Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Protagonist Therapeutics, Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 275
- +3 vs. Q2 2025
- Shares held
- 70.7M
- −267.3K (−0.4%) vs. Q2 2025
- Total value
- $4.70B
- +$772.8M (+19.7%) vs. Q2 2025
- New holders
- 42
- 84 more added
- Sold out
- 39
- 109 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9,404,232 | $624.7M | 0.01% | −226,109−2.3% | Reduced |
| Farallon Capital Management, L.L.C. | 6,196,006 | $411.6M | 2.33% | +24,000+0.4% | Added |
| RTW Investments, LP | 5,756,277 | $382.4M | 4.71% | 00.0% | Unchanged |
| Vanguard Group Inc | 4,257,229 | $282.8M | 0.00% | −101,366−2.3% | Reduced |
| State Street Corp | 3,165,795 | $210.3M | 0.01% | −41,748−1.3% | Reduced |
| BVF Inc | 2,560,916 | $170.1M | 6.90% | −650,125−20.2% | Reduced |
| Johnson & Johnson | 2,449,183 | $162.7M | 32.29% | 00.0% | Unchanged |
| Wellington Management Group LLP | 1,908,446 | $126.8M | 0.02% | +870,708+83.9% | Added |
| UBS Group AG | 1,896,008 | $126.0M | 0.02% | −605,243−24.2% | Reduced |
| Deep Track Capital, LP | 1,715,691 | $114.0M | 3.18% | −1,530,208−47.1% | Reduced |
| Woodline Partners LP | 1,438,247 | $95.5M | 0.45% | +491,363+51.9% | Added |
| Geode Capital Management, LLC | 1,416,646 | $94.1M | 0.01% | −27,584−1.9% | Reduced |
| Price T Rowe Associates Inc | 1,220,436 | $81.1M | 0.01% | +283,733+30.3% | Added |
| Driehaus Capital Management LLC | 1,139,854 | $75.7M | 0.54% | +382,144+50.4% | Added |
| Janus Henderson Group PLC | 1,100,821 | $73.2M | 0.03% | +653,993+146.4% | Added |
| Marshall Wace, LLP | 1,085,564 | $72.1M | 0.08% | +1,085,564 | New |
| Perceptive Advisors LLC | 1,030,134 | $68.4M | 1.98% | −44,314−4.1% | Reduced |
| Commodore Capital LP | 1,025,000 | $68.1M | 3.32% | −50,000−4.7% | Reduced |
| Invesco Ltd. | 1,003,706 | $66.7M | 0.01% | +282,026+39.1% | Added |
| ADAR1 Capital Management, LLC | 989,182 | $65.7M | 6.51% | +41,113+4.3% | Added |
| Bank of America Corp | 829,877 | $55.1M | 0.00% | −21,955−2.6% | Reduced |
| Pictet Asset Management Holding SA | 822,212 | $54.6M | 0.05% | +70,235+9.3% | Added |
| Jefferies Financial Group Inc. | 821,503 | $54.6M | 0.50% | −2,516−0.3% | Reduced |
| Goldman Sachs Group Inc | 781,711 | $51.9M | 0.01% | +4,404+0.6% | Added |
| Morgan Stanley | 768,359 | $51.0M | 0.00% | −100,604−11.6% | Reduced |
| Adage Capital Partners GP, L.L.C. | 718,202 | $47.7M | 0.08% | −374,060−34.2% | Reduced |
| Lynx1 Capital Management LP | 700,014 | $46.5M | 9.47% | −33,000−4.5% | Reduced |
| Northern Trust Corp | 603,222 | $40.1M | 0.01% | −11,844−1.9% | Reduced |
| American Century Companies Inc | 600,047 | $39.9M | 0.02% | −213,948−26.3% | Reduced |
| Charles Schwab Investment Management Inc | 552,877 | $36.7M | 0.01% | −22,487−3.9% | Reduced |
