Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 241
- +4 vs. Q3 2024
- Shares held
- 63.3M
- +1.83M (+3.0%) vs. Q3 2024
- Total value
- $2.44B
- −$321.9M (−11.6%) vs. Q3 2024
- New holders
- 45
- 91 more added
- Sold out
- 41
- 76 more reduced
3 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9,884,617 | $381.5M | 0.01% | −339,678−3.3% | Reduced |
| Farallon Capital Management, L.L.C. | 5,930,006 | $228.9M | 1.21% | +69,000+1.2% | Added |
| RTW Investments, LP | 5,498,545 | $212.2M | 3.21% | +72,433+1.3% | Added |
| Vanguard Group Inc | 4,220,037 | $162.9M | 0.00% | +3,956+0.1% | Added |
| State Street Corp | 3,331,061 | $128.6M | 0.01% | +147,519+4.6% | Added |
| Johnson & Johnson | 2,449,183 | $94.5M | 24.48% | 00.0% | Unchanged |
| BVF Inc | 1,900,015 | $73.3M | 2.49% | +49,848+2.7% | Added |
| Pacer Advisors, Inc. | 1,876,466 | $72.4M | 0.16% | +142,376+8.2% | Added |
| Jefferies Financial Group Inc. | 1,489,495 | $57.5M | 0.64% | −325,201−17.9% | Reduced |
| Price T Rowe Associates Inc | 1,392,652 | $53.8M | 0.01% | +83,185+6.4% | Added |
| Geode Capital Management, LLC | 1,377,063 | $53.2M | 0.00% | +2,366+0.2% | Added |
| Perceptive Advisors LLC | 1,271,662 | $49.1M | 1.37% | −102,901−7.5% | Reduced |
| ADAR1 Capital Management, LLC | 1,020,333 | $39.4M | 8.12% | +39,038+4.0% | Added |
| Deep Track Capital, LP | 1,000,000 | $38.6M | 1.45% | +1,000,000 | New |
| Wellington Management Group LLP | 940,077 | $36.3M | 0.01% | +909,998+3,025.4% | Added |
| American Century Companies Inc | 928,286 | $35.8M | 0.02% | +353,511+61.5% | Added |
| Goldman Sachs Group Inc | 758,690 | $29.3M | 0.01% | −63,166−7.7% | Reduced |
| Invesco Ltd. | 738,952 | $28.5M | 0.01% | +85,800+13.1% | Added |
| Eversept Partners, LP | 678,787 | $26.2M | 2.70% | +233,583+52.5% | Added |
| Northern Trust Corp | 628,580 | $24.3M | 0.00% | +48,491+8.4% | Added |
| Woodline Partners LP | 582,327 | $22.5M | 0.15% | +115,809+24.8% | Added |
| Charles Schwab Investment Management Inc | 578,409 | $22.3M | 0.00% | +12,906+2.3% | Added |
| JPMorgan Chase & Co | 576,977 | $22.3M | 0.00% | +73,992+14.7% | Added |
| Morgan Stanley | 540,315 | $20.9M | 0.00% | −88,308−14.0% | Reduced |
| FMR LLC | 442,516 | $17.1M | 0.00% | −11,680−2.6% | Reduced |
| Colony Group, LLC | 425,557 | $16.4M | 0.04% | −1,104−0.3% | Reduced |
| 683 Capital Management, LLC | 410,000 | $15.8M | 1.56% | −10,000−2.4% | Reduced |
| Mangrove Partners | 395,383 | $15.3M | 1.82% | −43,931−10.0% | Reduced |
| Kynam Capital Management, LP | 390,792 | $15.1M | 1.00% | −65,577−14.4% | Reduced |
| Bank of New York Mellon Corp | 390,788 | $15.1M | 0.00% | +34,455+9.7% | Added |
| Polar Capital Holdings Plc | 350,000 | $13.5M | 0.08% | 00.0% | Unchanged |
| Toronto Dominion Bank | 340,974 | $13.2M | 0.03% | +340,974 | New |
| Driehaus Capital Management LLC | 339,698 | $13.1M | 0.11% | −105,654−23.7% | Reduced |
| Principal Financial Group Inc | 337,809 | $13.0M | 0.01% | +16,977+5.3% | Added |
| Kennedy Capital Management, Inc. | 321,526 | $12.4M | 0.28% | +54,493+20.4% | Added |
| Qube Research & Technologies Ltd | 312,319 | $12.1M | 0.02% | −10,670−3.3% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 310,650 | $12.0M | 0.05% | +80,536+35.0% | Added |
| Raymond James Financial Inc | 303,313 | $11.7M | 0.00% | +303,313 | New |
| Pictet Asset Management Holding SA | 296,511 | $11.4M | 0.01% | +289,213+3,962.9% | Added |
| Artia Global Partners LP | 293,851 | $11.3M | 4.57% | +169,411+136.1% | Added |
| UBS Asset Management Americas Inc | 287,911 | $11.1M | 0.00% | −80,221−21.8% | Reduced |
| Soleus Capital Management, L.P. | 275,000 | $10.6M | 0.80% | +275,000 | New |
| Victory Capital Management Inc | 240,817 | $9.30M | 0.01% | +110,020+84.1% | Added |
| Dimensional Fund Advisors LP | 225,600 | $8.71M | 0.00% | +110.0% | Added |
| Renaissance Technologies LLC | 221,167 | $8.54M | 0.01% | +77,000+53.4% | Added |
| Arrowstreet Capital, Limited Partnership | 216,069 | $8.34M | 0.01% | +58,002+36.7% | Added |
| TD Asset Management Inc | 173,702 | $6.70M | 0.01% | +1,500+0.9% | Added |
| Citadel Advisors LLC | 164,146 | $6.34M | 0.01% | +159,116+3,163.3% | Added |
