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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

Q1 2026 vs. Q4 2025

How the institutions holding Xenon Pharmaceuticals Inc. changed between Q4 2025 and Q1 2026.

All holders in Q1 2026All holders in Q4 2025

13F holders of XENE: Q4 2025 compared with Q1 2026
MeasureQ4 2025Of which not filed for Q1 2026Q1 2026Change
Holders2454290+49
Shares84.4M903.4K100.2M+16.7M (+20.0%)
Value$3.78B$40.5M$5.80B+$2.06B (+55.0%)

4 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (82)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q1 2026 but not at the end of Q4 2025.

Institutions new to XENE in Q1 2026
InstitutionSharesValue% of portfolio
Alyeska Investment Group, L.P.1,299,469$75.6M0.21%
Vanguard Portfolio Management LLC543,062$31.6M0.00%
Octagon Capital Advisors LP490,000$28.5M3.15%
Novo Holdings A/S485,438$28.2M2.29%
Logos Global Management LP450,000$26.2M1.35%
Schonfeld Strategic Advisors LLC324,722$18.9M0.15%
Renaissance Technologies LLC300,500$17.5M0.03%
Soleus Capital Management, L.P.292,000$17.0M0.69%
Allspring Global Investments Holdings, LLC246,306$14.0M0.02%
Duquesne Family Office LLCSuperinvestorDuquesne Family Office238,600$13.9M0.47%
Integral Health Asset Management, LLC200,000$11.6M0.62%
Silverarc Capital Management, LLC197,759$11.5M1.36%
ExodusPoint Capital Management, LP173,425$10.1M0.10%
Woodline Partners LP150,302$8.74M0.03%
Sphera Funds Management Ltd.127,000$7.39M1.27%
HSBC Holdings PLC121,558$7.07M0.00%
Burkehill Global Management, LP100,000$5.82M0.29%
Axiom Investors LLC99,568$5.79M0.06%
Aquatic Capital Management LLC79,199$4.61M0.13%
Vanguard Fiduciary Trust Co75,117$4.37M0.00%
Seven Grand Managers, LLC75,000$4.36M0.29%
Vanguard Asset Management, Ltd74,481$4.33M0.00%
Trexquant Investment LP67,361$3.92M0.03%
EAM Investors, LLC66,550$3.87M0.45%
Vanguard Capital Management LLC65,961$3.84M0.00%
Castleark Management LLC64,563$3.75M0.12%
LMR Partners LLP56,200$3.27M0.03%
Victory Capital Management Inc49,970$2.91M0.00%
HighVista Strategies LLC49,050$2.85M0.79%
Qube Research & Technologies Ltd44,044$2.56M0.00%
ACT Capital Management, LLC33,500$1.95M1.53%
Calamos Advisors LLC30,374$1.77M0.01%
CI Private Wealth, LLC28,302$1.65M0.00%
Swedbank AB26,200$1.52M0.00%
SummitTX Capital, L.P.26,186$1.52M0.05%
Sanders Morris Harris LLC21,500$1.25M0.20%
Teachers Retirement System of the State of Kentucky21,133$1.23M0.01%
Vanguard Investments Australia, Ltd.19,954$1.16M0.00%
Connor, Clark & Lunn Investment Management Ltd.19,439$1.13M0.00%
State Board of Administration of Florida Retirement System19,097$1.11M0.00%
Martingale Asset Management L P18,806$1.09M0.03%
Susquehanna Portfolio Strategies, LLC18,468$1.07M0.02%
Hudson Bay Capital Management LP14,072$818.3K0.00%
Prudential Financial Inc13,010$756.5K0.00%
Brevan Howard Capital Management LP12,041$700.2K0.01%
Covalis Capital LLP10,000$581.5K0.04%
Engineers Gate Manager LP9,326$542.3K0.01%
AQR Capital Management LLC7,279$423.3K0.00%
Bridgefront Capital, LLC6,564$381.7K0.09%
Longaeva Partners L.P.6,250$363.4K0.02%
Toroso Investments, LLC6,225$362.0K0.00%
Headlands Technologies LLC6,120$355.9K0.04%
DRW Securities, LLC5,461$317.6K0.02%
LPL Financial LLC4,964$288.7K0.00%
Swiss Life Asset Management Ltd4,847$281.9K0.00%
CIBC Bancorp USA Inc.4,349$252.9K0.00%
Oppenheimer Asset Management Inc.4,325$251.5K0.00%
Snowden Capital Advisors LLC4,223$245.6K0.01%
FNY Investment Advisers, LLC4,200$244.0K0.11%
Aigen Investment Management, LP4,123$239.8K0.06%
Cetera Investment Advisers3,624$210.7K0.00%
Seeds Investor LLC3,423$203.2K0.03%
Jane Street Group, LLC3,468$201.7K0.00%
Eurizon Capital SGR S.p.A.2,649$147.9K0.00%
Axiom Investment Management LLC1,000$58.1K0.04%
Acadian Asset Management LLC677$39.0K0.00%
Bayforest Capital Ltd555$32.3K0.04%
Vanguard Global Advisers, LLC494$28.7K0.00%
Huntington National Bank288$16.7K0.00%
Basecamp Wealth Advisors LLC280$16.3K0.00%
Quantbot Technologies LP162$9.42K0.00%
SMA Capital LLC139$8.08K0.00%
TD Waterhouse Canada Inc.130$7.33K0.00%
Root Financial Partners, LLC40$2.33K0.00%
Golden State Equity Partners35$2.04K0.00%
Twin Peaks Wealth Advisors, LLC32$1.86K0.00%
First Horizon Corp24$1.40K0.00%
WPG Advisers, LLC9$5230.00%
Pinnacle Wealth Planning Services, Inc.4$2330.00%
Hughes Financial Services, LLC4$2330.00%
Keating Financial Advisory Services, Inc.2$1160.00%
TFC Financial Management1$590.00%

