Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 219
- +15 vs. Q2 2025
- Shares held
- 84.3M
- +1.20M (+1.4%) vs. Q2 2025
- Total value
- $3.39B
- +$783.3M (+30.1%) vs. Q2 2025
- New holders
- 35
- 68 more added
- Sold out
- 20
- 71 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 8,918,907 | $358.1M | 0.02% | +34,544+0.4% | Added |
| Avoro Capital Advisors LLC | 5,400,000 | $216.8M | 2.80% | 00.0% | Unchanged |
| BlackRock, Inc. | 4,770,951 | $191.6M | 0.00% | −594,376−11.1% | Reduced |
| Driehaus Capital Management LLC | 4,169,114 | $167.4M | 1.20% | −166,534−3.8% | Reduced |
| Janus Henderson Group PLC | 3,943,885 | $158.3M | 0.07% | +366,150+10.2% | Added |
| Wellington Management Group LLP | 3,609,857 | $144.9M | 0.03% | +1,435,096+66.0% | Added |
| Braidwell LP | 3,605,029 | $144.7M | 4.29% | 00.0% | Unchanged |
| Capital International Investors | 3,181,493 | $127.7M | 0.02% | −560.0% | Reduced |
| Commodore Capital LP | 2,700,000 | $108.4M | 5.29% | −325,000−10.7% | Reduced |
| Polar Capital Holdings Plc | 2,546,766 | $102.3M | 0.49% | −156,490−5.8% | Reduced |
| Holocene Advisors, LP | 1,976,553 | $79.4M | 0.18% | +167,078+9.2% | Added |
| Alliancebernstein L.P. | 1,654,417 | $66.4M | 0.02% | +135,890+8.9% | Added |
| State Street Corp | 1,466,467 | $58.9M | 0.00% | +86,007+6.2% | Added |
| Affinity Asset Advisors, LLC | 1,400,000 | $56.2M | 5.23% | +300,000+27.3% | Added |
| JPMorgan Chase & Co | 1,399,033 | $56.2M | 0.00% | +142,452+11.3% | Added |
| Millennium Management LLC | 1,384,007 | $55.6M | 0.04% | +501,172+56.8% | Added |
| Pictet Asset Management Holding SA | 1,262,579 | $50.6M | 0.05% | −211,870−14.4% | Reduced |
| Westfield Capital Management Co LP | 1,206,066 | $48.4M | 0.20% | +53,461+4.6% | Added |
| Deep Track Capital, LP | 1,200,000 | $48.2M | 1.34% | −150,000−11.1% | Reduced |
| Jennison Associates LLC | 1,135,235 | $45.6M | 0.03% | +438,852+63.0% | Added |
| Vestal Point Capital, LP | 1,100,000 | $44.2M | 2.00% | −900,000−45.0% | Reduced |
| Geode Capital Management, LLC | 977,435 | $39.2M | 0.00% | +7,092+0.7% | Added |
| Citadel Advisors LLC | 959,098 | $38.5M | 0.03% | +839,053+698.9% | Added |
| Rock Springs Capital Management LP | 851,744 | $34.2M | 2.00% | −79,937−8.6% | Reduced |
| Vanguard Group Inc | 851,386 | $34.2M | 0.00% | −21,842−2.5% | Reduced |
| Adage Capital Partners GP, L.L.C. | 835,100 | $33.5M | 0.05% | −455,000−35.3% | Reduced |
| Siren, L.L.C. | 812,761 | $32.6M | 1.28% | 00.0% | Unchanged |
| First Turn Management, LLC | 799,743 | $32.1M | 4.82% | +139,126+21.1% | Added |
| Goldman Sachs Group Inc | 720,659 | $28.9M | 0.00% | +158,859+28.3% | Added |
| Franklin Resources Inc | 695,900 | $27.9M | 0.01% | +29,434+4.4% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 670,257 | $26.9M | 0.07% | +9,175+1.4% | Added |
