Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 322
- +10 vs. Q4 2025
- Shares held
- 78.9M
- +13.3M (+20.3%) vs. Q4 2025
- Total value
- $8.31B
- +$2.61B (+45.7%) vs. Q4 2025
- New holders
- 60
- 111 more added
- Sold out
- 50
- 104 more reduced
7 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9,779,369 | $1.03B | 0.02% | +63,370+0.7% | Added |
| Farallon Capital Management, L.L.C. | 6,348,906 | $669.2M | 3.97% | +204,900+3.3% | Added |
| UBS Group AG | 5,177,796 | $545.7M | 0.10% | +2,407,775+86.9% | Added |
| RTW Investments, LP | 5,059,053 | $533.2M | 5.31% | 00.0% | Unchanged |
| Wellington Management Group LLP | 3,599,644 | $379.4M | 0.07% | +428,221+13.5% | Added |
| Vanguard Portfolio Management LLC | 3,481,211 | $366.9M | 0.02% | +3,481,211 | New |
| State Street Corp | 3,116,749 | $328.5M | 0.01% | −82,980−2.6% | Reduced |
| Janus Henderson Group PLC | 2,891,527 | $304.9M | 0.15% | +241,546+9.1% | Added |
| Vanguard Capital Management LLC | 2,805,896 | $295.7M | 0.01% | +2,805,896 | New |
| Johnson & Johnson | 2,449,183 | $258.1M | 39.57% | 00.0% | Unchanged |
| Invesco Ltd. | 2,164,670 | $228.2M | 0.02% | +596,830+38.1% | Added |
| Geode Capital Management, LLC | 1,669,371 | $176.0M | 0.01% | +216,443+14.9% | Added |
| Price T Rowe Associates Inc | 1,665,497 | $175.5M | 0.02% | +264,759+18.9% | Added |
| Citadel Advisors LLC | 1,551,900 | $163.6M | 0.12% | +425,213+37.7% | Added |
| Woodline Partners LP | 1,414,173 | $149.1M | 0.56% | +5,401+0.4% | Added |
| Bank of America Corp | 1,295,434 | $136.5M | 0.01% | +427,854+49.3% | Added |
| Perceptive Advisors LLC | 1,230,879 | $129.7M | 2.56% | −119,546−8.9% | Reduced |
| Jennison Associates LLC | 1,072,011 | $113.0M | 0.08% | +740,847+223.7% | Added |
| Morgan Stanley | 1,018,222 | $107.3M | 0.01% | +139,198+15.8% | Added |
| ADAR1 Capital Management, LLC | 994,119 | $104.8M | 6.30% | −55,049−5.2% | Reduced |
| Hood River Capital Management LLC | 829,285 | $87.4M | 0.88% | +829,285 | New |
| Goldman Sachs Group Inc | 778,945 | $82.1M | 0.01% | −182,204−19.0% | Reduced |
| Driehaus Capital Management LLC | 720,928 | $76.0M | 0.56% | −378,242−34.4% | Reduced |
| FMR LLC | 661,997 | $69.8M | 0.00% | +122,119+22.6% | Added |
| Marshall Wace, LLP | 628,075 | $66.2M | 0.07% | −396,850−38.7% | Reduced |
| Clearbridge Investments, LLC | 621,820 | $65.5M | 0.06% | +131,978+26.9% | Added |
| Alyeska Investment Group, L.P. | 593,197 | $62.5M | 0.18% | +393,674+197.3% | Added |
| Northern Trust Corp | 587,968 | $62.0M | 0.01% | +12,850+2.2% | Added |
| Pictet Asset Management Holding SA | 581,083 | $61.2M | 0.06% | +51,452+9.7% | Added |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 571,825 | $60.3M | 5.11% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 552,956 | $58.3M | 0.01% | −3,806−0.7% | Reduced |
| American Century Companies Inc | 537,320 | $56.6M | 0.03% | +1,897+0.4% | Added |
| Dimensional Fund Advisors LP | 508,103 | $53.5M | 0.01% | +93,688+22.6% | Added |
| Voya Investment Management LLC | 454,383 | $47.9M | 0.05% | +88,218+24.1% | Added |
| Rubric Capital Management LP | 427,998 | $45.1M | 0.55% | +427,998 | New |
| Vanguard Fiduciary Trust Co | 412,730 | $43.5M | 0.01% | +412,730 | New |
| Principal Financial Group Inc | 367,822 | $38.8M | 0.02% | +19,890+5.7% | Added |
| 683 Capital Management, LLC | 355,000 | $37.4M | 3.47% | −25,669−6.7% | Reduced |
| Bank of New York Mellon Corp | 341,465 | $36.0M | 0.01% | −8,923−2.5% | Reduced |
| Vestal Point Capital, LP | 326,159 | $34.4M | 0.96% | +326,159 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 306,037 | $32.3M | 0.04% | −24,767−7.5% | Reduced |
| Adage Capital Partners GP, L.L.C. | 282,436 | $29.8M | 0.05% | +49,600+21.3% | Added |
| SEB Asset Management AB | 232,416 | $24.5M | 0.10% | +232,416 | New |
| NEXTBio Capital Management LP | 229,619 | $24.2M | 11.24% | 00.0% | Unchanged |
| Segall Bryant & Hamill, LLC | 212,714 | $22.4M | 0.32% | +83,654+64.8% | Added |
| Public Sector Pension Investment Board | 210,280 | $22.2M | 0.07% | +6,854+3.4% | Added |
| Holocene Advisors, LP | 209,916 | $22.1M | 0.05% | −1030.0% | Reduced |
| BNP Paribas Arbitrage, SA | 194,530 | $20.5M | 0.01% | +96,766+99.0% | Added |
| TD Asset Management Inc | 183,700 | $19.4M | 0.02% | +24,970+15.7% | Added |
| Eagle Health Investments LP | 179,322 | $18.9M | 3.97% | +122,022+213.0% | Added |
| Fisher Asset Management, LLC | 173,971 | $18.3M | 0.01% | +108,857+167.2% | Added |
| Affinity Asset Advisors, LLC | 172,125 | $18.1M | 1.06% | 00.0% | Unchanged |
| Boxer Capital Management, LLC | 170,000 | $17.9M | 2.35% | 00.0% | Unchanged |
| Raymond James Financial Inc | 177,361 | $17.8M | 0.01% | −4,142−2.3% | Reduced |
| Susquehanna International Group, LLP | 167,576 | $17.7M | 0.02% | +155,814+1,324.7% | Added |
| JPMorgan Chase & Co | 172,990 | $17.3M | 0.00% | +17,690+11.4% | Added |
| Lord, Abbett & Co. LLC | 163,459 | $17.2M | 0.06% | +163,459 | New |
| Nan Fung Trinity (HK) Ltd | 160,670 | $16.9M | 1.86% | −20,000−11.1% | Reduced |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 159,700 | $16.8M | 0.57% | 00.0% | Unchanged |
| Citigroup Inc | 158,711 | $16.7M | 0.01% | +63,802+67.2% | Added |
| Rhumbline Advisers | 157,413 | $16.6M | 0.01% | +2,463+1.6% | Added |
| Ameriprise Financial Inc | 145,690 | $15.4M | 0.00% | −23,828−14.1% | Reduced |
| Neuberger Berman Group LLC | 141,441 | $14.9M | 0.01% | +42,968+43.6% | Added |
| Franklin Resources Inc | 137,871 | $14.5M | 0.00% | +61,429+80.4% | Added |
| Kennedy Capital Management, Inc. | 137,099 | $14.5M | 0.31% | −84,345−38.1% | Reduced |
