| Aug 31, 2026 (view filing)9:59 PM ET | Aug 28 | 3 days | Kenney Christopher JohnChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.07K | $60.25 | −$425.8K | −100.0%2 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 13, 2026 (view filing)4:33 PM ET | Aug 11 | 2 days | Gannon StevenDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $64.06 | −$640.5K | −84.2%1.87K after | |
| Jun 8, 2026 (view filing) | Jun 5 | 3 days | Patou GaryDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.32K | $53.14 | −$70.3K | −5.0%24.9K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 8, 2026 (view filing) | Jun 5 | 3 days | Cannon GillianDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.19K | $53.14 | −$63.2K | −45.0%1.46K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 13, 2026 (view filing) | Mar 13 | Same day | Kenney Christopher JohnChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.41K | $55.23 | −$77.9K | −16.6%7.07K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 13, 2026 (view filing) | Mar 13 | Same day | DiFabio AndreaChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.34K | $55.23 | −$74.1K | −15.5%7.30K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 13, 2026 (view filing) | Mar 13 | Same day | Mortimer IanPRESIDENT & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.31K | $55.23 | −$403.6K | −26.8%19.9K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 11, 2026 (view filing) | Mar 10 | 1 day | Kenney Christopher JohnChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.77K | $60.11 | −$166.6K | −36.9%4.73K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 11, 2026 (view filing) | Mar 10 | 1 day | DiFabio AndreaChief Legal Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.61K | $60.11 | −$156.7K | −34.8%4.89K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 11, 2026 (view filing) | Mar 9-10 | 2 days | Mortimer IanPRESIDENT & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −281.3K | $60.32 | −$17.0M | −95.0%14.7K after | 10 lotsThis row combines 10 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 2, 2026 (view filing) | Jan 2 | Same day | Mortimer IanPRESIDENT & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −40.0K | $44.43 | −$1.78M | −87.0%6.00K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 9, 2025 (view filing) | Dec 5-8 | 4 days | Mortimer IanPRESIDENT & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.2K | $45.33 | −$1.14M | −80.8%6.00K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 3, 2025 (view filing) | Nov 28 | 5 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | Mortimer IanPRESIDENT & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −97 | $45.01 | −$4.37K | −0.3%31.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 1, 2025 (view filing) | Oct 1 | Same day | Mortimer IanPRESIDENT, CEO & INTERIM CFO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $40.16 | −$1.00M | −44.4%31.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 6, 2025 (view filing) | Jun 5 | 1 day | Gannon StevenDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3 | $30.48 | −$91.44 | 0.0%7.14K after | |
| Jan 27, 2025 (view filing) | Jan 23-27 | 4 days | Mortimer IanPRESIDENT & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −55.0K | $40.25 | −$2.21M | −63.7%31.3K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 19, 2024 (view filing) | Dec 18 | 1 day | Aulin SherryChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.7K | $41.21 | −$770.9K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 22, 2024 (view filing) | Nov 22 | Same day | Patou GaryDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.89K | $41.08 | −$200.9K | −17.2%23.6K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 11, 2024 (view filing) | Mar 8 | 3 days | Garofalo Elizabeth A.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.09K | $45.69 | −$95.6K | −100.0%0 after | |
| Mar 8, 2024 (view filing) | Mar 7 | 1 day | Robin SherringtonEVP, Strategy & Innovation | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.14K | $46.28 | −$330.3K | −45.9%8.40K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 8, 2024 (view filing) | Mar 7 | 1 day | Gannon StevenDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −13.0K | $46.28 | −$601.6K | −86.7%2.00K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 15, 2023 (view filing) | Dec 14 | 1 day | Patou GaryDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.60K | $41.05 | −$311.9K | −60.8%4.90K after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing. |
| Aug 24, 2023 (view filing) | Aug 24 | Same day | Svoronos DawnDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $38.70 | −$967.5K | −50.0%25.0K after | |
| Jun 1, 2023 (view filing) | May 30-Jun 1 | 2 days | Pimstone Simon N.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −131.2K | $38.90 | −$5.10M | −95.6%6.00K after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average. |
| May 26, 2023 (view filing) | May 24 | 2 days | Mortimer IanPRESIDENT & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −31.7K | $41.41 | −$1.31M | −50.3%31.3K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 24, 2023 (view filing) | Mar 24 | Same day | Kenney Christopher JohnChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −700 | $35.01 | −$24.5K | −100.0%0 after | |
| Mar 9, 2023 (view filing) | Mar 7 | 2 days | Pimstone Simon N.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −19.2K | $36.98 | −$711.2K | −25.9%55.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 28, 2022 (view filing) | Nov 23-25 | 5 days | Patou GaryDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.99K | $34.55 | −$138.0K | −14.5%23.6K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 7, 2022 (view filing) | Sep 2 | 5 days | Aulin SherryChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −15.4K | $39.57 | −$607.6K | −100.0%0 after | |
| Sep 2, 2022 (view filing) | Aug 31-Sep 1 | 2 days | Robin SherringtonEVP, Strategy & Innovation | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −65.2K | $38.31 | −$2.50M | −79.5%16.8K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 16, 2022 (view filing) | Aug 12 | 4 days | Empfield James R.EVP, Drug Discovery | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −57.7K | $38.31 | −$2.21M | −85.2%10.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 16, 2022 (view filing) | Aug 12-16 | 4 days | Pimstone Simon N.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −177.1K | $38.25 | −$6.78M | −96.7%6.00K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 8, 2022 (view filing) | Mar 8 | Same day | Pimstone Simon N.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.50K | $30.80 | −$77.0K | −1.3%193.1K after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing. |
| Mar 8, 2022 (view filing) | Mar 4 | 4 days | Robin SherringtonEVP, Strategy & Innovation | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −21.7K | $30.50 | −$662.2K | −55.7%17.2K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 8, 2022 (view filing) | Mar 4-7 | 4 days | Empfield James R.EVP, Drug Discovery | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −51.2K | $30.63 | −$1.57M | −83.7%10.0K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 21, 2022 (view filing) | Jan 21 | Same day | Kenney Christopher JohnChief Medical Officer | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +700 | $28.81 | +$20.2K | New position700 after | |
| Dec 7, 2021 (view filing) | Dec 6 | 1 day | Von Seggern ChristopherChief Commercial Officer | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +4.00K | $24.40 | +$97.6K | New position4.00K after | |
| Nov 16, 2021 (view filing) | Nov 15 | 1 day | Pimstone Simon N.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −17.6K | $31.33 | −$550.1K | −7.7%210.2K after | |