| FMR LLC | 520,664 | $34.6M | 0.00% | −17,768−3.3% | Reduced |
| Mangrove Partners | 478,413 | $31.8M | 2.64% | +83,030+21.0% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 451,766 | $30.0M | 0.08% | +5,740+1.3% | Added |
| Colony Group, LLC | 448,988 | $29.8M | 0.05% | +448,988 | New |
| Toronto Dominion Bank | 445,440 | $29.6M | 0.06% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 438,515 | $29.1M | 0.01% | +258,465+143.6% | Added |
| 683 Capital Management, LLC | 407,500 | $27.1M | 2.46% | −37,500−8.4% | Reduced |
| Bank of New York Mellon Corp | 363,261 | $24.1M | 0.00% | −24,821−6.4% | Reduced |
| Principal Financial Group Inc | 326,088 | $21.7M | 0.01% | −4,046−1.2% | Reduced |
| Voya Investment Management LLC | 305,419 | $20.3M | 0.02% | +25,065+8.9% | Added |
| Logos Global Management LP | 300,000 | $19.9M | 1.97% | +300,000 | New |
| Raymond James Financial Inc | 294,296 | $19.6M | 0.01% | −17,690−5.7% | Reduced |
| Alliancebernstein L.P. | 260,854 | $17.3M | 0.01% | +192,954+284.2% | Added |
| JPMorgan Chase & Co | 252,400 | $16.8M | 0.00% | −193,292−43.4% | Reduced |
| Citadel Advisors LLC | 237,881 | $15.8M | 0.01% | +210,680+774.5% | Added |
| Public Sector Pension Investment Board | 228,146 | $15.2M | 0.06% | +16,865+8.0% | Added |
| Affinity Asset Advisors, LLC | 220,600 | $14.7M | 1.36% | −219,400−49.9% | Reduced |
| Kennedy Capital Management, Inc. | 208,437 | $13.8M | 0.31% | +73,547+54.5% | Added |
| Barclays PLC | 171,406 | $11.4M | 0.00% | −40,706−19.2% | Reduced |
| Rhumbline Advisers | 163,980 | $10.9M | 0.01% | −9,048−5.2% | Reduced |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 159,700 | $10.6M | 0.27% | +159,700 | New |
| Legal & General Group Plc | 155,829 | $10.4M | 0.00% | −10,352−6.2% | Reduced |
| Ameriprise Financial Inc | 153,191 | $10.2M | 0.00% | −15,180−9.0% | Reduced |
| Citigroup Inc | 152,580 | $10.1M | 0.01% | +74,629+95.7% | Added |
| TD Asset Management Inc | 150,428 | $9.99M | 0.01% | +34,096+29.3% | Added |
| Panagora Asset Management Inc | 148,729 | $9.88M | 0.04% | −610.0% | Reduced |
| Nan Fung Trinity (HK) Ltd | 144,892 | $9.63M | 0.96% | +9,842+7.3% | Added |
| Moody Aldrich Partners LLC | 143,060 | $9.50M | 1.80% | −27,510−16.1% | Reduced |
| Manufacturers Life Insurance Company, The | 135,096 | $8.97M | 0.01% | +40,295+42.5% | Added |
| Nuveen, LLC | 128,384 | $8.53M | 0.00% | −1,127−0.9% | Reduced |
| Millennium Management LLC | 127,560 | $8.47M | 0.01% | +112,369+739.7% | Added |
| Prudential Financial Inc | 126,403 | $8.40M | 0.01% | +48,995+63.3% | Added |
| ExodusPoint Capital Management, LP | 124,929 | $8.30M | 0.12% | +124,929 | New |
| Neuberger Berman Group LLC | 123,377 | $8.20M | 0.01% | +29,795+31.8% | Added |
| Segall Bryant & Hamill, LLC | 123,125 | $8.18M | 0.11% | +2,966+2.5% | Added |