| American Century Companies Inc | 659,257 | $26.5M | 0.01% | −20,600−3.0% | Reduced |
| Capital World Investors | 655,737 | $26.3M | 0.00% | 00.0% | Unchanged |
| Loomis Sayles & Co L P | 640,626 | $25.7M | 0.03% | −16,539−2.5% | Reduced |
| Marshall Wace, LLP | 611,982 | $24.6M | 0.03% | −408,272−40.0% | Reduced |
| T. Rowe Price Investment Management, Inc. | 599,113 | $24.1M | 0.01% | +522,170+678.6% | Added |
| Standard Life Aberdeen plc | 579,145 | $23.3M | 0.04% | +57,653+11.1% | Added |
| TimesSquare Capital Management, LLC | 556,800 | $22.4M | 0.32% | −14,442−2.5% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 542,020 | $21.8M | 0.33% | 00.0% | Unchanged |
| Fiera Capital Corp | 519,999 | $20.9M | 0.07% | −10,684−2.0% | Reduced |
| Saturn V Capital Management LLC | 503,701 | $20.2M | 4.44% | +35,337+7.5% | Added |
| MPM Oncology Impact Management LP | 503,398 | $20.2M | 3.31% | +180,000+55.7% | Added |
| Northern Trust Corp | 498,147 | $20.0M | 0.00% | +8,207+1.7% | Added |
| Dimensional Fund Advisors LP | 454,023 | $18.2M | 0.00% | +74,035+19.5% | Added |
| Caligan Partners LP | 444,565 | $17.8M | 2.48% | +444,565 | New |
| OrbiMed Advisors LLC | 419,600 | $16.8M | 0.40% | −528,277−55.7% | Reduced |
| Bank of New York Mellon Corp | 418,416 | $16.8M | 0.00% | −17,604−4.0% | Reduced |
| Candriam Luxembourg S.C.A. | 396,636 | $15.9M | 0.08% | 00.0% | Unchanged |
| Baker Bros. Advisors LP | 370,208 | $14.9M | 0.11% | 00.0% | Unchanged |
| Morgan Stanley | 366,572 | $14.7M | 0.00% | −21,024−5.4% | Reduced |
| Tri Locum Partners LP | 366,102 | $14.7M | 3.38% | +366,102 | New |
| Balyasny Asset Management LLC | 322,456 | $12.9M | 0.03% | +253,587+368.2% | Added |
| DAFNA Capital Management LLC | 287,939 | $11.6M | 2.86% | 00.0% | Unchanged |
| Jain Global LLC | 252,379 | $10.1M | 0.13% | +252,379 | New |
| DnB Asset Management AS | 249,081 | $10.0M | 0.04% | +14,924+6.4% | Added |
| Federated Hermes, Inc. | 232,500 | $9.33M | 0.02% | 00.0% | Unchanged |
| Nuveen, LLC | 224,289 | $9.01M | 0.00% | −4,278−1.9% | Reduced |
| State of Wisconsin Investment Board | 208,372 | $8.37M | 0.02% | +33,522+19.2% | Added |
| Perceptive Advisors LLC | 200,791 | $8.06M | 0.23% | 00.0% | Unchanged |
| Great Point Partners LLC | 200,000 | $8.03M | 3.35% | 00.0% | Unchanged |
| Bank of America Corp | 199,106 | $7.99M | 0.00% | −159,326−44.5% | Reduced |
| StemPoint Capital LP | 192,295 | $7.72M | 1.56% | +192,295 | New |
| ADAR1 Capital Management, LLC | 189,098 | $7.59M | 0.75% | −70,405−27.1% | Reduced |
| Charles Schwab Investment Management Inc | 188,747 | $7.58M | 0.00% | −3,495−1.8% | Reduced |
| AXA Investment Managers S.A. | 176,157 | $7.07M | 0.02% | +176,157 | New |
| Parkman Healthcare Partners LLC | 176,137 | $7.07M | 0.78% | +25,764+17.1% | Added |
