Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 245
- +28 vs. Q3 2025
- Shares held
- 84.4M
- +294.5K (+0.4%) vs. Q3 2025
- Total value
- $3.78B
- +$405.9M (+12.0%) vs. Q3 2025
- New holders
- 50
- 81 more added
- Sold out
- 22
- 74 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Caitong International Asset Management Co., Ltd | 1,225 | $54.9K | 0.01% | +1,225 | New |
| Clearstead Advisors, LLC | 1,215 | $54.5K | 0.00% | +829+214.8% | Added |
| Rockefeller Capital Management L.P. | 1,100 | $49.3K | 0.00% | +900+450.0% | Added |
| Farther Finance Advisors, LLC | 1,058 | $47.4K | 0.00% | +212+25.1% | Added |
| Nisa Investment Advisors, LLC | 924 | $41.4K | 0.00% | 00.0% | Unchanged |
| Danske Bank A/S | 800 | $35.9K | 0.00% | 00.0% | Unchanged |
| Ronald Blue Trust, Inc. | 745 | $33.4K | 0.00% | +717+2,560.7% | Added |
| Kestra Advisory Services, LLC | 740 | $33.2K | 0.00% | +740 | New |
| Sterling Capital Management LLC | 491 | $22.0K | 0.00% | +307+166.8% | Added |
| Signaturefd, LLC | 473 | $21.2K | 0.00% | +57+13.7% | Added |
| CWM, LLC | 366 | $16.0K | 0.00% | +31+9.3% | Added |
| Advisor Group Holdings, Inc. | 319 | $14.3K | 0.00% | −1,055−76.8% | Reduced |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 276 | $12.3K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 264 | $11.8K | 0.00% | +79+42.7% | Added |
| MAI Capital Management | 261 | $11.7K | 0.00% | +261 | New |
| Covestor Ltd | 247 | $11.0K | 0.01% | +244+8,133.3% | Added |
| UBS Asset Management Americas Inc | 236 | $10.6K | 0.00% | +236 | New |
| Zions Bancorporation, National Association | 235 | $10.5K | 0.00% | +235 | New |
| Daiwa Securities Group Inc. | 229 | $10.0K | 0.00% | −23−9.1% | Reduced |
| EverSource Wealth Advisors, LLC | 212 | $9.50K | 0.00% | +172+430.0% | Added |
| National Bank of Canada | 190 | $8.52K | 0.00% | −10−5.0% | Reduced |
| US Bancorp | 175 | $7.84K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 150 | $6.72K | 0.00% | +150 | New |
| Parallel Advisors, LLC | 147 | $6.59K | 0.00% | 00.0% | Unchanged |
| Kemnay Advisory Services Inc. | 123 | $5.51K | 0.00% | +123 | New |
| Allworth Financial LP | 116 | $5.20K | 0.00% | −10−7.9% | Reduced |
| Rothschild Investment LLC | 111 | $4.97K | 0.00% | −4−3.5% | Reduced |
| Bell Investment Advisors, Inc | 100 | $4.48K | 0.00% | +89+809.1% | Added |
| J.Safra Asset Management Corp | 87 | $3.90K | 0.00% | 00.0% | Unchanged |
| Rossby Financial, LCC | 47 | $2.11K | 0.00% | +7+17.5% | Added |
| Motiv8 Investments LLC | 40 | $2.00K | 0.00% | +40 | New |
| Cape Investment Advisory, Inc. | 39 | $1.75K | 0.00% | 00.0% | Unchanged |
| Aster Capital Management (DIFC) Ltd | 36 | $1.61K | 0.00% | −923−96.2% | Reduced |
| CVA Family Office, LLC | 33 | $1.48K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 30 | $1.34K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 27 | $1.21K | 0.00% | −92−77.3% | Reduced |
| Hantz Financial Services, Inc. | 25 | $1.00K | 0.00% | +25 | New |
| CoreCap Advisors, LLC | 17 | $762 | 0.00% | +17 | New |
| Park Place Capital Corp | 16 | $717 | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 16 | $706 | 0.00% | +16 | New |
| UMA Financial Services, Inc. | 13 | $583 | 0.00% | +13 | New |
| Massmutual Trust Co FSB | 11 | $493 | 0.00% | +11 | New |
| TD Private Client Wealth LLC | 3 | $134 | 0.00% | +3 | New |
| Larson Financial Group LLC | 2 | $90 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 1 | $45 | 0.00% | 00.0% | Unchanged |
| Saturn V Capital Management LLC | 0 | $0 | 0.00% | −503,701−100.0% | Sold out |
| Tri Locum Partners LP | 0 | $0 | 0.00% | −366,102−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −200,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −89,879−100.0% | Sold out |
| HighVista Strategies LLC | 0 | $0 | 0.00% | −82,190−100.0% | Sold out |
| Avidity Partners Management LP | 0 | $0 | 0.00% | −53,400−100.0% | Sold out |
| NJ State Employees Deferred Compensation Plan | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Sanders Morris Harris LLC | 0 | $0 | 0.00% | −21,500−100.0% | Sold out |
| Natixis Advisors, L.P. | 0 | $0 | 0.00% | −17,564−100.0% | Sold out |
| CenterBook Partners LP | 0 | $0 | 0.00% | −14,770−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −12,652−100.0% | Sold out |
| DRW Securities, LLC | 0 | $0 | 0.00% | −9,273−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −8,850−100.0% | Sold out |
| Freestone Grove Partners LP | 0 | $0 | 0.00% | −6,748−100.0% | Sold out |
| Inceptionr LLC | 0 | $0 | 0.00% | −6,322−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −5,200−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −3,556−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −2,500−100.0% | Sold out |
| United Community Bank | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −68−100.0% | Sold out |
| American National Bank | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Tortoise Investment Management, LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| AXA Investment Managers S.A. | – | – | – | – | Not filed |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |