Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 322
- +10 vs. Q4 2025
- Shares held
- 78.9M
- +13.3M (+20.3%) vs. Q4 2025
- Total value
- $8.31B
- +$2.61B (+45.7%) vs. Q4 2025
- New holders
- 60
- 111 more added
- Sold out
- 50
- 104 more reduced
7 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Assetmark, Inc | 46,442 | $4.89M | 0.01% | +46,157+16,195.4% | Added |
| Vanguard Asset Management, Ltd | 46,386 | $4.89M | 0.00% | +46,386 | New |
| OrbiMed Advisors LLC | 42,100 | $4.44M | 0.10% | +20,400+94.0% | Added |
| Russell Investments Group, Ltd. | 40,376 | $4.26M | 0.00% | +34,653+605.5% | Added |
| Thrivent Financial for Lutherans | 39,225 | $4.13M | 0.01% | −1,155−2.9% | Reduced |
| Elmind Capital, LP | 38,000 | $4.01M | 1.14% | 00.0% | Unchanged |
| State of Alaska, Department of Revenue | 37,147 | $3.91M | 0.04% | −952−2.5% | Reduced |
| Birchview Capital, LP | 35,000 | $3.69M | 2.10% | −20,000−36.4% | Reduced |
| HighVista Strategies LLC | 33,852 | $3.57M | 0.99% | −39,693−54.0% | Reduced |
| MetLife Investment Management | 31,799 | $3.35M | 0.02% | −641−2.0% | Reduced |
| LMR Partners LLP | 30,850 | $3.25M | 0.03% | −9,150−22.9% | Reduced |
| State of Wisconsin Investment Board | 30,767 | $3.24M | 0.01% | −4,019−11.6% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 30,604 | $3.21M | 0.00% | −185−0.6% | Reduced |
| Wells Fargo & Company | 30,072 | $3.17M | 0.00% | −41,573−58.0% | Reduced |
| Allspring Global Investments Holdings, LLC | 29,916 | $3.10M | 0.01% | +25,931+650.7% | Added |
| Illinois Municipal Retirement Fund | 28,596 | $3.01M | 0.04% | −2,648−8.5% | Reduced |
| Pathstone Holdings, LLC | 28,252 | $2.98M | 0.01% | +11,811+71.8% | Added |
| EAM Investors, LLC | 27,914 | $2.94M | 0.34% | −50,584−64.4% | Reduced |
| Granahan Investment Management Inc | 27,391 | $2.89M | 0.14% | +27,391 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 27,260 | $2.87M | 0.01% | +13,990+105.4% | Added |
| Teachers Retirement System of the State of Kentucky | 26,528 | $2.80M | 0.02% | 00.0% | Unchanged |
| Louisiana State Employees Retirement System | 26,100 | $2.75M | 0.05% | −800−3.0% | Reduced |
| Vanguard Global Advisers, LLC | 24,665 | $2.60M | 0.00% | +24,665 | New |
| Polen Capital Management LLC | 24,337 | $2.57M | 0.02% | +3,988+19.6% | Added |
| Exchange Traded Concepts, LLC | 23,773 | $2.51M | 0.02% | −11,266−32.2% | Reduced |
| Calamos Advisors LLC | 23,473 | $2.47M | 0.01% | +23,473 | New |
| State of Tennessee, Treasury Department | 23,297 | $2.46M | 0.01% | −229−1.0% | Reduced |
| Artia Global Partners LP | 22,931 | $2.42M | 0.54% | −20−0.1% | Reduced |
| Profund Advisors LLC | 22,867 | $2.41M | 0.09% | −2,707−10.6% | Reduced |
| Natixis Advisors, L.P. | 22,638 | $2.39M | 0.00% | +2,143+10.5% | Added |
| Gotham Asset Management, LLC | 21,155 | $2.23M | 0.01% | −440−2.0% | Reduced |
| Handelsbanken Fonder AB | 19,900 | $2.10M | 0.01% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 18,382 | $1.94M | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 18,097 | $1.91M | 0.00% | −1,900−9.5% | Reduced |
| State of New Jersey Common Pension Fund D | 17,092 | $1.80M | 0.01% | +105+0.6% | Added |
| Amalgamated Bank | 16,852 | $1.78M | 0.01% | −211−1.2% | Reduced |
| Envestnet Asset Management Inc | 16,317 | $1.72M | 0.00% | +1,644+11.2% | Added |
| State Board of Administration of Florida Retirement System | 16,303 | $1.72M | 0.00% | 00.0% | Unchanged |
| Yousif Capital Management, LLC | 16,232 | $1.71M | 0.02% | −49−0.3% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 15,834 | $1.67M | 0.01% | 00.0% | Unchanged |
| STRS Ohio | 15,400 | $1.62M | 0.01% | −500−3.1% | Reduced |
| Guggenheim Capital LLC | 15,280 | $1.61M | 0.01% | −15,816−50.9% | Reduced |
| Bamco Inc | 15,000 | $1.58M | 0.00% | +6,700+80.7% | Added |
| China Universal Asset Management Co., Ltd. | 14,923 | $1.57M | 0.12% | +1,136+8.2% | Added |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 14,532 | $1.53M | 0.01% | −16−0.1% | Reduced |
| Bellevue Group AG | 14,447 | $1.52M | 0.04% | −2,096−12.7% | Reduced |
| Barclays PLC | 14,405 | $1.52M | 0.00% | −173,237−92.3% | Reduced |
