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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q3 2023

Institutional positions in Xenon Pharmaceuticals Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
181
+8 vs. Q2 2023
Shares held
61.3M
+2.13M (+3.6%) vs. Q2 2023
Total value
$2.10B
−$183.4M (−8.0%) vs. Q2 2023
New holders
23
71 more added
Sold out
15
50 more reduced

2 institutions that held it in Q2 2023 haven't filed for Q3 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2023: 181 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ3 2023: $2.10B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q3 2023

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q2 2023.

Institutions holding XENE in Q3 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Avoro Capital Advisors LLC4,900,000$167.4M2.61%00.0%Unchanged
Driehaus Capital Management LLC4,513,005$154.2M2.00%−247,848−5.2%Reduced
FMR LLC4,252,866$145.3M0.01%−935,841−18.0%Reduced
Polar Capital Holdings Plc3,003,747$102.6M0.76%−18,324−0.6%Reduced
Capital International Investors2,446,820$83.6M0.02%+124,829+5.4%Added
Capital World Investors2,274,974$77.7M0.02%00.0%Unchanged
Marshall Wace, LLP2,154,394$73.6M0.16%−166,025−7.2%Reduced
Braidwell LP2,103,396$71.9M2.27%+275,043+15.0%Added
Pictet Asset Management Holding SA1,938,779$66.2M0.08%+1,938,779New
Commodore Capital LP1,845,000$63.0M7.37%00.0%Unchanged
BVF Inc1,827,958$62.4M1.68%00.0%Unchanged
Wellington Management Group LLP1,728,108$59.0M0.01%+677,057+64.4%Added
Paradigm Biocapital Advisors LP1,491,835$51.0M3.48%+502,508+50.8%Added
Rock Springs Capital Management LP1,178,002$40.2M1.08%00.0%Unchanged
Lord, Abbett & Co. LLC1,149,168$39.3M0.15%−809,372−41.3%Reduced
Point72 Asset Management, L.P.1,125,708$38.5M0.13%+977,500+659.5%Added
Alliancebernstein L.P.1,084,337$37.0M0.02%+1,018,321+1,542.5%Added
BlackRock Inc.991,457$33.9M0.00%−2,583−0.3%Reduced
OrbiMed Advisors LLC958,793$32.8M0.76%−137,207−12.5%Reduced
Samlyn Capital, LLC951,755$32.5M0.58%+11,846+1.3%Added
Nicholas Investment Partners, LP854,447$29.2M2.18%+63,329+8.0%Added
Baker Bros. Advisors LP751,639$25.7M0.15%00.0%Unchanged
Loomis Sayles & Co L P730,716$25.0M0.04%−22,810−3.0%Reduced
Citadel Advisors LLC723,524$24.7M0.03%+222,512+44.4%Added
Invesco Ltd.716,303$24.5M0.01%+16,318+2.3%Added
Perceptive Advisors LLC617,500$21.1M0.71%−605,877−49.5%Reduced
First Light Asset Management, LLC602,070$20.6M1.95%+263,424+77.8%Added
Boxer Capital, LLC600,000$20.5M1.09%00.0%Unchanged
TimesSquare Capital Management, LLC590,575$20.2M0.31%+163,650+38.3%Added
Candriam Luxembourg S.C.A.569,884$19.5M0.16%−136,000−19.3%Reduced
Fiera Capital Corp560,546$19.1M0.06%+11,205+2.0%Added
Adage Capital Partners GP, L.L.C.550,000$18.8M0.04%−120,000−17.9%Reduced
Great Point Partners LLC500,001$17.1M3.21%−29,999−5.7%Reduced
Logos Global Management LP450,000$15.4M2.19%+175,000+63.6%Added
Dimensional Fund Advisors LP427,125$14.6M0.00%+165,018+63.0%Added
Redmile Group, LLC419,568$14.3M0.68%−700,908−62.6%Reduced
Eventide Asset Management, LLC413,906$14.1M0.25%00.0%Unchanged
Janus Henderson Group PLC382,305$13.1M0.01%+54,961+16.8%Added
ExodusPoint Capital Management, LP359,838$12.3M0.16%+359,838New
Avidity Partners Management LP321,400$11.0M0.44%−159,900−33.2%Reduced
Affinity Asset Advisors, LLC300,438$10.3M3.35%+240,062+397.6%Added
DAFNA Capital Management LLC280,538$9.58M2.98%00.0%Unchanged
Ally Bridge Group (NY) LLC266,961$9.12M10.70%00.0%Unchanged
