Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 319
- +48 vs. Q3 2025
- Shares held
- 71.0M
- +458.8K (+0.7%) vs. Q3 2025
- Total value
- $6.18B
- +$1.49B (+31.8%) vs. Q3 2025
- New holders
- 84
- 99 more added
- Sold out
- 36
- 104 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ameritas Investment Partners, Inc. | 4,725 | $412.7K | 0.01% | −138−2.8% | Reduced |
| Advisors Asset Management, Inc. | 4,704 | $410.8K | 0.01% | −20.0% | Reduced |
| Cornerstone Investment Partners, LLC | 4,634 | $404.7K | 0.02% | +20.0% | Added |
| Xponance, Inc. | 4,588 | $400.7K | 0.00% | +54+1.2% | Added |
| Ensign Peak Advisors, Inc | 4,486 | $391.8K | 0.00% | −6,500−59.2% | Reduced |
| Brinker Capital Investments, LLC | 4,396 | $383.9K | 0.00% | −2,532−36.5% | Reduced |
| US Bancorp | 4,395 | $383.9K | 0.00% | −1,457−24.9% | Reduced |
| O'Shaughnessy Asset Management, LLC | 4,369 | $381.6K | 0.00% | +4,369 | New |
| Skopos Labs, Inc. | 4,331 | $380.8K | 0.02% | +4,331 | New |
| Los Angeles Capital Management LLC | 4,727 | $368.0K | 0.00% | +4,727 | New |
| Advisor Group Holdings, Inc. | 4,201 | $366.9K | 0.00% | +2,810+202.0% | Added |
| Vident Advisory, LLC | 4,191 | $366.0K | 0.00% | −879−17.3% | Reduced |
| New Vernon Capital Holdings II LLC | 4,137 | $361.3K | 0.17% | −3,061−42.5% | Reduced |
| King Wealth | 4,000 | $349.0K | 0.04% | −2,000−33.3% | Reduced |
| Allspring Global Investments Holdings, LLC | 3,985 | $347.4K | 0.00% | +3,985 | New |
| Crossmark Global Holdings, Inc. | 3,960 | $345.9K | 0.00% | −6−0.2% | Reduced |
| CIBC World Markets Corp | 3,851 | $336.3K | 0.00% | +3,851 | New |
| Bank of Montreal | 3,808 | $332.3K | 0.00% | −56−1.4% | Reduced |
| Nisa Investment Advisors, LLC | 3,780 | $330.1K | 0.00% | −205−5.1% | Reduced |
| Vestcor Inc | 3,765 | $329.0K | 0.01% | −1,257−25.0% | Reduced |
| Abacus Wealth Partners, LLC | 3,763 | $328.7K | 0.03% | +3,763 | New |
| M&T Bank Corp | 3,753 | $327.9K | 0.00% | +3,753 | New |
| Velan Capital Investment Management LP | 3,700 | $323.2K | 0.19% | 00.0% | Unchanged |
| Burney Co | 3,680 | $321.4K | 0.01% | −1,384−27.3% | Reduced |
| Mackenzie Financial Corp | 3,648 | $317.7K | 0.00% | −416−10.2% | Reduced |
| JustInvest LLC | 3,573 | $312.1K | 0.00% | +275+8.3% | Added |
| Wealth Enhancement Advisory Services, LLC | 3,554 | $292.4K | 0.00% | +43+1.2% | Added |
| Rockefeller Capital Management L.P. | 3,292 | $287.5K | 0.00% | +312+10.5% | Added |
| LPL Financial LLC | 3,265 | $285.2K | 0.00% | −1,729−34.6% | Reduced |
| Camden Capital, LLC | 3,251 | $283.9K | 0.02% | −1,284−28.3% | Reduced |
| Royal Bank of Canada | 3,183 | $278.0K | 0.00% | −66,813−95.5% | Reduced |
| AlphaGrep UK Ltd | 3,070 | $268.1K | 0.09% | +3,070 | New |
| Mirae Asset Global Investments Co., Ltd. | 3,038 | $265.3K | 0.00% | +633+26.3% | Added |
| Vise Technologies, Inc. | 2,996 | $261.7K | 0.01% | +2,996 | New |
| NBC Securities, Inc. | 2,977 | $260.0K | 0.02% | +19+0.6% | Added |
| The PNC Financial Services Group, Inc. | 2,959 | $258.4K | 0.00% | +221+8.1% | Added |
| Pinnacle Wealth Planning Services, Inc. | 2,864 | $250.1K | 0.03% | +2,864 | New |
| Evergreen Capital Management LLC | 2,812 | $245.6K | 0.01% | +2,812 | New |
| Virtus Investment Advisers, Inc. | 2,790 | $243.7K | 0.07% | +770+38.1% | Added |
| New Age Alpha Advisors, LLC | 2,784 | $243.2K | 0.01% | +2,784 | New |
| Captrust Financial Advisors | 2,732 | $238.6K | 0.00% | −580−17.5% | Reduced |
| GAMMA Investing LLC | 2,672 | $233.4K | 0.01% | +1,024+62.1% | Added |
| CIBC Asset Management Inc | 2,667 | $232.9K | 0.00% | +2,667 | New |
| Sumitomo Mitsui Trust Holdings, Inc. | 2,560 | $223.6K | 0.00% | +2,560 | New |
| Highland Capital Management, LLC | 2,462 | $215.0K | 0.01% | +2,462 | New |
| Swiss Life Asset Management Ltd | 2,431 | $212.3K | 0.00% | +2,431 | New |
| State of Wyoming | 2,070 | $180.8K | 0.02% | +2,070 | New |
| Tower Research Capital LLC (TRC) | 2,047 | $178.8K | 0.00% | −1,754−46.1% | Reduced |
| Smartleaf Asset Management LLC | 1,727 | $150.7K | 0.01% | +324+23.1% | Added |
| Quest Partners LLC | 1,617 | $141.2K | 0.01% | −1−0.1% | Reduced |
| KBC Group NV | 1,574 | $137.0K | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 1,467 | $128.1K | 0.00% | +115+8.5% | Added |
| Covestor Ltd | 1,437 | $125.0K | 0.07% | +447+45.2% | Added |
| GF Fund Management Co. Ltd. | 1,227 | $107.2K | 0.00% | −111−8.3% | Reduced |
| Truvestments Capital LLC | 1,161 | $101.4K | 0.02% | +439+60.8% | Added |
| Global Retirement Partners, LLC | 1,044 | $91.2K | 0.00% | +728+230.4% | Added |
| Canton Hathaway, LLC | 1,000 | $87.3K | 0.02% | +1,000 | New |
| Hantz Financial Services, Inc. | 951 | $83.0K | 0.00% | +656+222.4% | Added |
| CFG Wealth Management Services, Inc. | 602 | $52.6K | 0.05% | +602 | New |
| CWM, LLC | 556 | $49.0K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 559 | $48.8K | 0.00% | +19+3.5% | Added |
| Clear Street Markets LLC | 500 | $43.7K | 0.01% | +500 | New |
| Salomon & Ludwin, LLC | 436 | $36.7K | 0.00% | −6−1.4% | Reduced |
| Sterling Capital Management LLC | 378 | $33.0K | 0.00% | +237+168.1% | Added |
| Umb Bank N A | 333 | $29.1K | 0.00% | +75+29.1% | Added |
| Fifth Third Bancorp | 327 | $28.6K | 0.00% | +20+6.5% | Added |
| Greenline Wealth Management LLC | 304 | $26.5K | 0.03% | +304 | New |
| Farther Finance Advisors, LLC | 297 | $25.9K | 0.00% | +156+110.6% | Added |
| Assetmark, Inc | 285 | $24.9K | 0.00% | +5+1.8% | Added |
| Sound Income Strategies, LLC | 284 | $23.3K | 0.00% | +284 | New |
| Allworth Financial LP | 255 | $22.3K | 0.00% | +8+3.2% | Added |
| Clearstead Advisors, LLC | 222 | $19.4K | 0.00% | +22+11.0% | Added |
| Daiwa Securities Group Inc. | 190 | $17.0K | 0.00% | 00.0% | Unchanged |
| Kemnay Advisory Services Inc. | 181 | $15.8K | 0.00% | +181 | New |
| Larson Financial Group LLC | 171 | $14.9K | 0.00% | +17+11.0% | Added |
| Signaturefd, LLC | 163 | $14.2K | 0.00% | +14+9.4% | Added |
| Matrix Trust Co | 143 | $12.0K | 0.00% | +143 | New |
| Massmutual Trust Co FSB | 119 | $10.4K | 0.00% | 00.0% | Unchanged |
| Bare Financial Services, Inc | 110 | $9.61K | 0.00% | +76+223.5% | Added |
| Parallel Advisors, LLC | 109 | $9.52K | 0.00% | +7+6.9% | Added |
| SageView Advisory Group, LLC | 106 | $9.26K | 0.00% | +106 | New |
| Danske Bank A/S | 100 | $8.73K | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 97 | $8.47K | 0.00% | +11+12.8% | Added |
| WPG Advisers, LLC | 96 | $8.38K | 0.01% | +18+23.1% | Added |
| Rothschild Investment LLC | 86 | $7.51K | 0.00% | +1+1.2% | Added |
| Parkside Financial Bank & Trust | 84 | $7.34K | 0.00% | +39+86.7% | Added |
| Brown Brothers Harriman & Co | 81 | $7.08K | 0.00% | 00.0% | Unchanged |
| Bell Investment Advisors, Inc | 81 | $7.08K | 0.00% | 00.0% | Unchanged |
| Annis Gardner Whiting Capital Advisors, LLC | 76 | $6.64K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 70 | $6.11K | 0.00% | +70 | New |
| Sankala Group LLC | 60 | $5.53K | 0.00% | +60 | New |
| Raffa Wealth Management, LLC | 60 | $5.24K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 46 | $4.02K | 0.00% | +26+130.0% | Added |
| Torren Management, LLC | 39 | $3.41K | 0.00% | +39 | New |
| Huntington National Bank | 35 | $3.06K | 0.00% | −4−10.3% | Reduced |
| Wolff Wiese Magana LLC | 35 | $3.06K | 0.00% | 00.0% | Unchanged |
| Farmers & Merchants Investments Inc | 35 | $3.06K | 0.00% | 00.0% | Unchanged |
| Marquette Asset Management, LLC | 28 | $2.45K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 27 | $2.36K | 0.00% | 00.0% | Unchanged |
| Picton Mahoney Asset Management | 25 | $2.18K | 0.00% | 00.0% | Unchanged |