% | Reduced |
| Integral Health Asset Management, LLC | 200,000 | $11.6M | 0.62% | +200,000 | New |
| Silverarc Capital Management, LLC | 197,759 | $11.5M | 1.36% | +197,759 | New |
| Charles Schwab Investment Management Inc | 189,080 | $11.0M | 0.00% | +210.0% | Added |
| New York State Common Retirement Fund | 188,505 | $11.0M | 0.02% | +1,800+1.0% | Added |
| NEXTBio Capital Management LP | 183,225 | $10.7M | 4.95% | −479−0.3% | Reduced |
| DnB Asset Management AS | 181,085 | $10.5M | 0.04% | −91,746−33.6% | Reduced |
| Susquehanna International Group, LLP | 177,137 | $10.3M | 0.01% | +168,818+2,029.3% | Added |
| ExodusPoint Capital Management, LP | 173,425 | $10.1M | 0.10% | +173,425 | New |
| Deutsche Bank AG | 162,682 | $9.46M | 0.00% | −27,551−14.5% | Reduced |
| Foresite Capital Management IV, LLC | 160,000 | $9.30M | 3.92% | 00.0% | Unchanged |
| Swiss National Bank | 157,700 | $9.17M | 0.01% | +43,700+38.3% | Added |
| Jump Financial, LLC | 155,776 | $9.06M | 0.13% | +124,789+402.7% | Added |
| Woodline Partners LP | 150,302 | $8.74M | 0.03% | +150,302 | New |
| Peregrine Capital Management LLC | 143,136 | $8.32M | 0.31% | −31,715−18.1% | Reduced |
| StemPoint Capital LP | 140,755 | $8.18M | 1.57% | −207,850−59.6% | Reduced |
| Neuberger Berman Group LLC | 130,438 | $7.58M | 0.01% | −48,309−27.0% | Reduced |
| Eversept Partners, LP | 129,574 | $7.53M | 0.50% | −101,806−44.0% | Reduced |
| Russell Investments Group, Ltd. | 129,399 | $7.52M | 0.01% | +43,179+50.1% | Added |
| KBC Group NV | 129,010 | $7.50M | 0.02% | +126,230+4,540.6% | Added |
| Sphera Funds Management Ltd. | 127,000 | $7.39M | 1.27% | +127,000 | New |
| HSBC Holdings PLC | 121,558 | $7.07M | 0.00% | +121,558 | New |
| Wells Fargo & Company | 115,652 | $6.73M | 0.00% | −36,645−24.1% | Reduced |
| Mutual of America Capital Management LLC | 115,594 | $6.72M | 0.08% | −494−0.4% | Reduced |
| SEI Investments Co | 114,381 | $6.65M | 0.01% | +70,523+160.8% | Added |