Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 319
- +48 vs. Q3 2025
- Shares held
- 71.0M
- +458.8K (+0.7%) vs. Q3 2025
- Total value
- $6.18B
- +$1.49B (+31.8%) vs. Q3 2025
- New holders
- 84
- 99 more added
- Sold out
- 36
- 104 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| J. Goldman & Co LP | 46,325 | $4.05M | 0.16% | +28,257+156.4% | Added |
| SummitTX Capital, L.P. | 42,266 | $3.69M | 0.11% | +10,776+34.2% | Added |
| Creative Planning | 41,254 | $3.60M | 0.00% | +5,040+13.9% | Added |
| Thrivent Financial for Lutherans | 40,380 | $3.53M | 0.01% | −1,808−4.3% | Reduced |
| LMR Partners LLP | 40,000 | $3.49M | 0.03% | +40,000 | New |
| State of Alaska, Department of Revenue | 38,099 | $3.33M | 0.04% | +8,674+29.5% | Added |
| Elmind Capital, LP | 38,000 | $3.32M | 0.98% | +38,000 | New |
| SEI Investments Co | 37,346 | $3.26M | 0.00% | −6,665−15.1% | Reduced |
| Aquatic Capital Management LLC | 36,615 | $3.20M | 0.09% | +36,615 | New |
| Exchange Traded Concepts, LLC | 35,039 | $3.06M | 0.03% | +1,487+4.4% | Added |
| State of Wisconsin Investment Board | 34,786 | $3.04M | 0.01% | −6,120−15.0% | Reduced |
| Jane Street Group, LLC | 34,307 | $3.00M | 0.00% | −10,032−22.6% | Reduced |
| Deeter Investments LLP | 300,000 | $2.87M | 0.62% | +300,000 | New |
| MetLife Investment Management | 32,440 | $2.83M | 0.01% | −1,406−4.2% | Reduced |
| Illinois Municipal Retirement Fund | 31,244 | $2.73M | 0.03% | −1,939−5.8% | Reduced |
| Guggenheim Capital LLC | 31,096 | $2.72M | 0.02% | +12,513+67.3% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 30,789 | $2.69M | 0.00% | −82−0.3% | Reduced |
| Louisiana State Employees Retirement System | 26,900 | $2.35M | 0.04% | 00.0% | Unchanged |
| Verition Fund Management LLC | 26,792 | $2.34M | 0.01% | +26,792 | New |
| Teachers Retirement System of the State of Kentucky | 26,528 | $2.32M | 0.02% | +9,232+53.4% | Added |
| Keystone Investors Pte Ltd | 26,390 | $2.30M | 0.21% | +26,390 | New |
| Parkman Healthcare Partners LLC | 25,973 | $2.27M | 0.22% | −35,876−58.0% | Reduced |
| Profund Advisors LLC | 25,574 | $2.23M | 0.07% | +7,417+40.8% | Added |
| Virginia Retirement Systems Et Al | 25,400 | $2.22M | 0.01% | +9,800+62.8% | Added |
| Artia Global Partners LP | 22,951 | $2.00M | 0.32% | 00.0% | Unchanged |
| Diadema Partners LP | 22,700 | $1.98M | 1.18% | −28,485−55.7% | Reduced |
| Intech Investment Management LLC | 22,485 | $1.96M | 0.02% | +842+3.9% | Added |
| State of Tennessee, Treasury Department | 23,526 | $1.92M | 0.01% | −2,964−11.2% | Reduced |
| OrbiMed Advisors LLC | 21,700 | $1.90M | 0.04% | +21,700 | New |
| Gotham Asset Management, LLC | 21,595 | $1.89M | 0.01% | −603−2.7% | Reduced |
| Campbell & CO Investment Adviser LLC | 21,054 | $1.84M | 0.09% | +21,054 | New |
| Natixis Advisors, L.P. | 20,495 | $1.79M | 0.00% | +3,640+21.6% | Added |
| Polen Capital Management LLC | 20,349 | $1.78M | 0.01% | +24+0.1% | Added |
| SG Americas Securities, LLC | 19,997 | $1.75M | 0.00% | −21,249−51.5% | Reduced |
| Handelsbanken Fonder AB | 19,900 | $1.74M | 0.01% | +1,000+5.3% | Added |
| New York State Common Retirement Fund | 18,382 | $1.61M | 0.00% | −1,200−6.1% | Reduced |
| Nomura Holdings Inc | 17,521 | $1.53M | 0.00% | +17,521 | New |
| Millennium Management LLC | 17,391 | $1.52M | 0.00% | −110,169−86.4% | Reduced |
| Headlands Technologies LLC | 17,079 | $1.49M | 0.12% | +17,079 | New |
| Amalgamated Bank | 17,063 | $1.49M | 0.01% | +237+1.4% | Added |
| Royce & Associates LP | 16,989 | $1.48M | 0.02% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 16,987 | $1.48M | 0.01% | −20,969−55.2% | Reduced |
| Bellevue Group AG | 16,543 | $1.44M | 0.03% | −4,038−19.6% | Reduced |
| Pathstone Holdings, LLC | 16,441 | $1.44M | 0.01% | +3,079+23.0% | Added |
| State Board of Administration of Florida Retirement System | 16,303 | $1.42M | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 15,900 | $1.39M | 0.01% | −1,900−10.7% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 15,834 | $1.38M | 0.01% | −285−1.8% | Reduced |
| Yousif Capital Management, LLC | 16,281 | $1.36M | 0.01% | −2,145−11.6% | Reduced |
