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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

Q2 2025 vs. Q1 2025

How the institutions holding Xenon Pharmaceuticals Inc. changed between Q1 2025 and Q2 2025.

All holders in Q2 2025All holders in Q1 2025

13F holders of XENE: Q1 2025 compared with Q2 2025
MeasureQ1 2025Of which not filed for Q2 2025Q2 2025Change
Holders2062206+2
Shares76.7M15.7K83.1M+6.43M (+8.4%)
Value$2.58B$527.7K$2.60B+$26.6M (+1.0%)

2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (42)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q2 2025 but not at the end of Q1 2025.

Institutions new to XENE in Q2 2025
InstitutionSharesValue% of portfolio
Holocene Advisors, LP1,809,475$56.6M0.14%
American Century Companies Inc679,857$21.3M0.01%
Deerfield Management Company, L.P. (Series C)542,020$17.0M0.31%
Nuveen, LLC228,567$7.15M0.00%
Susquehanna International Group, LLP222,352$6.96M0.01%
Charles Schwab Investment Management Inc192,242$6.02M0.00%
Foresite Capital Management IV, LLC160,000$5.01M4.05%
Foresite Capital Management VI LLC160,000$5.01M2.82%
Nan Fung Trinity (HK) Ltd158,605$4.96M0.59%
Caption Management, LLC100,940$3.16M0.29%
Soleus Capital Management, L.P.78,800$2.47M0.17%
Man Group plc62,348$1.95M0.00%
MetLife Investment Management45,547$1.43M0.01%
Jane Street Group, LLC43,676$1.37M0.00%
Woodline Partners LP43,380$1.36M0.01%
Mirae Asset Global ETFs Holdings Ltd.41,648$1.30M0.00%
Price T Rowe Associates Inc37,935$1.19M0.00%
Intech Investment Management LLC34,312$1.07M0.01%
Manufacturers Life Insurance Company, The26,079$816.3K0.00%
Polar Asset Management Partners Inc.25,300$791.9K0.02%
Readystate Asset Management LP24,814$776.7K0.03%
ProShare Advisors LLC18,448$577.4K0.00%
Police & Firemen's Retirement System of New Jersey17,358$543.3K0.01%
Jump Financial, LLC16,991$531.8K0.01%
PEAK6 LLC15,000$469.5K0.02%
CIBC World Markets Corp9,363$293.1K0.00%
Ameritas Investment Partners, Inc.7,758$242.8K0.01%
Group One Trading, L.P.4,653$145.6K0.00%
Amalgamated Bank2,595$81.0K0.00%
L1 Capital Pty Ltd1,296$40.6K0.00%
Mount Yale Investment Advisors, LLC1,015$31.8K0.00%
Danske Bank A/S800$25.0K0.00%
Farther Finance Advisors, LLC784$24.5K0.00%
Nisa Investment Advisors, LLC689$21.6K0.00%
United Community Bank200$6.26K0.00%
Sterling Capital Management LLC184$5.76K0.00%
Rothschild Investment LLC130$4.07K0.00%
Skopos Labs, Inc.103$3.22K0.00%
Cape Investment Advisory, Inc.39$1.22K0.00%
Parkside Financial Bank & Trust30$9390.00%
American National Bank5$1570.00%
Twin Peaks Wealth Advisors, LLC1$360.00%

Sold out (40)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q1 2025 and filed for Q2 2025 without it.

Institutions that sold out of XENE in Q2 2025
InstitutionShares, Q1 2025Value, Q1 2025
Samlyn Capital, LLC1,016,381$34.1M
Logos Global Management LP650,000$21.8M
Boxer Capital Management, LLC600,000$20.1M
Alyeska Investment Group, L.P.367,233$12.3M
StemPoint Capital LP274,633$9.21M
Two Sigma Investments, LP236,983$7.95M
Point72 Asset Management, L.P.209,759$7.04M
Nan Fung Group Holdings Ltd158,605$5.32M
Bridger Management, LLC146,800$4.93M
PFM Health Sciences, LP92,236$3.09M
Lord, Abbett & Co. LLC87,981$2.95M
Ally Bridge Group (NY) LLC69,603$2.34M
Altium Capital Management LP60,251$2.02M
ExodusPoint Capital Management, LP42,000$1.41M
Allostery Investments LP30,000$1.01M
Sphera Funds Management Ltd.26,097$875.6K
Atika Capital Management LLC24,000$805.2K
Sanders Morris Harris LLC21,500$658.8K
Prelude Capital Management, LLC18,266$612.8K
BIT Capital GmbH17,352$582.2K
Occudo Quantitative Strategies LP16,975$581.6K
Verition Fund Management LLC12,508$419.6K
Y-Intercept (Hong Kong) Ltd11,949$400.9K
Fox Run Management, L.L.C.11,372$381.5K
Aquatic Capital Management LLC10,511$352.6K
Silverarc Capital Management, LLC10,121$339.6K
EntryPoint Capital, LLC8,872$297.7K
Vident Advisory, LLC6,574$220.6K
Twinbeech Capital LP6,445$216.2K
NEOS Investment Management LLC6,111$205.0K
Tema ETFs LLC6,111$205.0K
Guggenheim Capital LLC6,019$201.9K
Coldstream Capital Management Inc648$21.7K
Point72 Hong Kong Ltd329$11.0K
Amundi114$3.50K
Point72 (DIFC) Ltd66$2.21K
Massmutual Trust Co FSB39$1.31K
CIBC Private Wealth Group, LLC39$1.10K
Continuum Advisory, LLC27$906
True Wealth Design, LLC9$302

Not filed for Q2 2025 yet (2)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q1 2025 and haven't filed a 13F for Q2 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding XENE in Q1 2025 that haven't filed for Q2 2025
InstitutionShares, Q1 2025Value, Q1 2025
Orion Portfolio Solutions, LLC15,531$521.1K
Lindbrook Capital, LLC198$6.64K