Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 245
- +28 vs. Q3 2025
- Shares held
- 84.4M
- +294.5K (+0.4%) vs. Q3 2025
- Total value
- $3.78B
- +$405.9M (+12.0%) vs. Q3 2025
- New holders
- 50
- 81 more added
- Sold out
- 22
- 74 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 8,920,250 | $399.8M | 0.02% | +1,3430.0% | Added |
| Avoro Capital Advisors LLC | 5,424,444 | $243.1M | 2.39% | +24,444+0.5% | Added |
| BlackRock, Inc. | 5,100,284 | $228.6M | 0.00% | +329,333+6.9% | Added |
| Wellington Management Group LLP | 4,764,779 | $213.6M | 0.04% | +1,154,922+32.0% | Added |
| Driehaus Capital Management LLC | 4,538,691 | $203.4M | 1.38% | +369,577+8.9% | Added |
| Janus Henderson Group PLC | 4,084,034 | $183.1M | 0.08% | +140,149+3.6% | Added |
| Capital International Investors | 3,414,959 | $153.1M | 0.02% | +233,466+7.3% | Added |
| Polar Capital Holdings Plc | 2,465,694 | $110.5M | 0.51% | −81,072−3.2% | Reduced |
| Braidwell LP | 1,825,076 | $81.8M | 2.62% | −1,779,953−49.4% | Reduced |
| Commodore Capital LP | 1,800,000 | $80.7M | 5.37% | −900,000−33.3% | Reduced |
| Alliancebernstein L.P. | 1,593,814 | $71.4M | 0.02% | −60,603−3.7% | Reduced |
| JPMorgan Chase & Co | 1,494,032 | $67.0M | 0.00% | +94,999+6.8% | Added |
| State Street Corp | 1,492,550 | $66.9M | 0.00% | +26,083+1.8% | Added |
| Citadel Advisors LLC | 1,321,213 | $59.2M | 0.04% | +362,115+37.8% | Added |
| Jennison Associates LLC | 1,292,055 | $57.9M | 0.03% | +156,820+13.8% | Added |
| Holocene Advisors, LP | 1,282,081 | $57.5M | 0.12% | −694,472−35.1% | Reduced |
| Affinity Asset Advisors, LLC | 1,250,000 | $56.0M | 4.03% | −150,000−10.7% | Reduced |
| Westfield Capital Management Co LP | 1,226,771 | $55.0M | 0.23% | +20,705+1.7% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,060,221 | $47.5M | 0.05% | +389,964+58.2% | Added |
| Geode Capital Management, LLC | 952,679 | $42.7M | 0.00% | −24,756−2.5% | Reduced |
| Price T Rowe Associates Inc | 862,300 | $38.6M | 0.00% | +820,608+1,968.3% | Added |
| Siren, L.L.C. | 812,761 | $36.4M | 1.09% | 00.0% | Unchanged |
| First Turn Management, LLC | 799,743 | $35.8M | 4.10% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 787,788 | $35.3M | 1.81% | −63,956−7.5% | Reduced |
| Franklin Resources Inc | 758,059 | $34.0M | 0.01% | +62,159+8.9% | Added |
| Standard Life Aberdeen plc | 750,291 | $33.6M | 0.05% | +171,146+29.6% | Added |
| Goldman Sachs Group Inc | 696,047 | $31.2M | 0.00% | −24,612−3.4% | Reduced |
| Fiera Capital Corp | 686,056 | $30.7M | 0.10% | +166,057+31.9% | Added |
| Adage Capital Partners GP, L.L.C. | 685,100 | $30.7M | 0.05% | −150,000−18.0% | Reduced |
| American Century Companies Inc | 680,473 | $30.5M | 0.02% | +21,216+3.2% | Added |
| Federated Hermes, Inc. | 672,237 | $30.1M | 0.05% | +439,737+189.1% | Added |
| Vanguard Group Inc | 664,641 | $29.8M | 0.00% | −186,745−21.9% | Reduced |
| Capital World Investors | 655,737 | $29.4M | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 635,056 | $28.5M | 0.02% | −748,951−54.1% | Reduced |
| Pictet Asset Management Holding SA | 625,985 | $28.0M | 0.03% | −636,594−50.4% | Reduced |
| Loomis Sayles & Co L P | 612,032 | $27.4M | 0.03% | −28,594−4.5% | Reduced |
| Barclays PLC | 600,964 | $26.9M | 0.01% | +489,664+439.9% | Added |
| Vestal Point Capital, LP | 600,000 | $26.9M | 0.99% | −500,000−45.5% | Reduced |
| Trails Edge Capital Partners, LP | 597,092 | $26.8M | 6.61% | +597,092 | New |
| Caligan Partners LP | 549,665 | $24.6M | 2.26% | +105,100+23.6% | Added |
| T. Rowe Price Investment Management, Inc. | 547,613 | $24.5M | 0.02% | −51,500−8.6% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 542,020 | $24.3M | 0.31% | 00.0% | Unchanged |
| TimesSquare Capital Management, LLC | 532,740 | $23.9M | 0.36% | −24,060−4.3% | Reduced |
| MPM Oncology Impact Management LP | 485,620 | $21.8M | 2.49% | −17,778−3.5% | Reduced |
| Dimensional Fund Advisors LP | 452,147 | $20.3M | 0.00% | −1,876−0.4% | Reduced |
| OrbiMed Advisors LLC | 447,200 | $20.0M | 0.41% | +27,600+6.6% | Added |
| Northern Trust Corp | 438,714 | $19.7M | 0.00% | −59,433−11.9% | Reduced |
| Two Sigma Investments, LP | 436,743 | $19.6M | 0.03% | +436,743 | New |
| Candriam Luxembourg S.C.A. | 417,402 | $18.7M | 0.09% | +20,766+5.2% | Added |
| Bank of New York Mellon Corp | 387,158 | $17.4M | 0.00% | −31,258−7.5% | Reduced |
| Baker Bros. Advisors LP | 370,208 | $16.6M | 0.10% | 00.0% | Unchanged |
| Deep Track Capital, LP | 366,435 | $16.4M | 0.37% | −833,565−69.5% | Reduced |
| StemPoint Capital LP | 348,605 | $15.6M | 2.68% | +156,310+81.3% | Added |
| Morgan Stanley | 294,332 | $13.2M | 0.00% | −72,240−19.7% | Reduced |
| DAFNA Capital Management LLC | 287,939 | $12.9M | 3.00% | 00.0% | Unchanged |
| DnB Asset Management AS | 272,831 | $12.2M | 0.04% | +23,750+9.5% | Added |
| Two Sigma Advisers, LP | 259,320 | $11.6M | 0.02% | +241,220+1,332.7% | Added |
| Tudor Investment Corp Et Al | 254,002 | $11.4M | 0.06% | +177,178+230.6% | Added |
| Nicholas Investment Partners, LP | 242,989 | $10.9M | 0.79% | +123,891+104.0% | Added |
| Iron Triangle Partners LP | 233,688 | $10.5M | 1.20% | +233,688 | New |
| Eversept Partners, LP | 231,380 | $10.4M | 0.58% | +231,380 | New |
| Nan Fung Trinity (HK) Ltd | 226,965 | $10.2M | 0.81% | +68,360+43.1% | Added |
| Bank of America Corp | 221,368 | $9.92M | 0.00% | +22,262+11.2% | Added |
| Nuveen, LLC | 216,238 | $9.69M | 0.00% | −8,051−3.6% | Reduced |
| State of Wisconsin Investment Board | 205,569 | $9.21M | 0.02% | −2,803−1.3% | Reduced |
