Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 275
- +38 vs. Q4 2024
- Shares held
- 65.3M
- +2.28M (+3.6%) vs. Q4 2024
- Total value
- $3.15B
- +$716.0M (+29.4%) vs. Q4 2024
- New holders
- 72
- 86 more added
- Sold out
- 34
- 90 more reduced
4 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9,736,767 | $470.9M | 0.01% | −147,850−1.5% | Reduced |
| Farallon Capital Management, L.L.C. | 6,107,006 | $295.3M | 1.59% | +177,000+3.0% | Added |
| RTW Investments, LP | 5,719,415 | $276.6M | 4.23% | +220,870+4.0% | Added |
| Vanguard Group Inc | 4,277,218 | $206.8M | 0.00% | +57,181+1.4% | Added |
| Deep Track Capital, LP | 3,000,000 | $145.1M | 4.70% | +2,000,000+200.0% | Added |
| State Street Corp | 2,706,619 | $130.9M | 0.01% | −624,442−18.7% | Reduced |
| BVF Inc | 2,575,015 | $124.5M | 5.08% | +675,000+35.5% | Added |
| Johnson & Johnson | 2,449,183 | $118.4M | 34.65% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 1,423,559 | $68.9M | 0.01% | +46,496+3.4% | Added |
| Price T Rowe Associates Inc | 1,322,006 | $63.9M | 0.01% | −70,646−5.1% | Reduced |
| Perceptive Advisors LLC | 1,091,271 | $52.8M | 1.87% | −180,391−14.2% | Reduced |
| Wellington Management Group LLP | 987,370 | $47.7M | 0.01% | +47,293+5.0% | Added |
| ADAR1 Capital Management, LLC | 939,669 | $45.4M | 8.74% | −80,664−7.9% | Reduced |
| Woodline Partners LP | 897,699 | $43.4M | 0.28% | +315,372+54.2% | Added |
| Invesco Ltd. | 859,648 | $41.6M | 0.01% | +120,696+16.3% | Added |
| Lynx1 Capital Management LP | 733,014 | $35.4M | 12.69% | +733,014 | New |
| American Century Companies Inc | 685,824 | $33.2M | 0.02% | −242,462−26.1% | Reduced |
| Northern Trust Corp | 639,507 | $30.9M | 0.00% | +10,927+1.7% | Added |
| Jefferies Financial Group Inc. | 631,893 | $30.6M | 0.53% | −857,602−57.6% | Reduced |
| Charles Schwab Investment Management Inc | 557,718 | $27.0M | 0.01% | −20,691−3.6% | Reduced |
| Goldman Sachs Group Inc | 555,551 | $26.9M | 0.01% | −203,139−26.8% | Reduced |
| Eversept Partners, LP | 547,116 | $26.5M | 2.99% | −131,671−19.4% | Reduced |
| 683 Capital Management, LLC | 500,000 | $24.2M | 2.45% | +90,000+22.0% | Added |
| Morgan Stanley | 497,105 | $24.0M | 0.00% | −43,210−8.0% | Reduced |
| FMR LLC | 478,343 | $23.1M | 0.00% | +35,827+8.1% | Added |
| Bank of America Corp | 471,745 | $22.8M | 0.00% | +336,873+249.8% | Added |
| JPMorgan Chase & Co | 468,899 | $22.7M | 0.00% | −108,078−18.7% | Reduced |
| Toronto Dominion Bank | 445,440 | $21.5M | 0.06% | +104,466+30.6% | Added |
| Colony Group, LLC | 435,097 | $21.0M | 0.05% | +9,540+2.2% | Added |
| Affinity Asset Advisors, LLC | 400,000 | $19.3M | 3.03% | +270,000+207.7% | Added |
