Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 206
- +2 vs. Q1 2025
- Shares held
- 83.1M
- +6.43M (+8.4%) vs. Q1 2025
- Total value
- $2.60B
- +$26.6M (+1.0%) vs. Q1 2025
- New holders
- 42
- 77 more added
- Sold out
- 40
- 55 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 8,884,363 | $278.1M | 0.02% | +596,864+7.2% | Added |
| Avoro Capital Advisors LLC | 5,400,000 | $169.0M | 2.96% | −341,666−6.0% | Reduced |
| BlackRock, Inc. | 5,365,327 | $167.9M | 0.00% | +3,329,202+163.5% | Added |
| Driehaus Capital Management LLC | 4,335,648 | $135.7M | 1.09% | −249,211−5.4% | Reduced |
| Braidwell LP | 3,605,029 | $112.8M | 3.86% | +895,154+33.0% | Added |
| Janus Henderson Group PLC | 3,577,735 | $112.0M | 0.05% | +252,642+7.6% | Added |
| Capital International Investors | 3,181,549 | $99.6M | 0.02% | +92,819+3.0% | Added |
| Commodore Capital LP | 3,025,000 | $94.7M | 6.68% | +700,000+30.1% | Added |
| Polar Capital Holdings Plc | 2,703,256 | $84.6M | 0.44% | +80,217+3.1% | Added |
| Wellington Management Group LLP | 2,174,761 | $68.1M | 0.01% | −1,614,436−42.6% | Reduced |
| Vestal Point Capital, LP | 2,000,000 | $62.6M | 3.30% | +700,000+53.8% | Added |
| Holocene Advisors, LP | 1,809,475 | $56.6M | 0.14% | +1,809,475 | New |
| Alliancebernstein L.P. | 1,518,527 | $47.5M | 0.02% | +189,141+14.2% | Added |
| Pictet Asset Management Holding SA | 1,474,449 | $46.2M | 0.05% | −3,168−0.2% | Reduced |
| State Street Corp | 1,380,460 | $43.2M | 0.00% | +1,074,840+351.7% | Added |
| Deep Track Capital, LP | 1,350,000 | $42.3M | 1.36% | +350,000+35.0% | Added |
| Adage Capital Partners GP, L.L.C. | 1,290,100 | $40.4M | 0.07% | −624,649−32.6% | Reduced |
| JPMorgan Chase & Co | 1,256,581 | $39.3M | 0.00% | −101,021−7.4% | Reduced |
| Westfield Capital Management Co LP | 1,152,605 | $36.1M | 0.15% | −238,765−17.2% | Reduced |
| Affinity Asset Advisors, LLC | 1,100,000 | $34.4M | 5.09% | −228,175−17.2% | Reduced |
| Marshall Wace, LLP | 1,020,254 | $31.9M | 0.04% | +262,109+34.6% | Added |
| Geode Capital Management, LLC | 970,343 | $30.4M | 0.00% | +900,746+1,294.2% | Added |
| OrbiMed Advisors LLC | 947,877 | $29.7M | 0.75% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 931,681 | $29.2M | 1.82% | 00.0% | Unchanged |
| Millennium Management LLC | 882,835 | $27.6M | 0.02% | +648,779+277.2% | Added |
| Vanguard Group Inc | 873,228 | $27.3M | 0.00% | +536,714+159.5% | Added |
| Siren, L.L.C. | 812,761 | $25.4M | 1.32% | +80,000+10.9% | Added |
| Jennison Associates LLC | 696,383 | $21.8M | 0.01% | −80,310−10.3% | Reduced |
| American Century Companies Inc | 679,857 | $21.3M | 0.01% | +679,857 | New |
| Franklin Resources Inc | 666,466 | $20.9M | 0.01% | +175,346+35.7% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 661,082 | $20.7M | 0.05% | −42,713−6.1% | Reduced |
