Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 275
- +38 vs. Q4 2024
- Shares held
- 65.3M
- +2.28M (+3.6%) vs. Q4 2024
- Total value
- $3.15B
- +$716.0M (+29.4%) vs. Q4 2024
- New holders
- 72
- 86 more added
- Sold out
- 34
- 90 more reduced
4 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| StemPoint Capital LP | 49,241 | $2.38M | 0.76% | −92,473−65.3% | Reduced |
| Birchview Capital, LP | 48,002 | $2.32M | 2.02% | +20.0% | Added |
| D. E. Shaw & Co., Inc. | 47,361 | $2.29M | 0.00% | +41,657+730.3% | Added |
| New York State Teachers Retirement System | 46,855 | $2.27M | 0.01% | +22,263+90.5% | Added |
| Assenagon Asset Management S.A. | 44,872 | $2.17M | 0.00% | −7,367−14.1% | Reduced |
| Rafferty Asset Management, LLC | 44,257 | $2.14M | 0.01% | −51,210−53.6% | Reduced |
| Thrivent Financial for Lutherans | 43,776 | $2.12M | 0.00% | −2,290−5.0% | Reduced |
| Tudor Investment Corp Et Al | 42,583 | $2.06M | 0.02% | +42,583 | New |
| California State Teachers Retirement System | 41,856 | $2.02M | 0.00% | −493−1.2% | Reduced |
| AQR Capital Management LLC | 40,087 | $1.94M | 0.00% | −110,010−73.3% | Reduced |
| Axiom Investors LLC | 39,969 | $1.93M | 0.02% | +39,969 | New |
| Wells Fargo & Company | 39,809 | $1.93M | 0.00% | +1,013+2.6% | Added |
| SEI Investments Co | 37,528 | $1.81M | 0.00% | +12,960+52.8% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 37,403 | $1.81M | 0.00% | +348+0.9% | Added |
| MetLife Investment Management | 34,790 | $1.68M | 0.01% | −1,008−2.8% | Reduced |
| State of Alaska, Department of Revenue | 33,023 | $1.60M | 0.02% | −848−2.5% | Reduced |
| Massachusetts Financial Services Co | 31,726 | $1.53M | 0.00% | −723−2.2% | Reduced |
| Corebridge Financial, Inc. | 31,020 | $1.50M | 0.01% | −135−0.4% | Reduced |
| Intech Investment Management LLC | 30,982 | $1.50M | 0.02% | −498−1.6% | Reduced |
| Louisiana State Employees Retirement System | 28,100 | $1.36M | 0.03% | −700−2.4% | Reduced |
| Exchange Traded Concepts, LLC | 27,392 | $1.32M | 0.02% | +26,367+2,572.4% | Added |
| Ensign Peak Advisors, Inc | 27,036 | $1.31M | 0.00% | 00.0% | Unchanged |
| State of Tennessee, Treasury Department | 26,485 | $1.28M | 0.00% | −591−2.2% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 26,066 | $1.26M | 0.06% | −6,008−18.7% | Reduced |
| Quadrature Capital Ltd | 26,061 | $1.26M | 0.03% | +26,061 | New |
| Simplex Trading, LLC | 25,934 | $1.25M | 0.04% | +20,447+372.6% | Added |
| Jain Global LLC | 24,867 | $1.20M | 0.02% | +24,867 | New |
| Gotham Asset Management, LLC | 23,072 | $1.12M | 0.01% | +23,072 | New |
| Mackenzie Financial Corp | 22,698 | $1.10M | 0.00% | +1,349+6.3% | Added |
| Yousif Capital Management, LLC | 22,337 | $1.08M | 0.01% | −581−2.5% | Reduced |
| CWM Advisors, LLC | 21,834 | $1.06M | 0.13% | +11,279+106.9% | Added |
| Janus Henderson Group PLC | 21,454 | $1.05M | 0.00% | 00.0% | Unchanged |
| Winton Group Ltd | 20,795 | $1.01M | 0.06% | −5,973−22.3% | Reduced |
| Glenmede Trust Co NA | 20,666 | $999.4K | 0.01% | +11,713+130.8% | Added |
| Comerica Bank | 20,241 | $978.9K | 0.00% | −317−1.5% | Reduced |
| Teachers Retirement System of the State of Kentucky | 20,200 | $977.0K | 0.01% | 00.0% | Unchanged |
| Y-Intercept (Hong Kong) Ltd | 20,169 | $975.4K | 0.07% | +20,169 | New |
| Verition Fund Management LLC | 19,847 | $959.8K | 0.01% | +19,847 | New |
| Coppell Advisory Solutions LLC | 20,765 | $947.3K | 0.14% | +20,765 | New |
| New York State Common Retirement Fund | 19,582 | $947.0K | 0.00% | +1,700+9.5% | Added |
| Illinois Municipal Retirement Fund | 19,509 | $943.5K | 0.01% | −14,000−41.8% | Reduced |
| Toroso Investments, LLC | 19,410 | $938.7K | 0.01% | −1,602−7.6% | Reduced |
| Campbell & CO Investment Adviser LLC | 19,015 | $919.6K | 0.07% | +19,015 | New |
| STRS Ohio | 19,000 | $918.8K | 0.00% | −4,500−19.1% | Reduced |
| Guggenheim Capital LLC | 18,905 | $914.2K | 0.01% | −173−0.9% | Reduced |
| China Universal Asset Management Co., Ltd. | 18,772 | $907.8K | 0.08% | +6,135+48.5% | Added |
| Algert Global LLC | 18,665 | $902.6K | 0.02% | +945+5.3% | Added |
| Jennison Associates LLC | 18,317 | $885.8K | 0.00% | +18,317 | New |