| Mangrove Partners | 395,383 | $19.1M | 2.16% | 00.0% | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 379,649 | $18.4M | 0.05% | +253,751+201.6% | Added |
| Bank of New York Mellon Corp | 376,863 | $18.2M | 0.00% | −13,925−3.6% | Reduced |
| UBS Group AG | 352,871 | $17.1M | 0.00% | +220,262+166.1% | Added |
| Principal Financial Group Inc | 347,095 | $16.8M | 0.01% | +9,286+2.7% | Added |
| Adage Capital Partners GP, L.L.C. | 343,504 | $16.6M | 0.03% | +343,504 | New |
| Qube Research & Technologies Ltd | 343,411 | $16.6M | 0.03% | +31,092+10.0% | Added |
| Artia Global Partners LP | 333,851 | $16.1M | 4.73% | +40,000+13.6% | Added |
| Renaissance Technologies LLC | 323,567 | $15.6M | 0.02% | +102,400+46.3% | Added |
| Raymond James Financial Inc | 298,827 | $14.5M | 0.01% | −4,486−1.5% | Reduced |
| Pictet Asset Management Holding SA | 295,593 | $14.3M | 0.02% | −918−0.3% | Reduced |
| Schonfeld Strategic Advisors LLC | 287,301 | $13.9M | 0.09% | +287,301 | New |
| Skandinaviska Enskilda Banken AB (publ) | 248,950 | $12.0M | 0.06% | −61,700−19.9% | Reduced |
| Driehaus Capital Management LLC | 235,073 | $11.4M | 0.11% | −104,625−30.8% | Reduced |
| UBS Asset Management Americas Inc | 208,756 | $10.1M | 0.00% | −79,155−27.5% | Reduced |
| Burney Co | 201,985 | $9.77M | 0.36% | +201,985 | New |
| Jane Street Group, LLC | 193,300 | $9.35M | 0.02% | +131,749+214.0% | Added |
| Susquehanna International Group, LLP | 192,239 | $9.30M | 0.02% | +122,302+174.9% | Added |
| Public Sector Pension Investment Board | 189,031 | $9.14M | 0.04% | +40,542+27.3% | Added |
| Checkpoint Capital L.P. | 175,184 | $8.47M | 4.65% | +175,184 | New |
| TD Asset Management Inc | 169,932 | $8.22M | 0.01% | −3,770−2.2% | Reduced |
| Soleus Capital Management, L.P. | 169,000 | $8.17M | 0.64% | −106,000−38.5% | Reduced |
| Jupiter Asset Management Ltd | 168,063 | $8.13M | 0.08% | +168,063 | New |
| Moody Aldrich Partners LLC | 163,483 | $7.91M | 1.66% | +96,068+142.5% | Added |
| Rhumbline Advisers | 162,065 | $7.84M | 0.01% | +101+0.1% | Added |
| Citadel Advisors LLC | 154,067 | $7.45M | 0.01% | −10,079−6.1% | Reduced |
| Nuveen, LLC | 152,771 | $7.39M | 0.00% | +152,771 | New |
| Great Lakes Advisors, LLC | 152,318 | $7.37M | 0.07% | +90,371+145.9% | Added |
| Panagora Asset Management Inc | 149,908 | $7.25M | 0.04% | +149,908 | New |
| New Vernon Capital Holdings II LLC | 348,095 | $7.20M | 0.17% | +345,034+11,271.9% | Added |
| Legal & General Group Plc | 148,107 | $7.16M | 0.00% | −4,455−2.9% | Reduced |
| Kennedy Capital Management, Inc. | 137,504 | $6.65M | 0.16% | −184,022−57.2% | Reduced |
| Ameriprise Financial Inc | 136,842 | $6.62M | 0.00% | −4,545−3.2% | Reduced |
| Millennium Management LLC | 134,269 | $6.49M | 0.01% | +134,269 | New |
| Jacobs Levy Equity Management, Inc | 128,654 | $6.22M | 0.02% | 00.0% | Unchanged |
