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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q3 2021

Institutional positions in Xenon Pharmaceuticals Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
118
+16 vs. Q2 2021
Shares held
34.1M
+556.1K (+1.7%) vs. Q2 2021
Total value
$521.7M
−$98.0M (−15.8%) vs. Q2 2021
New holders
25
35 more added
Sold out
9
30 more reduced

1 institution that held it in Q2 2021 haven't filed for Q3 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2021: 118 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ3 2021: $521.7M
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q3 2021

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q2 2021.

Institutions holding XENE in Q3 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Avoro Capital Advisors LLC3,650,000$55.8M0.88%00.0%Unchanged
FMR LLC3,056,756$46.7M0.00%−15,688−0.5%Reduced
Perceptive Advisors LLC2,022,051$30.9M0.45%+343,078+20.4%Added
BVF Inc1,571,778$24.0M0.94%00.0%Unchanged
Driehaus Capital Management LLC1,511,543$23.1M0.27%+566,408+59.9%Added
Adage Capital Partners GP, L.L.C.1,175,000$18.0M0.04%−350,000−23.0%Reduced
Suvretta Capital Management, LLC1,158,961$17.7M0.30%+564,850+95.1%Added
Point72 Asset Management, L.P.1,077,800$16.5M0.08%+175,500+19.5%Added
Capital International Investors1,055,726$16.1M0.00%00.0%Unchanged
NEA Management Company, LLC992,107$15.2M0.19%00.0%Unchanged
Capital World Investors963,500$14.7M0.00%00.0%Unchanged
Bank of New York Mellon Corp934,643$14.3M0.00%−899−0.1%Reduced
Boxer Capital, LLC857,000$13.1M0.46%00.0%Unchanged
Citadel Advisors LLC841,216$12.9M0.01%−202,327−19.4%Reduced
Ghost Tree Capital, LLC790,000$12.1M3.98%−60,000−7.1%Reduced
Baker Bros. Advisors LP751,639$11.5M0.05%00.0%Unchanged
Candriam Luxembourg S.C.A.715,722$10.9M0.07%00.0%Unchanged
Great Point Partners LLC700,000$10.7M2.53%+700,000New
Renaissance Technologies LLC619,077$9.46M0.01%−38,900−5.9%Reduced
Rock Springs Capital Management LP583,100$8.91M0.19%+10,600+1.9%Added
Commodore Capital LP579,432$8.85M2.33%+253,096+77.6%Added
OrbiMed Advisors LLC477,000$7.29M0.08%−857,217−64.2%Reduced
BlackRock Inc.443,052$6.77M0.00%+31,800+7.7%Added
Acuta Capital Partners, LLC417,409$6.38M2.27%00.0%Unchanged
DAFNA Capital Management LLC406,535$6.21M1.65%00.0%Unchanged
Lord, Abbett & Co. LLC378,358$5.78M0.01%−6,367−1.7%Reduced
Ikarian Capital, LLC377,438$5.77M1.32%−263,168−41.1%Reduced
Sphera Funds Management Ltd.373,510$5.71M0.57%+97,380+35.3%Added
Marshall Wace North America L.P.338,301$5.17M0.02%−72,958−17.7%Reduced
Parkman Healthcare Partners LLC311,207$4.75M1.20%−90,000−22.4%Reduced
Tri Locum Partners LP264,134$4.04M1.88%+264,134New
Alliancebernstein L.P.263,103$4.02M0.00%+243,195+1,221.6%Added
Millennium Management LLC236,219$3.61M0.00%−65,529−21.7%Reduced
Altium Capital Management LP216,000$3.30M0.88%+61,000+39.4%Added
Soleus Capital Management, L.P.215,697$3.30M0.51%−18,000−7.7%Reduced
Woodline Partners LP199,984$3.06M0.05%+199,984New
Nan Fung Group Holdings Ltd197,880$3.02M0.97%00.0%Unchanged
Monashee Investment Management LLC180,000$2.75M0.51%+180,000New
Two Sigma Advisers, LP175,800$2.69M0.01%+92,800+111.8%Added
Altrinsic Global Advisors LLC170,000$2.60M0.08%00.0%Unchanged
Two Sigma Investments, LP169,676$2.59M0.01%+84,458+99.1%Added
Tekla Capital Management LLC169,030$2.58M0.08%00.0%Unchanged
AXA S.A.159,643$2.44M0.01%+159,643New