| Envestnet Asset Management Inc | 14,673 | $1.28M | 0.00% | −9,585−39.5% | Reduced |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 14,548 | $1.27M | 0.01% | −345−2.3% | Reduced |
| ProShare Advisors LLC | 14,084 | $1.23M | 0.00% | +897+6.8% | Added |
| Arizona State Retirement System | 14,025 | $1.22M | 0.01% | −644−4.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 13,787 | $1.20M | 0.09% | −2,118−13.3% | Reduced |
| Erste Asset Management GmbH | 13,500 | $1.19M | 0.01% | 00.0% | Unchanged |
| Oregon Public Employees Retirement Fund | 13,393 | $1.17M | 0.01% | +193+1.5% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 13,270 | $1.16M | 0.00% | +13,270 | New |
| Comerica Bank | 13,005 | $1.14M | 0.00% | −3,390−20.7% | Reduced |
| Allianz Asset Management GmbH | 13,000 | $1.14M | 0.00% | −6,678−33.9% | Reduced |
| Jain Global LLC | 12,850 | $1.12M | 0.01% | −2,000−13.5% | Reduced |
| Glenmede Trust Co NA | 12,755 | $1.11M | 0.01% | +12,755 | New |
| Hussman Strategic Advisors, Inc. | 12,600 | $1.10M | 0.27% | −8,400−40.0% | Reduced |
| Susquehanna International Group, LLP | 11,762 | $1.03M | 0.00% | −51,426−81.4% | Reduced |
| Winton Group Ltd | 11,471 | $1.00M | 0.03% | −7,090−38.2% | Reduced |
| Franklin Street Advisors Inc | 11,300 | $986.9K | 0.06% | 00.0% | Unchanged |
| KLP Kapitalforvaltning AS | 10,600 | $925.8K | 0.00% | +200+1.9% | Added |
| Cache Advisors, LLC | 10,143 | $885.9K | 0.11% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,073 | $879.8K | 0.00% | 00.0% | Unchanged |
| Dymon Asia Capital (Singapore) Pte. Ltd. | 10,000 | $873.4K | 0.19% | +10,000 | New |
| Cerity Partners LLC | 9,049 | $790.3K | 0.00% | +431+5.0% | Added |
| FORA Capital, LLC | 9,130 | $788.4K | 0.10% | +5,445+147.8% | Added |
| Maryland State Retirement & Pension System | 8,603 | $751.4K | 0.02% | +196+2.3% | Added |
| AlphaCentric Advisors LLC | 8,549 | $746.7K | 0.74% | +8,549 | New |
| Bamco Inc | 8,300 | $724.9K | 0.00% | +8,300 | New |
| Renaissance Technologies LLC | 8,167 | $713.3K | 0.00% | +8,167 | New |
| Seven Fleet Capital Management LP | 8,000 | $698.7K | 0.47% | +8,000 | New |
| Persistent Asset Partners Ltd | 7,908 | $690.7K | 0.33% | −3,872−32.9% | Reduced |
| Tudor Investment Corp Et Al | 7,718 | $674.1K | 0.00% | +7,718 | New |
| Mariner, LLC | 7,620 | $665.6K | 0.00% | −5,931−43.8% | Reduced |
| Horizon Investments, LLC | 7,461 | $651.6K | 0.01% | +7,461 | New |
| Teacher Retirement System of Texas | 7,350 | $641.9K | 0.00% | −4,756−39.3% | Reduced |
| HighTower Advisors, LLC | 7,127 | $622.5K | 0.00% | −1,486−17.3% | Reduced |
| Cambria Investment Management, L.P. | 6,960 | $607.9K | 0.04% | −3,984−36.4% | Reduced |
| AQR Capital Management LLC | 6,954 | $607.4K | 0.00% | −1,616−18.9% | Reduced |
| Mutual of America Capital Management LLC | 6,716 | $586.6K | 0.01% | +165+2.5% | Added |
| Fox Run Management, L.L.C. | 6,654 | $581.2K | 0.09% | +3,551+114.4% | Added |
| Palumbo Wealth Management LLC | 6,340 | $553.7K | 0.14% | +1,072+20.3% | Added |
| PSP Research LLC | 6,121 | $534.6K | 0.47% | +6,121 | New |
| Public Employees Retirement Association of Colorado | 6,001 | $524.0K | 0.00% | 00.0% | Unchanged |
| CAPROCK Group, Inc. | 5,991 | $523.3K | 0.01% | +189+3.3% | Added |
| Fieldview Capital Management, LLC | 5,841 | $510.2K | 0.09% | +5,841 | New |
| Russell Investments Group, Ltd. | 5,723 | $499.8K | 0.00% | −201−3.4% | Reduced |
| Aviva PLC | 5,609 | $489.9K | 0.00% | −2,183−28.0% | Reduced |
| DekaBank Deutsche Girozentrale | 15,800 | $489.0K | 0.00% | 00.0% | Unchanged |
| CWM Advisors, LLC | 5,460 | $476.9K | 0.04% | −1,478−21.3% | Reduced |
| Kestra Advisory Services, LLC | 5,142 | $449.1K | 0.00% | −81−1.6% | Reduced |
| Algert Global LLC | 5,090 | $444.6K | 0.01% | +5,090 | New |
| Arrowstreet Capital, Limited Partnership | 5,076 | $443.3K | 0.00% | +5,076 | New |
| Jefferies Financial Group Inc. | 5,000 | $436.7K | 0.00% | −816,503−99.4% | Reduced |
| Taconic Capital Advisors LP | 5,000 | $436.7K | 0.16% | +5,000 | New |
| Quantinno Capital Management LP | 4,948 | $432.2K | 0.00% | +901+22.3% | Added |