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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2021

Institutional positions in Xenon Pharmaceuticals Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
103
+12 vs. Q1 2021
Shares held
33.6M
+608.3K (+1.8%) vs. Q1 2021
Total value
$620.0M
+$30.0M (+5.1%) vs. Q1 2021
New holders
16
29 more added
Sold out
4
31 more reduced

Compare with Q1 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2021: 103 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ2 2021: $620.0M
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q2 2021

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q1 2021.

Institutions holding XENE in Q2 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Avoro Capital Advisors LLC3,650,000$68.0M1.18%00.0%Unchanged
FMR LLC3,072,444$57.2M0.00%−14,800−0.5%Reduced
Perceptive Advisors LLC1,678,973$31.3M0.41%+1,163,931+226.0%Added
BVF Inc1,571,778$29.3M1.10%−1,910,000−54.9%Reduced
Adage Capital Partners GP, L.L.C.1,525,000$28.4M0.06%−1,025,000−40.2%Reduced
Eventide Asset Management, LLC1,490,000$27.7M0.37%00.0%Unchanged
OrbiMed Advisors LLC1,334,217$24.8M0.25%−1,163,700−46.6%Reduced
Capital International Investors1,055,726$19.7M0.00%00.0%Unchanged
Citadel Advisors LLC1,043,543$19.4M0.02%+820,991+368.9%Added
NEA Management Company, LLC992,107$18.5M0.24%00.0%Unchanged
Capital World Investors963,500$17.9M0.00%00.0%Unchanged
Driehaus Capital Management LLC945,135$17.6M0.23%+173,725+22.5%Added
Bank of New York Mellon Corp935,542$17.4M0.00%−22,611−2.4%Reduced
Point72 Asset Management, L.P.902,300$16.8M0.08%+141,299+18.6%Added
Boxer Capital, LLC857,000$16.0M0.56%+857,000New
Ghost Tree Capital, LLC850,000$15.8M4.95%00.0%Unchanged
Baker Bros. Advisors LP751,639$14.0M0.06%00.0%Unchanged
Candriam Luxembourg S.C.A.715,722$13.3M0.09%+715,722New
Renaissance Technologies LLC657,977$12.3M0.02%−35,000−5.1%Reduced
Ikarian Capital, LLC640,606$11.9M2.13%+300.0%Added
Suvretta Capital Management, LLC594,111$11.1M0.17%+154,047+35.0%Added
Rock Springs Capital Management LP572,500$10.7M0.21%00.0%Unchanged
Acuta Capital Partners, LLC417,409$7.77M3.33%+4,909+1.2%Added
BlackRock Inc.411,252$7.66M0.00%+13,129+3.3%Added
Marshall Wace North America L.P.411,259$7.66M0.03%+411,259New
DAFNA Capital Management LLC406,535$7.57M1.58%00.0%Unchanged
Parkman Healthcare Partners LLC401,207$7.47M1.63%+26,812+7.2%Added
Lord, Abbett & Co. LLC384,725$7.16M0.02%−33,825−8.1%Reduced
Commodore Capital LP326,336$6.08M2.12%+24,944+8.3%Added
UBS Asset Management Americas Inc319,090$5.94M0.00%−15,651−4.7%Reduced
Millennium Management LLC301,748$5.62M0.01%−41,151−12.0%Reduced
Soleus Capital Management, L.P.233,697$4.35M0.67%−474,420−67.0%Reduced
Nan Fung Group Holdings Ltd197,880$3.69M1.14%+197,880New
Altrinsic Global Advisors LLC170,000$3.17M0.10%00.0%Unchanged
Tekla Capital Management LLC169,030$3.15M0.10%+3,132+1.9%Added
D. E. Shaw & Co., Inc.164,071$3.06M0.00%−10,924−6.2%Reduced
Altium Capital Management LP155,000$2.89M0.67%+155,000New
Goldman Sachs Group Inc152,218$2.83M0.00%+16,999+12.6%Added
Knott David M140,551$2.62M1.01%−3,550−2.5%Reduced
State Street Corp130,595$2.43M0.00%+32,507+33.1%Added
Granite Point Capital Management, L.P.110,000$2.05M0.61%+40,000+57.1%Added
Vanguard Group Inc103,436$1.93M0.00%−3,359−3.1%Reduced
Schonfeld Strategic Advisors LLC96,600$1.80M0.02%+13,200+15.8%Added