Dimensional Fund Advisors LP151,197$2.31M0.00%+136,187+907.3%Added
D. E. Shaw & Co., Inc.148,879$2.27M0.00%−15,192−9.3%Reduced
State Street Corp147,447$2.25M0.00%+16,852+12.9%Added
Schonfeld Strategic Advisors LLC120,121$1.84M0.02%+23,521+24.3%Added
Vanguard Group Inc107,192$1.64M0.00%+3,756+3.6%Added
Fred Alger Management, LLC105,989$1.62M0.00%+105,989New
Goldman Sachs Group Inc95,985$1.47M0.00%−56,233−36.9%Reduced
Knott David M94,488$1.44M0.60%−46,063−32.8%Reduced
Granahan Investment Management Inc83,854$1.28M0.02%+605+0.7%Added
Bank of Montreal82,967$1.25M0.00%−4,189−4.8%Reduced
HighVista Strategies LLC75,046$1.15M0.76%+34,087+83.2%Added
Swiss National Bank63,400$969.0K0.00%+1,500+2.4%Added
Endurant Capital Management LP62,743$959.0K0.29%+62,743New
Altshuler Shaham Ltd53,600$823.0K0.01%+53,600New
Boothbay Fund Management, LLC51,324$784.0K0.03%−44,433−46.4%Reduced
Alps Advisors Inc50,415$770.0K0.01%−3,544−6.6%Reduced
Sanders Morris Harris LLC24,500$770.0K0.14%00.0%Unchanged
Pura Vida Investments, LLC50,000$764.0K0.06%+50,000New
Affinity Asset Advisors, LLC50,000$764.0K0.30%+50,000New
Morgan Stanley40,736$623.0K0.00%−11,864−22.6%Reduced
Northern Trust Corp37,850$579.0K0.00%−6,871−15.4%Reduced
Scotia Capital Inc.37,136$567.0K0.00%−2,881−7.2%Reduced
Simplex Trading, LLC30,607$566.0K0.02%+400+1.3%Added
M&G Investment Management Ltd34,103$512.0K0.00%00.0%Unchanged
Ensign Peak Advisors, Inc31,515$482.0K0.00%+31,515New
Marshall Wace, LLP29,803$456.0K0.00%+19,350+185.1%Added
Nuveen Asset Management, LLC29,298$448.0K0.00%−24,156−45.2%Reduced
Susquehanna International Group, LLP26,279$402.0K0.00%−25,702−49.4%Reduced
International Biotechnology Trust PLC25,500$388.0K0.10%00.0%Unchanged
Royal Bank of Canada25,313$387.0K0.00%−57−0.2%Reduced
Shell Asset Management Co25,165$385.0K0.01%−1,080−4.1%Reduced
NJ State Employees Deferred Compensation Plan25,000$382.0K0.05%00.0%Unchanged
California State Teachers Retirement System23,330$356.0K0.00%+23,330New
Trexquant Investment LP23,213$355.0K0.03%+23,213New
Geode Capital Management, LLC21,650$330.0K0.00%00.0%Unchanged
Susquehanna Fundamental Investments, LLC20,866$319.0K0.01%+20,866New
Crestline Management, LP20,417$312.0K0.03%+20,417New
Silverarc Capital Management, LLC19,432$297.0K0.17%+19,432New
Credit Suisse AG18,698$286.0K0.00%+81+0.4%Added
Ameriprise Financial Inc14,700$225.0K0.00%+14,700New
Bank of America Corp14,387$220.0K0.00%+7,408+106.1%Added
Engineers Gate Manager LP14,150$216.0K0.01%+14,150New
Gyon Technologies Capital Management, LP12,834$196.0K0.05%+12,834New
ExodusPoint Capital Management, LP11,866$181.0K0.00%+11,866New
Virtus ETF Advisers LLC11,494$176.0K0.08%−597−4.9%Reduced
Supplemental Annuity Collective Trust of NJ11,000$168.0K0.06%00.0%Unchanged
Stifel Financial Corp10,928$167.0K0.00%+10,928New
DekaBank Deutsche Girozentrale11,000$162.0K0.00%00.0%Unchanged
HRT Financial LP10,357$158.0K0.00%−8,297−44.5%Reduced
Guggenheim Capital LLC10,075$154.0K0.00%+10,075New
Interwest Venture Management Co8,293$127.0K0.05%00.0%Unchanged
Deutsche Bank AG7,987$122.0K0.00%+7,934+14,969.8%Added
Cubist Systematic Strategies, LLC7,888$121.0K0.00%+6,047+328.5%Added
Legal & General Group Plc6,748$103.0K0.00%+5,552+464.2%Added
Zurcher Kantonalbank (Zurich Cantonalbank)4,201$64.0K0.00%+110+2.7%Added
Accel Wealth Management3,900$60.0K0.04%+3,900New
Macquarie Group Ltd3,514$54.0K0.00%+2,975+551.9%Added