| Rhumbline Advisers | 161,964 | $6.25M | 0.01% | −2,214−1.3% | Reduced |
| Man Group plc | 157,963 | $6.10M | 0.02% | +102,132+182.9% | Added |
| Legal & General Group Plc | 152,562 | $5.89M | 0.00% | −444−0.3% | Reduced |
| Nuveen Asset Management, LLC | 151,197 | $5.84M | 0.00% | −80,877−34.8% | Reduced |
| AQR Capital Management LLC | 150,097 | $5.79M | 0.01% | +12,926+9.4% | Added |
| Public Sector Pension Investment Board | 148,489 | $5.73M | 0.02% | +23,540+18.8% | Added |
| StemPoint Capital LP | 141,714 | $5.47M | 1.37% | +141,714 | New |
| Ameriprise Financial Inc | 141,387 | $5.46M | 0.00% | −2,420−1.7% | Reduced |
| First Trust Advisors LP | 140,951 | $5.44M | 0.00% | +270.0% | Added |
| Deutsche Bank AG | 137,932 | $5.32M | 0.00% | +17,763+14.8% | Added |
| Bank of America Corp | 134,872 | $5.21M | 0.00% | −18,645−12.1% | Reduced |
| UBS Group AG | 132,609 | $5.12M | 0.00% | +53,810+68.3% | Added |
| Affinity Asset Advisors, LLC | 130,000 | $5.02M | 0.78% | +130,000 | New |
| Jacobs Levy Equity Management, Inc | 128,654 | $4.97M | 0.02% | 00.0% | Unchanged |
| Barclays PLC | 126,733 | $4.89M | 0.00% | −262−0.2% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 125,898 | $4.86M | 0.01% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 124,341 | $4.80M | 0.00% | +8,576+7.4% | Added |
| Citigroup Inc | 121,022 | $4.67M | 0.00% | +47,532+64.7% | Added |
| Opaleye Management Inc. | 105,000 | $4.05M | 0.71% | 00.0% | Unchanged |
| Hussman Strategic Advisors, Inc. | 105,000 | $4.05M | 1.20% | +105,000 | New |
| Caption Management, LLC | 98,934 | $3.82M | 0.16% | +76,834+347.7% | Added |
| Rafferty Asset Management, LLC | 95,467 | $3.69M | 0.01% | +5,591+6.2% | Added |
| Trexquant Investment LP | 92,788 | $3.58M | 0.04% | +69,697+301.8% | Added |
| Franklin Resources Inc | 88,870 | $3.43M | 0.00% | +7,279+8.9% | Added |
| Swiss National Bank | 86,900 | $3.35M | 0.00% | +1,000+1.2% | Added |
| Silvercrest Asset Management Group LLC | 84,426 | $3.26M | 0.02% | −828−1.0% | Reduced |
| Voya Investment Management LLC | 82,627 | $3.19M | 0.00% | −31,225−27.4% | Reduced |
| Northwestern Mutual Wealth Management Co | 78,894 | $3.05M | 0.00% | 00.0% | Unchanged |
| Aquilo Capital Management, LLC | 76,592 | $2.96M | 5.06% | +76,592 | New |
| E Fund Management Co., Ltd. | 76,087 | $2.94M | 0.15% | +4,421+6.2% | Added |
| Ikarian Capital, LLC | 70,000 | $2.70M | 0.77% | +70,000 | New |
| Susquehanna International Group, LLP | 69,937 | $2.70M | 0.00% | +29,580+73.3% | Added |
| Superstring Capital Management LP | 68,892 | $2.66M | 2.34% | +68,892 | New |
| Alliancebernstein L.P. | 68,225 | $2.63M | 0.00% | −13,694−16.7% | Reduced |
| Moody Aldrich Partners LLC | 67,415 | $2.60M | 0.48% | −51,872−43.5% | Reduced |
| HighVista Strategies LLC | 62,518 | $2.41M | 0.90% | −26,990−30.2% | Reduced |
| Great Lakes Advisors, LLC | 61,947 | $2.39M | 0.02% | −7,678−11.0% | Reduced |
| Jane Street Group, LLC | 61,551 | $2.38M | 0.00% | +28,693+87.3% | Added |
| Prudential Financial Inc | 59,998 | $2.32M | 0.00% | −800−1.3% | Reduced |
| Great West Life Assurance Co | 56,536 | $2.18M | 0.00% | 00.0% | Unchanged |
| Alps Advisors Inc | 55,941 | $2.16M | 0.01% | +3,909+7.5% | Added |
| Knott David M Jr | 52,368 | $2.02M | 0.73% | 00.0% | Unchanged |
| Assenagon Asset Management S.A. | 52,239 | $2.02M | 0.00% | +52,239 | New |
| State of Wisconsin Investment Board | 50,782 | $1.96M | 0.01% | +3,622+7.7% | Added |
| Swedbank AB | 50,000 | $1.93M | 0.00% | 00.0% | Unchanged |
| Birchview Capital, LP | 48,000 | $1.85M | 1.51% | 00.0% | Unchanged |
| Thrivent Financial for Lutherans | 46,066 | $1.78M | 0.00% | −191−0.4% | Reduced |
| California State Teachers Retirement System | 42,349 | $1.63M | 0.00% | −316−0.7% | Reduced |
| Wells Fargo & Company | 38,796 | $1.50M | 0.00% | +9,423+32.1% | Added |
| Quantedge Capital Pte Ltd | 37,200 | $1.44M | 0.52% | +4,217+12.8% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 37,055 | $1.43M | 0.00% | +1,550+4.4% | Added |
| MetLife Investment Management | 35,798 | $1.38M | 0.01% | +1,993+5.9% | Added |