Boothbay Fund Management, LLC95,757$1.78M0.07%+4,941+5.4%Added
Bank of Montreal87,156$1.62M0.00%+24,588+39.3%Added
Two Sigma Investments, LP85,218$1.59M0.00%+8,512+11.1%Added
Granahan Investment Management Inc83,249$1.55M0.03%+161+0.2%Added
Two Sigma Advisers, LP83,000$1.54M0.00%−5,900−6.6%Reduced
Swiss National Bank61,900$1.15M0.00%−2,100−3.3%Reduced
Alps Advisors Inc53,959$1.00M0.01%−9,372−14.8%Reduced
Nuveen Asset Management, LLC53,454$995.0K0.00%+35,811+203.0%Added
Morgan Stanley52,600$979.0K0.00%+47,641+960.7%Added
Susquehanna International Group, LLP51,981$968.0K0.00%+25,999+100.1%Added
The PNC Financial Services Group, Inc.45,722$851.0K0.00%00.0%Unchanged
Northern Trust Corp44,721$832.0K0.00%−5,841−11.6%Reduced
HighVista Strategies LLC40,959$763.0K0.54%+40,959New
Scotia Capital Inc.40,017$745.0K0.01%−1,120−2.7%Reduced
M&G Investment Management Ltd34,103$648.0K0.00%+34,103New
Simplex Trading, LLC30,207$562.0K0.02%+10,065+50.0%Added
Shell Asset Management Co26,245$489.0K0.01%+1,440+5.8%Added
International Biotechnology Trust PLC25,500$474.0K0.13%+25,500New
Royal Bank of Canada25,370$472.0K0.00%00.0%Unchanged
NJ State Employees Deferred Compensation Plan25,000$466.0K0.06%00.0%Unchanged
Sanders Morris Harris LLC24,500$455.0K0.09%00.0%Unchanged
Geode Capital Management, LLC21,650$403.0K0.00%+2,408+12.5%Added
Alliancebernstein L.P.19,908$371.0K0.00%+19,908New
Elmwood Wealth Management, Inc.18,729$349.0K0.18%00.0%Unchanged
HRT Financial LP18,654$347.0K0.00%−2,224−10.7%Reduced
Credit Suisse AG18,617$346.0K0.00%−5,474−22.7%Reduced
Dimensional Fund Advisors LP15,010$279.0K0.00%+15,010New
Quantitative Systematic Strategies LLC12,343$230.0K0.08%−12,865−51.0%Reduced
Virtus ETF Advisers LLC12,091$225.0K0.09%−12,728−51.3%Reduced
Vident Investment Advisory, LLC11,731$218.0K0.01%+11,731New
Supplemental Annuity Collective Trust of NJ11,000$205.0K0.07%00.0%Unchanged
DekaBank Deutsche Girozentrale11,000$196.0K0.00%00.0%Unchanged
Marshall Wace, LLP10,453$195.0K0.00%+10,453New
Interwest Venture Management Co8,293$148.0K0.05%00.0%Unchanged
Bank of America Corp6,979$130.0K0.00%−10,293−59.6%Reduced
Zurcher Kantonalbank (Zurich Cantonalbank)4,091$76.0K0.00%00.0%Unchanged
Citigroup Inc3,000$56.0K0.00%+2,039+212.2%Added
Eaton Vance Management2,500$47.0K0.00%00.0%Unchanged
Acadian Asset Management LLC2,365$44.0K0.00%−24,288−91.1%Reduced
JPMorgan Chase & Co2,039$38.0K0.00%−4,466−68.7%Reduced
Proequities, Inc.2,000$37.0K0.00%00.0%Unchanged
Cubist Systematic Strategies, LLC1,841$34.0K0.00%−3,770−67.2%Reduced
Legal & General Group Plc1,196$22.0K0.00%00.0%Unchanged
Great West Life Assurance Co1,104$21.0K0.00%−1,313−54.3%Reduced
UBS Group AG1,021$19.0K0.00%+21+2.1%Added
IFP Advisors, Inc1,000$19.0K0.00%00.0%Unchanged
Penserra Capital Management LLC935$17.0K0.00%+140+17.6%Added
Group One Trading, L.P.890$17.0K0.00%+890New
Cutler Group LP893$16.0K0.00%+893New
Macquarie Group Ltd539$10.0K0.00%00.0%Unchanged
BNP Paribas Arbitrage, SA490$9.12K0.00%+261+114.0%Added
Advisor Group Holdings, Inc.375$7.00K0.00%−375−50.0%Reduced
Tower Research Capital LLC (TRC)389$7.00K0.00%−16−4.0%Reduced
Barclays PLC40$1.00K0.00%−142−78.0%Reduced
Deutsche Bank AG53$1.00K0.00%−35−39.8%Reduced
Daiwa Securities Group Inc.66$1.00K0.00%00.0%Unchanged
Carmichael Hill & Associates, Inc.80$1.00K0.00%00.0%Unchanged