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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2026

Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
290
+49 vs. Q4 2025
Shares held
100.2M
+16.7M (+20.0%) vs. Q4 2025
Total value
$5.80B
+$2.06B (+55.0%) vs. Q4 2025
New holders
82
123 more added
Sold out
33
60 more reduced

4 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 290 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ1 2026: $5.80B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2025.

Institutions holding XENE in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
TFC Financial Management1$590.00%+1New
Keating Financial Advisory Services, Inc.2$1160.00%+2New
Pinnacle Wealth Planning Services, Inc.4$2330.00%+4New
Hughes Financial Services, LLC4$2330.00%+4New
WPG Advisers, LLC9$5230.00%+9New
Smartleaf Asset Management LLC12$6670.00%−4−25.0%Reduced
UMA Financial Services, Inc.13$7560.00%00.0%Unchanged
Park Place Capital Corp16$9300.00%00.0%Unchanged
CoreCap Advisors, LLC17$9890.00%00.0%Unchanged
Massmutual Trust Co FSB17$9890.00%+6+54.5%Added
Covestor Ltd10$1.00K0.00%−237−96.0%Reduced
Hantz Financial Services, Inc.25$1.00K0.00%00.0%Unchanged
First Horizon Corp24$1.40K0.00%+24New
Parkside Financial Bank & Trust30$1.75K0.00%00.0%Unchanged
Twin Peaks Wealth Advisors, LLC32$1.86K0.00%+32New
CVA Family Office, LLC33$1.92K0.00%00.0%Unchanged
Golden State Equity Partners35$2.04K0.00%+35New
Allworth Financial LP38$2.21K0.00%−78−67.2%Reduced
Root Financial Partners, LLC40$2.33K0.00%+40New
Larson Financial Group LLC52$3.02K0.00%+50+2,500.0%Added
EverSource Wealth Advisors, LLC77$4.48K0.00%−135−63.7%Reduced
Danske Bank A/S100$5.82K0.00%−700−87.5%Reduced
Bell Investment Advisors, Inc100$5.82K0.00%00.0%Unchanged
Rothschild Investment LLC126$7.33K0.00%+15+13.5%Added
TD Waterhouse Canada Inc.130$7.33K0.00%+130New
SMA Capital LLC139$8.08K0.00%+139New
Parallel Advisors, LLC152$8.84K0.00%+5+3.4%Added
Quantbot Technologies LP162$9.42K0.00%+162New
Rossby Financial, LCC181$10.3K0.00%+134+285.1%Added
Farther Finance Advisors, LLC189$10.7K0.00%−869−82.1%Reduced
Rockefeller Capital Management L.P.200$11.6K0.00%−900−81.8%Reduced
National Bank of Canada235$13.7K0.00%+45+23.7%Added
J.Safra Asset Management Corp268$15.6K0.00%+181+208.0%Added
US Bancorp272$15.8K0.00%+97+55.4%Added
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.276$16.0K0.00%00.0%Unchanged
Basecamp Wealth Advisors LLC280$16.3K0.00%+280New
Huntington National Bank288$16.7K0.00%+288New
Zions Bancorporation, National Association305$17.7K0.00%+70+29.8%Added
GAMMA Investing LLC373$21.7K0.00%+109+41.3%Added
Advisor Group Holdings, Inc.389$22.6K0.00%+70+21.9%Added
MAI Capital Management392$22.8K0.00%+131+50.2%Added
Vanguard Global Advisers, LLC494$28.7K0.00%+494New
CWM, LLC510$29.7K0.00%+144+39.3%Added
Signaturefd, LLC553$32.2K0.00%+80+16.9%Added
Bayforest Capital Ltd555$32.3K0.04%+555New
Sterling Capital Management LLC560$32.6K0.00%+69+14.1%Added
Acadian Asset Management LLC677$39.0K0.00%+677New
Ronald Blue Trust, Inc.745$43.3K0.00%00.0%Unchanged