| Man Group plc | 128,606 | $6.22M | 0.02% | −29,357−18.6% | Reduced |
| Citigroup Inc | 121,844 | $5.89M | 0.00% | +822+0.7% | Added |
| Dimensional Fund Advisors LP | 121,554 | $5.88M | 0.00% | −104,046−46.1% | Reduced |
| Nan Fung Group Holdings Ltd | 121,400 | $5.87M | 4.79% | +121,400 | New |
| Manufacturers Life Insurance Company, The | 120,850 | $5.84M | 0.01% | −3,491−2.8% | Reduced |
| Barclays PLC | 111,432 | $5.39M | 0.00% | −15,301−12.1% | Reduced |
| Opaleye Management Inc. | 105,000 | $5.08M | 1.13% | 00.0% | Unchanged |
| Trexquant Investment LP | 103,983 | $5.03M | 0.06% | +11,195+12.1% | Added |
| Empowered Funds, LLC | 102,532 | $4.96M | 0.07% | +102,532 | New |
| Victory Capital Management Inc | 102,411 | $4.95M | 0.01% | −138,406−57.5% | Reduced |
| Lazard Asset Management LLC | 96,420 | $4.66M | 0.01% | +96,420 | New |
| Swiss National Bank | 86,900 | $4.20M | 0.00% | 00.0% | Unchanged |
| Aquilo Capital Management, LLC | 81,692 | $3.95M | 10.65% | +5,100+6.7% | Added |
| First Trust Advisors LP | 81,686 | $3.95M | 0.00% | −59,265−42.0% | Reduced |
| Franklin Resources Inc | 79,044 | $3.82M | 0.00% | −9,826−11.1% | Reduced |
| Northwestern Mutual Wealth Management Co | 78,894 | $3.82M | 0.00% | 00.0% | Unchanged |
| HighVista Strategies LLC | 78,452 | $3.79M | 1.46% | +15,934+25.5% | Added |
| Knott David M Jr | 76,000 | $3.68M | 1.73% | +23,632+45.1% | Added |
| EFG Asset Management (North America) Corp. | 71,134 | $3.44M | 0.57% | +71,134 | New |
| EAM Global Investors LLC | 69,750 | $3.37M | 0.92% | +69,750 | New |
| HRT Financial LP | 69,242 | $3.35M | 0.02% | +61,217+762.8% | Added |
| EAM Investors, LLC | 69,181 | $3.35M | 0.58% | +69,181 | New |
| Alliancebernstein L.P. | 67,900 | $3.28M | 0.00% | −325−0.5% | Reduced |
| Deutsche Bank AG | 65,695 | $3.18M | 0.00% | −72,237−52.4% | Reduced |
| J. Goldman & Co LP | 65,244 | $3.16M | 0.11% | +65,244 | New |
| Voya Investment Management LLC | 59,678 | $2.89M | 0.00% | −22,949−27.8% | Reduced |
| BCJ Capital Management, LLC | 58,413 | $2.82M | 0.20% | +58,413 | New |
| Prudential Financial Inc | 58,358 | $2.82M | 0.00% | −1,640−2.7% | Reduced |
| Jump Financial, LLC | 56,780 | $2.75M | 0.04% | +56,780 | New |
| Silvercrest Asset Management Group LLC | 54,723 | $2.65M | 0.02% | −29,703−35.2% | Reduced |
| State of Wisconsin Investment Board | 53,740 | $2.60M | 0.01% | +2,958+5.8% | Added |
| State of New Jersey Common Pension Fund D | 53,736 | $2.60M | 0.01% | +53,736 | New |
| Alps Advisors Inc | 52,974 | $2.56M | 0.01% | −2,967−5.3% | Reduced |
| Hussman Strategic Advisors, Inc. | 52,500 | $2.54M | 0.62% | −52,500−50.0% | Reduced |
| Great West Life Assurance Co | 50,955 | $2.46M | 0.00% | −5,581−9.9% | Reduced |