Sold out (33)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q4 2025 and filed for Q1 2026 without it.

Institutions that sold out of XENE in Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
Dimensional Fund Advisors LP452,147$20.3M
Deep Track Capital, LP366,435$16.4M
Two Sigma Advisers, LP259,320$11.6M
Perceptive Advisors LLC200,791$9.00M
Jain Global LLC173,882$7.79M
Marshall Wace, LLP162,551$7.29M
Moore Capital Management, LP140,000$6.27M
Assenagon Asset Management S.A.119,186$5.34M
Man Group plc114,826$5.15M
Squadron Capital Management LLC105,551$4.73M
Dark Forest Capital Management LP33,459$1.50M
Lighthouse Investment Partners, LLC25,000$1.12M
Cinctive Capital Management LP23,317$1.05M
Walleye Capital LLC19,587$877.9K
Entropy Technologies, LP17,025$763.1K
Himension Fund11,279$505.5K
Supplemental Annuity Collective Trust of NJ11,000$493.0K
Knott David M Jr10,962$491.3K
Marex Group plc10,557$473.2K
Harbor Capital Advisors, Inc.10,053$451.0K
Altfest L J & Co Inc8,232$369.0K
Abel Hall, LLC6,757$302.8K
Magnetar Financial LLC5,153$231.0K
Mackenzie Financial Corp4,772$210.1K
Whalen Wealth Management Inc.4,641$208.0K
Amalgamated Bank2,387$107.0K
Clearstead Advisors, LLC1,215$54.5K
Kestra Advisory Services, LLC740$33.2K
Daiwa Securities Group Inc.229$10.0K
Cape Investment Advisory, Inc.39$1.75K
Aster Capital Management (DIFC) Ltd36$1.61K
SRS Capital Advisors, Inc.27$1.21K
TD Private Client Wealth LLC3$134

Not filed for Q1 2026 yet (4)

Institutions that held Xenon Pharmaceuticals Inc. at the end of Q4 2025 and haven't filed a 13F for Q1 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding XENE in Q4 2025 that haven't filed for Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
Vanguard Group Inc664,641$29.8M
Iron Triangle Partners LP233,688$10.5M
CIBC World Markets Corp5,027$225.3K
Motiv8 Investments LLC40$2.00K