Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
Holders of 5% or more of PTGX
Holders whose latest Schedule 13D or 13G filing reports 5% or more of Protagonist Therapeutics, Inc, largest stake first. The change is against the holder's previous filing.
| Holder | Latest form | Stake | Change | First filed | Latest filing | Filing |
|---|---|---|---|---|---|---|
| BlackRock, Inc. | 13G/A | 13.80%8.58M shares | −1.00 ppfrom 14.80% | Feb 5, 20253 filings | Oct 17, 2025 | SEC |
| Farallon Capital Management, L.L.C. | 13G/A | 9.99%6.43M shares | – | Feb 16, 20213 filings | Aug 13, 2026 | SEC |
| Farallon Capital Partners, L.P. | 13G/A | 9.99%6.25M shares | 0.00 ppfrom 9.99% | Feb 9, 20234 filings | Feb 6, 2026 | SEC |
| RTW Investments, LP | 13G/A | 8.10%5.06M shares | – | Feb 12, 20215 filings | Feb 17, 2026 | SEC |
| Vanguard Portfolio Management LLC | 13G | 5.53%3.53M shares | New | Apr 29, 20261 filing | Apr 29, 2026 | SEC |
| State Street Corp | 13G | 5.20%3.32M shares | +0.30 ppfrom 4.90% | Feb 10, 20229 filings | Aug 7, 2026 | SEC |
| Wellington Management Group LLP | 13G | 5.10%3.17M shares | New | Feb 10, 20261 filing | Feb 10, 2026 | SEC |
| Vanguard Capital Management LLC | 13G | 5.09%3.25M shares | New | Apr 30, 20261 filing | Apr 30, 2026 | SEC |
Stakes are as of each holder's latest filing. Holders whose last filing was in the old format (before December 18, 2024) have no stake on record and are not listed, and after an acquisition or delisting holders usually stop filing.
13D and 13G filings
67 Schedule 13D and 13G filings on Protagonist Therapeutics, Inc, newest first, including old-format filings without a stake.
| Filed (ET) | Filer | Form | Stake | Change | Event date | Filing |
|---|---|---|---|---|---|---|
| Feb 14, 2022 | Biotechnology Value Fund L P | 13G/AOld format | – | – | – | SEC |
| Feb 14, 2022 | RTW Investments, LP | 13G/AOld format | – | – | – | SEC |
| Feb 14, 2022 | Point72 Asset Management, L.P. | 13G/AOld format | – | – | – | SEC |
| Feb 11, 2022 | Farallon Capital Management, L.L.C. | 13G/AOld format | – | – | – | SEC |
| Feb 10, 2022 | State Street Corp | 13GOld format | – | New | – | SEC |
| Feb 9, 2022 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Feb 2, 20227:11 PM ET | BlackRock Inc. | 13G/AOld format | – | – | – | SEC |
| Sep 21, 2021 | Point72 Asset Management, L.P. | 13GOld format | – | New | – | SEC |
| Feb 17, 2021 | Consonance Capital Management LP | 13GOld format | – | – | – | SEC |
| Feb 16, 2021 | Farallon Capital Management, L.L.C. | 13G/AOld format | – | – | – | SEC |
| Feb 16, 2021 | Consonance Capital Management LP | 13GOld format | – | New | – | SEC |
| Feb 16, 2021 | Biotechnology Value Fund L P | 13G/AOld format | – | – | – | SEC |
| Feb 12, 2021 | RTW Investments, LP | 13G/AOld format | – | – | – | SEC |
| Feb 11, 2021 | Adage Capital Partners GP, L.L.C. | 13G/AOld format | – | – | – | SEC |
| Feb 8, 2021 | FMR LLC | 13G/AOld format | – | – | – | SEC |
| Feb 2, 20213:13 PM ET | BlackRock Inc. | 13GOld format | – | New | – | SEC |
| Feb 1, 20215:41 PM ET | Johnson & Johnson | 13G/AOld format | – | – | – | SEC |
Form 144: proposed insider sales
48 notices from officers, directors and other affiliates planning to sell Protagonist Therapeutics, Inc shares, newest first.