| Scientech Research LLC | 18,271 | $883.6K | 0.23% | +6,217+51.6% | Added |
| Bellevue Group AG | 17,622 | $852.2K | 0.02% | −6,096−25.7% | Reduced |
| Virginia Retirement Systems Et Al | 17,600 | $851.1K | 0.01% | +17,600 | New |
| Maryland State Retirement & Pension System | 17,398 | $841.4K | 0.02% | −2,772−13.7% | Reduced |
| Creative Planning | 17,333 | $838.2K | 0.00% | +10,885+168.8% | Added |
| Amalgamated Bank | 16,938 | $819.0K | 0.01% | −467−2.7% | Reduced |
| ProShare Advisors LLC | 16,758 | $810.4K | 0.00% | −3,699−18.1% | Reduced |
| Envestnet Asset Management Inc | 16,679 | $806.6K | 0.00% | +7,698+85.7% | Added |
| Mariner, LLC | 16,631 | $804.3K | 0.00% | −1,352−7.5% | Reduced |
| State Board of Administration of Florida Retirement System | 16,303 | $788.4K | 0.00% | 00.0% | Unchanged |
| Brevan Howard Capital Management LP | 16,114 | $779.3K | 0.02% | +16,114 | New |
| DekaBank Deutsche Girozentrale | 15,800 | $771.0K | 0.00% | 00.0% | Unchanged |
| Harvest Investment Services, LLC | 15,911 | $769.5K | 0.22% | +15,911 | New |
| Moran Wealth Management, LLC | 15,895 | $768.7K | 0.03% | −66−0.4% | Reduced |
| Engineers Gate Manager LP | 15,327 | $741.2K | 0.01% | +15,327 | New |
| Aquatic Capital Management LLC | 15,107 | $730.6K | 0.02% | +15,107 | New |
| Handelsbanken Fonder AB | 14,400 | $696.0K | 0.00% | −3,200−18.2% | Reduced |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 14,262 | $689.7K | 0.00% | +1,539+12.1% | Added |
| XTX Topco Ltd | 14,257 | $689.5K | 0.04% | +7,513+111.4% | Added |
| BNP Paribas Arbitrage, SA | 14,169 | $685.2K | 0.00% | −5,296−27.2% | Reduced |
| Oregon Public Employees Retirement Fund | 13,700 | $662.5K | 0.01% | −300−2.1% | Reduced |
| Erste Asset Management GmbH | 13,500 | $659.9K | 0.01% | 00.0% | Unchanged |
| UBS Oconnor LLC | 13,340 | $645.1K | 0.02% | +13,340 | New |
| Aviva PLC | 13,200 | $638.4K | 0.00% | −1,427−9.8% | Reduced |
| CIBC World Markets Corp | 13,178 | $637.3K | 0.01% | +7,710+141.0% | Added |
| Police & Firemen's Retirement System of New Jersey | 12,928 | $625.2K | 0.01% | +487+3.9% | Added |
| Springhill Fund Asset Management (HK) Co Ltd | 12,859 | $621.9K | 2.98% | +12,859 | New |
| Arizona State Retirement System | 12,801 | $619.1K | 0.00% | −40.0% | Reduced |
| Royce & Associates LP | 12,255 | $592.7K | 0.01% | +12,255 | New |
| Teacher Retirement System of Texas | 12,025 | $581.5K | 0.00% | −1,074−8.2% | Reduced |
| Gsa Capital Partners LLP | 11,963 | $579.0K | 0.05% | +11,963 | New |
| Profund Advisors LLC | 11,559 | $559.0K | 0.02% | −9,090−44.0% | Reduced |
| Franklin Street Advisors Inc | 11,300 | $546.0K | 0.04% | 00.0% | Unchanged |
| Magnetar Financial LLC | 11,154 | $539.4K | 0.01% | +11,154 | New |
| Cache Advisors, LLC | 10,143 | $490.5K | 0.19% | 00.0% | Unchanged |
| Royal Bank of Canada | 9,964 | $482.0K | 0.00% | +2,334+30.6% | Added |
| Cerity Partners LLC | 9,245 | $447.1K | 0.00% | −3,811−29.2% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,092 | $439.7K | 0.00% | −610−6.3% | Reduced |
| Cambria Investment Management, L.P. | 9,000 | $435.2K | 0.03% | −1,575−14.9% | Reduced |
| Bank of Montreal | 8,936 | $432.1K | 0.00% | +2,686+43.0% | Added |
| Quantessence Capital LLC | 8,900 | $430.4K | 0.11% | +8,900 | New |
| KLP Kapitalforvaltning AS | 8,700 | $420.7K | 0.00% | 00.0% | Unchanged |
| Mutual of America Capital Management LLC | 8,679 | $419.7K | 0.00% | −348−3.9% | Reduced |
| Advantage Alpha Capital Partners LP | 8,634 | $417.5K | 0.10% | +2,892+50.4% | Added |
| HSBC Holdings PLC | 8,458 | $404.9K | 0.00% | +330+4.1% | Added |
| Occudo Quantitative Strategies LP | 8,281 | $404.8K | 0.05% | +8,281 | New |
| Landscape Capital Management, L.L.C. | 7,758 | $375.2K | 0.03% | +7,758 | New |
| Capula Management Ltd | 7,684 | $371.6K | 0.00% | +7,684 | New |
| Fred Alger Management, LLC | 7,477 | $361.6K | 0.00% | +7,477 | New |
| Brinker Capital Investments, LLC | 6,731 | $325.5K | 0.00% | +6,731 | New |
| Orion Portfolio Solutions, LLC | 6,731 | $325.5K | 0.00% | +6,731 | New |
| HighTower Advisors, LLC | 6,518 | $315.2K | 0.00% | +6,518 | New |