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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2025

Institutional positions in Xenon Pharmaceuticals Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
206
+2 vs. Q1 2025
Shares held
83.1M
+6.43M (+8.4%) vs. Q1 2025
Total value
$2.60B
+$26.6M (+1.0%) vs. Q1 2025
New holders
42
77 more added
Sold out
40
55 more reduced

2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 206 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ2 2025: $2.60B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q1 2025.

Institutions holding XENE in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Russell Investments Group, Ltd.52,136$1.63M0.00%−23,205−30.8%Reduced
Erste Asset Management GmbH50,000$1.62M0.01%00.0%Unchanged
Prudential Financial Inc47,755$1.53M0.00%+8,755+22.4%Added
Skandinaviska Enskilda Banken AB (publ)47,457$1.49M0.01%00.0%Unchanged
HighVista Strategies LLC45,620$1.43M0.52%−21,168−31.7%Reduced
MetLife Investment Management45,547$1.43M0.01%+45,547New
Jane Street Group, LLC43,676$1.37M0.00%+43,676New
Woodline Partners LP43,380$1.36M0.01%+43,380New
Mirae Asset Global ETFs Holdings Ltd.41,648$1.30M0.00%+41,648New
Alps Advisors Inc41,380$1.30M0.01%−13,952−25.2%Reduced
DekaBank Deutsche Girozentrale39,000$1.26M0.00%00.0%Unchanged
Artia Global Partners LP40,000$1.25M0.32%00.0%Unchanged
Envestnet Asset Management Inc39,403$1.23M0.00%−3,447−8.0%Reduced
Price T Rowe Associates Inc37,935$1.19M0.00%+37,935New
Citigroup Inc36,290$1.14M0.00%+29,261+416.3%Added
Rhenman & Partners Asset Management AB35,000$1.10M0.14%00.0%Unchanged
Intech Investment Management LLC34,312$1.07M0.01%+34,312New
TLS Advisors LLC32,956$1.03M3.22%00.0%Unchanged
Harbor Capital Advisors, Inc.30,036$940.0K0.04%−26,555−46.9%Reduced
HighMark Wealth Management LLC26,100$816.9K0.40%+20,000+327.9%Added
Ensign Peak Advisors, Inc26,094$816.7K0.00%00.0%Unchanged
Manufacturers Life Insurance Company, The26,079$816.3K0.00%+26,079New
Polar Asset Management Partners Inc.25,300$791.9K0.02%+25,300New
NJ State Employees Deferred Compensation Plan25,000$782.5K0.09%00.0%Unchanged
Readystate Asset Management LP24,814$776.7K0.03%+24,814New
CenterBook Partners LP24,664$772.0K0.04%+2,453+11.0%Added
Zurcher Kantonalbank (Zurich Cantonalbank)23,866$747.0K0.00%+4,910+25.9%Added
Rathbone Brothers plc23,666$740.7K0.00%00.0%Unchanged
SEI Investments Co22,723$711.2K0.00%+13,319+141.6%Added
Handelsbanken Fonder AB22,700$711.0K0.00%00.0%Unchanged
Assetmark, Inc21,250$665.1K0.00%+1,316+6.6%Added
Oxford Asset Management LLP21,138$661.6K0.22%+14,964+242.4%Added
Birchview Capital, LP21,000$657.3K0.65%00.0%Unchanged
Stifel Financial Corp20,622$645.5K0.00%+95+0.5%Added
SG Americas Securities, LLC19,177$600.0K0.00%+10,522+121.6%Added
Arizona State Retirement System18,956$593.3K0.00%+377+2.0%Added
ProShare Advisors LLC18,448$577.4K0.00%+18,448New
BNP Paribas Arbitrage, SA17,844$558.5K0.00%+14,634+455.9%Added
Teacher Retirement System of Texas17,534$548.8K0.00%+95+0.5%Added
Natixis Advisors, L.P.17,424$545.0K0.00%−6,586−27.4%Reduced
Police & Firemen's Retirement System of New Jersey17,358$543.3K0.01%+17,358New
Jump Financial, LLC16,991$531.8K0.01%+16,991New
CIBC World Markets Inc.16,335$511.3K0.00%00.0%Unchanged