| First Turn Management, LLC | 660,617 | $20.7M | 3.86% | −22,834−3.3% | Reduced |
| Loomis Sayles & Co L P | 657,165 | $20.6M | 0.03% | −15,846−2.4% | Reduced |
| Capital World Investors | 655,737 | $20.5M | 0.00% | −1,568,978−70.5% | Reduced |
| TimesSquare Capital Management, LLC | 571,242 | $17.9M | 0.26% | −174,309−23.4% | Reduced |
| Goldman Sachs Group Inc | 561,800 | $17.6M | 0.00% | +119,068+26.9% | Added |
| Deerfield Management Company, L.P. (Series C) | 542,020 | $17.0M | 0.31% | +542,020 | New |
| Fiera Capital Corp | 530,683 | $16.6M | 0.06% | +1,241+0.2% | Added |
| Standard Life Aberdeen plc | 521,492 | $16.3M | 0.03% | +117,338+29.0% | Added |
| Northern Trust Corp | 489,940 | $15.3M | 0.00% | +408,916+504.7% | Added |
| Saturn V Capital Management LLC | 468,364 | $14.7M | 5.94% | +54,653+13.2% | Added |
| Assenagon Asset Management S.A. | 436,974 | $13.7M | 0.02% | +195,768+81.2% | Added |
| Bank of New York Mellon Corp | 436,020 | $13.6M | 0.00% | +184,873+73.6% | Added |
| UBS Asset Management Americas Inc | 404,384 | $12.7M | 0.00% | +340,816+536.1% | Added |
| Candriam Luxembourg S.C.A. | 396,636 | $12.4M | 0.07% | −58,014−12.8% | Reduced |
| Morgan Stanley | 387,596 | $12.1M | 0.00% | +258,105+199.3% | Added |
| Dimensional Fund Advisors LP | 379,988 | $11.9M | 0.00% | +165,128+76.9% | Added |
| Baker Bros. Advisors LP | 370,208 | $11.6M | 0.11% | +22,800+6.6% | Added |
| Bank of America Corp | 358,432 | $11.2M | 0.00% | +221,863+162.5% | Added |
| MPM Oncology Impact Management LP | 323,398 | $10.1M | 1.75% | +20,000+6.6% | Added |
| DAFNA Capital Management LLC | 287,939 | $9.01M | 2.49% | +14,200+5.2% | Added |
| ADAR1 Capital Management, LLC | 259,503 | $8.12M | 1.32% | +131,955+103.5% | Added |
| Granahan Investment Management Inc | 240,038 | $7.51M | 0.31% | +56,230+30.6% | Added |
| DnB Asset Management AS | 234,157 | $7.33M | 0.03% | +4,675+2.0% | Added |
| Federated Hermes, Inc. | 232,500 | $7.28M | 0.01% | 00.0% | Unchanged |
| Nuveen, LLC | 228,567 | $7.15M | 0.00% | +228,567 | New |
| Susquehanna International Group, LLP | 222,352 | $6.96M | 0.01% | +222,352 | New |
| Perceptive Advisors LLC | 200,791 | $6.28M | 0.24% | −124,533−38.3% | Reduced |
| Great Point Partners LLC | 200,000 | $6.26M | 4.07% | −45,272−18.5% | Reduced |
| Charles Schwab Investment Management Inc | 192,242 | $6.02M | 0.00% | +192,242 | New |
| First Light Asset Management, LLC | 188,367 | $5.90M | 0.76% | −439,537−70.0% | Reduced |
| AXA S.A. | 175,632 | $5.50M | 0.02% | +282+0.2% | Added |
| State of Wisconsin Investment Board | 174,850 | $5.47M | 0.01% | +77,701+80.0% | Added |
| New York State Common Retirement Fund | 166,472 | $5.21M | 0.01% | +24,100+16.9% | Added |
| Foresite Capital Management IV, LLC | 160,000 | $5.01M | 4.05% | +160,000 | New |
