Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Protagonist Therapeutics, Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 274
- +3 vs. Q1 2025
- Shares held
- 71.0M
- +5.66M (+8.7%) vs. Q1 2025
- Total value
- $3.92B
- +$774.8M (+24.6%) vs. Q1 2025
- New holders
- 52
- 120 more added
- Sold out
- 49
- 76 more reduced
4 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9,630,341 | $532.3M | 0.01% | −106,426−1.1% | Reduced |
| Farallon Capital Management, L.L.C. | 6,172,006 | $341.1M | 1.56% | +65,000+1.1% | Added |
| RTW Investments, LP | 5,756,277 | $318.1M | 4.53% | +36,862+0.6% | Added |
| Vanguard Group Inc | 4,358,595 | $240.9M | 0.00% | +81,377+1.9% | Added |
| Deep Track Capital, LP | 3,245,899 | $179.4M | 5.77% | +245,899+8.2% | Added |
| BVF Inc | 3,211,041 | $177.5M | 6.34% | +636,026+24.7% | Added |
| State Street Corp | 3,207,543 | $177.3M | 0.01% | +500,924+18.5% | Added |
| UBS Group AG | 2,501,251 | $138.2M | 0.03% | +2,148,380+608.8% | Added |
| Johnson & Johnson | 2,449,183 | $136.4M | 40.83% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 1,444,230 | $79.8M | 0.01% | +20,671+1.5% | Added |
| Adage Capital Partners GP, L.L.C. | 1,092,262 | $60.4M | 0.10% | +748,758+218.0% | Added |
| Commodore Capital LP | 1,075,000 | $59.4M | 4.19% | +1,075,000 | New |
| Perceptive Advisors LLC | 1,074,448 | $59.4M | 2.23% | −16,823−1.5% | Reduced |
| Wellington Management Group LLP | 1,037,738 | $57.4M | 0.01% | +50,368+5.1% | Added |
| ADAR1 Capital Management, LLC | 948,069 | $52.4M | 8.51% | +8,400+0.9% | Added |
| Woodline Partners LP | 946,884 | $52.3M | 0.28% | +49,185+5.5% | Added |
| Price T Rowe Associates Inc | 936,703 | $51.8M | 0.01% | −385,303−29.1% | Reduced |
| Morgan Stanley | 868,963 | $48.0M | 0.00% | +371,858+74.8% | Added |
| Bank of America Corp | 851,832 | $47.1M | 0.00% | +380,087+80.6% | Added |
| Jefferies Financial Group Inc. | 824,019 | $45.5M | 0.75% | +192,126+30.4% | Added |
| American Century Companies Inc | 813,995 | $45.0M | 0.02% | +128,171+18.7% | Added |
| Goldman Sachs Group Inc | 777,307 | $43.0M | 0.01% | +221,756+39.9% | Added |
| Driehaus Capital Management LLC | 757,710 | $41.9M | 0.34% | +522,637+222.3% | Added |
| Pictet Asset Management Holding SA | 751,977 | $41.6M | 0.04% | +456,384+154.4% | Added |
| Lynx1 Capital Management LP | 733,014 | $40.5M | 11.70% | 00.0% | Unchanged |
| Invesco Ltd. | 721,680 | $39.9M | 0.01% | −137,968−16.0% | Reduced |
| Northern Trust Corp | 615,066 | $34.0M | 0.00% | −24,441−3.8% | Reduced |
| Charles Schwab Investment Management Inc | 575,364 | $31.8M | 0.01% | +17,646+3.2% | Added |
| FMR LLC | 538,432 | $29.8M | 0.00% | +60,089+12.6% | Added |
| Holocene Advisors, LP | 530,326 | $29.3M | 0.07% | +530,326 | New |
| Janus Henderson Group PLC | 446,828 | $24.7M | 0.01% | +425,374+1,982.7% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 446,026 | $24.7M | 0.06% | +66,377+17.5% | Added |
| JPMorgan Chase & Co | 445,692 | $24.6M | 0.00% | −23,207−4.9% | Reduced |
| Toronto Dominion Bank | 445,440 | $24.6M | 0.05% | 00.0% | Unchanged |
| 683 Capital Management, LLC | 445,000 | $24.6M | 2.49% | −55,000−11.0% | Reduced |
| Affinity Asset Advisors, LLC | 440,000 | $24.3M | 3.60% | +40,000+10.0% | Added |
| Jupiter Asset Management Ltd | 405,644 | $22.4M | 0.19% | +237,581+141.4% | Added |
| Mangrove Partners | 395,383 | $21.9M | 2.35% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 388,082 | $21.4M | 0.00% | +11,219+3.0% | Added |
| Principal Financial Group Inc | 330,134 | $18.2M | 0.01% | −16,961−4.9% | Reduced |
| Raymond James Financial Inc | 311,986 | $17.2M | 0.01% | +13,159+4.4% | Added |
| Voya Investment Management LLC | 280,354 | $15.5M | 0.02% | +220,676+369.8% | Added |
| Eversept Partners, LP | 277,316 | $15.3M | 1.54% | −269,800−49.3% | Reduced |
| UBS Asset Management Americas Inc | 243,373 | $13.5M | 0.00% | +34,617+16.6% | Added |
| Barclays PLC | 212,112 | $11.7M | 0.00% | +100,680+90.4% | Added |
| Public Sector Pension Investment Board | 211,281 | $11.7M | 0.05% | +22,250+11.8% | Added |
| Dimensional Fund Advisors LP | 180,050 | $9.95M | 0.00% | +58,496+48.1% | Added |
