Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 319
- +48 vs. Q3 2025
- Shares held
- 71.0M
- +458.8K (+0.7%) vs. Q3 2025
- Total value
- $6.18B
- +$1.49B (+31.8%) vs. Q3 2025
- New holders
- 84
- 99 more added
- Sold out
- 36
- 104 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9,715,999 | $848.6M | 0.01% | +311,767+3.3% | Added |
| Farallon Capital Management, L.L.C. | 6,144,006 | $536.6M | 2.79% | −52,000−0.8% | Reduced |
| Vanguard Group Inc | 5,413,690 | $472.8M | 0.01% | +1,156,461+27.2% | Added |
| RTW Investments, LP | 5,059,053 | $441.9M | 4.43% | −697,224−12.1% | Reduced |
| State Street Corp | 3,199,729 | $279.5M | 0.01% | +33,934+1.1% | Added |
| Wellington Management Group LLP | 3,171,423 | $277.0M | 0.05% | +1,262,977+66.2% | Added |
| UBS Group AG | 2,770,021 | $241.9M | 0.05% | +874,013+46.1% | Added |
| Janus Henderson Group PLC | 2,649,981 | $231.4M | 0.10% | +1,549,160+140.7% | Added |
| Johnson & Johnson | 2,449,183 | $213.9M | 38.54% | 00.0% | Unchanged |
| Invesco Ltd. | 1,567,840 | $136.9M | 0.01% | +564,134+56.2% | Added |
| Geode Capital Management, LLC | 1,452,928 | $126.9M | 0.01% | +36,282+2.6% | Added |
| Woodline Partners LP | 1,408,772 | $123.0M | 0.48% | −29,475−2.0% | Reduced |
| Price T Rowe Associates Inc | 1,400,738 | $122.3M | 0.01% | +180,302+14.8% | Added |
| Perceptive Advisors LLC | 1,350,425 | $117.9M | 2.16% | +320,291+31.1% | Added |
| Citadel Advisors LLC | 1,126,687 | $98.4M | 0.07% | +888,806+373.6% | Added |
| Driehaus Capital Management LLC | 1,099,170 | $96.0M | 0.65% | −40,684−3.6% | Reduced |
| ADAR1 Capital Management, LLC | 1,049,168 | $91.6M | 6.85% | +59,986+6.1% | Added |
| Marshall Wace, LLP | 1,024,925 | $89.5M | 0.09% | −60,639−5.6% | Reduced |
| Goldman Sachs Group Inc | 961,149 | $83.9M | 0.01% | +179,438+23.0% | Added |
| Morgan Stanley | 879,024 | $76.8M | 0.00% | +110,665+14.4% | Added |
| Bank of America Corp | 867,580 | $75.8M | 0.01% | +37,703+4.5% | Added |
| Northern Trust Corp | 575,118 | $50.2M | 0.01% | −28,104−4.7% | Reduced |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 571,825 | $49.9M | 4.43% | +571,825 | New |
| Charles Schwab Investment Management Inc | 556,762 | $48.6M | 0.01% | +3,885+0.7% | Added |
| FMR LLC | 539,878 | $47.2M | 0.00% | +19,214+3.7% | Added |
| American Century Companies Inc | 535,423 | $46.8M | 0.02% | −64,624−10.8% | Reduced |
| Pictet Asset Management Holding SA | 529,631 | $46.3M | 0.04% | −292,581−35.6% | Reduced |
| Clearbridge Investments, LLC | 489,842 | $42.8M | 0.03% | +489,842 | New |
| Commodore Capital LP | 450,000 | $39.3M | 2.62% | −575,000−56.1% | Reduced |
| Dimensional Fund Advisors LP | 414,415 | $36.2M | 0.01% | −24,100−5.5% | Reduced |
| 683 Capital Management, LLC | 380,669 | $33.2M | 2.76% | −26,831−6.6% | Reduced |
| Voya Investment Management LLC | 366,165 | $32.0M | 0.03% | +60,746+19.9% | Added |
| Bank of New York Mellon Corp | 350,388 | $30.6M | 0.01% | −12,873−3.5% | Reduced |
| Principal Financial Group Inc | 347,932 | $30.4M | 0.02% | +21,844+6.7% | Added |
| Jennison Associates LLC | 331,164 | $28.9M | 0.02% | +331,164 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 330,804 | $28.9M | 0.03% | −120,962−26.8% | Reduced |
| Adage Capital Partners GP, L.L.C. | 232,836 | $20.3M | 0.03% | −485,366−67.6% | Reduced |
| NEXTBio Capital Management LP | 229,619 | $20.1M | 11.76% | +229,619 | New |
| Kennedy Capital Management, Inc. | 221,444 | $19.3M | 0.41% | +13,007+6.2% | Added |
| Holocene Advisors, LP | 210,019 | $18.3M | 0.04% | +210,019 | New |
| Skandinaviska Enskilda Banken AB (publ) | 205,574 | $18.0M | 0.07% | +126,778+160.9% | Added |
| Public Sector Pension Investment Board | 203,426 | $17.8M | 0.06% | −24,720−10.8% | Reduced |
| Alyeska Investment Group, L.P. | 199,523 | $17.4M | 0.05% | +199,523 | New |
| MPM Oncology Impact Management LP | 199,471 | $17.4M | 1.99% | +199,471 | New |
| AIHC Capital Management Ltd | 189,823 | $16.6M | 15.54% | +189,823 | New |
| Barclays PLC | 187,642 | $16.4M | 0.01% | +16,236+9.5% | Added |
| Raymond James Financial Inc | 181,503 | $15.8M | 0.00% | −112,793−38.3% | Reduced |
| Nan Fung Trinity (HK) Ltd | 180,670 | $15.8M | 1.25% | +35,778+24.7% | Added |
