Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 149
- +17 vs. Q3 2021
- Shares held
- 49.4M
- +3.04M (+6.6%) vs. Q3 2021
- Total value
- $1.68B
- +$863.7M (+105.2%) vs. Q3 2021
- New holders
- 36
- 58 more added
- Sold out
- 19
- 36 more reduced
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 6,847,277 | $234.2M | 0.02% | +354,639+5.5% | Added |
| BVF Inc | 3,651,759 | $124.9M | 4.53% | −250,000−6.4% | Reduced |
| BlackRock Inc. | 3,281,636 | $112.2M | 0.00% | +82,140+2.6% | Added |
| EcoR1 Capital, LLC | 2,639,706 | $90.3M | 2.89% | +1,195,906+82.8% | Added |
| RTW Investments, LP | 2,599,822 | $88.9M | 1.30% | +846,127+48.2% | Added |
| State Street Corp | 2,571,570 | $87.9M | 0.00% | +557,591+27.7% | Added |
| Johnson & Johnson | 2,449,183 | $83.8M | 9.54% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 2,419,763 | $82.8M | 0.37% | −1,967,537−44.8% | Reduced |
| Vanguard Group Inc | 2,348,166 | $80.3M | 0.00% | −5,620−0.2% | Reduced |
| Farallon Capital Management, L.L.C. | 1,917,134 | $65.6M | 0.37% | −474,866−19.9% | Reduced |
| Artal Group S.A. | 1,250,000 | $42.8M | 1.26% | −250,000−16.7% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 1,172,943 | $40.1M | 0.84% | −221,057−15.9% | Reduced |
| Dimensional Fund Advisors LP | 874,651 | $29.9M | 0.01% | −1,081−0.1% | Reduced |
| Deutsche Bank AG | 824,872 | $28.2M | 0.01% | +1,582+0.2% | Added |
| Commodore Capital LP | 805,573 | $27.6M | 6.38% | +307,494+61.7% | Added |
| Obermeyer Wood Investment Counsel, LLLP | 788,942 | $27.0M | 1.45% | +12,253+1.6% | Added |
| Geode Capital Management, LLC | 778,081 | $26.6M | 0.00% | +49,151+6.7% | Added |
| Woodline Partners LP | 492,987 | $16.9M | 0.25% | +492,987 | New |
| Rothschild & Co Asset Management US Inc. | 491,024 | $16.8M | 0.20% | +273,541+125.8% | Added |
| Sofinnova Investments, Inc. | 482,257 | $16.5M | 1.06% | +184,548+62.0% | Added |
| Northern Trust Corp | 455,411 | $15.6M | 0.00% | −1,566−0.3% | Reduced |
| Adage Capital Partners GP, L.L.C. | 450,045 | $15.4M | 0.03% | +150,000+50.0% | Added |
| Samlyn Capital, LLC | 448,908 | $15.4M | 0.24% | +448,908 | New |
| JPMorgan Chase & Co | 436,453 | $14.9M | 0.00% | +7,758+1.8% | Added |
| Mangrove Partners | 433,137 | $14.8M | 1.10% | +433,137 | New |
| Deep Track Capital, LP | 421,660 | $14.4M | 1.07% | +421,660 | New |
| Millennium Management LLC | 391,073 | $13.4M | 0.01% | −131,798−25.2% | Reduced |
| Price T Rowe Associates Inc | 377,132 | $12.9M | 0.00% | −114,509−23.3% | Reduced |
| Altium Capital Management LP | 346,000 | $11.8M | 3.32% | 00.0% | Unchanged |
| Opaleye Management Inc. | 342,000 | $11.7M | 2.48% | +11,778+3.6% | Added |
| Charles Schwab Investment Management Inc | 317,179 | $10.8M | 0.00% | +7,347+2.4% | Added |
| Tri Locum Partners LP | 313,929 | $10.7M | 4.30% | +313,929 | New |
| Polar Capital Holdings Plc | 303,429 | $10.4M | 0.05% | +84,493+38.6% | Added |
| Susquehanna International Group, LLP | 296,413 | $10.1M | 0.02% | +29,030+10.9% | Added |
| Logos Global Management LP | 250,000 | $8.55M | 0.88% | +250,000 | New |
| Affinity Asset Advisors, LLC | 241,119 | $8.25M | 3.52% | +241,119 | New |
| Caption Management, LLC | 192,702 | $6.59M | 0.41% | +82,702+75.2% | Added |
| Voloridge Investment Management, LLC | 183,648 | $6.28M | 0.03% | −366,435−66.6% | Reduced |
| Rafferty Asset Management, LLC | 165,772 | $5.67M | 0.03% | +96,642+139.8% | Added |
| Lord, Abbett & Co. LLC | 163,664 | $5.60M | 0.01% | +163,664 | New |
| Russell Investments Group, Ltd. | 163,589 | $5.59M | 0.01% | +86,587+112.4% | Added |
| Twin Lakes Capital Management, LLC | 138,580 | $4.74M | 2.53% | −707−0.5% | Reduced |
| Bank of New York Mellon Corp | 138,494 | $4.74M | 0.00% | +7,361+5.6% | Added |
| Citigroup Inc | 137,751 | $4.71M | 0.00% | +86,566+169.1% | Added |
| Allianz Asset Management GmbH | 134,793 | $4.61M | 0.00% | +85,622+174.1% | Added |
| SEI Investments Co | 132,313 | $4.53M | 0.01% | +86,138+186.5% | Added |
| J. Goldman & Co LP | 130,517 | $4.46M | 0.41% | +130,517 | New |
| Goldman Sachs Group Inc | 123,629 | $4.23M | 0.00% | −299,566−70.8% | Reduced |
