Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 130
- +14 vs. Q3 2021
- Shares held
- 47.7M
- +14.0M (+41.6%) vs. Q3 2021
- Total value
- $1.49B
- +$974.8M (+189.3%) vs. Q3 2021
- New holders
- 38
- 50 more added
- Sold out
- 24
- 27 more reduced
2 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 4,985,000 | $155.7M | 2.65% | +1,335,000+36.6% | Added |
| FMR LLC | 3,910,017 | $122.1M | 0.01% | +853,261+27.9% | Added |
| BVF Inc | 3,289,540 | $102.8M | 3.73% | +1,717,762+109.3% | Added |
| Driehaus Capital Management LLC | 3,123,229 | $97.6M | 1.00% | +1,611,686+106.6% | Added |
| Point72 Asset Management, L.P. | 2,992,597 | $93.5M | 0.41% | +1,914,797+177.7% | Added |
| Perceptive Advisors LLC | 2,411,447 | $75.3M | 1.16% | +389,396+19.3% | Added |
| Capital World Investors | 2,274,974 | $71.1M | 0.01% | +1,311,474+136.1% | Added |
| Lord, Abbett & Co. LLC | 1,795,080 | $56.1M | 0.13% | +1,416,722+374.4% | Added |
| Polar Capital Holdings Plc | 1,688,044 | $52.7M | 0.27% | +1,688,044 | New |
| Citadel Advisors LLC | 1,287,803 | $40.2M | 0.04% | +446,587+53.1% | Added |
| Marshall Wace, LLP | 1,220,957 | $38.1M | 0.08% | +1,191,154+3,996.8% | Added |
| Commodore Capital LP | 1,090,126 | $34.1M | 7.89% | +510,694+88.1% | Added |
| Capital International Investors | 1,055,726 | $33.0M | 0.01% | 00.0% | Unchanged |
| Great Point Partners LLC | 950,000 | $29.7M | 6.63% | +250,000+35.7% | Added |
| Morgan Stanley | 872,084 | $27.2M | 0.00% | +831,348+2,040.8% | Added |
| Bank of New York Mellon Corp | 791,525 | $24.7M | 0.00% | −143,118−15.3% | Reduced |
| Rock Springs Capital Management LP | 771,367 | $24.1M | 0.56% | +188,267+32.3% | Added |
| Baker Bros. Advisors LP | 751,639 | $23.5M | 0.11% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 692,000 | $21.6M | 0.42% | −466,961−40.3% | Reduced |
| Kynam Capital Management, LP | 670,093 | $20.9M | 11.19% | +670,093 | New |
| Adage Capital Partners GP, L.L.C. | 665,000 | $20.8M | 0.04% | −510,000−43.4% | Reduced |
| OrbiMed Advisors LLC | 631,000 | $19.7M | 0.26% | +154,000+32.3% | Added |
| Boxer Capital, LLC | 600,000 | $18.7M | 0.75% | −257,000−30.0% | Reduced |
| BlackRock Inc. | 567,572 | $17.7M | 0.00% | +124,520+28.1% | Added |
| Candriam Luxembourg S.C.A. | 530,511 | $16.6M | 0.11% | −185,211−25.9% | Reduced |
| Samlyn Capital, LLC | 521,640 | $16.3M | 0.25% | +521,640 | New |
| D. E. Shaw & Co., Inc. | 475,140 | $14.8M | 0.02% | +326,261+219.1% | Added |
| DAFNA Capital Management LLC | 402,667 | $12.6M | 3.16% | −3,868−1.0% | Reduced |
| Renaissance Technologies LLC | 380,877 | $11.9M | 0.01% | −238,200−38.5% | Reduced |
| Soleus Capital Management, L.P. | 378,997 | $11.8M | 1.60% | +163,300+75.7% | Added |
| Parkman Healthcare Partners LLC | 360,502 | $11.3M | 2.55% | +49,295+15.8% | Added |
| Alliancebernstein L.P. | 294,098 | $9.19M | 0.00% | +30,995+11.8% | Added |
| Invesco Ltd. | 294,100 | $9.19M | 0.00% | +294,100 | New |
| Dimensional Fund Advisors LP | 291,946 | $9.12M | 0.00% | +140,749+93.1% | Added |
| Two Sigma Investments, LP | 278,343 | $8.70M | 0.02% | +108,667+64.0% | Added |
| Acuta Capital Partners, LLC | 225,000 | $7.03M | 2.95% | −192,409−46.1% | Reduced |
| Granahan Investment Management Inc | 217,301 | $6.79M | 0.14% | +133,447+159.1% | Added |
| Eversept Partners, LP | 209,519 | $6.55M | 0.54% | +209,519 | New |
| Nan Fung Group Holdings Ltd | 197,880 | $6.18M | 1.83% | 00.0% | Unchanged |
| AXA S.A. | 195,048 | $6.09M | 0.02% | +35,405+22.2% | Added |
| Ikarian Capital, LLC | 179,138 | $5.60M | 1.60% | −198,300−52.5% | Reduced |
| Goldman Sachs Group Inc | 171,394 | $5.35M | 0.00% | +75,409+78.6% | Added |
| Altrinsic Global Advisors LLC | 170,000 | $5.31M | 0.17% | 00.0% | Unchanged |
| State Street Corp | 161,249 | $5.04M | 0.00% | +13,802+9.4% | Added |
| Vanguard Group Inc | 153,366 | $4.79M | 0.00% | +46,174+43.1% | Added |
| Affinity Asset Advisors, LLC | 150,500 | $4.70M | 2.01% | +100,500+201.0% | Added |
| Two Sigma Advisers, LP | 126,600 | $3.96M | 0.01% | −49,200−28.0% | Reduced |
| Ghost Tree Capital, LLC | 100,000 | $3.12M | 1.20% | −690,000−87.3% | Reduced |