| Renaissance Technologies LLC | 173,134 | $9.57M | 0.01% | −150,433−46.5% | Reduced |
| Rhumbline Advisers | 173,028 | $9.56M | 0.01% | +10,963+6.8% | Added |
| Moody Aldrich Partners LLC | 170,570 | $9.43M | 1.82% | +7,087+4.3% | Added |
| Ameriprise Financial Inc | 168,371 | $9.31M | 0.00% | +31,529+23.0% | Added |
| Legal & General Group Plc | 166,181 | $9.18M | 0.00% | +18,074+12.2% | Added |
| Panagora Asset Management Inc | 148,790 | $8.22M | 0.04% | −1,118−0.7% | Reduced |
| Great Lakes Advisors, LLC | 139,391 | $7.70M | 0.06% | −12,927−8.5% | Reduced |
| Nan Fung Trinity (HK) Ltd | 135,050 | $7.46M | 0.89% | +135,050 | New |
| Kennedy Capital Management, Inc. | 134,890 | $7.46M | 0.18% | −2,614−1.9% | Reduced |
| Nuveen, LLC | 129,511 | $7.16M | 0.00% | −23,260−15.2% | Reduced |
| Segall Bryant & Hamill, LLC | 120,159 | $6.64M | 0.09% | +120,159 | New |
| TD Asset Management Inc | 116,332 | $6.43M | 0.01% | −53,600−31.5% | Reduced |
| Capitolis Liquid Global Markets LLC | 116,100 | $6.42M | 0.05% | +116,100 | New |
| First Trust Advisors LP | 113,907 | $6.30M | 0.01% | +32,221+39.4% | Added |
| Deutsche Bank AG | 111,164 | $6.14M | 0.00% | +45,469+69.2% | Added |
| Opaleye Management Inc. | 105,000 | $5.80M | 1.17% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 94,801 | $5.24M | 0.00% | −26,049−21.6% | Reduced |
| Swiss National Bank | 93,800 | $5.18M | 0.00% | +6,900+7.9% | Added |
| Neuberger Berman Group LLC | 93,582 | $5.17M | 0.00% | +93,582 | New |
| Assenagon Asset Management S.A. | 91,875 | $5.08M | 0.01% | +47,003+104.7% | Added |
| Victory Capital Management Inc | 90,932 | $5.03M | 0.00% | −11,479−11.2% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 82,750 | $4.57M | 0.02% | −166,200−66.8% | Reduced |
| Franklin Resources Inc | 82,579 | $4.56M | 0.00% | +3,535+4.5% | Added |
| EFG Asset Management (North America) Corp. | 81,726 | $4.52M | 0.64% | +10,592+14.9% | Added |
| Checkpoint Capital L.P. | 81,311 | $4.49M | 2.09% | −93,873−53.6% | Reduced |
| Rafferty Asset Management, LLC | 80,543 | $4.45M | 0.01% | +36,286+82.0% | Added |
| Knott David M Jr | 80,000 | $4.42M | 2.00% | +4,000+5.3% | Added |
| Northwestern Mutual Wealth Management Co | 78,894 | $4.36M | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 77,951 | $4.31M | 0.00% | −43,893−36.0% | Reduced |
| Prudential Financial Inc | 77,408 | $4.28M | 0.01% | +19,050+32.6% | Added |
| Schonfeld Strategic Advisors LLC | 77,068 | $4.26M | 0.03% | −210,233−73.2% | Reduced |
| Diadema Partners LP | 76,185 | $4.21M | 2.62% | +76,185 | New |
| Royal Bank of Canada | 74,734 | $4.13M | 0.00% | +64,770+650.0% | Added |
| EAM Investors, LLC | 71,971 | $3.98M | 0.60% | +2,790+4.0% | Added |
| Susquehanna International Group, LLP | 71,241 | $3.94M | 0.01% | −120,998−62.9% | Reduced |
| EAM Global Investors LLC | 69,726 | $3.85M | 1.00% | −240.0% | Reduced |
| Qube Research & Technologies Ltd | 68,983 | $3.81M | 0.01% | −274,428−79.9% | Reduced |
| Alliancebernstein L.P. | 67,900 | $3.75M | 0.00% | 00.0% | Unchanged |
| Parkman Healthcare Partners LLC | 61,596 | $3.40M | 0.39% | +61,596 | New |
| Boxer Capital Management, LLC | 60,000 | $3.32M | 1.67% | +60,000 | New |
| HighVista Strategies LLC | 57,851 | $3.20M | 1.17% | −20,601−26.3% | Reduced |
| New York State Teachers Retirement System | 55,713 | $3.08M | 0.01% | +8,858+18.9% | Added |
| Silvercrest Asset Management Group LLC | 54,723 | $3.02M | 0.02% | 00.0% | Unchanged |
| Axiom Investors LLC | 51,233 | $2.83M | 0.02% | +11,264+28.2% | Added |
| California State Teachers Retirement System | 51,195 | $2.83M | 0.00% | +9,339+22.3% | Added |
| Great West Life Assurance Co | 50,242 | $2.78M | 0.00% | −713−1.4% | Reduced |
| Capital Fund Management S.A. | 49,805 | $2.75M | 0.03% | +49,805 | New |
| Birchview Capital, LP | 48,000 | $2.65M | 2.63% | −20.0% | Reduced |
| Exchange Traded Concepts, LLC | 47,391 | $2.62M | 0.03% | +19,999+73.0% | Added |
| Thrivent Financial for Lutherans | 45,576 | $2.52M | 0.01% | +1,800+4.1% | Added |
| SEI Investments Co | 44,932 | $2.48M | 0.00% | +7,404+19.7% | Added |
| Natixis | 42,040 | $2.32M | 0.01% | +42,040 | New |
| Aquatic Capital Management LLC | 42,000 | $2.32M | 0.05% | +26,893+178.0% | Added |