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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2024

Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
220
+17 vs. Q4 2023
Shares held
73.5M
+1.65M (+2.3%) vs. Q4 2023
Total value
$3.16B
−$145.6M (−4.4%) vs. Q4 2023
New holders
36
80 more added
Sold out
19
66 more reduced

1 institution that held it in Q4 2023 haven't filed for Q1 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2024: 220 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ1 2024: $3.16B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q1 2024

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2023.

Institutions holding XENE in Q1 2024
InstitutionSharesValue% of portfolioChange in sharesAction
FMR LLC6,601,830$284.2M0.02%+945,908+16.7%Added
Avoro Capital Advisors LLC5,666,666$243.9M2.85%00.0%Unchanged
Driehaus Capital Management LLC4,321,740$186.1M1.85%−23,440−0.5%Reduced
Wellington Management Group LLP3,922,058$168.8M0.03%−240,596−5.8%Reduced
Capital World Investors2,681,537$115.4M0.02%00.0%Unchanged
Polar Capital Holdings Plc2,612,108$112.5M0.68%−454,520−14.8%Reduced
Paradigm Biocapital Advisors LP2,484,874$107.0M3.77%+357,474+16.8%Added
Capital International Investors2,475,859$106.6M0.02%+20,176+0.8%Added
Commodore Capital LP2,167,793$93.3M6.24%00.0%Unchanged
BlackRock Inc.2,121,928$91.3M0.00%+54,865+2.7%Added
Adage Capital Partners GP, L.L.C.1,671,917$72.0M0.14%+623,192+59.4%Added
Pictet Asset Management Holding SA1,515,426$65.2M0.07%−524,974−25.7%Reduced
Alliancebernstein L.P.1,468,446$63.2M0.02%−106,122−6.7%Reduced
Marshall Wace, LLP1,450,342$62.4M0.10%−78,306−5.1%Reduced
T. Rowe Price Investment Management, Inc.1,426,339$61.4M0.04%+535,190+60.1%Added
First Light Asset Management, LLC1,320,172$56.8M4.35%−325,318−19.8%Reduced
Braidwell LP1,308,011$56.3M1.81%−339,300−20.6%Reduced
Citadel Advisors LLC1,287,075$55.4M0.05%+20,231+1.6%Added
Rock Springs Capital Management LP1,255,577$54.1M1.37%00.0%Unchanged
Invesco Ltd.1,049,526$45.2M0.01%+329,808+45.8%Added
Baker Bros. Advisors LP993,679$42.8M0.54%00.0%Unchanged
Janus Henderson Group PLC941,569$40.5M0.02%−24,496−2.5%Reduced
Lord, Abbett & Co. LLC895,196$38.5M0.12%+177,224+24.7%Added
Perceptive Advisors LLC892,208$38.4M0.68%−208,540−18.9%Reduced
Affinity Asset Advisors, LLC837,387$36.0M5.86%+377,387+82.0%Added
TimesSquare Capital Management, LLC737,173$31.7M0.46%−56,781−7.2%Reduced
Federated Hermes, Inc.734,900$31.6M0.07%+388,304+112.0%Added
Avidity Partners Management LP710,000$30.6M1.09%−105,993−13.0%Reduced
Loomis Sayles & Co L P686,510$29.6M0.04%−21,785−3.1%Reduced
First Turn Management, LLC680,389$29.3M4.38%00.0%Unchanged
Boxer Capital, LLC600,000$25.8M1.28%00.0%Unchanged
Fiera Capital Corp576,542$24.8M0.07%+23,512+4.3%Added
Jennison Associates LLC563,952$24.3M0.02%−2,444−0.4%Reduced
Candriam Luxembourg S.C.A.560,884$24.1M0.15%+30,000+5.7%Added
OrbiMed Advisors LLC550,000$23.7M0.46%00.0%Unchanged
Franklin Resources Inc542,289$23.3M0.01%+248,464+84.6%Added
Great Point Partners LLC456,148$19.6M3.06%−143,852−24.0%Reduced
BNP PARIBAS ASSET MANAGEMENT Holding S.A.416,736$17.9M0.05%+416,736New
Dimensional Fund Advisors LP410,207$17.7M0.00%+7,539+1.9%Added
Vestal Point Capital, LP400,000$17.2M1.42%+225,000+128.6%Added
Samlyn Capital, LLC396,196$17.1M0.30%−24,959−5.9%Reduced
Morgan Stanley386,199$16.6M0.00%+161,052+71.5%Added
Altium Capital Management LP348,000$15.0M6.69%+57,465+19.8%Added
Westfield Capital Management Co LP347,351$15.0M0.08%+109,856+46.3%Added