| Affinity Asset Advisors, LLC | 172,125 | $15.0M | 1.08% | −48,475−22.0% | Reduced |
| Boxer Capital Management, LLC | 170,000 | $14.8M | 3.25% | +60,000+54.5% | Added |
| Ameriprise Financial Inc | 169,518 | $14.8M | 0.00% | +16,327+10.7% | Added |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 159,700 | $13.9M | 0.33% | 00.0% | Unchanged |
| TD Asset Management Inc | 158,730 | $13.9M | 0.01% | +8,302+5.5% | Added |
| JPMorgan Chase & Co | 155,300 | $13.6M | 0.00% | −97,100−38.5% | Reduced |
| Rhumbline Advisers | 154,950 | $13.5M | 0.01% | −9,030−5.5% | Reduced |
| Qube Research & Technologies Ltd | 153,876 | $13.4M | 0.02% | +153,876 | New |
| Legal & General Group Plc | 149,164 | $13.0M | 0.00% | −6,665−4.3% | Reduced |
| Segall Bryant & Hamill, LLC | 129,060 | $11.3M | 0.15% | +5,935+4.8% | Added |
| Nuveen, LLC | 125,861 | $11.0M | 0.00% | −2,523−2.0% | Reduced |
| Panagora Asset Management Inc | 125,384 | $11.0M | 0.04% | −23,345−15.7% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 114,036 | $9.96M | 0.02% | +23,719+26.3% | Added |
| Manufacturers Life Insurance Company, The | 113,340 | $9.89M | 0.01% | −21,756−16.1% | Reduced |
| Prudential Financial Inc | 110,360 | $9.64M | 0.01% | −16,043−12.7% | Reduced |
| Hudson Bay Capital Management LP | 109,615 | $9.57M | 0.05% | +109,615 | New |
| Deutsche Bank AG | 105,460 | $9.21M | 0.00% | −11,752−10.0% | Reduced |
| Opaleye Management Inc. | 105,000 | $9.17M | 1.21% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 104,528 | $9.13M | 0.00% | −5,701−5.2% | Reduced |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 100,000 | $8.73M | 0.12% | +100,000 | New |
| Neuberger Berman Group LLC | 98,473 | $8.60M | 0.01% | −24,904−20.2% | Reduced |
| Swiss National Bank | 98,200 | $8.58M | 0.01% | +2,100+2.2% | Added |
| BNP Paribas Arbitrage, SA | 97,764 | $8.54M | 0.01% | +84,627+644.2% | Added |
| Citigroup Inc | 94,909 | $8.29M | 0.01% | −57,671−37.8% | Reduced |
| Axiom Investors LLC | 89,468 | $7.81M | 0.07% | +9,355+11.7% | Added |
| Atika Capital Management LLC | 86,000 | $7.51M | 1.05% | +3,000+3.6% | Added |
| Moody Aldrich Partners LLC | 80,623 | $7.04M | 1.31% | −62,437−43.6% | Reduced |
| Victory Capital Management Inc | 80,571 | $7.04M | 0.00% | −4,923−5.8% | Reduced |
| EAM Investors, LLC | 78,498 | $6.86M | 0.76% | −1,569−2.0% | Reduced |
| Franklin Resources Inc | 76,442 | $6.68M | 0.00% | −6,476−7.8% | Reduced |
| Great Lakes Advisors, LLC | 73,966 | $6.46M | 0.05% | −15,205−17.1% | Reduced |
| HighVista Strategies LLC | 73,545 | $6.42M | 1.65% | −48,137−39.6% | Reduced |
| Alliancebernstein L.P. | 73,222 | $6.40M | 0.00% | −187,632−71.9% | Reduced |
| Knott David M Jr | 73,000 | $6.38M | 2.95% | −10,000−12.0% | Reduced |
| EFG International AG | 72,623 | $6.34M | 0.12% | +72,623 | New |
| Wells Fargo & Company | 71,645 | $6.26M | 0.00% | +23,851+49.9% | Added |
| Fisher Asset Management, LLC | 65,114 | $5.69M | 0.00% | +65,114 | New |
| Rafferty Asset Management, LLC | 63,661 | $5.56M | 0.02% | −11,166−14.9% | Reduced |
| StemPoint Capital LP | 59,430 | $5.19M | 0.89% | +11,476+23.9% | Added |
| Eagle Health Investments LP | 57,300 | $5.00M | 1.10% | +57,300 | New |
| Quinn Opportunity Partners LLC | 55,259 | $4.83M | 0.21% | +55,259 | New |
| Birchview Capital, LP | 55,000 | $4.80M | 2.81% | +7,000+14.6% | Added |
| Bessemer Group Inc | 54,162 | $4.73M | 0.01% | +49,887+1,166.9% | Added |
| Silvercrest Asset Management Group LLC | 53,217 | $4.65M | 0.03% | 00.0% | Unchanged |
| KVP Capital Advisors, LP | 53,000 | $4.63M | 4.78% | +53,000 | New |
| Eversept Partners, LP | 52,961 | $4.63M | 0.26% | +52,961 | New |
| Pentwater Capital Management LP | 50,000 | $4.37M | 0.03% | +50,000 | New |
| Great West Life Assurance Co | 49,640 | $4.33M | 0.01% | +1,233+2.5% | Added |
| New York State Teachers Retirement System | 49,350 | $4.31M | 0.01% | −200−0.4% | Reduced |
| Northwestern Mutual Wealth Management Co | 48,894 | $4.27M | 0.00% | −10,000−17.0% | Reduced |
| California State Teachers Retirement System | 48,033 | $4.20M | 0.00% | +596+1.3% | Added |
| First Trust Advisors LP | 46,454 | $4.06M | 0.00% | −16,270−25.9% | Reduced |