| Barclays PLC | 120,597 | $4.12M | 0.00% | +83,600+226.0% | Added |
| Bank of America Corp | 119,607 | $4.09M | 0.00% | +61,956+107.5% | Added |
| Silvercrest Asset Management Group LLC | 118,715 | $4.06M | 0.03% | +47,372+66.4% | Added |
| Morgan Stanley | 107,416 | $3.67M | 0.00% | −366,899−77.4% | Reduced |
| Kennedy Capital Management, Inc. | 105,394 | $3.60M | 0.08% | −6,871−6.1% | Reduced |
| Tekla Capital Management LLC | 101,037 | $3.46M | 0.11% | +14,800+17.2% | Added |
| Alberta Investment Management Corp | 100,000 | $3.42M | 0.02% | +100,000 | New |
| Walleye Capital LLC | 97,998 | $3.35M | 0.11% | +87,882+868.7% | Added |
| Swiss National Bank | 94,200 | $3.22M | 0.00% | +6,800+7.8% | Added |
| Candriam Luxembourg S.C.A. | 83,646 | $2.86M | 0.02% | 00.0% | Unchanged |
| Jane Street Group, LLC | 76,396 | $2.61M | 0.01% | +18,542+32.0% | Added |
| Industrial Alliance Investment Management Inc. | 75,235 | $2.57M | 0.06% | +75,235 | New |
| UBS Group AG | 66,311 | $2.27M | 0.00% | −2,904−4.2% | Reduced |
| State of Wisconsin Investment Board | 64,600 | $2.21M | 0.00% | −6,600−9.3% | Reduced |
| Squarepoint Ops LLC | 60,490 | $2.07M | 0.01% | +60,490 | New |
| California State Teachers Retirement System | 60,465 | $2.07M | 0.00% | +3,957+7.0% | Added |
| Alps Advisors Inc | 55,232 | $1.89M | 0.02% | +55,232 | New |
| Resolute Capital Asset Partners LLC | 55,000 | $1.88M | 1.23% | +55,000 | New |
| Nuveen Asset Management, LLC | 239,929 | $1.85M | 0.00% | +76,843+47.1% | Added |
| Alliancebernstein L.P. | 45,900 | $1.57M | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 43,969 | $1.50M | 0.00% | +1,274+3.0% | Added |
| D. E. Shaw & Co., Inc. | 43,286 | $1.48M | 0.00% | −72,627−62.7% | Reduced |
| Wells Fargo & Company | 40,358 | $1.38M | 0.00% | −18,371−31.3% | Reduced |
| Two Sigma Advisers, LP | 38,800 | $1.33M | 0.00% | −106,500−73.3% | Reduced |
| BNP Paribas Arbitrage, SA | 38,658 | $1.32M | 0.00% | +30,651+382.8% | Added |
| SG Americas Securities, LLC | 38,550 | $1.32M | 0.01% | +19,184+99.1% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 38,304 | $1.31M | 0.01% | 00.0% | Unchanged |
| Birchview Capital, LP | 38,000 | $1.30M | 0.84% | 00.0% | Unchanged |
| Jump Financial, LLC | 37,100 | $1.27M | 0.08% | +37,100 | New |
| Citadel Advisors LLC | 35,548 | $1.22M | 0.00% | −83,156−70.1% | Reduced |
| New York State Common Retirement Fund | 33,161 | $1.13M | 0.00% | +3,223+10.8% | Added |
| TD Asset Management Inc | 33,042 | $1.13M | 0.00% | −14,000−29.8% | Reduced |
| UBS Asset Management Americas Inc | 32,664 | $1.12M | 0.00% | +5,066+18.4% | Added |
| HighVista Strategies LLC | 30,999 | $1.06M | 0.84% | +2,688+9.5% | Added |
| Prudential Financial Inc | 30,105 | $1.03M | 0.00% | −190−0.6% | Reduced |
| Credit Suisse AG | 28,348 | $969.0K | 0.00% | +653+2.4% | Added |
| Two Sigma Investments, LP | 28,100 | $961.0K | 0.00% | +3,500+14.2% | Added |
| Bamco Inc | 26,000 | $889.0K | 0.00% | +26,000 | New |
| Allspring Global Investments Holdings, LLC | 25,371 | $867.0K | 0.00% | +25,371 | New |
| American International Group, Inc. | 23,772 | $813.0K | 0.00% | −711−2.9% | Reduced |
| Nisa Investment Advisors, LLC | 27,150 | $795.0K | 0.01% | +26,700+5,933.3% | Added |
| Manufacturers Life Insurance Company, The | 22,822 | $781.0K | 0.00% | −759−3.2% | Reduced |
| Parametric Portfolio Associates LLC | 22,651 | $775.0K | 0.00% | +2,217+10.8% | Added |
| Franklin Street Advisors Inc | 22,220 | $760.0K | 0.06% | 00.0% | Unchanged |
| King Wealth | 22,000 | $752.0K | 0.14% | 00.0% | Unchanged |
| Bank of Montreal | 21,400 | $734.0K | 0.00% | −405−1.9% | Reduced |
| Legal & General Group Plc | 21,264 | $727.0K | 0.00% | +632+3.1% | Added |
| Vontobel Holding Ltd. | 20,000 | $684.0K | 0.01% | 00.0% | Unchanged |
| Invesco Ltd. | 19,825 | $678.0K | 0.00% | −2,627−11.7% | Reduced |
| HAP Trading, LLC | 19,166 | $655.0K | 0.05% | −1,743−8.3% | Reduced |
| Gyon Technologies Capital Management, LP | 18,882 | $646.0K | 0.12% | +18,882 | New |
| Harvest Investment Services, LLC | 18,627 | $637.0K | 0.27% | −2,280−10.9% | Reduced |