Vanguard Group Inc335,635$14.4M0.00%+12,140+3.8%Added
Ally Bridge Group (NY) LLC309,369$13.3M7.40%+67,408+27.9%Added
Goldman Sachs Group Inc299,774$12.9M0.00%−76,528−20.3%Reduced
Boone Capital Management LLC291,403$12.5M2.54%+35,971+14.1%Added
Point72 Asset Management, L.P.275,859$11.9M0.03%−599,206−68.5%Reduced
Two Sigma Investments, LP274,626$11.8M0.03%−65,389−19.2%Reduced
DAFNA Capital Management LLC273,739$11.8M2.68%−3,000−1.1%Reduced
Artal Group S.A.253,387$10.9M0.28%+253,387New
Granahan Investment Management Inc244,080$10.5M0.37%−58,501−19.3%Reduced
State Street Corp242,640$10.4M0.00%+15,600+6.9%Added
Laurion Capital Management LP239,126$10.3M0.29%+164,126+218.8%Added
Alyeska Investment Group, L.P.238,843$10.3M0.06%+238,843New
Two Sigma Advisers, LP229,200$9.87M0.02%−23,500−9.3%Reduced
Parkman Healthcare Partners LLC223,942$9.64M1.18%−70,846−24.0%Reduced
Tri Locum Partners LP207,465$8.93M3.10%−18,099−8.0%Reduced
Balyasny Asset Management LLC201,274$8.66M0.02%+185,423+1,169.8%Added
D. E. Shaw & Co., Inc.198,526$8.55M0.01%+114,373+135.9%Added
New York State Common Retirement Fund192,752$8.30M0.01%+2,440+1.3%Added
AXA S.A.187,872$8.09M0.02%+510.0%Added
Assenagon Asset Management S.A.186,606$8.03M0.02%+86,875+87.1%Added
Algert Global LLC184,015$7.92M0.31%−33,305−15.3%Reduced
Russell Investments Group, Ltd.178,099$7.67M0.01%+3,813+2.2%Added
Nicholas Investment Partners, LP167,926$7.23M0.74%+80,174+91.4%Added
Ensign Peak Advisors, Inc163,064$7.02M0.01%−1,316−0.8%Reduced
Bank of America Corp157,104$6.76M0.00%+23,692+17.8%Added
ExodusPoint Capital Management, LP154,038$6.63M0.08%−11,229−6.8%Reduced
PFM Health Sciences, LP150,554$6.48M0.32%−42,302−21.9%Reduced
Bridger Management, LLC146,800$6.32M2.85%00.0%Unchanged
DnB Asset Management AS126,250$5.44M0.03%−125−0.1%Reduced
Swiss National Bank123,800$5.33M0.00%00.0%Unchanged
Atika Capital Management LLC122,000$5.25M0.59%+28,766+30.9%Added
Ikarian Capital, LLC107,187$4.61M1.26%+107,187New
Nan Fung Group Holdings Ltd106,680$4.59M4.26%00.0%Unchanged
Bamco Inc100,100$4.31M0.01%00.0%Unchanged
Twinbeech Capital LP98,042$4.22M0.09%+98,042New
State of Wisconsin Investment Board91,785$3.95M0.01%−3,551−3.7%Reduced
Schroder Investment Management Group91,500$3.94M0.00%00.0%Unchanged
Credit Suisse AG85,339$3.67M0.00%+3,544+4.3%Added
Millennium Management LLC83,661$3.60M0.00%+6,696+8.7%Added
Schonfeld Strategic Advisors LLC79,951$3.44M0.03%−7,549−8.6%Reduced
UBS Asset Management Americas Inc77,484$3.34M0.00%00.0%Unchanged
HighVista Strategies LLC72,715$3.13M1.12%+20,914+40.4%Added
Bank of New York Mellon Corp66,910$2.88M0.00%+251+0.4%Added
Silverarc Capital Management, LLC66,090$2.85M0.80%−97,078−59.5%Reduced
Jefferies Financial Group Inc.65,637$2.83M0.06%−1,086−1.6%Reduced
Voya Investment Management LLC64,940$2.80M0.00%00.0%Unchanged
Geode Capital Management, LLC64,229$2.77M0.00%+2,156+3.5%Added
Wells Fargo & Company61,457$2.65M0.00%+3,034+5.2%Added
Prudential Financial Inc59,000$2.54M0.00%00.0%Unchanged
State of New Jersey Common Pension Fund D56,750$2.44M0.01%−14,263−20.1%Reduced
California State Teachers Retirement System56,477$2.43M0.00%+490+0.9%Added
Renaissance Technologies LLC56,400$2.43M0.00%+23,800+73.0%Added
Legal & General Group Plc55,010$2.37M0.00%+1,361+2.5%Added
Moore Capital Management, LP55,000$2.37M0.05%−10,000−15.4%Reduced
Alps Advisors Inc53,200$2.29M0.02%+2,420+4.8%Added
Erste Asset Management GmbH50,000$2.15M0.03%00.0%Unchanged