Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 245
- +28 vs. Q3 2025
- Shares held
- 84.4M
- +294.5K (+0.4%) vs. Q3 2025
- Total value
- $3.78B
- +$405.9M (+12.0%) vs. Q3 2025
- New holders
- 50
- 81 more added
- Sold out
- 22
- 74 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Lazard Asset Management LLC | 78,663 | $3.53M | 0.01% | +78,663 | New |
| Y-Intercept (Hong Kong) Ltd | 72,957 | $3.27M | 0.07% | +72,957 | New |
| Legal & General Group Plc | 70,265 | $3.15M | 0.00% | −9,583−12.0% | Reduced |
| Alps Advisors Inc | 63,302 | $2.84M | 0.02% | +26,002+69.7% | Added |
| Voya Investment Management LLC | 60,858 | $2.73M | 0.00% | 00.0% | Unchanged |
| Sofinnova Investments, Inc. | 59,900 | $2.68M | 0.12% | +59,900 | New |
| California State Teachers Retirement System | 56,564 | $2.54M | 0.00% | −3,673−6.1% | Reduced |
| UBS Group AG | 52,539 | $2.35M | 0.00% | −54,205−50.8% | Reduced |
| Invesco Ltd. | 50,947 | $2.28M | 0.00% | −5,117−9.1% | Reduced |
| Erste Asset Management GmbH | 50,000 | $2.22M | 0.02% | 00.0% | Unchanged |
| Nomura Asset Management International Inc. | 47,957 | $2.15M | 0.00% | +47,957 | New |
| SEI Investments Co | 43,858 | $1.97M | 0.00% | +21,435+95.6% | Added |
| MetLife Investment Management | 42,025 | $1.88M | 0.01% | −2,196−5.0% | Reduced |
| DekaBank Deutsche Girozentrale | 39,000 | $1.82M | 0.00% | 00.0% | Unchanged |
| Artia Global Partners LP | 40,000 | $1.79M | 0.29% | 00.0% | Unchanged |
| TD Asset Management Inc | 38,148 | $1.71M | 0.00% | +21,918+135.0% | Added |
| Legato Capital Management LLC | 37,038 | $1.66M | 0.14% | +22,829+160.7% | Added |
| Envestnet Asset Management Inc | 35,801 | $1.60M | 0.00% | −1,647−4.4% | Reduced |
| Boothbay Fund Management, LLC | 35,681 | $1.60M | 0.04% | +6,822+23.6% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 35,310 | $1.58M | 0.00% | +90.0% | Added |
| Dark Forest Capital Management LP | 33,459 | $1.50M | 0.07% | +33,459 | New |
| Manufacturers Life Insurance Company, The | 32,622 | $1.45M | 0.00% | +8,690+36.3% | Added |
| Jump Financial, LLC | 30,987 | $1.39M | 0.02% | +24,487+376.7% | Added |
| D. E. Shaw & Co., Inc. | 30,851 | $1.38M | 0.00% | −17,604−36.3% | Reduced |
| Bamco Inc | 30,000 | $1.34M | 0.00% | 00.0% | Unchanged |
| Handelsbanken Fonder AB | 29,800 | $1.34M | 0.00% | +7,100+31.3% | Added |
| Intech Investment Management LLC | 25,840 | $1.16M | 0.01% | +2,754+11.9% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25,589 | $1.15M | 0.00% | 00.0% | Unchanged |
| Lighthouse Investment Partners, LLC | 25,000 | $1.12M | 0.04% | +25,000 | New |
| Quantinno Capital Management LP | 24,628 | $1.10M | 0.00% | +11,257+84.2% | Added |
| Rathbone Brothers plc | 23,666 | $1.06M | 0.00% | 00.0% | Unchanged |
| Cinctive Capital Management LP | 23,317 | $1.05M | 0.06% | +263+1.1% | Added |
| HighMark Wealth Management LLC | 23,000 | $1.03M | 0.42% | −3,100−11.9% | Reduced |
| Vestmark Advisory Solutions, Inc. | 21,884 | $980.8K | 0.01% | +21,884 | New |
| XTX Topco Ltd | 21,498 | $963.5K | 0.03% | +21,498 | New |
| Assetmark, Inc | 21,269 | $953.3K | 0.00% | −1,297−5.7% | Reduced |
| Birchview Capital, LP | 21,000 | $941.2K | 0.55% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 20,128 | $902.1K | 0.01% | −904−4.3% | Reduced |
| State of New Jersey Common Pension Fund D | 19,738 | $884.7K | 0.00% | −35,973−64.6% | Reduced |
| Walleye Capital LLC | 19,587 | $877.9K | 0.01% | +19,587 | New |
| Creative Planning | 19,200 | $860.5K | 0.00% | +5,990+45.3% | Added |
| Stifel Financial Corp | 17,548 | $786.5K | 0.00% | −1,167−6.2% | Reduced |
| ProShare Advisors LLC | 17,279 | $774.4K | 0.00% | +1,539+9.8% | Added |
| Entropy Technologies, LP | 17,025 | $763.1K | 0.04% | +17,025 | New |
| Arizona State Retirement System | 16,179 | $725.1K | 0.00% | −3,111−16.1% | Reduced |
| Campbell & CO Investment Adviser LLC | 16,105 | $721.8K | 0.03% | −12,564−43.8% | Reduced |
| Brinker Capital Investments, LLC | 14,407 | $645.7K | 0.00% | −511−3.4% | Reduced |