Vanguard Group Inc266,826$9.11M0.00%+5,473+2.1%Added
Goldman Sachs Group Inc255,368$8.72M0.00%−19,712−7.2%Reduced
Morgan Stanley243,145$8.31M0.00%+37,609+18.3%Added
Granahan Investment Management Inc236,290$8.07M0.29%−463−0.2%Reduced
Altium Capital Management LP228,000$7.79M4.51%00.0%Unchanged
Parkman Healthcare Partners LLC216,644$7.40M1.36%−1,096−0.5%Reduced
Jennison Associates LLC213,823$7.30M0.01%+25,432+13.5%Added
State Street Corp212,370$7.25M0.00%−180−0.1%Reduced
Schonfeld Strategic Advisors LLC198,984$6.80M0.06%+18,841+10.5%Added
AXA S.A.192,363$6.57M0.02%−672−0.3%Reduced
New York State Common Retirement Fund184,632$6.31M0.01%+10.0%Added
Holocene Advisors, LP178,470$6.10M0.03%−534,008−75.0%Reduced
Franklin Resources Inc172,612$5.90M0.00%00.0%Unchanged
Putnam Investments LLC171,936$5.87M0.01%+6,674+4.0%Added
Tri Locum Partners LP171,755$5.87M1.88%+147,534+609.1%Added
Russell Investments Group, Ltd.169,388$5.79M0.01%+18,932+12.6%Added
Bank of New York Mellon Corp167,349$5.72M0.00%−44,392−21.0%Reduced
Ensign Peak Advisors, Inc164,380$5.62M0.01%00.0%Unchanged
Assenagon Asset Management S.A.147,693$5.05M0.02%+147,693New
Woodline Partners LP143,451$4.90M0.06%−146,949−50.6%Reduced
Algert Global LLC128,487$4.39M0.21%−16,390−11.3%Reduced
Walleye Capital LLC126,028$4.31M0.06%+36,324+40.5%Added
Bank of America Corp123,967$4.23M0.00%−35,409−22.2%Reduced
DnB Asset Management AS121,770$4.16M0.02%+9,141+8.1%Added
Swiss National Bank111,700$3.82M0.00%+1,900+1.7%Added
Nan Fung Group Holdings Ltd106,680$3.64M2.95%−7,700−6.7%Reduced
Bamco Inc100,100$3.42M0.01%00.0%Unchanged
Ghost Tree Capital, LLC98,951$3.38M1.64%−86,049−46.5%Reduced
State of Wisconsin Investment Board96,074$3.28M0.01%−116,055−54.7%Reduced
Millennium Management LLC95,493$3.26M0.00%−117,845−55.2%Reduced
International Biotechnology Trust PLC91,500$3.12M1.05%+66,000+258.8%Added
Two Sigma Investments, LP80,633$2.75M0.01%+62,000+332.7%Added
PFM Health Sciences, LP78,587$2.68M0.13%−21,560−21.5%Reduced
Moran Wealth Management, LLC69,510$2.37M0.09%+580+0.8%Added
Northern Trust Corp69,167$2.36M0.00%+3,684+5.6%Added
UBS Asset Management Americas Inc68,801$2.35M0.00%+15,749+29.7%Added
Voya Investment Management LLC67,140$2.29M0.00%00.0%Unchanged
Credit Suisse AG65,586$2.24M0.00%−241−0.4%Reduced
Two Sigma Advisers, LP64,900$2.22M0.01%+64,900New
State of New Jersey Common Pension Fund D64,454$2.20M0.01%00.0%Unchanged
Wells Fargo & Company59,633$2.04M0.00%+1,040+1.8%Added
SG Americas Securities, LLC56,752$1.94M0.03%+17,490+44.5%Added
Geode Capital Management, LLC55,945$1.91M0.00%+30+0.1%Added
Qube Research & Technologies Ltd54,285$1.85M0.01%+24,318+81.1%Added
Silverarc Capital Management, LLC53,996$1.84M0.69%−45,760−45.9%Reduced
Soleus Capital Management, L.P.52,000$1.78M0.18%−14,000−21.2%Reduced
JPMorgan Chase & Co50,297$1.72M0.00%−28,920−36.5%Reduced
UBS Oconnor LLC48,676$1.66M0.03%+10,000+25.9%Added
Alps Advisors Inc47,349$1.62M0.01%+626+1.3%Added
CIBC World Markets Inc.45,372$1.55M0.01%+4,150+10.1%Added
California State Teachers Retirement System44,950$1.54M0.00%+575+1.3%Added
Legal & General Group Plc44,713$1.53M0.00%+1,921+4.5%Added
Envestnet Asset Management Inc44,102$1.51M0.00%+27,580+166.9%Added
Nuveen Asset Management, LLC41,695$1.42M0.00%+1,496+3.7%Added
D. E. Shaw & Co., Inc.40,547$1.39M0.00%−58,198−58.9%Reduced
Sphera Funds Management Ltd.38,959$1.33M0.32%+38,959New
Advisory Research Inc38,326$1.31M0.18%−6,096−13.7%Reduced