Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Protagonist Therapeutics, Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 319
- +48 vs. Q3 2025
- Shares held
- 71.0M
- +458.8K (+0.7%) vs. Q3 2025
- Total value
- $6.18B
- +$1.49B (+31.8%) vs. Q3 2025
- New holders
- 84
- 99 more added
- Sold out
- 36
- 104 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Avion Wealth | 6 | $0 | 0.00% | +6 | New |
| Harbour Investments, Inc. | 2 | $175 | 0.00% | +2 | New |
| Hughes Financial Services, LLC | 2 | $175 | 0.00% | +2 | New |
| Keating Financial Advisory Services, Inc. | 2 | $175 | 0.00% | +2 | New |
| Root Financial Partners, LLC | 3 | $262 | 0.00% | +3 | New |
| TD Capital Management LLC | 4 | $349 | 0.00% | +4 | New |
| Abound Wealth Management | 4 | $350 | 0.00% | 00.0% | Unchanged |
| Kilter Group LLC | 4 | $350 | 0.00% | 00.0% | Unchanged |
| DecisionPoint Financial, LLC | 4 | $350 | 0.00% | 00.0% | Unchanged |
| Gilpin Wealth Management, LLC | 5 | $437 | 0.00% | +5 | New |
| Flagship Harbor Advisors, LLC | 6 | $524 | 0.00% | +6 | New |
| Trust Co | 7 | $611 | 0.00% | +7 | New |
| SRS Capital Advisors, Inc. | 10 | $874 | 0.00% | −82−89.1% | Reduced |
| Ankerstar Wealth, LLC | 12 | $1.05K | 0.00% | +12 | New |
| CIBC Private Wealth Group, LLC | 13 | $1.14K | 0.00% | +13 | New |
| Triumph Capital Management | 18 | $1.57K | 0.00% | +18 | New |
| ORG Partners LLC | 19 | $1.66K | 0.00% | +19 | New |
| UMA Financial Services, Inc. | 21 | $1.83K | 0.00% | +12+133.3% | Added |
| Elyxium Wealth, LLC | 22 | $1.92K | 0.00% | +22 | New |
| Picton Mahoney Asset Management | 25 | $2.18K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 27 | $2.36K | 0.00% | 00.0% | Unchanged |
| Marquette Asset Management, LLC | 28 | $2.45K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 35 | $3.06K | 0.00% | −4−10.3% | Reduced |
| Wolff Wiese Magana LLC | 35 | $3.06K | 0.00% | 00.0% | Unchanged |
| Farmers & Merchants Investments Inc | 35 | $3.06K | 0.00% | 00.0% | Unchanged |
| Torren Management, LLC | 39 | $3.41K | 0.00% | +39 | New |
| Jones Financial Companies LLLP | 46 | $4.02K | 0.00% | +26+130.0% | Added |
| Raffa Wealth Management, LLC | 60 | $5.24K | 0.00% | 00.0% | Unchanged |
| Sankala Group LLC | 60 | $5.53K | 0.00% | +60 | New |
| SBI Securities Co., Ltd. | 70 | $6.11K | 0.00% | +70 | New |
| Annis Gardner Whiting Capital Advisors, LLC | 76 | $6.64K | 0.00% | 00.0% | Unchanged |
| Brown Brothers Harriman & Co | 81 | $7.08K | 0.00% | 00.0% | Unchanged |
| Bell Investment Advisors, Inc | 81 | $7.08K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 84 | $7.34K | 0.00% | +39+86.7% | Added |
| Rothschild Investment LLC | 86 | $7.51K | 0.00% | +1+1.2% | Added |
| WPG Advisers, LLC | 96 | $8.38K | 0.01% | +18+23.1% | Added |
| MAI Capital Management | 97 | $8.47K | 0.00% | +11+12.8% | Added |
| Danske Bank A/S | 100 | $8.73K | 0.00% | 00.0% | Unchanged |
| SageView Advisory Group, LLC | 106 | $9.26K | 0.00% | +106 | New |
| Parallel Advisors, LLC | 109 | $9.52K | 0.00% | +7+6.9% | Added |
| Bare Financial Services, Inc | 110 | $9.61K | 0.00% | +76+223.5% | Added |
| Massmutual Trust Co FSB | 119 | $10.4K | 0.00% | 00.0% | Unchanged |
| Matrix Trust Co | 143 | $12.0K | 0.00% | +143 | New |
| Signaturefd, LLC | 163 | $14.2K | 0.00% | +14+9.4% | Added |
| Larson Financial Group LLC | 171 | $14.9K | 0.00% | +17+11.0% | Added |
| Kemnay Advisory Services Inc. | 181 | $15.8K | 0.00% | +181 | New |
| Daiwa Securities Group Inc. | 190 | $17.0K | 0.00% | 00.0% | Unchanged |
| Clearstead Advisors, LLC | 222 | $19.4K | 0.00% | +22+11.0% | Added |
| Allworth Financial LP | 255 | $22.3K | 0.00% | +8+3.2% | Added |
| Sound Income Strategies, LLC | 284 | $23.3K | 0.00% | +284 | New |