| Silverarc Capital Management, LLC | 100,000 | $3.12M | 1.40% | +80,568+414.6% | Added |
| Millennium Management LLC | 90,621 | $2.83M | 0.00% | −145,598−61.6% | Reduced |
| Schonfeld Strategic Advisors LLC | 88,900 | $2.78M | 0.03% | −31,221−26.0% | Reduced |
| Swiss National Bank | 87,400 | $2.73M | 0.00% | +24,000+37.9% | Added |
| Knott David M Jr | 86,488 | $2.70M | 1.02% | +86,488 | New |
| Polar Asset Management Partners Inc. | 78,300 | $2.45M | 0.03% | +78,300 | New |
| Walleye Capital LLC | 71,984 | $2.25M | 0.07% | +71,984 | New |
| Allianz Asset Management GmbH | 69,905 | $2.19M | 0.00% | +69,905 | New |
| HighVista Strategies LLC | 62,906 | $1.97M | 1.56% | −12,140−16.2% | Reduced |
| Alps Advisors Inc | 59,702 | $1.86M | 0.02% | +9,287+18.4% | Added |
| Ameriprise Financial Inc | 58,321 | $1.82M | 0.00% | +43,621+296.7% | Added |
| Altshuler Shaham Ltd | 53,600 | $1.67M | 0.04% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 52,171 | $1.63M | 0.00% | +52,171 | New |
| Northern Trust Corp | 50,596 | $1.58M | 0.00% | +12,746+33.7% | Added |
| CIBC World Markets Inc. | 49,634 | $1.55M | 0.01% | +49,634 | New |
| Pura Vida Investments, LLC | 48,502 | $1.51M | 0.16% | −1,498−3.0% | Reduced |
| Voloridge Investment Management, LLC | 47,920 | $1.50M | 0.01% | +47,920 | New |
| Bank of America Corp | 42,798 | $1.34M | 0.00% | +28,411+197.5% | Added |
| Cinctive Capital Management LP | 42,303 | $1.32M | 0.06% | +42,303 | New |
| Bamco Inc | 42,000 | $1.31M | 0.00% | +42,000 | New |
| Nuveen Asset Management, LLC | 41,884 | $1.31M | 0.00% | +12,586+43.0% | Added |
| Ensign Peak Advisors, Inc | 37,115 | $1.16M | 0.00% | +5,600+17.8% | Added |
| Teacher Retirement System of Texas | 37,028 | $1.16M | 0.01% | +37,028 | New |
| Gyon Technologies Capital Management, LP | 36,279 | $1.13M | 0.21% | +23,445+182.7% | Added |
| Erste Asset Management GmbH | 35,000 | $1.10M | 0.02% | +35,000 | New |
| Scotia Capital Inc. | 33,696 | $1.05M | 0.01% | −3,440−9.3% | Reduced |
| California State Teachers Retirement System | 33,508 | $1.05M | 0.00% | +10,178+43.6% | Added |
| Jump Financial, LLC | 31,300 | $978.0K | 0.06% | +31,300 | New |
| Geode Capital Management, LLC | 28,198 | $880.0K | 0.00% | +6,548+30.2% | Added |
| UBS Asset Management Americas Inc | 28,062 | $876.7K | 0.00% | +28,062 | New |
| International Biotechnology Trust PLC | 25,500 | $797.0K | 0.18% | 00.0% | Unchanged |
| Shell Asset Management Co | 25,329 | $791.0K | 0.02% | +164+0.7% | Added |
| Tri Locum Partners LP | 25,043 | $782.0K | 0.31% | −239,091−90.5% | Reduced |
| NJ State Employees Deferred Compensation Plan | 25,000 | $781.0K | 0.10% | 00.0% | Unchanged |
| Granite Point Capital Management, L.P. | 25,000 | $781.0K | 0.30% | +25,000 | New |
| Credit Suisse AG | 24,904 | $777.0K | 0.00% | +6,206+33.2% | Added |
| Sanders Morris Harris LLC | 24,500 | $771.0K | 0.13% | 00.0% | Unchanged |
| Royal Bank of Canada | 24,313 | $760.0K | 0.00% | −1,000−4.0% | Reduced |
| Susquehanna Fundamental Investments, LLC | 20,866 | $652.0K | 0.02% | 00.0% | Unchanged |
| Handelsbanken Fonder AB | 20,700 | $647.0K | 0.00% | +20,700 | New |
| Boothbay Fund Management, LLC | 18,376 | $574.0K | 0.02% | −32,948−64.2% | Reduced |
| Elmwood Wealth Management, Inc. | 18,080 | $565.0K | 0.27% | +18,080 | New |
| Cubist Systematic Strategies, LLC | 14,541 | $454.0K | 0.00% | +6,653+84.3% | Added |
| Qube Research & Technologies Ltd | 14,304 | $447.0K | 0.00% | +14,304 | New |
| Guggenheim Capital LLC | 13,684 | $427.0K | 0.00% | +3,609+35.8% | Added |
| Brown Advisory Inc | 12,911 | $403.0K | 0.00% | +12,911 | New |
| Sender Co & Partners, Inc. | 12,215 | $382.0K | 0.24% | +12,215 | New |
| DekaBank Deutsche Girozentrale | 11,300 | $359.0K | 0.00% | +300+2.7% | Added |
| Stifel Financial Corp | 11,484 | $358.0K | 0.00% | +556+5.1% | Added |
| Supplemental Annuity Collective Trust of NJ | 11,000 | $344.0K | 0.11% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 11,014 | $344.0K | 0.00% | +11,014 | New |
| Arizona State Retirement System | 10,679 | $334.0K | 0.00% | +10,679 | New |