| Legal & General Group Plc | 135,367 | $14.3M | 0.00% | −13,797−9.2% | Reduced |
| Nuveen, LLC | 127,914 | $13.5M | 0.00% | +2,053+1.6% | Added |
| Manufacturers Life Insurance Company, The | 127,818 | $13.5M | 0.01% | +14,478+12.8% | Added |
| Deutsche Bank AG | 125,451 | $13.2M | 0.00% | +19,991+19.0% | Added |
| Panagora Asset Management Inc | 116,609 | $12.3M | 0.05% | −8,775−7.0% | Reduced |
| UBS Asset Management Americas Inc | 107,437 | $11.3M | 0.00% | +2,909+2.8% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 105,514 | $11.1M | 0.02% | −8,522−7.5% | Reduced |
| Balyasny Asset Management LLC | 101,299 | $10.7M | 0.02% | +101,299 | New |
| Opaleye Management Inc. | 100,000 | $10.5M | 1.39% | −5,000−4.8% | Reduced |
| Swiss National Bank | 98,900 | $10.4M | 0.01% | +700+0.7% | Added |
| Prudential Financial Inc | 95,235 | $10.0M | 0.01% | −15,125−13.7% | Reduced |
| Schroder Investment Management Group | 100,166 | $10.0M | 0.01% | +100,166 | New |
| First Trust Advisors LP | 87,858 | $9.26M | 0.01% | +41,404+89.1% | Added |
| Axiom Investors LLC | 85,475 | $9.01M | 0.10% | −3,993−4.5% | Reduced |
| Victory Capital Management Inc | 83,544 | $8.81M | 0.01% | +2,973+3.7% | Added |
| SEI Investments Co | 83,197 | $8.77M | 0.01% | +45,851+122.8% | Added |
| Algert Global LLC | 78,470 | $8.27M | 0.12% | +73,380+1,441.7% | Added |
| StemPoint Capital LP | 72,577 | $7.65M | 1.47% | +13,147+22.1% | Added |
| Great Lakes Advisors, LLC | 71,043 | $7.49M | 0.06% | −2,923−4.0% | Reduced |
| Knott David M Jr | 63,000 | $6.64M | 3.95% | −10,000−13.7% | Reduced |
| Atika Capital Management LLC | 62,100 | $6.55M | 1.03% | −23,900−27.8% | Reduced |
| Alliancebernstein L.P. | 73,790 | $6.44M | 0.00% | +568+0.8% | Added |
| California State Teachers Retirement System | 58,677 | $6.18M | 0.01% | +10,644+22.2% | Added |
| Bessemer Group Inc | 54,178 | $5.71M | 0.01% | +160.0% | Added |
| Moody Aldrich Partners LLC | 53,893 | $5.68M | 1.02% | −26,730−33.2% | Reduced |
| KVP Capital Advisors, LP | 53,000 | $5.59M | 4.17% | 00.0% | Unchanged |
| Nordea Investment Management AB | 51,821 | $5.33M | 0.00% | +51,821 | New |
| EFG International AG | 50,086 | $5.28M | 0.11% | −22,537−31.0% | Reduced |
| Integral Health Asset Management, LLC | 50,000 | $5.27M | 0.28% | +50,000 | New |
| Northwestern Mutual Wealth Management Co | 49,020 | $5.17M | 0.00% | +126+0.3% | Added |
| Creative Planning | 47,971 | $5.06M | 0.00% | +6,717+16.3% | Added |
| Silvercrest Asset Management Group LLC | 47,931 | $5.05M | 0.04% | −5,286−9.9% | Reduced |
| Great West Life Assurance Co | 47,440 | $5.00M | 0.01% | −2,200−4.4% | Reduced |
| New York State Teachers Retirement System | 47,424 | $5.00M | 0.01% | −1,926−3.9% | Reduced |
| Rafferty Asset Management, LLC | 46,752 | $4.93M | 0.02% | −16,909−26.6% | Reduced |