| Neuberger Berman Group LLC | 172,354 | $6.92M | 0.01% | +24,943+16.9% | Added |
| New York State Common Retirement Fund | 171,708 | $6.89M | 0.01% | +5,236+3.1% | Added |
| Foresite Capital Management IV, LLC | 160,000 | $6.42M | 3.52% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 159,238 | $6.39M | 0.00% | +141,394+792.4% | Added |
| Nan Fung Trinity (HK) Ltd | 158,605 | $6.37M | 0.64% | 00.0% | Unchanged |
| Moore Capital Management, LP | 140,000 | $5.62M | 0.11% | +50,000+55.6% | Added |
| Swiss National Bank | 126,400 | $5.07M | 0.00% | +2,100+1.7% | Added |
| Royal Bank of Canada | 120,545 | $4.84M | 0.00% | −26,681−18.1% | Reduced |
| Nicholas Investment Partners, LP | 119,098 | $4.78M | 0.37% | +50,202+72.9% | Added |
| Wells Fargo & Company | 115,221 | $4.63M | 0.00% | +2,659+2.4% | Added |
| Deutsche Bank AG | 112,951 | $4.53M | 0.00% | +8,417+8.1% | Added |
| Barclays PLC | 111,300 | $4.47M | 0.00% | −41,470−27.1% | Reduced |
| Rhumbline Advisers | 106,791 | $4.29M | 0.00% | −2,909−2.7% | Reduced |
| UBS Group AG | 106,744 | $4.29M | 0.00% | −46,314−30.3% | Reduced |
| Ameriprise Financial Inc | 97,567 | $3.92M | 0.00% | −24,459−20.0% | Reduced |
| Mutual of America Capital Management LLC | 94,935 | $3.81M | 0.04% | −633−0.7% | Reduced |
| Jane Street Group, LLC | 89,879 | $3.61M | 0.00% | +46,203+105.8% | Added |
| Granahan Investment Management Inc | 87,470 | $3.51M | 0.14% | −152,568−63.6% | Reduced |
| HighVista Strategies LLC | 82,190 | $3.30M | 0.81% | +36,570+80.2% | Added |
| Rhenman & Partners Asset Management AB | 81,000 | $3.25M | 0.36% | +46,000+131.4% | Added |
| Legal & General Group Plc | 79,848 | $3.21M | 0.00% | −1,944−2.4% | Reduced |
| Schroder Investment Management Group | 81,156 | $3.17M | 0.00% | −47,947−37.1% | Reduced |
| Tudor Investment Corp Et Al | 76,824 | $3.08M | 0.02% | +76,824 | New |
| Raymond James Financial Inc | 69,922 | $2.81M | 0.00% | +4,708+7.2% | Added |
| Russell Investments Group, Ltd. | 69,892 | $2.81M | 0.00% | +17,756+34.1% | Added |
| Voya Investment Management LLC | 60,858 | $2.44M | 0.00% | +1,393+2.3% | Added |
| California State Teachers Retirement System | 60,237 | $2.42M | 0.00% | +40.0% | Added |
| Verition Fund Management LLC | 57,117 | $2.29M | 0.01% | +57,117 | New |
| Invesco Ltd. | 56,064 | $2.25M | 0.00% | −3,534−5.9% | Reduced |
| State of New Jersey Common Pension Fund D | 55,711 | $2.24M | 0.01% | −6,061−9.8% | Reduced |
| Algert Global LLC | 54,255 | $2.18M | 0.04% | −48,090−47.0% | Reduced |
| Avidity Partners Management LP | 53,400 | $2.14M | 0.49% | −54,491−50.5% | Reduced |
| Neo Ivy Capital Management | 49,838 | $2.00M | 0.49% | +49,838 | New |
| Erste Asset Management GmbH | 50,000 | $1.95M | 0.02% | 00.0% | Unchanged |