Xenon Pharmaceuticals Inc.

XENE

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001582313

SEC filings (opens in a new tab)

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

Q4 2025 vs. Q3 2025

How the institutions holding Xenon Pharmaceuticals Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025 All holders in Q3 2025

13F holders of XENE: Q3 2025 compared with Q4 2025
Measure	Q3 2025	Of which not filed for Q4 2025	Q4 2025	Change
Holders	219	2	245	+28
Shares	84.3M	184.3K	84.4M	+294.5K (+0.4%)
Value	$3.39B	$7.40M	$3.78B	+$405.9M (+12.0%)

2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (50)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to XENE in Q4 2025
Institution	Shares	Value	% of portfolio
Trails Edge Capital Partners, LP	597,092	$26.8M	6.61%
Two Sigma Investments, LP	436,743	$19.6M	0.03%
Iron Triangle Partners LP	233,688	$10.5M	1.20%
Eversept Partners, LP	231,380	$10.4M	0.58%
NEXTBio Capital Management LP	183,704	$8.23M	4.83%
Peregrine Capital Management LLC	174,851	$7.84M	0.24%
Patient Square Capital LP	136,500	$6.12M	1.31%
Redmile Group, LLC	133,882	$6.00M	0.44%
Assenagon Asset Management S.A.	119,186	$5.34M	0.01%
Squadron Capital Management LLC	105,551	$4.73M	2.11%
Palo Alto Investors LP	96,519	$4.33M	0.60%
Lazard Asset Management LLC	78,663	$3.53M	0.01%
Y-Intercept (Hong Kong) Ltd	72,957	$3.27M	0.07%
Sofinnova Investments, Inc.	59,900	$2.68M	0.12%
Nomura Asset Management International Inc.	47,957	$2.15M	0.00%
Dark Forest Capital Management LP	33,459	$1.50M	0.07%
Lighthouse Investment Partners, LLC	25,000	$1.12M	0.04%
Vestmark Advisory Solutions, Inc.	21,884	$980.8K	0.01%
XTX Topco Ltd	21,498	$963.5K	0.03%
Walleye Capital LLC	19,587	$877.9K	0.01%
Entropy Technologies, LP	17,025	$763.1K	0.04%
SBI Okasan Asset Management Co.Ltd.	14,400	$638.4K	0.04%
PSP Research LLC	11,678	$523.4K	0.46%
Himension Fund	11,279	$505.5K	0.03%
Marex Group plc	10,557	$473.2K	0.01%
Abel Hall, LLC	6,757	$302.8K	0.07%
First Trust Advisors LP	6,361	$285.1K	0.00%
Letson Investment Management, Inc.	6,000	$268.9K	0.10%
Magnetar Financial LLC	5,153	$231.0K	0.00%
CAPROCK Group, Inc.	5,069	$227.2K	0.00%
CIBC World Markets Corp	5,027	$225.3K	0.00%
Mackenzie Financial Corp	4,772	$210.1K	0.00%
Whalen Wealth Management Inc.	4,641	$208.0K	0.11%
Amundi	4,609	$206.6K	0.00%
JustInvest LLC	4,533	$203.2K	0.00%
STRS Ohio	1,300	$58.3K	0.00%
Caitong International Asset Management Co., Ltd	1,225	$54.9K	0.01%
Kestra Advisory Services, LLC	740	$33.2K	0.00%
MAI Capital Management	261	$11.7K	0.00%
UBS Asset Management Americas Inc	236	$10.6K	0.00%
Zions Bancorporation, National Association	235	$10.5K	0.00%
Jones Financial Companies LLLP	150	$6.72K	0.00%
Kemnay Advisory Services Inc.	123	$5.51K	0.00%
Motiv8 Investments LLC	40	$2.00K	0.00%
Hantz Financial Services, Inc.	25	$1.00K	0.00%
CoreCap Advisors, LLC	17	$762	0.00%
Smartleaf Asset Management LLC	16	$706	0.00%
UMA Financial Services, Inc.	13	$583	0.00%
Massmutual Trust Co FSB	11	$493	0.00%
TD Private Client Wealth LLC	3	$134	0.00%

Sold out (22)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Institutions that sold out of XENE in Q4 2025
Institution	Shares, Q3 2025	Value, Q3 2025
Saturn V Capital Management LLC	503,701	$20.2M
Tri Locum Partners LP	366,102	$14.7M
Great Point Partners LLC	200,000	$8.03M
Jane Street Group, LLC	89,879	$3.61M
HighVista Strategies LLC	82,190	$3.30M
Avidity Partners Management LP	53,400	$2.14M
NJ State Employees Deferred Compensation Plan	25,000	$1.00M
Sanders Morris Harris LLC	21,500	$863.2K
Natixis Advisors, L.P.	17,564	$705.0K
CenterBook Partners LP	14,770	$593.0K
Schonfeld Strategic Advisors LLC	12,652	$508.0K
DRW Securities, LLC	9,273	$373.6K
Prudential Financial Inc	8,850	$355.3K
Freestone Grove Partners LP	6,748	$270.9K
Inceptionr LLC	6,322	$253.8K
Renaissance Technologies LLC	5,200	$208.8K
Group One Trading, L.P.	3,556	$142.8K
Quarry LP	2,500	$100.4K
United Community Bank	200	$8.03K
Principal Securities, Inc.	68	$2.73K
American National Bank	5	$201
Tortoise Investment Management, LLC	2	$80

Not filed for Q4 2025 yet (2)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding XENE in Q3 2025 that haven't filed for Q4 2025
Institution	Shares, Q3 2025	Value, Q3 2025
AXA Investment Managers S.A.	176,157	$7.07M
CIBC Bancorp USA Inc.	8,100	$325.2K