| ADAR1 Capital Management, LLC | 203,969 | $9.14M | 0.68% | +14,871+7.9% | Added |
| Perceptive Advisors LLC | 200,791 | $9.00M | 0.16% | 00.0% | Unchanged |
| Deutsche Bank AG | 190,233 | $8.53M | 0.00% | +77,282+68.4% | Added |
| Charles Schwab Investment Management Inc | 189,059 | $8.47M | 0.00% | +312+0.2% | Added |
| New York State Common Retirement Fund | 186,705 | $8.37M | 0.01% | +14,997+8.7% | Added |
| NEXTBio Capital Management LP | 183,704 | $8.23M | 4.83% | +183,704 | New |
| Neuberger Berman Group LLC | 178,747 | $8.01M | 0.01% | +6,393+3.7% | Added |
| Peregrine Capital Management LLC | 174,851 | $7.84M | 0.24% | +174,851 | New |
| Jain Global LLC | 173,882 | $7.79M | 0.08% | −78,497−31.1% | Reduced |
| Marshall Wace, LLP | 162,551 | $7.29M | 0.01% | −449,431−73.4% | Reduced |
| Foresite Capital Management IV, LLC | 160,000 | $7.17M | 3.12% | 00.0% | Unchanged |
| Parkman Healthcare Partners LLC | 154,184 | $6.91M | 0.66% | −21,953−12.5% | Reduced |
| Wells Fargo & Company | 152,297 | $6.83M | 0.00% | +37,076+32.2% | Added |
| Moore Capital Management, LP | 140,000 | $6.27M | 0.13% | 00.0% | Unchanged |
| Rhenman & Partners Asset Management AB | 139,000 | $6.23M | 0.58% | +58,000+71.6% | Added |
| Patient Square Capital LP | 136,500 | $6.12M | 1.31% | +136,500 | New |
| Redmile Group, LLC | 133,882 | $6.00M | 0.44% | +133,882 | New |
| Algert Global LLC | 123,189 | $5.52M | 0.09% | +68,934+127.1% | Added |
| Assenagon Asset Management S.A. | 119,186 | $5.34M | 0.01% | +119,186 | New |
| Mutual of America Capital Management LLC | 116,088 | $5.20M | 0.05% | +21,153+22.3% | Added |
| Man Group plc | 114,826 | $5.15M | 0.01% | +91,707+396.7% | Added |
| Swiss National Bank | 114,000 | $5.11M | 0.00% | −12,400−9.8% | Reduced |
| Ameriprise Financial Inc | 109,544 | $4.91M | 0.00% | +11,977+12.3% | Added |
| Squadron Capital Management LLC | 105,551 | $4.73M | 2.11% | +105,551 | New |
| Palo Alto Investors LP | 96,519 | $4.33M | 0.60% | +96,519 | New |
| Verition Fund Management LLC | 93,756 | $4.20M | 0.02% | +36,639+64.1% | Added |
| BNP Paribas Arbitrage, SA | 93,462 | $4.19M | 0.00% | −65,776−41.3% | Reduced |
| Granahan Investment Management Inc | 92,778 | $4.16M | 0.18% | +5,308+6.1% | Added |
| Atika Capital Management LLC | 92,506 | $4.15M | 0.58% | +54,506+143.4% | Added |
| Rhumbline Advisers | 90,143 | $4.04M | 0.00% | −16,648−15.6% | Reduced |
| Royal Bank of Canada | 89,757 | $4.02M | 0.00% | −30,788−25.5% | Reduced |
| Russell Investments Group, Ltd. | 86,220 | $3.86M | 0.00% | +16,328+23.4% | Added |
| Balyasny Asset Management LLC | 84,360 | $3.78M | 0.01% | −238,096−73.8% | Reduced |
| Raymond James Financial Inc | 83,255 | $3.73M | 0.00% | +13,333+19.1% | Added |
| Schroder Investment Management Group | 81,156 | $3.58M | 0.00% | 00.0% | Unchanged |