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Protagonist Therapeutics, Inc

PTGX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001377121

In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.

Holders of 5% or more of PTGX

Holders whose latest Schedule 13D or 13G filing reports 5% or more of Protagonist Therapeutics, Inc, largest stake first. The change is against the holder's previous filing.

Holders of 5% or more of PTGX
HolderLatest formStakeChangeFirst filedLatest filingFiling
BlackRock, Inc.13G/A13.80%8.58M shares−1.00 ppfrom 14.80%Feb 5, 20253 filingsOct 17, 2025SEC
Farallon Capital Management, L.L.C.13G/A9.99%6.43M shares–Feb 16, 20213 filingsAug 13, 2026SEC
Farallon Capital Partners, L.P.13G/A9.99%6.25M shares0.00 ppfrom 9.99%Feb 9, 20234 filingsFeb 6, 2026SEC
RTW Investments, LP13G/A8.10%5.06M shares–Feb 12, 20215 filingsFeb 17, 2026SEC
Vanguard Portfolio Management LLC13G5.53%3.53M sharesNewApr 29, 20261 filingApr 29, 2026SEC
State Street Corp13G5.20%3.32M shares+0.30 ppfrom 4.90%Feb 10, 20229 filingsAug 7, 2026SEC
Wellington Management Group LLP13G5.10%3.17M sharesNewFeb 10, 20261 filingFeb 10, 2026SEC
Vanguard Capital Management LLC13G5.09%3.25M sharesNewApr 30, 20261 filingApr 30, 2026SEC

Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.

13D and 13G filings

67 Schedule 13D and 13G filings on Protagonist Therapeutics, Inc, newest first, including old-format filings without a stake.

Schedule 13D and 13G filings on PTGX
Filed (ET)FilerFormStakeChangeEvent dateFiling
Aug 13, 20265:18 PM ETFarallon Capital Management, L.L.C.and 28 others13G/A9.99%6.43M shares–Jun 30, 2026SEC
Aug 7, 202610:45 AM ETState Street Corp13G5.20%3.32M shares+0.30 ppfrom 4.90%Jun 30, 2026SEC
May 12, 202611:51 AM ETState Street Corp13G4.90%3.12M shares−0.30 ppfrom 5.20%Below 5%Mar 31, 2026SEC
Apr 30, 202611:57 AM ETVanguard Capital Management LLC13G5.09%3.25M sharesNewMar 31, 2026SEC
Apr 29, 20262:43 PM ETVanguard Portfolio Management LLC13G5.53%3.53M sharesNewMar 31, 2026SEC
Mar 27, 202611:33 AM ETVanguard Group Inc13G/A0.00%0 shares−8.65 ppfrom 8.65%Below 5%Mar 13, 2026SEC
Feb 17, 20268:41 AM ETRTW Investments, LPand 1 other13G/A8.10%5.06M shares–Dec 31, 2025SEC
Feb 10, 202611:19 AM ETWellington Management Group LLPand 2 others13G5.10%3.17M sharesNewDec 31, 2025SEC
Feb 6, 20264:10 PM ETFarallon Capital Partners, L.P.and 30 others13G/A9.99%6.25M shares0.00 ppfrom 9.99%Dec 31, 2025SEC
Jan 30, 20262:43 PM ETVanguard Group Inc13G/A8.65%5.41M shares–Dec 31, 2025SEC
Nov 14, 20254:17 PM ETBiotechnology Value Fund L Pand 9 others13G/A4.10%2.56M shares−1.10 ppfrom 5.20%Below 5%Sep 30, 2025SEC
Nov 14, 20258:23 AM ETDeep Track Capital, LPand 2 others13G/A2.76%1.72M shares−2.53 ppfrom 5.29%Below 5%Sep 30, 2025SEC
Oct 17, 20256:24 PM ETBlackRock, Inc.13G/A13.80%8.58M shares−1.00 ppfrom 14.80%Sep 30, 2025SEC
Aug 11, 20258:04 AM ETState Street Corp13G5.20%3.21M shares+0.80 ppfrom 4.40%Jun 30, 2025SEC
Jun 16, 20255:30 PM ETBiotechnology Value Fund L Pand 9 others13G5.20%3.21M shares–Jun 9, 2025SEC
May 13, 202512:10 PM ETState Street Corp13G4.40%2.71M shares–Below 5%Mar 31, 2025SEC
Apr 29, 20252:53 PM ETBlackRock, Inc.13G/A14.80%9.08M shares−1.80 ppfrom 16.60%Mar 31, 2025SEC
Apr 10, 20254:14 PM ETDeep Track Capital, LPand 2 others13G5.29%3.25M sharesNewApr 3, 2025SEC
Feb 10, 20259:00 AM ETFarallon Capital Partners, L.P.and 29 others13G/A9.99%5.96M shares–Dec 31, 2024SEC
Feb 5, 20251:23 PM ETBlackRock, Inc.13G/A16.60%9.88M shares–Dec 31, 2024SEC
Nov 14, 2024Biotechnology Value Fund L P13G/AOld format–––SEC
Nov 12, 2024Vanguard Group Inc13G/AOld format–––SEC
Nov 4, 2024Vanguard Group Inc13G/AOld format–––SEC
Oct 16, 2024State Street Corp13GOld format–––SEC
Aug 7, 20244:10 PM ETBlackRock Inc.13G/AOld format–––SEC
Feb 14, 2024Citadel Advisors LLC13G/AOld format–––SEC
Feb 14, 2024Biotechnology Value Fund L P13G/AOld format–––SEC
Feb 14, 2024RTW Investments, LP13G/AOld format–––SEC
Feb 14, 2024Point72 Asset Management, L.P.13G/AOld format–––SEC
Feb 13, 2024Vanguard Group Inc13G/AOld format–––SEC
Feb 7, 2024Adage Capital Partners GP, L.L.C.13G/AOld format–––SEC
Feb 2, 2024Farallon Capital Partners, L.P.13G/AOld format–––SEC
Jan 24, 20242:27 PM ETBlackRock Inc.13G/AOld format–––SEC
Jan 23, 2024State Street Corp13G/AOld format–––SEC
Dec 18, 2023Point72 Asset Management, L.P.13GOld format–––SEC
Apr 13, 2023Adage Capital Partners GP, L.L.C.13GOld format–––SEC
Mar 20, 2023Biotechnology Value Fund L P13GOld format–––SEC
Feb 14, 2023Biotechnology Value Fund L P13G/AOld format–––SEC
Feb 14, 2023RTW Investments, LP13G/AOld format–––SEC
Feb 14, 2023Point72 Asset Management, L.P.13G/AOld format–––SEC
Feb 9, 2023Farallon Capital Partners, L.P.13G/AOld format–––SEC
Feb 9, 2023Vanguard Group Inc13GOld format–New–SEC
Jan 31, 20231:58 PM ETBlackRock Inc.13G/AOld format–––SEC
Jan 11, 20231:00 PM ETJohnson & Johnson13G/AOld format–––SEC
Jan 10, 2023State Street Corp13G/AOld format–––SEC
Jan 3, 2023Citadel Advisors LLC13GOld format–New–SEC
Dec 12, 2022FMR LLC13G/AOld format–––SEC
Jul 11, 2022State Street Corp13G/AOld format–––SEC
Jun 10, 2022FMR LLC13G/AOld format–––SEC
Feb 14, 2022Consonance Capital Management LP13G/AOld format–––SEC

Form 144: proposed insider sales

Notices from officers, directors and other affiliates planning to sell Protagonist Therapeutics, Inc shares.

No Form 144 notices for Protagonist Therapeutics, Inc are on file.