Kemnay Advisory Services Inc.764$44.4K0.01%+641+521.1%Added
Nisa Investment Advisors, LLC951$55.3K0.00%+27+2.9%Added
SBI Securities Co., Ltd.988$57.5K0.00%+987+98,700.0%Added
Axiom Investment Management LLC1,000$58.1K0.04%+1,000New
State of Wyoming1,381$80.3K0.01%−120−8.0%Reduced
GF Fund Management Co. Ltd.1,735$100.9K0.00%+218+14.4%Added
IFP Advisors, Inc1,871$108.8K0.00%−6−0.3%Reduced
Jones Financial Companies LLLP2,399$130.7K0.00%+2,249+1,499.3%Added
Eurizon Capital SGR S.p.A.2,649$147.9K0.00%+2,649New
Caitong International Asset Management Co., Ltd3,330$193.6K0.04%+2,105+171.8%Added
Jane Street Group, LLC3,468$201.7K0.00%+3,468New
Seeds Investor LLC3,423$203.2K0.03%+3,423New
Cetera Investment Advisers3,624$210.7K0.00%+3,624New
Aigen Investment Management, LP4,123$239.8K0.06%+4,123New
FNY Investment Advisers, LLC4,200$244.0K0.11%+4,200New
PSP Research LLC4,200$244.2K0.17%−7,478−64.0%Reduced
Snowden Capital Advisors LLC4,223$245.6K0.01%+4,223New
Oppenheimer Asset Management Inc.4,325$251.5K0.00%+4,325New
Mirae Asset Global Investments Co., Ltd.4,339$252.3K0.00%+584+15.6%Added
CIBC Bancorp USA Inc.4,349$252.9K0.00%+4,349New
Swiss Life Asset Management Ltd4,847$281.9K0.00%+4,847New
Citizens Financial Group Inc4,963$288.6K0.00%−37−0.7%Reduced
LPL Financial LLC4,964$288.7K0.00%+4,964New
Northwestern Mutual Wealth Management Co5,000$290.8K0.00%00.0%Unchanged
Ensign Peak Advisors, Inc5,194$302.0K0.00%00.0%Unchanged
CAPROCK Group, Inc.5,291$307.7K0.01%+222+4.4%Added
DRW Securities, LLC5,461$317.6K0.02%+5,461New
STRS Ohio5,700$331.5K0.00%+4,400+338.5%Added
Letson Investment Management, Inc.6,000$348.9K0.13%00.0%Unchanged
Tower Research Capital LLC (TRC)6,105$355.0K0.01%+2,873+88.9%Added
Headlands Technologies LLC6,120$355.9K0.04%+6,120New
Virtus Investment Advisers, Inc.6,188$359.8K0.10%+151+2.5%Added
Toroso Investments, LLC6,225$362.0K0.00%+6,225New
Principal Financial Group Inc6,244$363.1K0.00%+1,756+39.1%Added
Longaeva Partners L.P.6,250$363.4K0.02%+6,250New
Bridgefront Capital, LLC6,564$381.7K0.09%+6,564New
PenderFund Capital Management Ltd.6,850$398.3K0.06%00.0%Unchanged
Oxford Asset Management LLP6,884$400.3K0.16%−495−6.7%Reduced
Advisors Asset Management, Inc.6,961$404.8K0.01%−1,051−13.1%Reduced
Great West Life Assurance Co7,024$411.0K0.00%00.0%Unchanged
Ameritas Investment Partners, Inc.7,138$415.1K0.01%+970+15.7%Added
AQR Capital Management LLC7,279$423.3K0.00%+7,279New
Teacher Retirement System of Texas7,599$441.9K0.00%−1,033−12.0%Reduced
Allianz Asset Management GmbH7,600$441.9K0.00%−1,800−19.1%Reduced
The PNC Financial Services Group, Inc.8,097$470.8K0.00%+1,523+23.2%Added
Xponance, Inc.8,465$492.2K0.00%+2,490+41.7%Added
JustInvest LLC8,761$509.5K0.01%+4,228+93.3%Added
EntryPoint Capital, LLC8,832$513.6K0.15%+3,804+75.7%Added
J. Safra Sarasin Holding AG9,071$527.5K0.01%−4,510−33.2%Reduced
SG Americas Securities, LLC9,119$530.0K0.00%+2,042+28.9%Added
Thrivent Financial for Lutherans9,122$531.0K0.00%+3,539+63.4%Added
First Trust Advisors LP9,133$531.1K0.00%+2,772+43.6%Added