| SBI Okasan Asset Management Co.Ltd. | 14,400 | $638.4K | 0.04% | +14,400 | New |
| J. Safra Sarasin Holding AG | 13,581 | $608.7K | 0.01% | −16,587−55.0% | Reduced |
| CIBC World Markets Inc. | 13,460 | $603.3K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 12,592 | $564.4K | 0.04% | −923−6.8% | Reduced |
| KLP Kapitalforvaltning AS | 12,300 | $551.3K | 0.00% | −500−3.9% | Reduced |
| PSP Research LLC | 11,678 | $523.4K | 0.46% | +11,678 | New |
| Himension Fund | 11,279 | $505.5K | 0.03% | +11,279 | New |
| Supplemental Annuity Collective Trust of NJ | 11,000 | $493.0K | 0.13% | 00.0% | Unchanged |
| Knott David M Jr | 10,962 | $491.3K | 0.23% | 00.0% | Unchanged |
| Elmwood Wealth Management, Inc. | 10,757 | $482.1K | 0.15% | −150−1.4% | Reduced |
| Public Employees Retirement Association of Colorado | 10,633 | $477.0K | 0.00% | 00.0% | Unchanged |
| Marex Group plc | 10,557 | $473.2K | 0.01% | +10,557 | New |
| Harbor Capital Advisors, Inc. | 10,053 | $451.0K | 0.04% | −1,165−10.4% | Reduced |
| Allianz Asset Management GmbH | 9,400 | $421.3K | 0.00% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 8,632 | $386.9K | 0.00% | −7,369−46.1% | Reduced |
| Susquehanna International Group, LLP | 8,319 | $372.9K | 0.00% | −37,588−81.9% | Reduced |
| Altfest L J & Co Inc | 8,232 | $369.0K | 0.04% | +501+6.5% | Added |
| Advisors Asset Management, Inc. | 8,012 | $359.1K | 0.01% | −3,452−30.1% | Reduced |
| Neo Ivy Capital Management | 7,477 | $335.1K | 0.05% | −42,361−85.0% | Reduced |
| Oxford Asset Management LLP | 7,379 | $330.7K | 0.12% | −14,783−66.7% | Reduced |
| Citigroup Inc | 7,361 | $329.9K | 0.00% | −7,509−50.5% | Reduced |
| SG Americas Securities, LLC | 7,077 | $317.0K | 0.00% | +149+2.2% | Added |
| Great West Life Assurance Co | 7,024 | $315.0K | 0.00% | 00.0% | Unchanged |
| PenderFund Capital Management Ltd. | 6,850 | $307.0K | 0.05% | 00.0% | Unchanged |
| TLS Advisors LLC | 18,858 | $307.0K | 0.81% | −14,098−42.8% | Reduced |
| Abel Hall, LLC | 6,757 | $302.8K | 0.07% | +6,757 | New |
| The PNC Financial Services Group, Inc. | 6,574 | $294.6K | 0.00% | +675+11.4% | Added |
| First Trust Advisors LP | 6,361 | $285.1K | 0.00% | +6,361 | New |
| Ameritas Investment Partners, Inc. | 6,168 | $276.4K | 0.01% | −390−5.9% | Reduced |
| Virtus Investment Advisers, Inc. | 6,037 | $270.6K | 0.07% | +2,568+74.0% | Added |
| Letson Investment Management, Inc. | 6,000 | $268.9K | 0.10% | +6,000 | New |
| Xponance, Inc. | 5,975 | $267.8K | 0.00% | +8+0.1% | Added |
| Thrivent Financial for Lutherans | 5,583 | $250.0K | 0.00% | −10,518−65.3% | Reduced |
| Ensign Peak Advisors, Inc | 5,194 | $232.8K | 0.00% | −10,050−65.9% | Reduced |
| Magnetar Financial LLC | 5,153 | $231.0K | 0.00% | +5,153 | New |
| CAPROCK Group, Inc. | 5,069 | $227.2K | 0.00% | +5,069 | New |
| EntryPoint Capital, LLC | 5,028 | $225.4K | 0.09% | 00.0% | Unchanged |
| CIBC World Markets Corp | 5,027 | $225.3K | 0.00% | +5,027 | New |
| Citizens Financial Group Inc | 5,000 | $224.1K | 0.00% | 00.0% | Unchanged |
| Northwestern Mutual Wealth Management Co | 5,000 | $224.1K | 0.00% | 00.0% | Unchanged |
| Mackenzie Financial Corp | 4,772 | $210.1K | 0.00% | +4,772 | New |
| Whalen Wealth Management Inc. | 4,641 | $208.0K | 0.11% | +4,641 | New |
| Amundi | 4,609 | $206.6K | 0.00% | +4,609 | New |
| JustInvest LLC | 4,533 | $203.2K | 0.00% | +4,533 | New |
| Principal Financial Group Inc | 4,488 | $201.2K | 0.00% | −1,330−22.9% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 3,755 | $168.3K | 0.00% | +774+26.0% | Added |
| Tower Research Capital LLC (TRC) | 3,232 | $144.9K | 0.00% | +1,715+113.1% | Added |
| KBC Group NV | 2,780 | $125.0K | 0.00% | +909+48.6% | Added |
| Amalgamated Bank | 2,387 | $107.0K | 0.00% | −208−8.0% | Reduced |
| IFP Advisors, Inc | 1,877 | $84.1K | 0.00% | −31−1.6% | Reduced |
| GF Fund Management Co. Ltd. | 1,517 | $68.0K | 0.00% | −142−8.6% | Reduced |
| State of Wyoming | 1,501 | $67.3K | 0.01% | +350+30.4% | Added |
| STRS Ohio | 1,300 | $58.3K | 0.00% | +1,300 | New |