| Filed (ET) | Seller | Shares to sell | Market value | Planned sale | Broker | Filing |
|---|---|---|---|---|---|---|
| Jun 23, 20264:27 PM ET | William WaddillDirector | 9.00K | $1.04M | Jun 23, 202610b5-1 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jun 10, 20264:29 PM ET | William WaddillDirector | 9.00K | $952.8K | Jun 10, 202610b5-1 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| May 29, 20264:23 PM ET | William WaddillDirector | 9.00K | $903.7K | May 29, 202610b5-1 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| May 12, 20265:29 PM ET | Dinesh PatelCEO | 75.0K | $7.76M | May 12, 202610b5-1 | J.P. Morgan Securities LLC | SEC |
| May 8, 20264:23 PM ET | Bryan M & Courtney L Giraudo RTDirector | 11.1K | $1.11M | May 8, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| May 7, 20265:21 PM ET | Bryan GiraudoDirector | 36.0K | $3.60M | May 7, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| May 7, 20264:49 PM ET | Bryan M & Courtney L Giraudo RTDirector | 12.0K | $1.20M | May 7, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Apr 21, 20264:57 PM ET | Asif AliOfficer | 1.75K | $184.6K | Apr 20, 2026 | Morgan Stanley Smith Barney Operations Department | SEC |
| Mar 26, 20264:05 PM ET | Harold SelickDirector | 24.0K | $2.52M | Mar 26, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Mar 26, 20264:05 PM ET | Asif AliOfficer | 24.8K | $2.58M | Mar 26, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Mar 26, 20264:01 PM ET | Arturo MolinaOfficer | 15.0K | $1.57M | Mar 26, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Mar 24, 20265:56 PM ET | Dinesh PatelCEO | 54.7K | $5.39M | Mar 24, 2026 | J.P. Morgan Securities LLC | SEC |
| Feb 17, 20265:27 PM ET | Lewis T WilliamsDirector | 18.0K | $1.48M | Feb 17, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Feb 6, 20264:04 PM ET | William D WaddillDirector | 20.0K | $1.67M | Feb 6, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jan 27, 20265:12 PM ET | Asif AliOfficer | 46.2K | $3.84M | Jan 27, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jan 27, 20264:01 PM ET | Arturo MolinaOfficer | 5.00K | $410.0K | Jan 27, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jan 26, 20264:29 PM ET | Arturo MolinaOfficer | 5.00K | $411.4K | Jan 26, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jan 23, 20264:32 PM ET | Arturo MolinaOfficer | 13.2K | $1.10M | Jan 23, 2026 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Jan 23, 20264:06 PM ET | Dinesh PatelCEO | 108.3K | $9.16M | Jan 23, 2026 | J.P. Morgan Securities LLC | SEC |
| Jan 21, 20265:12 PM ET | Arturo Molina MDOfficer | 9.51K | $784.7K | Jan 20, 2026 | Morgan Stanley Smith Barney Operations Department | SEC |
| Jan 21, 20265:11 PM ET | Dinesh V Patel PH DOfficer, Director | 34.4K | $2.84M | Jan 20, 2026 | Morgan Stanley Smith Barney Operations Department | SEC |
| Jan 21, 20265:10 PM ET | Asif AliOfficer | 8.59K | $708.3K | Jan 20, 2026 | Morgan Stanley Smith Barney Operations Department | SEC |
| Oct 10, 20254:18 PM ET | William WaddillDirector | 12.0K | $804.5K | Oct 10, 202510b5-1 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Sep 22, 20254:27 PM ET | William WaddillDirector | 4.00K | $248.8K | Sep 22, 202510b5-1 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
| Aug 27, 20254:33 PM ET | William WaddillDirector | 4.00K | $228.0K | Aug 27, 202510b5-1 | Morgan Stanley Smith Barney LLC Executive Financial Services | SEC |
Showing the latest 25. See the PTGX notices from the last 12 months