| Assetmark, Inc | 285 | $24.9K | 0.00% | +5+1.8% | Added |
| Farther Finance Advisors, LLC | 297 | $25.9K | 0.00% | +156+110.6% | Added |
| Greenline Wealth Management LLC | 304 | $26.5K | 0.03% | +304 | New |
| Fifth Third Bancorp | 327 | $28.6K | 0.00% | +20+6.5% | Added |
| Umb Bank N A | 333 | $29.1K | 0.00% | +75+29.1% | Added |
| Sterling Capital Management LLC | 378 | $33.0K | 0.00% | +237+168.1% | Added |
| Salomon & Ludwin, LLC | 436 | $36.7K | 0.00% | −6−1.4% | Reduced |
| Clear Street Markets LLC | 500 | $43.7K | 0.01% | +500 | New |
| EverSource Wealth Advisors, LLC | 559 | $48.8K | 0.00% | +19+3.5% | Added |
| CWM, LLC | 556 | $49.0K | 0.00% | 00.0% | Unchanged |
| CFG Wealth Management Services, Inc. | 602 | $52.6K | 0.05% | +602 | New |
| Hantz Financial Services, Inc. | 951 | $83.0K | 0.00% | +656+222.4% | Added |
| Canton Hathaway, LLC | 1,000 | $87.3K | 0.02% | +1,000 | New |
| Global Retirement Partners, LLC | 1,044 | $91.2K | 0.00% | +728+230.4% | Added |
| Truvestments Capital LLC | 1,161 | $101.4K | 0.02% | +439+60.8% | Added |
| GF Fund Management Co. Ltd. | 1,227 | $107.2K | 0.00% | −111−8.3% | Reduced |
| Covestor Ltd | 1,437 | $125.0K | 0.07% | +447+45.2% | Added |
| Quadrant Capital Group LLC | 1,467 | $128.1K | 0.00% | +115+8.5% | Added |
| KBC Group NV | 1,574 | $137.0K | 0.00% | 00.0% | Unchanged |
| Quest Partners LLC | 1,617 | $141.2K | 0.01% | −1−0.1% | Reduced |
| Smartleaf Asset Management LLC | 1,727 | $150.7K | 0.01% | +324+23.1% | Added |
| Tower Research Capital LLC (TRC) | 2,047 | $178.8K | 0.00% | −1,754−46.1% | Reduced |
| State of Wyoming | 2,070 | $180.8K | 0.02% | +2,070 | New |
| Swiss Life Asset Management Ltd | 2,431 | $212.3K | 0.00% | +2,431 | New |
| Highland Capital Management, LLC | 2,462 | $215.0K | 0.01% | +2,462 | New |
| Sumitomo Mitsui Trust Holdings, Inc. | 2,560 | $223.6K | 0.00% | +2,560 | New |
| CIBC Asset Management Inc | 2,667 | $232.9K | 0.00% | +2,667 | New |
| GAMMA Investing LLC | 2,672 | $233.4K | 0.01% | +1,024+62.1% | Added |
| Captrust Financial Advisors | 2,732 | $238.6K | 0.00% | −580−17.5% | Reduced |
| New Age Alpha Advisors, LLC | 2,784 | $243.2K | 0.01% | +2,784 | New |
| Virtus Investment Advisers, Inc. | 2,790 | $243.7K | 0.07% | +770+38.1% | Added |
| Evergreen Capital Management LLC | 2,812 | $245.6K | 0.01% | +2,812 | New |
| Pinnacle Wealth Planning Services, Inc. | 2,864 | $250.1K | 0.03% | +2,864 | New |
| The PNC Financial Services Group, Inc. | 2,959 | $258.4K | 0.00% | +221+8.1% | Added |
| NBC Securities, Inc. | 2,977 | $260.0K | 0.02% | +19+0.6% | Added |
| Vise Technologies, Inc. | 2,996 | $261.7K | 0.01% | +2,996 | New |
| Mirae Asset Global Investments Co., Ltd. | 3,038 | $265.3K | 0.00% | +633+26.3% | Added |
| AlphaGrep UK Ltd | 3,070 | $268.1K | 0.09% | +3,070 | New |
| Royal Bank of Canada | 3,183 | $278.0K | 0.00% | −66,813−95.5% | Reduced |
| Camden Capital, LLC | 3,251 | $283.9K | 0.02% | −1,284−28.3% | Reduced |
| LPL Financial LLC | 3,265 | $285.2K | 0.00% | −1,729−34.6% | Reduced |
| Rockefeller Capital Management L.P. | 3,292 | $287.5K | 0.00% | +312+10.5% | Added |
| Wealth Enhancement Advisory Services, LLC | 3,554 | $292.4K | 0.00% | +43+1.2% | Added |
| JustInvest LLC | 3,573 | $312.1K | 0.00% | +275+8.3% | Added |
| Mackenzie Financial Corp | 3,648 | $317.7K | 0.00% | −416−10.2% | Reduced |
| Burney Co | 3,680 | $321.4K | 0.01% | −1,384−27.3% | Reduced |
| Velan Capital Investment Management LP | 3,700 | $323.2K | 0.19% | 00.0% | Unchanged |
| M&T Bank Corp | 3,753 | $327.9K | 0.00% | +3,753 | New |
| Abacus Wealth Partners, LLC | 3,763 | $328.7K | 0.03% | +3,763 | New |
| Vestcor Inc | 3,765 | $329.0K | 0.01% | −1,257−25.0% | Reduced |