| Royce & Associates LP | 14,349 | $1.51M | 0.01% | −2,640−15.5% | Reduced |
| Arizona State Retirement System | 13,738 | $1.45M | 0.01% | −287−2.0% | Reduced |
| Oregon Public Employees Retirement Fund | 13,456 | $1.42M | 0.02% | +63+0.5% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,412 | $1.41M | 0.00% | +3,339+33.1% | Added |
| Fifth Third Bancorp | 13,202 | $1.39M | 0.00% | +12,875+3,937.3% | Added |
| Intech Investment Management LLC | 13,006 | $1.37M | 0.01% | −9,479−42.2% | Reduced |
| Virginia Retirement Systems Et Al | 13,000 | $1.37M | 0.01% | −12,400−48.8% | Reduced |
| Bleakley Financial Group, LLC | 12,802 | $1.35M | 0.02% | +12,802 | New |
| Erste Asset Management GmbH | 13,500 | $1.35M | 0.01% | 00.0% | Unchanged |
| Winton Group Ltd | 12,673 | $1.34M | 0.05% | +1,202+10.5% | Added |
| Vanguard Investments Australia, Ltd. | 12,130 | $1.28M | 0.00% | +12,130 | New |
| ProShare Advisors LLC | 11,918 | $1.26M | 0.00% | −2,166−15.4% | Reduced |
| AQR Capital Management LLC | 11,874 | $1.25M | 0.00% | +4,920+70.8% | Added |
| Franklin Street Advisors Inc | 11,085 | $1.17M | 0.07% | −215−1.9% | Reduced |
| Toroso Investments, LLC | 11,034 | $1.16M | 0.00% | +11,034 | New |
| KLP Kapitalforvaltning AS | 11,000 | $1.16M | 0.00% | +400+3.8% | Added |
| Hussman Strategic Advisors, Inc. | 10,500 | $1.11M | 0.24% | −2,100−16.7% | Reduced |
| Nomura Holdings Inc | 10,479 | $1.10M | 0.01% | −7,042−40.2% | Reduced |
| Cache Advisors, LLC | 10,143 | $1.07M | 0.12% | 00.0% | Unchanged |
| Weiss Asset Management LP | 9,780 | $1.03M | 0.02% | +9,780 | New |
| J. Goldman & Co LP | 9,714 | $1.02M | 0.05% | −36,611−79.0% | Reduced |
| Allianz Asset Management GmbH | 9,600 | $1.01M | 0.00% | −3,400−26.2% | Reduced |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 9,334 | $983.8K | 1.43% | +9,334 | New |
| Glenmede Trust Co NA | 9,235 | $973.4K | 0.00% | −3,520−27.6% | Reduced |
| AlphaCentric Advisors LLC | 9,040 | $952.8K | 0.95% | +491+5.7% | Added |
| Maryland State Retirement & Pension System | 8,567 | $903.0K | 0.02% | −36−0.4% | Reduced |
| Cambria Investment Management, L.P. | 6,865 | $723.6K | 0.04% | −95−1.4% | Reduced |
| Mutual of America Capital Management LLC | 6,725 | $708.8K | 0.01% | +9+0.1% | Added |
| Teacher Retirement System of Texas | 6,448 | $679.6K | 0.00% | −902−12.3% | Reduced |
| Quantinno Capital Management LP | 6,437 | $678.5K | 0.00% | +1,489+30.1% | Added |
| Brinker Capital Investments, LLC | 6,407 | $675.3K | 0.01% | +2,011+45.7% | Added |
| Palumbo Wealth Management LLC | 6,083 | $641.1K | 0.16% | −257−4.1% | Reduced |
| E Fund Management Co., Ltd. | 6,033 | $635.9K | 0.02% | +6,033 | New |
| Public Employees Retirement Association of Colorado | 6,001 | $633.0K | 0.00% | 00.0% | Unchanged |
| Bank of Montreal | 5,757 | $606.8K | 0.00% | +1,949+51.2% | Added |
| Cerity Partners LLC | 5,693 | $600.0K | 0.00% | −3,356−37.1% | Reduced |
| JustInvest LLC | 5,672 | $597.8K | 0.01% | +2,099+58.7% | Added |
| Xponance, Inc. | 5,472 | $576.7K | 0.00% | +884+19.3% | Added |
| HighTower Advisors, LLC | 5,386 | $567.7K | 0.00% | −1,741−24.4% | Reduced |
| Bridgewater Associates, LP | 5,276 | $556.1K | 0.00% | +5,276 | New |
| Kestra Advisory Services, LLC | 5,054 | $532.7K | 0.00% | −88−1.7% | Reduced |
| CWM Advisors, LLC | 5,036 | $530.8K | 0.03% | −424−7.8% | Reduced |
| Tower Research Capital LLC (TRC) | 4,961 | $522.9K | 0.01% | +2,914+142.4% | Added |
| Skopos Labs, Inc. | 4,925 | $519.1K | 0.02% | +594+13.7% | Added |
| Pacer Advisors, Inc. | 4,916 | $518.0K | 0.00% | +4,916 | New |
| Rockefeller Capital Management L.P. | 4,828 | $508.9K | 0.00% | +1,536+46.7% | Added |
| Los Angeles Capital Management LLC | 4,727 | $498.2K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 4,725 | $498.0K | 0.02% | 00.0% | Unchanged |
| Advisors Asset Management, Inc. | 4,644 | $489.5K | 0.01% | −60−1.3% | Reduced |
| Cynosure Management, LLC | 4,635 | $488.5K | 0.06% | +4,635 | New |
| Dymon Asia Capital (Singapore) Pte. Ltd. | 4,600 | $484.8K | 0.11% | −5,400−54.0% | Reduced |
| Ensign Peak Advisors, Inc | 4,486 | $472.8K | 0.00% | 00.0% | Unchanged |
| Vident Advisory, LLC | 4,481 | $472.3K | 0.00% | +290+6.9% | Added |