China Universal Asset Management Co., Ltd.15,412$482.4K0.05%+59+0.4%Added
PEAK6 LLC15,000$469.5K0.02%+15,000New
Brinker Capital Investments, LLC14,916$466.9K0.00%−615−4.0%Reduced
KLP Kapitalforvaltning AS12,800$400.6K0.00%00.0%Unchanged
Advisors Asset Management, Inc.12,205$382.0K0.01%−2,076−14.5%Reduced
Supplemental Annuity Collective Trust of NJ11,000$344.3K0.10%00.0%Unchanged
Knott David M Jr10,962$343.1K0.16%−4,904−30.9%Reduced
Elmwood Wealth Management, Inc.10,824$338.8K0.13%−183−1.7%Reduced
Public Employees Retirement Association of Colorado10,633$333.0K0.00%00.0%Unchanged
Schonfeld Strategic Advisors LLC10,538$329.8K0.00%−12,416−54.1%Reduced
Legato Capital Management LLC9,622$301.2K0.04%00.0%Unchanged
Allianz Asset Management GmbH9,400$294.2K0.00%00.0%Unchanged
CIBC World Markets Corp9,363$293.1K0.00%+9,363New
Renaissance Technologies LLC8,600$269.2K0.00%−146,100−94.4%Reduced
Ameritas Investment Partners, Inc.7,758$242.8K0.01%+7,758New
Great West Life Assurance Co7,024$220.0K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)5,357$167.7K0.00%+5,307+10,614.0%Added
Northwestern Mutual Wealth Management Co5,000$156.5K0.00%00.0%Unchanged
Group One Trading, L.P.4,653$145.6K0.00%+4,653New
The PNC Financial Services Group, Inc.3,462$108.4K0.00%−1,758−33.7%Reduced
Mirae Asset Global Investments Co., Ltd.2,964$92.8K0.00%+403+15.7%Added
Virtus Investment Advisers, Inc.2,867$89.7K0.03%−1,294−31.1%Reduced
Amalgamated Bank2,595$81.0K0.00%+2,595New
Quarry LP2,000$62.6K0.01%00.0%Unchanged
IFP Advisors, Inc1,865$61.5K0.00%−56−2.9%Reduced
GF Fund Management Co. Ltd.1,952$61.1K0.00%00.0%Unchanged
KBC Group NV1,871$59.0K0.00%−890−32.2%Reduced
L1 Capital Pty Ltd1,296$40.6K0.00%+1,296New
Advisor Group Holdings, Inc.1,225$40.2K0.00%+1,034+541.4%Added
Mount Yale Investment Advisors, LLC1,015$31.8K0.00%+1,015New
Danske Bank A/S800$25.0K0.00%+800New
Farther Finance Advisors, LLC784$24.5K0.00%+784New
Nisa Investment Advisors, LLC689$21.6K0.00%+689New
Signaturefd, LLC661$20.7K0.00%+476+257.3%Added
State of Wyoming541$16.9K0.00%−33−5.7%Reduced
Clearstead Advisors, LLC347$10.9K0.00%+129+59.2%Added
First Horizon Advisors, Inc.345$10.8K0.00%−25−6.8%Reduced
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.276$8.64K0.00%00.0%Unchanged
Daiwa Securities Group Inc.252$8.00K0.00%00.0%Unchanged
National Bank of Canada235$7.35K0.00%00.0%Unchanged
CWM, LLC237$7.00K0.00%−2−0.8%Reduced
Spire Wealth Management200$6.26K0.00%00.0%Unchanged
United Community Bank200$6.26K0.00%+200New
Sterling Capital Management LLC184$5.76K0.00%+184New
US Bancorp181$5.67K0.00%−94−34.2%Reduced
Parallel Advisors, LLC135$4.23K0.00%−553−80.4%Reduced
Rothschild Investment LLC130$4.07K0.00%+130New
Caitong International Asset Management Co., Ltd104$3.25K0.00%−801−88.5%Reduced
Skopos Labs, Inc.103$3.22K0.00%+103New
J.Safra Asset Management Corp87$2.72K0.00%+3+3.6%Added
Principal Securities, Inc.68$2.13K0.00%+10+17.2%Added
Cape Investment Advisory, Inc.39$1.22K0.00%+39New
Whittier Trust Co of Nevada Inc36$1.13K0.00%00.0%Unchanged
Allworth Financial LP35$1.10K0.00%+23+191.7%Added
CVA Family Office, LLC33$1.03K0.00%00.0%Unchanged
Parkside Financial Bank & Trust30$9390.00%+30New
Ronald Blue Trust, Inc.28$8760.00%−242−89.6%Reduced