| HighVista Strategies LLC | 121,682 | $8.08M | 1.98% | +63,831+110.3% | Added |
| Deutsche Bank AG | 117,212 | $7.79M | 0.00% | +6,048+5.4% | Added |
| UBS Asset Management Americas Inc | 110,229 | $7.32M | 0.00% | −133,144−54.7% | Reduced |
| Boxer Capital Management, LLC | 110,000 | $7.31M | 2.33% | +50,000+83.3% | Added |
| Opaleye Management Inc. | 105,000 | $6.98M | 0.99% | 00.0% | Unchanged |
| Swiss National Bank | 96,100 | $6.38M | 0.00% | +2,300+2.5% | Added |
| Schonfeld Strategic Advisors LLC | 95,190 | $6.32M | 0.04% | +18,122+23.5% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 90,317 | $6.00M | 0.01% | +49,833+123.1% | Added |
| Great Lakes Advisors, LLC | 89,171 | $5.92M | 0.05% | −50,220−36.0% | Reduced |
| Victory Capital Management Inc | 85,494 | $5.68M | 0.00% | −5,438−6.0% | Reduced |
| Knott David M Jr | 83,000 | $5.51M | 2.31% | +3,000+3.8% | Added |
| Atika Capital Management LLC | 83,000 | $5.51M | 0.47% | +83,000 | New |
| Franklin Resources Inc | 82,918 | $5.51M | 0.00% | +339+0.4% | Added |
| EFG Asset Management (North America) Corp. | 82,639 | $5.49M | 0.71% | +913+1.1% | Added |
| Axiom Investors LLC | 80,113 | $5.32M | 0.04% | +28,880+56.4% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 78,796 | $5.23M | 0.02% | −3,954−4.8% | Reduced |
| EAM Investors, LLC | 80,067 | $5.23M | 0.60% | +8,096+11.2% | Added |
| Rafferty Asset Management, LLC | 74,827 | $4.97M | 0.02% | −5,716−7.1% | Reduced |
| Royal Bank of Canada | 69,996 | $4.65M | 0.00% | −4,738−6.3% | Reduced |
| Assenagon Asset Management S.A. | 65,756 | $4.37M | 0.01% | −26,119−28.4% | Reduced |
| Susquehanna International Group, LLP | 63,188 | $4.20M | 0.01% | −8,053−11.3% | Reduced |
| First Trust Advisors LP | 62,724 | $4.17M | 0.00% | −51,183−44.9% | Reduced |
| Parkman Healthcare Partners LLC | 61,849 | $4.11M | 0.45% | +253+0.4% | Added |
| Northwestern Mutual Wealth Management Co | 58,894 | $3.91M | 0.00% | −20,000−25.4% | Reduced |
| Silvercrest Asset Management Group LLC | 53,217 | $3.54M | 0.02% | −1,506−2.8% | Reduced |
| Diadema Partners LP | 51,185 | $3.40M | 2.37% | −25,000−32.8% | Reduced |
| New York State Teachers Retirement System | 49,550 | $3.29M | 0.01% | −6,163−11.1% | Reduced |
| Birchview Capital, LP | 48,000 | $3.19M | 2.41% | 00.0% | Unchanged |
| StemPoint Capital LP | 47,954 | $3.19M | 0.64% | +31,184+186.0% | Added |
| Wells Fargo & Company | 47,794 | $3.17M | 0.00% | +6,107+14.6% | Added |
| California State Teachers Retirement System | 47,437 | $3.15M | 0.00% | −3,758−7.3% | Reduced |
| Great West Life Assurance Co | 48,407 | $3.15M | 0.00% | −1,835−3.7% | Reduced |
| Jane Street Group, LLC | 44,339 | $2.95M | 0.00% | +44,339 | New |
| SEI Investments Co | 44,011 | $2.92M | 0.00% | −921−2.0% | Reduced |
| Thrivent Financial for Lutherans | 42,188 | $2.80M | 0.01% | −3,388−7.4% | Reduced |