| Foresite Capital Management VI LLC | 160,000 | $5.01M | 2.82% | +160,000 | New |
| Nan Fung Trinity (HK) Ltd | 158,605 | $4.96M | 0.59% | +158,605 | New |
| UBS Group AG | 153,058 | $4.79M | 0.00% | +47,725+45.3% | Added |
| Barclays PLC | 152,770 | $4.78M | 0.00% | +133,500+692.8% | Added |
| Parkman Healthcare Partners LLC | 150,373 | $4.71M | 0.54% | −24,203−13.9% | Reduced |
| Neuberger Berman Group LLC | 147,411 | $4.61M | 0.00% | +102,559+228.7% | Added |
| Royal Bank of Canada | 147,226 | $4.61M | 0.00% | +87,860+148.0% | Added |
| D. E. Shaw & Co., Inc. | 141,783 | $4.44M | 0.00% | −10,405−6.8% | Reduced |
| Schroder Investment Management Group | 129,103 | $4.04M | 0.00% | −8,118−5.9% | Reduced |
| Swiss National Bank | 124,300 | $3.89M | 0.00% | −1,300−1.0% | Reduced |
| Ameriprise Financial Inc | 122,026 | $3.82M | 0.00% | +18,402+17.8% | Added |
| Citadel Advisors LLC | 120,045 | $3.76M | 0.00% | −567,043−82.5% | Reduced |
| Wells Fargo & Company | 112,562 | $3.52M | 0.00% | +46,650+70.8% | Added |
| Rhumbline Advisers | 109,700 | $3.43M | 0.00% | +109,671+378,175.9% | Added |
| Avidity Partners Management LP | 107,891 | $3.38M | 0.68% | −121,109−52.9% | Reduced |
| Deutsche Bank AG | 104,534 | $3.27M | 0.00% | +50,823+94.6% | Added |
| Algert Global LLC | 102,345 | $3.20M | 0.07% | −21,070−17.1% | Reduced |
| Caption Management, LLC | 100,940 | $3.16M | 0.29% | +100,940 | New |
| Mutual of America Capital Management LLC | 95,568 | $2.99M | 0.03% | +46,805+96.0% | Added |
| Two Sigma Advisers, LP | 95,300 | $2.98M | 0.01% | −203,500−68.1% | Reduced |
| Moore Capital Management, LP | 90,000 | $2.82M | 0.06% | +35,000+63.6% | Added |
| J. Safra Sarasin Holding AG | 82,048 | $2.57M | 0.04% | +51,475+168.4% | Added |
| Legal & General Group Plc | 81,792 | $2.56M | 0.00% | +21,386+35.4% | Added |
| Soleus Capital Management, L.P. | 78,800 | $2.47M | 0.17% | +78,800 | New |
| T. Rowe Price Investment Management, Inc. | 76,943 | $2.41M | 0.00% | −720,043−90.3% | Reduced |
| Nicholas Investment Partners, LP | 68,896 | $2.16M | 0.19% | −18,072−20.8% | Reduced |
| Balyasny Asset Management LLC | 68,869 | $2.16M | 0.00% | −198,273−74.2% | Reduced |
| Raymond James Financial Inc | 65,214 | $2.04M | 0.00% | +1,829+2.9% | Added |
| Man Group plc | 62,348 | $1.95M | 0.00% | +62,348 | New |
| State of New Jersey Common Pension Fund D | 61,772 | $1.93M | 0.01% | +11,355+22.5% | Added |
| California State Teachers Retirement System | 60,233 | $1.89M | 0.00% | +4,741+8.5% | Added |
| Nebula Research & Development LLC | 60,223 | $1.88M | 0.16% | +13,662+29.3% | Added |
| Invesco Ltd. | 59,598 | $1.87M | 0.00% | −146,165−71.0% | Reduced |
| Voya Investment Management LLC | 59,465 | $1.86M | 0.00% | +11,400+23.7% | Added |
| Bamco Inc | 56,000 | $1.75M | 0.00% | −44,100−44.1% | Reduced |